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Chow HM, Sun JK, Hart RP, Cheng KK, Hung CHL, Lau TM, Kwan KM. Low-Density Lipoprotein Receptor-Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes. Adv Sci (Weinh). 2021 Aug;8(16):e2004993. doi: 10.1002/advs.202004993. Epub 2021 Jun 27. PubMed PMID: 34180138; PubMed Central PMCID: PMC8373092.
Lai D, Kapoor M, Wetherill L, Schwandt M, Ramchandani VA, Goldman D, Chao M, Almasy L, Bucholz K, Hart RP, Kamarajan C, Meyers JL, Nurnberger JI, Tischfield J, Edenberg HJ, Schuckit M, Goate A, Scott DM, Porjesz B, Agrawal A, Foroud T. Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations. Am J Med Genet B Neuropsychiatr Genet. 2021 Apr;186(3):151-161. doi: 10.1002/ajmg.b.32805. Epub 2020 Jul 11. PubMed PMID: 32652861.
Scarnati MS, Boreland AJ, Joel M, Hart RP, Pang ZP. Differential sensitivity of human neurons carrying μ opioid receptor (MOR) N40D variants in response to ethanol. Alcohol. 2020 Sep;87:97-109. doi: 10.1016/j.alcohol.2020.05.004. Epub 2020 Jun 17. PubMed PMID: 32561311; PubMed Central PMCID: PMC7958146.
Halikere A, Popova D, Scarnati MS, Hamod A, Swerdel MR, Moore JC, Tischfield JA, Hart RP, Pang ZP. Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons. Mol Psychiatry. 2020 Jul;25(7):1406-1419. doi: 10.1038/s41380-019-0507-0. Epub 2019 Sep 3. PubMed PMID: 31481756; PubMed Central PMCID: PMC7051890.
Popovitchenko T, Park Y, Page NF, Luo X, Krsnik Z, Liu Y, Salamon I, Stephenson JD, Kraushar ML, Volk NL, Patel SM, Wijeratne HRS, Li D, Suthar KS, Wach A, Sun M, Arnold SJ, Akamatsu W, Okano H, Paillard L, Zhang H, Buyske S, Kostovic I, De Rubeis S, Hart RP, Rasin MR. Translational derepression of Elavl4 isoforms at their alternative 5' UTRs determines neuronal development. Nat Commun. 2020 Apr 3;11(1):1674. doi: 10.1038/s41467-020-15412-8. PubMed PMID: 32245946; PubMed Central PMCID: PMC7125149.
Xu R, Li X, Boreland AJ, Posyton A, Kwan K, Hart RP, Jiang P. Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain. Nat Commun. 2020 Mar 27;11(1):1577. doi: 10.1038/s41467-020-15411-9. PubMed PMID: 32221280; PubMed Central PMCID: PMC7101330.
Fantuzzo JA, Robles DA, Mirabella VR, Hart RP, Pang ZP, Zahn JD. Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications. Lab Chip. 2020 Mar 17;20(6):1140-1152. doi: 10.1039/c9lc01179j. PubMed PMID: 32064487; PubMed Central PMCID: PMC7339603.
Gokhale S, Lu W, Zhu S, Liu Y, Hart RP, Rabinowitz JD, Xie P. Elevated Choline Kinase α-Mediated Choline Metabolism Supports the Prolonged Survival of TRAF3-Deficient B Lymphocytes. J Immunol. 2020 Jan 15;204(2):459-471. doi: 10.4049/jimmunol.1900658. Epub 2019 Dec 11. PubMed PMID: 31826940; PubMed Central PMCID: PMC6946882.
Hart RP. Strategies for Integrating Single-Cell RNA Sequencing Results With Multiple Species. bioRxiv. 2019 June. doi: 10.1101/671115.
Xu R, Brawner AT, Li S, Liu JJ, Kim H, Xue H, Pang ZP, Kim WY, Hart RP, Liu Y, Jiang P. OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome. Cell Stem Cell. 2019 Jun 6;24(6):908-926.e8. doi: 10.1016/j.stem.2019.04.014. Epub 2019 May 23. PubMed PMID: 31130512; PubMed Central PMCID: PMC6944064.
Grudzien-Nogalska E, Wu Y, Jiao X, Cui H, Mateyak MK, Hart RP, Tong L, Kiledjian M. Structural and mechanistic basis of mammalian Nudt12 RNA deNADding. Nat Chem Biol. 2019 Jun;15(6):575-582. doi: 10.1038/s41589-019-0293-7. Epub 2019 May 17. PubMed PMID: 31101919; PubMed Central PMCID: PMC6527130.
Vajtay TJ, Bandi A, Upadhyay A, Swerdel MR, Hart RP, Lee CR, Margolis DJ. Optogenetic and transcriptomic interrogation of enhanced muscle function in the paralyzed mouse whisker pad. J Neurophysiol. 2019 Apr 1;121(4):1491-1500. doi: 10.1152/jn.00837.2018. Epub 2019 Feb 20. PubMed PMID: 30785807; PubMed Central PMCID: PMC6485730.
Chow HM, Cheng A, Song X, Swerdel MR, Hart RP, Herrup K. ATM is activated by ATP depletion and modulates mitochondrial function through NRF1. J Cell Biol. 2019 Mar 4;218(3):909-928. doi: 10.1083/jcb.201806197. Epub 2019 Jan 14. PubMed PMID: 30642892; PubMed Central PMCID: PMC6400560.
Fantuzzo JA, Hart RP, Zahn JD, Pang ZP. Compartmentalized Devices as Tools for Investigation of Human Brain Network Dynamics. Dev Dyn. 2019 Jan;248(1):65-77. doi: 10.1002/dvdy.24665. Epub 2018 Sep 12. Review. PubMed PMID: 30117633; PubMed Central PMCID: PMC6312734.
Zucco AJ, Pozzo VD, Afinogenova A, Hart RP, Devinsky O, D'Arcangelo G. Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation. Mol Cell Neurosci. 2018 Oct;92:149-163. doi: 10.1016/j.mcn.2018.08.004. Epub 2018 Aug 23. PubMed PMID: 30144504; PubMed Central PMCID: PMC6250058.
Tiethof AK, Richardson JR, Hart RP. Knockdown of Butyrylcholinesterase but Not Inhibition by Chlorpyrifos Alters Early Differentiation Mechanisms in Human Neural Stem Cells. Toxics. 2018 Sep 1;6(3). doi: 10.3390/toxics6030052. PubMed PMID: 30200437; PubMed Central PMCID: PMC6160911.
Prytkova I, Goate A, Hart RP, Slesinger PA. Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?. Alcohol Clin Exp Res. 2018 Sep;42(9):1572-1590. doi: 10.1111/acer.13811. Epub 2018 Jul 5. Review. PubMed PMID: 29897633; PubMed Central PMCID: PMC6120805.
McGowan H, Mirabella VR, Hamod A, Karakhanyan A, Mlynaryk N, Moore JC, Tischfield JA, Hart RP, Pang ZP. hsa-let-7c miRNA Regulates Synaptic and Neuronal Function in Human Neurons. Front Synaptic Neurosci. 2018;10:19. doi: 10.3389/fnsyn.2018.00019. eCollection 2018. PubMed PMID: 30065644; PubMed Central PMCID: PMC6056636.
Guo Y, Wu R, Gaspar JM, Sargsyan D, Su ZY, Zhang C, Gao L, Cheng D, Li W, Wang C, Yin R, Fang M, Verzi MP, Hart RP, Kong AN. DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice. Carcinogenesis. 2018 May 3;39(5):669-680. doi: 10.1093/carcin/bgy043. PubMed PMID: 29547900; PubMed Central PMCID: PMC6248359.
Eid A, Bihaqi SW, Hemme C, Gaspar JM, Hart RP, Zawia NH. Histone acetylation maps in aged mice developmentally exposed to lead: epigenetic drift and Alzheimer-related genes. Epigenomics. 2018 May;10(5):573-583. doi: 10.2217/epi-2017-0143. Epub 2018 May 3. PubMed PMID: 29722544; PubMed Central PMCID: PMC5992572.
Li W, Huang Y, Sargsyan D, Khor TO, Guo Y, Shu L, Yang AY, Zhang C, Paredes-Gonzalez X, Verzi M, Hart RP, Kong AN. Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq. Cell Biosci. 2018;8:3. doi: 10.1186/s13578-018-0201-y. eCollection 2018. PubMed PMID: 29344347; PubMed Central PMCID: PMC5767006.
Fantuzzo JA, Mirabella VR, Hamod AH, Hart RP, Zahn JD, Pang ZP. Intellicount: High-Throughput Quantification of Fluorescent Synaptic Protein Puncta by Machine Learning. eNeuro. 2017 Nov-Dec;4(6). doi: 10.1523/ENEURO.0219-17.2017. eCollection 2017 Nov-Dec. PubMed PMID: 29218324; PubMed Central PMCID: PMC5718246.
Gaspar JM, Hart RP. DMRfinder: efficiently identifying differentially methylated regions from MethylC-seq data. BMC Bioinformatics. 2017 Nov 29;18(1):528. doi: 10.1186/s12859-017-1909-0. PubMed PMID: 29187143; PubMed Central PMCID: PMC5817627.
Li Y, Hao H, Swerdel MR, Cho HY, Lee KB, Hart RP, Lyu YL, Cai L. Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network. J Neurosci Res. 2017 Oct;95(10):1951-1964. doi: 10.1002/jnr.24037. Epub 2017 Mar 30. PubMed PMID: 28370415; PubMed Central PMCID: PMC5561520.
Guo Y, Su ZY, Zhang C, Gaspar JM, Wang R, Hart RP, Verzi MP, Kong AN. Mechanisms of colitis-accelerated colon carcinogenesis and its prevention with the combination of aspirin and curcumin: Transcriptomic analysis using RNA-seq. Biochem Pharmacol. 2017 Jul 1;135:22-34. doi: 10.1016/j.bcp.2017.02.021. Epub 2017 Mar 4. PubMed PMID: 28267439; PubMed Central PMCID: PMC5541256.
Fantuzzo JA, De Filippis L, McGowan H, Yang N, Ng YH, Halikere A, Liu JJ, Hart RP, Wernig M, Zahn JD, Pang ZP. μNeurocircuitry: Establishing in vitro models of neurocircuits with human neurons. Technology (Singap World Sci). 2017 Jun;5(2):87-97. doi: 10.1142/S2339547817500054. PubMed PMID: 28781993; PubMed Central PMCID: PMC5541685.
Jiao X, Doamekpor SK, Bird JG, Nickels BE, Tong L, Hart RP, Kiledjian M. 5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding. Cell. 2017 Mar 9;168(6):1015-1027.e10. doi: 10.1016/j.cell.2017.02.019. PubMed PMID: 28283058; PubMed Central PMCID: PMC5371429.
Chen J, Chen Y, Vail G, Chow H, Zhang Y, Louie L, Li J, Hart RP, Plummer MR, Herrup K. Erratum to: The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment. Mol Neurodegener. 2017 Jan 12;12(1):4. doi: 10.1186/s13024-017-0151-6. PubMed PMID: 28081717; PubMed Central PMCID: PMC5234131.
Hart RP, Goff LA. Long noncoding RNAs: Central to nervous system development. Int J Dev Neurosci. 2016 Dec;55:109-116. doi: 10.1016/j.ijdevneu.2016.06.001. Epub 2016 Jun 11. Review. PubMed PMID: 27296516; PubMed Central PMCID: PMC5148644.
Oni EN, Halikere A, Li G, Toro-Ramos AJ, Swerdel MR, Verpeut JL, Moore JC, Bello NT, Bierut LJ, Goate A, Tischfield JA, Pang ZP, Hart RP. Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele. Sci Rep. 2016 Oct 4;6:34341. doi: 10.1038/srep34341. PubMed PMID: 27698409; PubMed Central PMCID: PMC5048107.
Oni EN, Hart RP. Bioinformatic Analysis of DNA Methylation in Neural Progenitor Cell Models of Alcohol Abuse. Curr Pharmacol Rep. 2016 Oct;2(5):203-210. doi: 10.1007/s40495-016-0065-y. Epub 2016 Aug 5. PubMed PMID: 27774408; PubMed Central PMCID: PMC5070667.
Chen J, Chen Y, Vail G, Chow H, Zhang Y, Louie L, Li J, Hart RP, Plummer MR, Herrup K. The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment. Mol Neurodegener. 2016 Aug 18;11(1):60. doi: 10.1186/s13024-016-0127-y. PubMed PMID: 27538496; PubMed Central PMCID: PMC4991002.
Popovitchenko T, Thompson K, Viljetic B, Jiao X, Kontonyiannis DL, Kiledjian M, Hart RP, Rasin MR. The RNA binding protein HuR determines the differential translation of autism-associated FoxP subfamily members in the developing neocortex. Sci Rep. 2016 Jul 7;6:28998. doi: 10.1038/srep28998. PubMed PMID: 27383233; PubMed Central PMCID: PMC4935837.
De Filippis L, Halikere A, McGowan H, Moore JC, Tischfield JA, Hart RP, Pang ZP. Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells. Mol Brain. 2016 May 10;9(1):51. doi: 10.1186/s13041-016-0221-7. PubMed PMID: 27160314; PubMed Central PMCID: PMC4862119.
Grudzien-Nogalska E, Jiao X, Song MG, Hart RP, Kiledjian M. Nudt3 is an mRNA decapping enzyme that modulates cell migration. RNA. 2016 May;22(5):773-81. doi: 10.1261/rna.055699.115. Epub 2016 Mar 1. PubMed PMID: 26932476; PubMed Central PMCID: PMC4836651.
Carlson AL, Bennett NK, Francis NL, Halikere A, Clarke S, Moore JC, Hart RP, Paradiso K, Wernig M, Kohn J, Pang ZP, Moghe PV. Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds. Nat Commun. 2016 Mar 17;7:10862. doi: 10.1038/ncomms10862. PubMed PMID: 26983594; PubMed Central PMCID: PMC4800432.
Lin L, Swerdel MR, Lazaropoulos MP, Hoffman GS, Toro-Ramos AJ, Wright J, Lederman H, Chen J, Moore JC, Hart RP. Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line. Stem Cell Reports. 2015 Dec 8;5(6):1097-1108. doi: 10.1016/j.stemcr.2015.10.010. Epub 2015 Nov 19. PubMed PMID: 26677768; PubMed Central PMCID: PMC4682125.
Jiang D, Zhang Y, Hart RP, Chen J, Herrup K, Li J. Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency. Brain. 2015 Dec;138(Pt 12):3520-36. doi: 10.1093/brain/awv284. Epub 2015 Oct 27. PubMed PMID: 26510954; PubMed Central PMCID: PMC4668921.
Kraushar ML, Viljetic B, Wijeratne HR, Thompson K, Jiao X, Pike JW, Medvedeva V, Groszer M, Kiledjian M, Hart RP, Rasin MR. Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes. J Neurosci. 2015 Aug 5;35(31):10911-26. doi: 10.1523/JNEUROSCI.0601-15.2015. PubMed PMID: 26245956; PubMed Central PMCID: PMC4524969.
Carmel JB, Young W, Hart RP. Flipping the transcriptional switch from myelin inhibition to axon growth in the CNS. Front Mol Neurosci. 2015;8:34. doi: 10.3389/fnmol.2015.00034. eCollection 2015. PubMed PMID: 26236189; PubMed Central PMCID: PMC4505142.
Siddiq MM, Hannila SS, Carmel JB, Bryson JB, Hou J, Nikulina E, Willis MR, Mellado W, Richman EL, Hilaire M, Hart RP, Filbin MT. Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System. J Biol Chem. 2015 Jun 26;290(26):16343-56. doi: 10.1074/jbc.M114.630574. Epub 2015 May 6. PubMed PMID: 25947372; PubMed Central PMCID: PMC4481232.
Guo Y, Lee JH, Shu L, Huang Y, Li W, Zhang C, Yang AY, Boyanapalli SS, Perekatt A, Hart RP, Verzi M, Kong AN. Association of aberrant DNA methylation in Apc(min/+) mice with the epithelial-mesenchymal transition and Wnt/β-catenin pathways: genome-wide analysis using MeDIP-seq. Cell Biosci. 2015;5:24. doi: 10.1186/s13578-015-0013-2. eCollection 2015. PubMed PMID: 26101583; PubMed Central PMCID: PMC4476183.
Xie P, Moore CR, Swerdel MR, Hart RP. Transcriptomic profiling of splenic B lymphomas spontaneously developed in B cell-specific TRAF3-deficient mice. Genom Data. 2014 Dec 1;2:386-388. doi: 10.1016/j.gdata.2014.10.017. PubMed PMID: 25419513; PubMed Central PMCID: PMC4236829.
Yang AY, Lee JH, Shu L, Zhang C, Su ZY, Lu Y, Huang MT, Ramirez C, Pung D, Huang Y, Verzi M, Hart RP, Kong AN. Genome-wide analysis of DNA methylation in UVB- and DMBA/TPA-induced mouse skin cancer models. Life Sci. 2014 Sep 15;113(1-2):45-54. doi: 10.1016/j.lfs.2014.07.031. Epub 2014 Aug 2. PubMed PMID: 25093921; PubMed Central PMCID: PMC5897904.
Edwards SK, Baron J, Moore CR, Liu Y, Perlman DH, Hart RP, Xie P. Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes. J Hematol Oncol. 2014 Sep 9;7:56. doi: 10.1186/s13045-014-0056-6. PubMed PMID: 25200342; PubMed Central PMCID: PMC4172902.
Kraushar ML, Thompson K, Wijeratne HR, Viljetic B, Sakers K, Marson JW, Kontoyiannis DL, Buyske S, Hart RP, Rasin MR. Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3815-24. doi: 10.1073/pnas.1408305111. Epub 2014 Aug 25. PubMed PMID: 25157170; PubMed Central PMCID: PMC4246959.
Davila JL, Goff LA, Ricupero CL, Camarillo C, Oni EN, Swerdel MR, Toro-Ramos AJ, Li J, Hart RP. A positive feedback mechanism that regulates expression of miR-9 during neurogenesis. PLoS One. 2014;9(4):e94348. doi: 10.1371/journal.pone.0094348. eCollection 2014. PubMed PMID: 24714615; PubMed Central PMCID: PMC3979806.
Sauvageau M, Goff LA, Lodato S, Bonev B, Groff AF, Gerhardinger C, Sanchez-Gomez DB, Hacisuleyman E, Li E, Spence M, Liapis SC, Mallard W, Morse M, Swerdel MR, D'Ecclessis MF, Moore JC, Lai V, Gong G, Yancopoulos GD, Frendewey D, Kellis M, Hart RP, Valenzuela DM, Arlotta P, Rinn JL. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Elife. 2013 Dec 31;2:e01749. doi: 10.7554/eLife.01749. PubMed PMID: 24381249; PubMed Central PMCID: PMC3874104.
Li J, Hart RP, Mallimo EM, Swerdel MR, Kusnecov AW, Herrup K. EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia. Nat Neurosci. 2013 Dec;16(12):1745-53. doi: 10.1038/nn.3564. Epub 2013 Oct 27. PubMed PMID: 24162653; PubMed Central PMCID: PMC3965909.
DeBoer EM, Kraushar ML, Hart RP, Rasin MR. Post-transcriptional regulatory elements and spatiotemporal specification of neocortical stem cells and projection neurons. Neuroscience. 2013 Sep 17;248:499-528. doi: 10.1016/j.neuroscience.2013.05.042. Epub 2013 May 30. Review. PubMed PMID: 23727006; PubMed Central PMCID: PMC3884001.
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