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Gil Alabarse P, Oliveira P, Qin H, Yan T, Migaud M, Terkeltaub R, Liu-Bryan R. The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target. Inflammation Research. 2024 March.
Hayat F, Deason JT, Bryan RL, Terkeltaub R, Song W, Kraus WL, Pluth J, Gassman NR, Migaud ME. Synthesis, Detection, and Metabolism of Pyridone Ribosides, Products of NAD Overoxidation. Chem Res Toxicol. 2024 Feb 19;37(2):248-258. doi: 10.1021/acs.chemrestox.3c00264. Epub 2024 Jan 10. PubMed PMID: 38198686; PubMed Central PMCID: PMC10880730.
Lee J, Sumpter N, Merriman TR, Liu-Bryan R, Terkeltaub R. lving Landscape of Gout in the Female: A Narrative Review. Gout, Urate, and Crystal Deposition Disease. 2023 December.
Liu-Bryan R, Guo T, Lee J, Terkeltaub R. Atherogenic Activation of Human Vascular Smooth Muscle Cells by Monosodium Urate Crystals. Gout, Urate, and Crystal Deposition Disease. 2023 August; 1(3):192-207.
Elsaid KA, Jay GD, Liu-Bryan R, Terkeltaub R. Proteoglycan 4 (PRG4)/Lubricin and the Extracellular Matrix in Gout. Gout, Urate, and Crystal Deposition Disease. 2023 July; 1(3):122-136.
Elsaid K, Merriman TR, Rossitto LA, Liu-Bryan R, Karsh J, Phipps-Green A, Jay GD, Elsayed S, Qadri M, Miner M, Cadzow M, Dambruoso TJ, Schmidt TA, Dalbeth N, Chhana A, Höglund J, Ghassemian M, Campeau A, Maltez N, Karlsson NG, Gonzalez DJ, Terkeltaub R. Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia. Arthritis Rheumatol. 2023 May;75(5):794-805. doi: 10.1002/art.42413. Epub 2023 Mar 10. PubMed PMID: 36457235; PubMed Central PMCID: PMC10191887.
Gil Alabarse P, Chen LY, Oliveira P, Qin H, Liu-Bryan R. Targeting CD38 to Suppress Osteoarthritis Development and Associated Pain After Joint Injury in Mice. Arthritis Rheumatol. 2023 Mar;75(3):364-374. doi: 10.1002/art.42351. Epub 2023 Jan 11. PubMed PMID: 36103412; PubMed Central PMCID: PMC9998345.
Hilsabeck TAU, Liu-Bryan R, Guo T, Wilson KA, Bose N, Raftery D, Beck JN, Lang S, Jin K, Nelson CS, Oron T, Stoller M, Promislow D, Brem RB, Terkeltaub R, Kapahi P. A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response. Geroscience. 2022 Aug;44(4):2195-2211. doi: 10.1007/s11357-022-00557-9. Epub 2022 Apr 6. PubMed PMID: 35381951; PubMed Central PMCID: PMC9616999.
Guma M, Dadpey B, Coras R, Mikuls TR, Hamilton B, Quehenberger O, Thorisdottir H, Bittleman D, Lauro K, Reilly SM, Liu-Bryan R, Terkeltaub R. Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes. Arthritis Res Ther. 2022 Jul 25;24(1):175. doi: 10.1186/s13075-022-02852-4. PubMed PMID: 35879786; PubMed Central PMCID: PMC9310412.
Cobo I, Cheng A, Murillo-Saich J, Coras R, Torres A, Abe Y, Lana AJ, Schlachetzki J, Liu-Bryan R, Terkeltaub R, Sanchez-Lopez E, Glass CK, Guma M. Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response. Cell Rep. 2022 Mar 8;38(10):110489. doi: 10.1016/j.celrep.2022.110489. PubMed PMID: 35263587; PubMed Central PMCID: PMC8989403.
Li J, Wang Y, Chen D, Liu-Bryan R. Oral administration of berberine limits post-traumatic osteoarthritis development and associated pain via AMP-activated protein kinase (AMPK) in mice. Osteoarthritis Cartilage. 2022 Jan;30(1):160-171. doi: 10.1016/j.joca.2021.10.004. Epub 2021 Oct 21. PubMed PMID: 34687898; PubMed Central PMCID: PMC8712393.
Ai X, Duan Y, Zhang Q, Sun D, Fang RH, Liu-Bryan R, Gao W, Zhang L. Cartilage-targeting ultrasmall lipid-polymer hybrid nanoparticles for the prevention of cartilage degradation. Bioeng Transl Med. 2021 Jan;6(1):e10187. doi: 10.1002/btm2.10187. eCollection 2021 Jan. PubMed PMID: 33532587; PubMed Central PMCID: PMC7823131.
Wang Y, Chen LY, Liu-Bryan R. Mitochondrial Biogenesis, Activity, and DNA Isolation in Chondrocytes. Methods Mol Biol. 2021;2245:195-213. doi: 10.1007/978-1-0716-1119-7_14. PubMed PMID: 33315204; PubMed Central PMCID: PMC9037760.
Wang Y, Zhao X, Liu-Bryan R. Role of TLR2 and TLR4 in regulation of articular chondrocyte homeostasis. Osteoarthritis Cartilage. 2020 May;28(5):669-674. doi: 10.1016/j.joca.2020.01.011. Epub 2020 Jan 30. PubMed PMID: 32007503; PubMed Central PMCID: PMC7214200.
Li J, Zhang B, Liu WX, Lu K, Pan H, Wang T, Oh CD, Yi D, Huang J, Zhao L, Ning G, Xing C, Xiao G, Liu-Bryan R, Feng S, Chen D. Metformin limits osteoarthritis development and progression through activation of AMPK signalling. Ann Rheum Dis. 2020 May;79(5):635-645. doi: 10.1136/annrheumdis-2019-216713. Epub 2020 Mar 10. PubMed PMID: 32156705; PubMed Central PMCID: PMC7213329.
Wang Z, Zhao Y, Phipps-Green A, Liu-Bryan R, Ceponis A, Boyle DL, Wang J, Merriman TR, Wang W, Terkeltaub R. Differential DNA Methylation of Networked Signaling, Transcriptional, Innate and Adaptive Immunity, and Osteoclastogenesis Genes and Pathways in Gout. Arthritis Rheumatol. 2020 May;72(5):802-814. doi: 10.1002/art.41173. Epub 2020 Mar 23. PubMed PMID: 31738005; PubMed Central PMCID: PMC7323903.
Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production. Cell Metab. 2019 Jun 4;29(6):1350-1362.e7. doi: 10.1016/j.cmet.2019.03.011. Epub 2019 Apr 11. PubMed PMID: 30982734; PubMed Central PMCID: PMC6675591.
Chen LY, Wang Y, Terkeltaub R, Liu-Bryan R. Activation of AMPK-SIRT3 signaling is chondroprotective by preserving mitochondrial DNA integrity and function. Osteoarthritis Cartilage. 2018 Nov;26(11):1539-1550. doi: 10.1016/j.joca.2018.07.004. Epub 2018 Jul 20. PubMed PMID: 30031925; PubMed Central PMCID: PMC6202232.
McWherter C, Choi YJ, Serrano RL, Mahata SK, Terkeltaub R, Liu-Bryan R. Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling. Arthritis Res Ther. 2018 Sep 6;20(1):204. doi: 10.1186/s13075-018-1699-4. PubMed PMID: 30189890; PubMed Central PMCID: PMC6127987.
Chen LY, Lotz M, Terkeltaub R, Liu-Bryan R. Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes. J Biol Chem. 2018 Aug 3;293(31):12259-12270. doi: 10.1074/jbc.RA118.002261. Epub 2018 Jun 21. PubMed PMID: 29929979; PubMed Central PMCID: PMC6078460.
Serrano RL, Chen LY, Lotz MK, Liu-Bryan R, Terkeltaub R. Impaired Proteasomal Function in Human Osteoarthritic Chondrocytes Can Contribute to Decreased Levels of SOX9 and Aggrecan. Arthritis Rheumatol. 2018 Jul;70(7):1030-1041. doi: 10.1002/art.40456. Epub 2018 May 27. PubMed PMID: 29457374; PubMed Central PMCID: PMC6019618.
Berenbaum F, Griffin TM, Liu-Bryan R. Review: Metabolic Regulation of Inflammation in Osteoarthritis. Arthritis Rheumatol. 2017 Jan;69(1):9-21. doi: 10.1002/art.39842. Review. PubMed PMID: 27564539; PubMed Central PMCID: PMC5341385.
June RK, Liu-Bryan R, Long F, Griffin TM. Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis. J Orthop Res. 2016 Dec;34(12):2048-2058. doi: 10.1002/jor.23420. Epub 2016 Sep 26. Review. PubMed PMID: 27605370; PubMed Central PMCID: PMC5365077.
Wang Y, Viollet B, Terkeltaub R, Liu-Bryan R. AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages. Ann Rheum Dis. 2016 Jan;75(1):286-94. doi: 10.1136/annrheumdis-2014-206074. Epub 2014 Oct 31. PubMed PMID: 25362043; PubMed Central PMCID: PMC4417082.
Liu-Bryan R. Inflammation and intracellular metabolism: new targets in OA. Osteoarthritis Cartilage. 2015 Nov;23(11):1835-42. doi: 10.1016/j.joca.2014.12.016. Review. PubMed PMID: 26521729; PubMed Central PMCID: PMC4668929.
Guma M, Wang Y, Viollet B, Liu-Bryan R. AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis. PLoS One. 2015;10(10):e0140452. doi: 10.1371/journal.pone.0140452. eCollection 2015. PubMed PMID: 26474486; PubMed Central PMCID: PMC4608670.
Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N. Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Sci Transl Med. 2015 May 20;7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616. PubMed PMID: 25995222; PubMed Central PMCID: PMC4458332.
Wang Y, Zhao X, Lotz M, Terkeltaub R, Liu-Bryan R. Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α. Arthritis Rheumatol. 2015 May;67(8):2141-53. doi: 10.1002/art.39182. PubMed PMID: 25940958; PubMed Central PMCID: PMC4519411.
Liu-Bryan R, Terkeltaub R. Emerging regulators of the inflammatory process in osteoarthritis. Nat Rev Rheumatol. 2015 Jan;11(1):35-44. doi: 10.1038/nrrheum.2014.162. Epub 2014 Sep 30. Review. PubMed PMID: 25266449; PubMed Central PMCID: PMC4374654.
Sacchetti C, Liu-Bryan R, Magrini A, Rosato N, Bottini N, Bottini M. Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes. ACS Nano. 2014 Dec 23;8(12):12280-91. doi: 10.1021/nn504537b. Epub 2014 Nov 26. PubMed PMID: 25415768; PubMed Central PMCID: PMC4373402.
Zhao X, Petursson F, Viollet B, Lotz M, Terkeltaub R, Liu-Bryan R. Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase. Arthritis Rheumatol. 2014 Nov;66(11):3073-82. doi: 10.1002/art.38791. PubMed PMID: 25047750; PubMed Central PMCID: PMC4343036.
Fernandez I, Harlow L, Zang Y, Liu-Bryan R, Ridgway WM, Clemens PR, Ascherman DP. Functional redundancy of MyD88-dependent signaling pathways in a murine model of histidyl-transfer RNA synthetase-induced myositis. J Immunol. 2013 Aug 15;191(4):1865-72. doi: 10.4049/jimmunol.1203070. Epub 2013 Jul 10. PubMed PMID: 23842751; PubMed Central PMCID: PMC4332536.
Petursson F, Husa M, June R, Lotz M, Terkeltaub R, Liu-Bryan R. Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes. Arthritis Res Ther. 2013 Jul 25;15(4):R77. doi: 10.1186/ar4254. PubMed PMID: 23883619; PubMed Central PMCID: PMC3979085.
Liu-Bryan R. Synovium and the innate inflammatory network in osteoarthritis progression. Curr Rheumatol Rep. 2013 May;15(5):323. doi: 10.1007/s11926-013-0323-5. Review. PubMed PMID: 23516014; PubMed Central PMCID: PMC3643293.
Liu-Bryan R. Pathophysiology and immunology of acute and chronic gout. In: Gout (eBook) UK: Future Science Group; 2013.
Husa M, Petursson F, Lotz M, Terkeltaub R, Liu-Bryan R. C/EBP homologous protein drives pro-catabolic responses in chondrocytes. Arthritis Res Ther. 2013;15(6):R218. doi: 10.1186/ar4415. PubMed PMID: 24351550; PubMed Central PMCID: PMC3978428.
Liu-Bryan R, Terkeltaub R. The growing array of innate inflammatory ignition switches in osteoarthritis. Arthritis Rheum. 2012 Jul;64(7):2055-8. doi: 10.1002/art.34492. PubMed PMID: 22488656; PubMed Central PMCID: PMC3711830.
Yu W, Liu-Bryan R, Stevens S, Damanahalli JK, Terkeltaub R. RAGE signaling mediates post-injury arterial neointima formation by suppression of liver kinase B1 and AMPK activity. Atherosclerosis. 2012 Jun;222(2):417-25. doi: 10.1016/j.atherosclerosis.2012.04.001. Epub 2012 Apr 11. PubMed PMID: 22552116; PubMed Central PMCID: PMC3361645.
Liu-Bryan R, Terkeltaub R. Tophus Biology and Pathogenesis of Monsodium Urate Crystal-induced Inflammation. In: Terkeltaub R, editor. Gout and Other Crystal Arthropathies First ed. Philadelphia: Elsevier; 2012. Chapter Chapter 6 (Section 2); p.72-84.
Terkeltaub R, Yang B, Lotz M, Liu-Bryan R. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α. Arthritis Rheum. 2011 Jul;63(7):1928-37. doi: 10.1002/art.30333. PubMed PMID: 21400477; PubMed Central PMCID: PMC3128233.
Hoffman HM, Scott P, Mueller JL, Misaghi A, Stevens S, Yancopoulos GD, Murphy A, Valenzuela DM, Liu-Bryan R. Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice. Arthritis Rheum. 2010 Jul;62(7):2170-9. doi: 10.1002/art.27456. PubMed PMID: 20506351; PubMed Central PMCID: PMC2929807.
Husa M, Liu-Bryan R, Terkeltaub R. Shifting HIFs in osteoarthritis. Nat Med. 2010 Jun;16(6):641-4. doi: 10.1038/nm0610-641. PubMed PMID: 20526316; PubMed Central PMCID: PMC2917906.
Liu-Bryan R. Intracellular innate immunity in gouty arthritis: role of NALP3 inflammasome. Immunol Cell Biol. 2010 Jan;88(1):20-3. doi: 10.1038/icb.2009.93. Epub 2009 Nov 24. Review. PubMed PMID: 19935768; PubMed Central PMCID: PMC4337950.
Guma M, Ronacher L, Liu-Bryan R, Takai S, Karin M, Corr M. Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum. 2009 Dec;60(12):3642-50. doi: 10.1002/art.24959. PubMed PMID: 19950258; PubMed Central PMCID: PMC2847793.
Torres R, Macdonald L, Croll SD, Reinhardt J, Dore A, Stevens S, Hylton DM, Rudge JS, Liu-Bryan R, Terkeltaub RA, Yancopoulos GD, Murphy AJ. Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis. Ann Rheum Dis. 2009 Oct;68(10):1602-8. doi: 10.1136/ard.2009.109355. Epub 2009 Jun 14. PubMed PMID: 19528034.
Nguyen MT, Favelyukis S, Nguyen AK, Reichart D, Scott PA, Jenn A, Liu-Bryan R, Glass CK, Neels JG, Olefsky JM. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem. 2007 Nov 30;282(48):35279-92. doi: 10.1074/jbc.M706762200. Epub 2007 Oct 4. PubMed PMID: 17916553.
Scott P, Ma H, Viriyakosol S, Terkeltaub R, Liu-Bryan R. Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals. J Immunol. 2006 Nov 1;177(9):6370-8. doi: 10.4049/jimmunol.177.9.6370. PubMed PMID: 17056568.
Rose DM, Liu-Bryan R. Innate immunity in triggering and resolution of acute gouty inflammation. Curr Rheumatol Rep. 2006 Jun;8(3):209-14. doi: 10.1007/s11926-996-0027-1. Review. PubMed PMID: 16901079.
Liu-Bryan R, Terkeltaub R. Evil humors take their toll as innate immunity makes gouty joints TREM-ble. Arthritis Rheum. 2006 Feb;54(2):383-6. doi: 10.1002/art.21634. PubMed PMID: 16447213.
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