My Bibliography

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Quadir SG, Zaidi SD, Cone MG, Patel S. Alcohol Withdrawal Alters the Inhibitory Landscape of the Prelimbic Cortex in an Interneuron- and Sex-specific Manner. Addict Neurosci. 2025 Dec;17. doi: 10.1016/j.addicn.2025.100237. Epub 2025 Sep 26. PubMed PMID: 41488468; PubMed Central PMCID: PMC12758890.

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Báldi R, Muthuswamy S, Yasmin F, Quadir S, Zaidi D, Kwon M, Kandil I, Johnson K, Loomba N, Patel S. Synaptic organization and associative learning-related activity of basolateral amygdala interneurons. Cell Rep. 2025 Oct 28;44(10):116295. doi: 10.1016/j.celrep.2025.116295. Epub 2025 Sep 18. PubMed PMID: 40971296; PubMed Central PMCID: PMC12588113.

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Quadir SG, Danyal Zaidi S, Cone MG, Patel S. Alcohol Withdrawal Alters the Inhibitory Landscape of the Prelimbic Cortex in an Interneuron- and Sex-specific Manner. bioRxiv. 2024 Nov 21;. doi: 10.1101/2024.11.19.624401. PubMed PMID: 39605607; PubMed Central PMCID: PMC11601661.

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Báldi R, Muthuswamy S, Loomba N, Patel S. Synaptic Organization-Function Relationships of Amygdala Interneurons Supporting Associative Learning. bioRxiv. 2024 Jun 19;. doi: 10.1101/2024.06.18.599631. PubMed PMID: 38948865; PubMed Central PMCID: PMC11212985.

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Rosas-Vidal LE, Naskar S, Mayo LM, Perini I, Altemus M, Engelbrektsson H, Jagasia P, Heilig M, Patel S. PREFRONTAL CORRELATES OF FEAR GENERALIZATION DURING ENDOCANNABINOID DEPLETION. bioRxiv. 2024 Jan 30;. doi: 10.1101/2024.01.30.577847. PubMed PMID: 38352388; PubMed Central PMCID: PMC10862899.

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Ramos-Medina L, Rosas-Vidal LE, Patel S. Pharmacological diacylglycerol lipase inhibition impairs contextual fear extinction in mice. Psychopharmacology (Berl). 2024 Mar;241(3):569-584. doi: 10.1007/s00213-023-06523-3. Epub 2024 Jan 6. PubMed PMID: 38182791; PubMed Central PMCID: PMC10884152.

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Luján MÁ, Covey DP, Young-Morrison R, Zhang L, Kim A, Morgado F, Patel S, Bass CE, Paladini C, Cheer JF. Mobilization of endocannabinoids by midbrain dopamine neurons is required for the encoding of reward prediction. Nat Commun. 2023 Nov 20;14(1):7545. doi: 10.1038/s41467-023-43131-3. PubMed PMID: 37985770; PubMed Central PMCID: PMC10662422.

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Kondev V, Najeed M, Yasmin F, Morgan A, Loomba N, Johnson K, Adank DN, Dong A, Delpire E, Li Y, Winder D, Grueter BA, Patel S. Endocannabinoid release at ventral hippocampal-amygdala synapses regulates stress-induced behavioral adaptation. Cell Rep. 2023 Sep 26;42(9):113027. doi: 10.1016/j.celrep.2023.113027. Epub 2023 Sep 12. PubMed PMID: 37703881; PubMed Central PMCID: PMC10846613.

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Kondev V, Najeed M, Loomba N, Brown J, Winder DG, Grueter BA, Patel S. Synaptic and cellular endocannabinoid signaling mechanisms regulate stress-induced plasticity of nucleus accumbens somatostatin neurons. Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2300585120. doi: 10.1073/pnas.2300585120. Epub 2023 Aug 17. PubMed PMID: 37590414; PubMed Central PMCID: PMC10450650.

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Gunduz-Cinar O, Castillo LI, Xia M, Van Leer E, Brockway ET, Pollack GA, Yasmin F, Bukalo O, Limoges A, Oreizi-Esfahani S, Kondev V, Báldi R, Dong A, Harvey-White J, Cinar R, Kunos G, Li Y, Zweifel LS, Patel S, Holmes A. A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction. Neuron. 2023 Oct 4;111(19):3053-3067.e10. doi: 10.1016/j.neuron.2023.06.023. Epub 2023 Jul 21. PubMed PMID: 37480845; PubMed Central PMCID: PMC10592324.

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Winters ND, Kondev V, Loomba N, Delpire E, Grueter BA, Patel S. Opposing retrograde and astrocyte-dependent endocannabinoid signaling mechanisms regulate lateral habenula synaptic transmission. Cell Rep. 2023 Mar 28;42(3):112159. doi: 10.1016/j.celrep.2023.112159. Epub 2023 Feb 26. PubMed PMID: 36842084; PubMed Central PMCID: PMC10846612.

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Kondev V, Bluett R, Najeed M, Rosas-Vidal LE, Grueter BA, Patel S. Ventral hippocampal diacylglycerol lipase-alpha deletion decreases avoidance behaviors and alters excitation-inhibition balance. Neurobiol Stress. 2023 Jan;22:100510. doi: 10.1016/j.ynstr.2022.100510. eCollection 2023 Jan. PubMed PMID: 36594052; PubMed Central PMCID: PMC9803955.

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Morgan A, Adank D, Johnson K, Butler E, Patel S. 2-Arachidonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice. Alcohol Clin Exp Res. 2022 Nov;46(11):2010-2024. doi: 10.1111/acer.14949. Epub 2022 Oct 12. PubMed PMID: 36125319; PubMed Central PMCID: PMC10091740.

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Scheyer A, Yasmin F, Naskar S, Patel S. Endocannabinoids at the synapse and beyond: implications for neuropsychiatric disease pathophysiology and treatment. Neuropsychopharmacology. 2023 Jan;48(1):37-53. doi: 10.1038/s41386-022-01438-7. Epub 2022 Sep 13. Review. PubMed PMID: 36100658; PubMed Central PMCID: PMC9700791.

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Patel S, Johnson K, Adank D, Rosas-Vidal LE. Longitudinal monitoring of prefrontal cortical ensemble dynamics reveals new insights into stress habituation. Neurobiol Stress. 2022 Sep;20:100481. doi: 10.1016/j.ynstr.2022.100481. eCollection 2022 Sep. PubMed PMID: 36160815; PubMed Central PMCID: PMC9489534.

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Haney M, Bedi G, Cooper ZD, Herrmann ES, Reed SC, Foltin RW, Kingsley PJ, Marnett LJ, Patel S. Impact of cyclooxygenase-2 inhibition on cannabis withdrawal and circulating endocannabinoids in daily cannabis smokers. Addict Biol. 2022 Jul;27(4):e13183. doi: 10.1111/adb.13183. PubMed PMID: 35754107; PubMed Central PMCID: PMC9245164.

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Kondev V, Morgan A, Najeed M, Winters ND, Kingsley PJ, Marnett L, Patel S. The Endocannabinoid 2-Arachidonoylglycerol Bidirectionally Modulates Acute and Protracted Effects of Predator Odor Exposure. Biol Psychiatry. 2022 Nov 1;92(9):739-749. doi: 10.1016/j.biopsych.2022.05.012. Epub 2022 May 17. PubMed PMID: 35961791; PubMed Central PMCID: PMC9827751.

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Farrell JS, Colangeli R, Dong A, George AG, Addo-Osafo K, Kingsley PJ, Morena M, Wolff MD, Dudok B, He K, Patrick TA, Sharkey KA, Patel S, Marnett LJ, Hill MN, Li Y, Teskey GC, Soltesz I. In vivo endocannabinoid dynamics at the timescale of physiological and pathological neural activity. Neuron. 2021 Aug 4;109(15):2398-2403.e4. doi: 10.1016/j.neuron.2021.05.026. PubMed PMID: 34352214; PubMed Central PMCID: PMC8351909.

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Winters ND, Bedse G, Astafyev AA, Patrick TA, Altemus M, Morgan AJ, Mukerjee S, Johnson KD, Mahajan VR, Uddin MJ, Kingsley PJ, Centanni SW, Siciliano CA, Samuels DC, Marnett LJ, Winder DG, Patel S. Targeting diacylglycerol lipase reduces alcohol consumption in preclinical models. J Clin Invest. 2021 Jul 22;131(17). doi: 10.1172/JCI146861. [Epub ahead of print] PubMed PMID: 34292886; PubMed Central PMCID: PMC8409586.

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Morgan A, Gaulden A, Altemus M, Williford K, Centanni S, Winder D, Patel S. Cyclooxygenase-2 inhibition prevents stress induced amygdala activation and anxiety-like behavior. Brain Behav Immun. 2020 Oct;89:513-517. doi: 10.1016/j.bbi.2020.07.046. Epub 2020 Aug 4. PubMed PMID: 32763310; PubMed Central PMCID: PMC7572634.

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Folkes OM, Báldi R, Kondev V, Marcus DJ, Hartley ND, Turner BD, Ayers JK, Baechle JJ, Misra MP, Altemus M, Grueter CA, Grueter BA, Patel S. An endocannabinoid-regulated basolateral amygdala-nucleus accumbens circuit modulates sociability. J Clin Invest. 2020 Apr 1;130(4):1728-1742. doi: 10.1172/JCI131752. PubMed PMID: 31874107; PubMed Central PMCID: PMC7108917.

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Bedse G, Hill MN, Patel S. 2-Arachidonoylglycerol Modulation of Anxiety and Stress Adaptation: From Grass Roots to Novel Therapeutics. Biol Psychiatry. 2020 Oct 1;88(7):520-530. doi: 10.1016/j.biopsych.2020.01.015. Epub 2020 Mar 17. Review. PubMed PMID: 32197779; PubMed Central PMCID: PMC7486996.

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Marcus DJ, Bedse G, Gaulden AD, Ryan JD, Kondev V, Winters ND, Rosas-Vidal LE, Altemus M, Mackie K, Lee FS, Delpire E, Patel S. Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening. Neuron. 2020 Mar 18;105(6):1062-1076.e6. doi: 10.1016/j.neuron.2019.12.024. Epub 2020 Jan 13. PubMed PMID: 31948734; PubMed Central PMCID: PMC7992313.

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Hartley ND, Gaulden AD, Báldi R, Winters ND, Salimando GJ, Rosas-Vidal LE, Jameson A, Winder DG, Patel S. Dynamic remodeling of a basolateral-to-central amygdala glutamatergic circuit across fear states. Nat Neurosci. 2019 Dec;22(12):2000-2012. doi: 10.1038/s41593-019-0528-7. Epub 2019 Nov 11. PubMed PMID: 31712775; PubMed Central PMCID: PMC6884697.

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Nakamura Y, Dryanovski DI, Kimura Y, Jackson SN, Woods AS, Yasui Y, Tsai SY, Patel S, Covey DP, Su TP, Lupica CR. Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion. Elife. 2019 Oct 9;8. doi: 10.7554/eLife.47209. PubMed PMID: 31596232; PubMed Central PMCID: PMC6850780.

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Centanni SW, Bedse G, Patel S, Winder DG. Driving the Downward Spiral: Alcohol-Induced Dysregulation of Extended Amygdala Circuits and Negative Affect. Alcohol Clin Exp Res. 2019 Oct;43(10):2000-2013. doi: 10.1111/acer.14178. Epub 2019 Aug 30. Review. PubMed PMID: 31403699; PubMed Central PMCID: PMC6779502.

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Bedse G, Centanni SW, Winder DG, Patel S. Endocannabinoid Signaling in the Central Amygdala and Bed Nucleus of the Stria Terminalis: Implications for the Pathophysiology and Treatment of Alcohol Use Disorder. Alcohol Clin Exp Res. 2019 Oct;43(10):2014-2027. doi: 10.1111/acer.14159. Epub 2019 Aug 21. Review. PubMed PMID: 31373708; PubMed Central PMCID: PMC6779484.

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Morgan A, Kondev V, Bedse G, Baldi R, Marcus D, Patel S. Cyclooxygenase-2 inhibition reduces anxiety-like behavior and normalizes enhanced amygdala glutamatergic transmission following chronic oral corticosterone treatment. Neurobiol Stress. 2019 Nov;11:100190. doi: 10.1016/j.ynstr.2019.100190. eCollection 2019 Nov. PubMed PMID: 31467944; PubMed Central PMCID: PMC6710559.

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Bruehl S, Burns JW, Morgan A, Koltyn K, Gupta R, Buvanendran A, Edwards D, Chont M, Kingsley PJ, Marnett L, Stone A, Patel S. The association between endogenous opioid function and morphine responsiveness: a moderating role for endocannabinoids. Pain. 2019 Mar;160(3):676-687. doi: 10.1097/j.pain.0000000000001447. PubMed PMID: 30562268; PubMed Central PMCID: PMC6377294.

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Centanni SW, Morris BD, Luchsinger JR, Bedse G, Fetterly TL, Patel S, Winder DG. Endocannabinoid control of the insular-bed nucleus of the stria terminalis circuit regulates negative affective behavior associated with alcohol abstinence. Neuropsychopharmacology. 2019 Feb;44(3):526-537. doi: 10.1038/s41386-018-0257-8. Epub 2018 Nov 2. PubMed PMID: 30390064; PubMed Central PMCID: PMC6333805.

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Cavener VS, Gaulden A, Pennipede D, Jagasia P, Uddin J, Marnett LJ, Patel S. Inhibition of Diacylglycerol Lipase Impairs Fear Extinction in Mice. Front Neurosci. 2018;12:479. doi: 10.3389/fnins.2018.00479. eCollection 2018. PubMed PMID: 30108473; PubMed Central PMCID: PMC6080414.

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Morgan AJ, Kingsley PJ, Mitchener MM, Altemus M, Patrick TA, Gaulden AD, Marnett LJ, Patel S. Detection of Cyclooxygenase-2-Derived Oxygenation Products of the Endogenous Cannabinoid 2-Arachidonoylglycerol in Mouse Brain. ACS Chem Neurosci. 2018 Jul 18;9(7):1552-1559. doi: 10.1021/acschemneuro.7b00499. Epub 2018 May 9. PubMed PMID: 29722963; PubMed Central PMCID: PMC6081739.

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Wenzel JM, Oleson EB, Gove WN, Cole AB, Gyawali U, Dantrassy HM, Bluett RJ, Dryanovski DI, Stuber GD, Deisseroth K, Mathur BN, Patel S, Lupica CR, Cheer JF. Phasic Dopamine Signals in the Nucleus Accumbens that Cause Active Avoidance Require Endocannabinoid Mobilization in the Midbrain. Curr Biol. 2018 May 7;28(9):1392-1404.e5. doi: 10.1016/j.cub.2018.03.037. Epub 2018 Apr 19. PubMed PMID: 29681476; PubMed Central PMCID: PMC5940536.

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Shonesy BC, Parrish WP, Haddad HK, Stephenson JR, Báldi R, Bluett RJ, Marks CR, Centanni SW, Folkes OM, Spiess K, Augustin SM, Mackie K, Lovinger DM, Winder DG, Patel S, Colbran RJ. Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior. Biol Psychiatry. 2018 Aug 15;84(4):304-315. doi: 10.1016/j.biopsych.2017.11.036. Epub 2017 Dec 28. PubMed PMID: 29458998; PubMed Central PMCID: PMC6023784.

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Patel S. Cannabis for Pain and Posttraumatic Stress Disorder: More Consensus Than Controversy or Vice Versa?. Ann Intern Med. 2017 Sep 5;167(5):355-356. doi: 10.7326/M17-1713. Epub 2017 Aug 15. PubMed PMID: 28806789.

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Hill MN, Campolongo P, Yehuda R, Patel S. Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder. Neuropsychopharmacology. 2018 Jan;43(1):80-102. doi: 10.1038/npp.2017.162. Epub 2017 Jul 26. Review. PubMed PMID: 28745306; PubMed Central PMCID: PMC5719095.

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Piomelli D, Cooper Z, Abrams D, Grant I, Patel S. A Guide to the National Academy of Science Report on Cannabis: An Exclusive Discussion with Panel Members. Cannabis Cannabinoid Res. 2017;2(1):155-159. doi: 10.1089/can.2017.29009.dpi. eCollection 2017. PubMed PMID: 28861515; PubMed Central PMCID: PMC5569624.

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Patel S, Hill MN, Cheer JF, Wotjak CT, Holmes A. The endocannabinoid system as a target for novel anxiolytic drugs. Neurosci Biobehav Rev. 2017 May;76(Pt A):56-66. doi: 10.1016/j.neubiorev.2016.12.033. Review. PubMed PMID: 28434588; PubMed Central PMCID: PMC5407316.

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Patel S, Williams JW Jr, Wallace RB. What We Do (and Don't) Know About the Health Effects of Cannabis and Whether Marijuana Is Medicine. Ann Intern Med. 2017 May 16;166(10):747-748. doi: 10.7326/M17-0501. Epub 2017 Apr 4. PubMed PMID: 28384665.

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Bluett RJ, Báldi R, Haymer A, Gaulden AD, Hartley ND, Parrish WP, Baechle J, Marcus DJ, Mardam-Bey R, Shonesy BC, Uddin MJ, Marnett LJ, Mackie K, Colbran RJ, Winder DG, Patel S. Endocannabinoid signalling modulates susceptibility to traumatic stress exposure. Nat Commun. 2017 Mar 28;8:14782. doi: 10.1038/ncomms14782. PubMed PMID: 28348378; PubMed Central PMCID: PMC5379055.

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Bedse G, Hartley ND, Neale E, Gaulden AD, Patrick TA, Kingsley PJ, Uddin MJ, Plath N, Marnett LJ, Patel S. Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety. Biol Psychiatry. 2017 Oct 1;82(7):488-499. doi: 10.1016/j.biopsych.2017.03.002. Epub 2017 Mar 15. PubMed PMID: 28438413; PubMed Central PMCID: PMC5585044.

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Foster DJ, Wilson JM, Remke DH, Mahmood MS, Uddin MJ, Wess J, Patel S, Marnett LJ, Niswender CM, Jones CK, Xiang Z, Lindsley CW, Rook JM, Conn PJ. Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release. Neuron. 2016 Sep 21;91(6):1244-1252. doi: 10.1016/j.neuron.2016.08.017. Epub 2016 Sep 8. PubMed PMID: 27618677; PubMed Central PMCID: PMC5033724.

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Doenni VM, Gray JM, Song CM, Patel S, Hill MN, Pittman QJ. Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling. Brain Behav Immun. 2016 Nov;58:237-247. doi: 10.1016/j.bbi.2016.07.152. Epub 2016 Jul 21. PubMed PMID: 27453335; PubMed Central PMCID: PMC5461973.

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Reddy IA, Pino JA, Weikop P, Osses N, Sørensen G, Bering T, Valle C, Bluett RJ, Erreger K, Wortwein G, Reyes JG, Graham D, Stanwood GD, Hackett TA, Patel S, Fink-Jensen A, Torres GE, Galli A. Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels. Transl Psychiatry. 2016 May 17;6(5):e809. doi: 10.1038/tp.2016.86. PubMed PMID: 27187231; PubMed Central PMCID: PMC5070047.

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Gamble-George JC, Baldi R, Halladay L, Kocharian A, Hartley N, Silva CG, Roberts H, Haymer A, Marnett LJ, Holmes A, Patel S. Cyclooxygenase-2 inhibition reduces stress-induced affective pathology. Elife. 2016 May 10;5. doi: 10.7554/eLife.14137. PubMed PMID: 27162170; PubMed Central PMCID: PMC4862754.

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Báldi R, Ghosh D, Grueter BA, Patel S. Electrophysiological Measurement of Cannabinoid-Mediated Synaptic Modulation in Acute Mouse Brain Slices. Curr Protoc Neurosci. 2016 Apr 8;75:6.29.1-6.29.19. doi: 10.1002/cpns.8. PubMed PMID: 27063786; PubMed Central PMCID: PMC4866814.

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Hartley ND, Gunduz-Cinar O, Halladay L, Bukalo O, Holmes A, Patel S. 2-arachidonoylglycerol signaling impairs short-term fear extinction. Transl Psychiatry. 2016 Mar 1;6(3):e749. doi: 10.1038/tp.2016.26. PubMed PMID: 26926885; PubMed Central PMCID: PMC4872450.

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Holleran KM, Wilson HH, Fetterly TL, Bluett RJ, Centanni SW, Gilfarb RA, Rocco LE, Patel S, Winder DG. Ketamine and MAG Lipase Inhibitor-Dependent Reversal of Evolving Depressive-Like Behavior During Forced Abstinence From Alcohol Drinking. Neuropsychopharmacology. 2016 Jul;41(8):2062-71. doi: 10.1038/npp.2016.3. Epub 2016 Jan 11. PubMed PMID: 26751284; PubMed Central PMCID: PMC4908652.

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Gray JM, Wilson CD, Lee TT, Pittman QJ, Deussing JM, Hillard CJ, McEwen BS, Schulkin J, Karatsoreos IN, Patel S, Hill MN. Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function. Psychoneuroendocrinology. 2016 Apr;66:151-8. doi: 10.1016/j.psyneuen.2016.01.004. Epub 2016 Jan 11. PubMed PMID: 26821211; PubMed Central PMCID: PMC4788523.

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Robinson SL, Alexander NJ, Bluett RJ, Patel S, McCool BA. Acute and chronic ethanol exposure differentially regulate CB1 receptor function at glutamatergic synapses in the rat basolateral amygdala. Neuropharmacology. 2016 Sep;108:474-84. doi: 10.1016/j.neuropharm.2015.12.005. Epub 2015 Dec 18. PubMed PMID: 26707595; PubMed Central PMCID: PMC4912876.