Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
  • Page of 1
Nappi F, Avtaar Singh SS, Padala M, Attias D, Nejjari M, Mihos CG, Benedetto U, Michler R. The Choice of Treatment in Ischemic Mitral Regurgitation With Reduced Left Ventricular Function. Ann Thorac Surg. 2019 Dec;108(6):1901-1912. doi: 10.1016/j.athoracsur.2019.06.039. Epub 2019 Aug 22. Review. PubMed PMID: 31445916; PubMed Central PMCID: PMC7424599.
Onohara D, Corporan D, Hernandez-Merlo RJ, Guyton RA, Padala M. Mitral Regurgitation Worsens Cardiac Remodeling in Ischemic Cardiomyopathy in an Experimental Model. Journal of Thoracic and Cardiovascular Surgery. 2019 August. doi:
Chawla SK, Frater RWM, Cunningham M, Padala M. Performance and healing of an expanded polytetrafluoroethylene multichordal device at 6 months after repair of mitral leaflet flail in swine. J Thorac Cardiovasc Surg. 2019 Mar;157(3):932-940.e3. doi: 10.1016/j.jtcvs.2018.07.103. Epub 2018 Sep 25. PubMed PMID: 30366754; PubMed Central PMCID: PMC6433545.
Padala M. Stress in the time of transcatheter aortic valve replacement. J Thorac Cardiovasc Surg. 2019 Feb;157(2):537. doi: 10.1016/j.jtcvs.2018.10.127. Epub 2018 Nov 8. PubMed PMID: 30527726; PubMed Central PMCID: PMC6677538.
Padala M. Aortic root anatomy as a factor in the fluid mechanics of transcatheter aortic valve replacement. J Thorac Cardiovasc Surg. 2019 Feb;157(2):550-551. doi: 10.1016/j.jtcvs.2018.10.093. Epub 2018 Oct 28. PubMed PMID: 30527722; PubMed Central PMCID: PMC6677542.
Sielicka A, Sarin EL, Shi W, Sulejmani F, Corporan D, Kalra K, Thourani VH, Sun W, Guyton RA, Padala M. Pathological Remodeling of Mitral Valve Leaflets from Unphysiologic Leaflet Mechanics after Undersized Mitral Annuloplasty to Repair Ischemic Mitral Regurgitation. J Am Heart Assoc. 2018 Nov 6;7(21):e009777. doi: 10.1161/JAHA.118.009777. PubMed PMID: 30571381; PubMed Central PMCID: PMC6404183.
Corporan D, Onohara D, Hernandez-Merlo R, Sielicka A, Padala M. Temporal changes in myocardial collagen, matrix metalloproteinases, and their tissue inhibitors in the left ventricular myocardium in experimental chronic mitral regurgitation in rodents. Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1269-H1278. doi: 10.1152/ajpheart.00099.2018. Epub 2018 Aug 24. PubMed PMID: 30141979; PubMed Central PMCID: PMC6297825.
Padala M. A heart valve is no stronger than its weakest link: The need to improve durability of pericardial leaflets. J Thorac Cardiovasc Surg. 2018 Jul;156(1):207-208. doi: 10.1016/j.jtcvs.2018.03.034. Epub 2018 Mar 17. PubMed PMID: 29636190; PubMed Central PMCID: PMC6677540.
Padala M. Patient-specific computational biomechanical modeling to guide mitral valve repair strategy: Practicality and value?. J Thorac Cardiovasc Surg. 2018 Feb;155(2):606-607. doi: 10.1016/j.jtcvs.2017.09.132. PubMed PMID: 29415388; PubMed Central PMCID: PMC6677541.
Padala M. The arithmetic of a successful mitral valve repair. J Thorac Cardiovasc Surg. 2017 Nov;154(5):1638-1640. doi: 10.1016/j.jtcvs.2017.07.043. Epub 2017 Aug 4. PubMed PMID: 28888372.
Chawla SK, Padala M, Chitwood WR Jr, Frater RWM. Use of a New Expanded Polytetrafluoroethylene Multichordal Mitral Apparatus (MitraPatch) to Repair Complex Mitral Valve Lesions. Innovations (Phila). 2017 Nov/Dec;12(6):411-417. doi: 10.1097/IMI.0000000000000434. PubMed PMID: 29232298.
Shi W, McIver BV, Kalra K, Sarin EL, Schmarkey S, Duggan M, Thourani VH, Guyton RA, Padala M. A Swine Model of Percutaneous Intracoronary Ethanol Induced Acute Myocardial Infarction and Ischemic Mitral Regurgitation. J Cardiovasc Transl Res. 2017 Aug;10(4):391-400. doi: 10.1007/s12265-017-9751-3. Epub 2017 Jun 2. PubMed PMID: 28577038.
Padala M. Invited Commentary. Ann Thorac Surg. 2017 Mar;103(3):827. doi: 10.1016/j.athoracsur.2016.08.018. PubMed PMID: 28219548.
Espiritu D, Onohara D, Kalra K, Sarin EL, Padala M. Transcatheter Mitral Valve Repair Therapies: Evolution, Status and Challenges. Ann Biomed Eng. 2017 Feb;45(2):332-359. doi: 10.1007/s10439-016-1655-x. Epub 2016 May 27. Review. PubMed PMID: 27234818.
Girish A, Padala M, Kalra K, McIver BV, Veeraswamy RK, Chen EP, Leshnower BG. The Impact of Intimal Tear Location and Partial False Lumen Thrombosis in Acute Type B Aortic Dissection. Ann Thorac Surg. 2016 Dec;102(6):1925-1932. doi: 10.1016/j.athoracsur.2016.05.020. Epub 2016 Jul 15. PubMed PMID: 27424468.
Padala M. Biomaterials for heart valve replacement: Conjectures and refutations. J Thorac Cardiovasc Surg. 2016 Oct;152(4):1175-6. doi: 10.1016/j.jtcvs.2016.05.055. Epub 2016 Jun 5. PubMed PMID: 27349286.
Padala M. Papillary Muscle Approximation Is an Anatomically Correct Repair for Ischemic Mitral Regurgitation. J Am Coll Cardiol. 2016 Sep 6;68(10):1146-7. doi: 10.1016/j.jacc.2016.06.030. PubMed PMID: 27585516.
Padala M. Invited Commentary on Ge et al. Ann Thorac Surg 2016;101:1691-9. Ann Thorac Surg. 2016 Jun;101(6):e211. doi: 10.1016/j.athoracsur.2015.11.046. PubMed PMID: 27211984.
Guyton RA, Padala M. Transcatheter Aortic Valve Replacement in Bicuspid Aortic Stenosis: Early Success But Concerning Red Flags. JACC Cardiovasc Interv. 2016 Apr 25;9(8):825-827. doi: 10.1016/j.jcin.2016.02.042. PubMed PMID: 27101907.
Chawla SK, Shi W, McIver BV, Vinten-Johansen J, Frater RW, Padala M. Pre-clinical Experience with a Multi-Chordal Patch for Mitral Valve Repair. J Cardiovasc Transl Res. 2016 Apr;9(2):127-34. doi: 10.1007/s12265-016-9674-4. Epub 2016 Jan 22. PubMed PMID: 26801477.
Padala M. Invited Commentary. Ann Thorac Surg. 2016 Feb;101(2):575. doi: 10.1016/j.athoracsur.2015.09.064. PubMed PMID: 26777921.
Sarin EL, Shi W, Duara R, Melone TA, Kalra K, Strong A, Girish A, McIver BV, Thourani VH, Guyton RA, Padala M. Swine (Sus scrofa) as a Model of Postinfarction Mitral Regurgitation and Techniques to Accommodate Its Effects during Surgical Repair. Comp Med. 2016;66(4):290-9. PubMed PMID: 27538860; PubMed Central PMCID: PMC4983171.
Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Le Marec H, Le Tourneau T, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH. Mitral valve disease--morphology and mechanisms. Nat Rev Cardiol. 2015 Dec;12(12):689-710. doi: 10.1038/nrcardio.2015.161. Epub 2015 Oct 20. Review. PubMed PMID: 26483167; PubMed Central PMCID: PMC4804623.
Kalra K, Wang Q, McIver BV, Shi W, Guyton RA, Sun W, Sarin EL, Thourani VH, Padala M. Temporal changes in interpapillary muscle dynamics as an active indicator of mitral valve and left ventricular interaction in ischemic mitral regurgitation. J Am Coll Cardiol. 2014 Nov 4;64(18):1867-79. doi: 10.1016/j.jacc.2014.07.988. Epub 2014 Oct 27. PubMed PMID: 25444139.
Lam A, Clement-Guinaudeau S, Padala M, Eisner RL, Thourani V, Vadnais D, Hurst S, Guyton RA, Oshinksi JN. Postsurgical hemodynamics of the aortic valve bypass operation evaluated with phase contrast magnetic resonance. J Magn Reson Imaging. 2014 Oct;40(4):899-905. doi: 10.1002/jmri.24423. Epub 2013 Nov 4. PubMed PMID: 24811700.
Miragoli M, Yacoub MH, El-Hamamsy I, Sanchez-Alonso JL, Moshkov A, Mongkoldhumrongkul N, Padala M, Paramagurunathan S, Sarathchandra P, Korchev YE, Gorelik J, Chester AH. Side-specific mechanical properties of valve endothelial cells. Am J Physiol Heart Circ Physiol. 2014 Jul 1;307(1):H15-24. doi: 10.1152/ajpheart.00228.2013. PubMed PMID: 24791787.
Padala M, Sweet M, Hooson S, Thourani VH, Yoganathan AP. Hemodynamic comparison of mitral valve repair: techniques for a flail anterior leaflet. J Heart Valve Dis. 2014 Mar;23(2):171-6. PubMed PMID: 25076547.
Padala M, Gyoneva LI, Thourani VH, Yoganathan AP. Impact of mitral valve geometry on hemodynamic efficacy of surgical repair in secondary mitral regurgitation. J Heart Valve Dis. 2014 Jan;23(1):79-87. PubMed PMID: 24779332.
Thourani VH, Gunter RL, Hurst S, Kilgo P, Padala M, Puskas JD, Lattouf OM, Halkos ME, Guyton RA. Postoperative warfarin following mitral valve repair or bioprosthetic valve replacement. J Heart Valve Dis. 2013 Sep;22(5):716-23. PubMed PMID: 24383387.
Padala M, Cardinau B, Gyoneva LI, Thourani VH, Yoganathan AP. Comparison of artificial neochordae and native chordal transfer in the repair of a flail posterior mitral leaflet: an experimental study. Ann Thorac Surg. 2013 Feb;95(2):629-33. doi: 10.1016/j.athoracsur.2012.09.055. Epub 2013 Jan 3. PubMed PMID: 23291143; PubMed Central PMCID: PMC3631597.
Padala M, Gyoneva L, Yoganathan AP. Effect of anterior strut chordal transection on the force distribution on the marginal chordae of the mitral valve. J Thorac Cardiovasc Surg. 2012 Sep;144(3):624-633.e2. doi: 10.1016/j.jtcvs.2011.10.032. Epub 2011 Dec 7. PubMed PMID: 22154223; PubMed Central PMCID: PMC3307892.
Padala M, Jimenez JH, Yoganathan AP, Chin A, Thourani VH. Transapical beating heart cardioscopy technique for off-pump visualization of heart valves. J Thorac Cardiovasc Surg. 2012 Jul;144(1):231-4. doi: 10.1016/j.jtcvs.2011.11.038. Epub 2012 Feb 15. PubMed PMID: 22341423.
Yamauchi H, Vasilyev NV, Marx GR, Loyola H, Padala M, Yoganathan AP, del Nido PJ. Right ventricular papillary muscle approximation as a novel technique of valve repair for functional tricuspid regurgitation in an ex vivo porcine model. J Thorac Cardiovasc Surg. 2012 Jul;144(1):235-42. doi: 10.1016/j.jtcvs.2012.01.028. Epub 2012 Feb 16. PubMed PMID: 22341187.
Balachandran K, Hussain S, Yap CH, Padala M, Chester AH, Yoganathan AP. Elevated cyclic stretch and serotonin result in altered aortic valve remodeling via a mechanosensitive 5-HT(2A) receptor-dependent pathway. Cardiovasc Pathol. 2012 May-Jun;21(3):206-13. doi: 10.1016/j.carpath.2011.07.005. Epub 2011 Aug 23. PubMed PMID: 21865058.
Saikrishnan N, Siefert AW, Rabbah JP, Padala M, Yoganathan AP. Letter regarding the article by Vismara et al published in Int J Artif Organs 2011; 34(4): 383-391. Int J Artif Organs. 2012 Feb;35(2):158-9; author reply 160-1. doi: 10.5301/ijao.5000073. PubMed PMID: 22395916.
Weiler M, Yap CH, Balachandran K, Padala M, Yoganathan AP. Regional analysis of dynamic deformation characteristics of native aortic valve leaflets. J Biomech. 2011 May 17;44(8):1459-65. doi: 10.1016/j.jbiomech.2011.03.017. Epub 2011 Apr 1. PubMed PMID: 21458817; PubMed Central PMCID: PMC3089945.
Padala M, Keeling WB, Guyton RA, Thourani VH. Innovations in therapies for heart valve disease. Circ J. 2011;75(5):1028-41. doi: 10.1253/circj.cj-11-0289. Epub 2011 Apr 9. Review. PubMed PMID: 21478626.
Walter EM, Vasilyev NV, Sill B, Padala M, Jimenez J, Yoganathan AP, Hetzer R, del Nido PJ. Creation of a tricuspid valve regurgitation model from tricuspid annular dilatation using the cardioport video-assisted imaging system. J Heart Valve Dis. 2011 Mar;20(2):184-8. PubMed PMID: 21560820.
Padala M, Sacks MS, Liou SW, Balachandran K, He Z, Yoganathan AP. Mechanics of the mitral valve strut chordae insertion region. J Biomech Eng. 2010 Aug;132(8):081004. doi: 10.1115/1.4001682. PubMed PMID: 20670053.
Padala M, Hutchison RA, Croft LR, Jimenez JH, Gorman RC, Gorman JH 3rd, Sacks MS, Yoganathan AP. Saddle shape of the mitral annulus reduces systolic strains on the P2 segment of the posterior mitral leaflet. Ann Thorac Surg. 2009 Nov;88(5):1499-504. doi: 10.1016/j.athoracsur.2009.06.042. PubMed PMID: 19853100; PubMed Central PMCID: PMC3021783.
Padala M, Powell SN, Croft LR, Thourani VH, Yoganathan AP, Adams DH. Mitral valve hemodynamics after repair of acute posterior leaflet prolapse: quadrangular resection versus triangular resection versus neochordoplasty. J Thorac Cardiovasc Surg. 2009 Aug;138(2):309-15. doi: 10.1016/j.jtcvs.2009.01.031. PubMed PMID: 19619772; PubMed Central PMCID: PMC4375960.
Erek E, Padala M, Pekkan K, Jimenez J, Yalçinba YK, Salihoğlu E, Sarioğlu T, Yoganathan AP. Mitral web--a new concept for mitral valve repair: improved engineering design and in-vitro studies. J Heart Valve Dis. 2009 May;18(3):300-6. PubMed PMID: 19557987.
Padala M, Vasilyev NV, Owen JW Jr, Jimenez JH, Dasi LP, del Nido PJ, Yoganathan AP. Cleft closure and undersizing annuloplasty improve mitral repair in atrioventricular canal defects. J Thorac Cardiovasc Surg. 2008 Nov;136(5):1243-9. doi: 10.1016/j.jtcvs.2008.05.043. Epub 2008 Sep 14. PubMed PMID: 19026810; PubMed Central PMCID: PMC2752502.
Sucosky P, Padala M, Elhammali A, Balachandran K, Jo H, Yoganathan AP. Design of an ex vivo culture system to investigate the effects of shear stress on cardiovascular tissue. J Biomech Eng. 2008 Jun;130(3):035001. doi: 10.1115/1.2907753. PubMed PMID: 18532871; PubMed Central PMCID: PMC8532251.
Jimenez JH, Liou SW, Padala M, He Z, Sacks M, Gorman RC, Gorman JH 3rd, Yoganathan AP. A saddle-shaped annulus reduces systolic strain on the central region of the mitral valve anterior leaflet. J Thorac Cardiovasc Surg. 2007 Dec;134(6):1562-8. doi: 10.1016/j.jtcvs.2007.08.037. PubMed PMID: 18023684; NIHMSID:NIHMS522248.
What would you like to do?
  • Page of 1