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Ma F, Akolkar H, Xu J, Liu Y, Popova D, Xie J, Youssef MM, Benosman R, Hart RP, Herrup K. The Amyloid Precursor Protein Modulates the Position and Length of the Axon Initial Segment. J Neurosci. 2023 Mar 8;43(10):1830-1844. doi: 10.1523/JNEUROSCI.0172-22.2023. Epub 2023 Jan 30. PubMed PMID: 36717226; PubMed Central PMCID: PMC10010458.
Popova D, Gameiro-Ros I, Youssef MM, Zalamea P, Morris AD, Prytkova I, Jadali A, Kwan KY, Kamarajan C, Salvatore JE, Xuei X, Chorlian DB, Porjesz B, Kuperman S, Dick DM, Goate A, Edenberg HJ, Tischfield JA, Pang ZP, Slesinger PA, Hart RP. Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons. Mol Psychiatry. 2023 Feb;28(2):746-758. doi: 10.1038/s41380-022-01818-x. Epub 2022 Oct 7. PubMed PMID: 36207584; PubMed Central PMCID: PMC9542475.
Sun JK, Wu D, Wong GC, Lau TM, Yang M, Hart RP, Kwan KM, Chan HYE, Chow HM. Chronic alcohol metabolism results in DNA repair infidelity and cell cycle-induced senescence in neurons. Aging Cell. 2023 Feb;22(2):e13772. doi: 10.1111/acel.13772. Epub 2023 Jan 23. PubMed PMID: 36691110; PubMed Central PMCID: PMC9924945.
Sammoura FM, Popova D, Morris A, Hart RP, Richardson JR. Methods for shipping live primary cortical and hippocampal neuron cultures from postnatal mice. Curr Res Neurobiol. 2023;4:100069. doi: 10.1016/j.crneur.2022.100069. eCollection 2023. Review. PubMed PMID: 36589676; PubMed Central PMCID: PMC9794877.
Wang L, Mirabella VR, Dai R, Su X, Xu R, Jadali A, Bernabucci M, Singh I, Chen Y, Tian J, Jiang P, Kwan KY, Pak C, Liu C, Comoletti D, Hart RP, Chen C, Südhof TC, Pang ZP. Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism. Mol Psychiatry. 2022 Oct 24;. doi: 10.1038/s41380-022-01834-x. [Epub ahead of print] PubMed PMID: 36280753.
Barr PB, Mallard TT, Sanchez-Roige S, Poore HE, Linnér RK, Waldman ID, Palmer AA, Harden KP, Dick DM. Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk. Transl Psychiatry. 2022 Sep 30;12(1):420. doi: 10.1038/s41398-022-02171-x. PubMed PMID: 36180423; PubMed Central PMCID: PMC9525649.
Eid A, Mhatre-Winters I, Sammoura FM, Edler MK, von Stein R, Hossain MM, Han Y, Lisci M, Carney K, Konsolaki M, Hart RP, Bennett JW, Richardson JR. Effects of DDT on Amyloid Precursor Protein Levels and Amyloid Beta Pathology: Mechanistic Links to Alzheimer's Disease Risk. Environ Health Perspect. 2022 Aug;130(8):87005. doi: 10.1289/EHP10576. Epub 2022 Aug 10. PubMed PMID: 35946953; PubMed Central PMCID: PMC9364816.
Song X, Gao HY, Herrup K, Hart RP. Optimized splitting of mixed-species RNA sequencing data. J Bioinform Comput Biol. 2022 Apr;20(2):2250001. doi: 10.1142/S0219720022500019. Epub 2022 Jan 6. PubMed PMID: 34991436; PubMed Central PMCID: PMC9081140.
Salamon I, Palsule G, Luo X, Roque A, Tucai S, Khosla I, Volk N, Liu W, Cui H, Pozzo VD, Zalamea P, Jiao X, D'Arcangelo G, Hart RP, Rasin MR, Kiledjian M. mRNA-Decapping Associated DcpS Enzyme Controls Critical Steps of Neuronal Development. Cereb Cortex. 2022 Mar 30;32(7):1494-1507. doi: 10.1093/cercor/bhab302. PubMed PMID: 34467373; PubMed Central PMCID: PMC8971079.
Chow HM, Sun JK, Hart RP, Cheng KK, Hung CHL, Lau TM, Kwan KM. Low-Density Lipoprotein Receptor-Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes. Adv Sci (Weinh). 2021 Aug;8(16):e2004993. doi: 10.1002/advs.202004993. Epub 2021 Jun 27. PubMed PMID: 34180138; PubMed Central PMCID: PMC8373092.
Lai D, Kapoor M, Wetherill L, Schwandt M, Ramchandani VA, Goldman D, Chao M, Almasy L, Bucholz K, Hart RP, Kamarajan C, Meyers JL, Nurnberger JI, Tischfield J, Edenberg HJ, Schuckit M, Goate A, Scott DM, Porjesz B, Agrawal A, Foroud T. Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations. Am J Med Genet B Neuropsychiatr Genet. 2021 Apr;186(3):151-161. doi: 10.1002/ajmg.b.32805. Epub 2020 Jul 11. PubMed PMID: 32652861; PubMed Central PMCID: PMC9376735.
Scarnati MS, Boreland AJ, Joel M, Hart RP, Pang ZP. Differential sensitivity of human neurons carrying μ opioid receptor (MOR) N40D variants in response to ethanol. Alcohol. 2020 Sep;87:97-109. doi: 10.1016/j.alcohol.2020.05.004. Epub 2020 Jun 17. PubMed PMID: 32561311; PubMed Central PMCID: PMC7958146.
Halikere A, Popova D, Scarnati MS, Hamod A, Swerdel MR, Moore JC, Tischfield JA, Hart RP, Pang ZP. Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons. Mol Psychiatry. 2020 Jul;25(7):1406-1419. doi: 10.1038/s41380-019-0507-0. Epub 2019 Sep 3. PubMed PMID: 31481756; PubMed Central PMCID: PMC7051890.
Popovitchenko T, Park Y, Page NF, Luo X, Krsnik Z, Liu Y, Salamon I, Stephenson JD, Kraushar ML, Volk NL, Patel SM, Wijeratne HRS, Li D, Suthar KS, Wach A, Sun M, Arnold SJ, Akamatsu W, Okano H, Paillard L, Zhang H, Buyske S, Kostovic I, De Rubeis S, Hart RP, Rasin MR. Translational derepression of Elavl4 isoforms at their alternative 5' UTRs determines neuronal development. Nat Commun. 2020 Apr 3;11(1):1674. doi: 10.1038/s41467-020-15412-8. PubMed PMID: 32245946; PubMed Central PMCID: PMC7125149.
Xu R, Li X, Boreland AJ, Posyton A, Kwan K, Hart RP, Jiang P. Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain. Nat Commun. 2020 Mar 27;11(1):1577. doi: 10.1038/s41467-020-15411-9. PubMed PMID: 32221280; PubMed Central PMCID: PMC7101330.
Fantuzzo JA, Robles DA, Mirabella VR, Hart RP, Pang ZP, Zahn JD. Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications. Lab Chip. 2020 Mar 17;20(6):1140-1152. doi: 10.1039/c9lc01179j. PubMed PMID: 32064487; PubMed Central PMCID: PMC7339603.
Gokhale S, Lu W, Zhu S, Liu Y, Hart RP, Rabinowitz JD, Xie P. Elevated Choline Kinase α-Mediated Choline Metabolism Supports the Prolonged Survival of TRAF3-Deficient B Lymphocytes. J Immunol. 2020 Jan 15;204(2):459-471. doi: 10.4049/jimmunol.1900658. Epub 2019 Dec 11. PubMed PMID: 31826940; PubMed Central PMCID: PMC6946882.
Hart RP. Strategies for Integrating Single-Cell RNA Sequencing Results With Multiple Species. bioRxiv. 2019 June. doi: 10.1101/671115.
Xu R, Brawner AT, Li S, Liu JJ, Kim H, Xue H, Pang ZP, Kim WY, Hart RP, Liu Y, Jiang P. OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome. Cell Stem Cell. 2019 Jun 6;24(6):908-926.e8. doi: 10.1016/j.stem.2019.04.014. Epub 2019 May 23. PubMed PMID: 31130512; PubMed Central PMCID: PMC6944064.
Grudzien-Nogalska E, Wu Y, Jiao X, Cui H, Mateyak MK, Hart RP, Tong L, Kiledjian M. Structural and mechanistic basis of mammalian Nudt12 RNA deNADding. Nat Chem Biol. 2019 Jun;15(6):575-582. doi: 10.1038/s41589-019-0293-7. Epub 2019 May 17. PubMed PMID: 31101919; PubMed Central PMCID: PMC6527130.
Vajtay TJ, Bandi A, Upadhyay A, Swerdel MR, Hart RP, Lee CR, Margolis DJ. Optogenetic and transcriptomic interrogation of enhanced muscle function in the paralyzed mouse whisker pad. J Neurophysiol. 2019 Apr 1;121(4):1491-1500. doi: 10.1152/jn.00837.2018. Epub 2019 Feb 20. PubMed PMID: 30785807; PubMed Central PMCID: PMC6485730.
Chow HM, Cheng A, Song X, Swerdel MR, Hart RP, Herrup K. ATM is activated by ATP depletion and modulates mitochondrial function through NRF1. J Cell Biol. 2019 Mar 4;218(3):909-928. doi: 10.1083/jcb.201806197. Epub 2019 Jan 14. PubMed PMID: 30642892; PubMed Central PMCID: PMC6400560.
Fantuzzo JA, Hart RP, Zahn JD, Pang ZP. Compartmentalized Devices as Tools for Investigation of Human Brain Network Dynamics. Dev Dyn. 2019 Jan;248(1):65-77. doi: 10.1002/dvdy.24665. Epub 2018 Sep 12. Review. PubMed PMID: 30117633; PubMed Central PMCID: PMC6312734.
Zucco AJ, Pozzo VD, Afinogenova A, Hart RP, Devinsky O, D'Arcangelo G. Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation. Mol Cell Neurosci. 2018 Oct;92:149-163. doi: 10.1016/j.mcn.2018.08.004. Epub 2018 Aug 23. PubMed PMID: 30144504; PubMed Central PMCID: PMC6250058.
Tiethof AK, Richardson JR, Hart RP. Knockdown of Butyrylcholinesterase but Not Inhibition by Chlorpyrifos Alters Early Differentiation Mechanisms in Human Neural Stem Cells. Toxics. 2018 Sep 1;6(3). doi: 10.3390/toxics6030052. PubMed PMID: 30200437; PubMed Central PMCID: PMC6160911.
Prytkova I, Goate A, Hart RP, Slesinger PA. Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?. Alcohol Clin Exp Res. 2018 Sep;42(9):1572-1590. doi: 10.1111/acer.13811. Epub 2018 Jul 5. Review. PubMed PMID: 29897633; PubMed Central PMCID: PMC6120805.
McGowan H, Mirabella VR, Hamod A, Karakhanyan A, Mlynaryk N, Moore JC, Tischfield JA, Hart RP, Pang ZP. hsa-let-7c miRNA Regulates Synaptic and Neuronal Function in Human Neurons. Front Synaptic Neurosci. 2018;10:19. doi: 10.3389/fnsyn.2018.00019. eCollection 2018. PubMed PMID: 30065644; PubMed Central PMCID: PMC6056636.
Guo Y, Wu R, Gaspar JM, Sargsyan D, Su ZY, Zhang C, Gao L, Cheng D, Li W, Wang C, Yin R, Fang M, Verzi MP, Hart RP, Kong AN. DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice. Carcinogenesis. 2018 May 3;39(5):669-680. doi: 10.1093/carcin/bgy043. PubMed PMID: 29547900; PubMed Central PMCID: PMC6248359.
Eid A, Bihaqi SW, Hemme C, Gaspar JM, Hart RP, Zawia NH. Histone acetylation maps in aged mice developmentally exposed to lead: epigenetic drift and Alzheimer-related genes. Epigenomics. 2018 May;10(5):573-583. doi: 10.2217/epi-2017-0143. Epub 2018 May 3. PubMed PMID: 29722544; PubMed Central PMCID: PMC5992572.
Li W, Huang Y, Sargsyan D, Khor TO, Guo Y, Shu L, Yang AY, Zhang C, Paredes-Gonzalez X, Verzi M, Hart RP, Kong AN. Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq. Cell Biosci. 2018;8:3. doi: 10.1186/s13578-018-0201-y. eCollection 2018. PubMed PMID: 29344347; PubMed Central PMCID: PMC5767006.
Fantuzzo JA, Mirabella VR, Hamod AH, Hart RP, Zahn JD, Pang ZP. Intellicount: High-Throughput Quantification of Fluorescent Synaptic Protein Puncta by Machine Learning. eNeuro. 2017 Nov-Dec;4(6). doi: 10.1523/ENEURO.0219-17.2017. eCollection 2017 Nov-Dec. PubMed PMID: 29218324; PubMed Central PMCID: PMC5718246.
Gaspar JM, Hart RP. DMRfinder: efficiently identifying differentially methylated regions from MethylC-seq data. BMC Bioinformatics. 2017 Nov 29;18(1):528. doi: 10.1186/s12859-017-1909-0. PubMed PMID: 29187143; PubMed Central PMCID: PMC5817627.
Li Y, Hao H, Swerdel MR, Cho HY, Lee KB, Hart RP, Lyu YL, Cai L. Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network. J Neurosci Res. 2017 Oct;95(10):1951-1964. doi: 10.1002/jnr.24037. Epub 2017 Mar 30. PubMed PMID: 28370415; PubMed Central PMCID: PMC5561520.
Guo Y, Su ZY, Zhang C, Gaspar JM, Wang R, Hart RP, Verzi MP, Kong AN. Mechanisms of colitis-accelerated colon carcinogenesis and its prevention with the combination of aspirin and curcumin: Transcriptomic analysis using RNA-seq. Biochem Pharmacol. 2017 Jul 1;135:22-34. doi: 10.1016/j.bcp.2017.02.021. Epub 2017 Mar 4. PubMed PMID: 28267439; PubMed Central PMCID: PMC5541256.
Fantuzzo JA, De Filippis L, McGowan H, Yang N, Ng YH, Halikere A, Liu JJ, Hart RP, Wernig M, Zahn JD, Pang ZP. μNeurocircuitry: Establishing in vitro models of neurocircuits with human neurons. Technology (Singap World Sci). 2017 Jun;5(2):87-97. doi: 10.1142/S2339547817500054. PubMed PMID: 28781993; PubMed Central PMCID: PMC5541685.
Jiao X, Doamekpor SK, Bird JG, Nickels BE, Tong L, Hart RP, Kiledjian M. 5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding. Cell. 2017 Mar 9;168(6):1015-1027.e10. doi: 10.1016/j.cell.2017.02.019. PubMed PMID: 28283058; PubMed Central PMCID: PMC5371429.
Chen J, Chen Y, Vail G, Chow H, Zhang Y, Louie L, Li J, Hart RP, Plummer MR, Herrup K. Erratum to: The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment. Mol Neurodegener. 2017 Jan 12;12(1):4. doi: 10.1186/s13024-017-0151-6. PubMed PMID: 28081717; PubMed Central PMCID: PMC5234131.
Hart RP, Goff LA. Long noncoding RNAs: Central to nervous system development. Int J Dev Neurosci. 2016 Dec;55:109-116. doi: 10.1016/j.ijdevneu.2016.06.001. Epub 2016 Jun 11. Review. PubMed PMID: 27296516; PubMed Central PMCID: PMC5148644.
Oni EN, Halikere A, Li G, Toro-Ramos AJ, Swerdel MR, Verpeut JL, Moore JC, Bello NT, Bierut LJ, Goate A, Tischfield JA, Pang ZP, Hart RP. Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele. Sci Rep. 2016 Oct 4;6:34341. doi: 10.1038/srep34341. PubMed PMID: 27698409; PubMed Central PMCID: PMC5048107.
Oni EN, Hart RP. Bioinformatic Analysis of DNA Methylation in Neural Progenitor Cell Models of Alcohol Abuse. Curr Pharmacol Rep. 2016 Oct;2(5):203-210. doi: 10.1007/s40495-016-0065-y. Epub 2016 Aug 5. PubMed PMID: 27774408; PubMed Central PMCID: PMC5070667.
Chen J, Chen Y, Vail G, Chow H, Zhang Y, Louie L, Li J, Hart RP, Plummer MR, Herrup K. The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment. Mol Neurodegener. 2016 Aug 18;11(1):60. doi: 10.1186/s13024-016-0127-y. PubMed PMID: 27538496; PubMed Central PMCID: PMC4991002.
Popovitchenko T, Thompson K, Viljetic B, Jiao X, Kontonyiannis DL, Kiledjian M, Hart RP, Rasin MR. The RNA binding protein HuR determines the differential translation of autism-associated FoxP subfamily members in the developing neocortex. Sci Rep. 2016 Jul 7;6:28998. doi: 10.1038/srep28998. PubMed PMID: 27383233; PubMed Central PMCID: PMC4935837.
De Filippis L, Halikere A, McGowan H, Moore JC, Tischfield JA, Hart RP, Pang ZP. Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells. Mol Brain. 2016 May 10;9(1):51. doi: 10.1186/s13041-016-0221-7. PubMed PMID: 27160314; PubMed Central PMCID: PMC4862119.
Grudzien-Nogalska E, Jiao X, Song MG, Hart RP, Kiledjian M. Nudt3 is an mRNA decapping enzyme that modulates cell migration. RNA. 2016 May;22(5):773-81. doi: 10.1261/rna.055699.115. Epub 2016 Mar 1. PubMed PMID: 26932476; PubMed Central PMCID: PMC4836651.
Carlson AL, Bennett NK, Francis NL, Halikere A, Clarke S, Moore JC, Hart RP, Paradiso K, Wernig M, Kohn J, Pang ZP, Moghe PV. Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds. Nat Commun. 2016 Mar 17;7:10862. doi: 10.1038/ncomms10862. PubMed PMID: 26983594; PubMed Central PMCID: PMC4800432.
Lin L, Swerdel MR, Lazaropoulos MP, Hoffman GS, Toro-Ramos AJ, Wright J, Lederman H, Chen J, Moore JC, Hart RP. Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line. Stem Cell Reports. 2015 Dec 8;5(6):1097-1108. doi: 10.1016/j.stemcr.2015.10.010. Epub 2015 Nov 19. PubMed PMID: 26677768; PubMed Central PMCID: PMC4682125.
Jiang D, Zhang Y, Hart RP, Chen J, Herrup K, Li J. Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency. Brain. 2015 Dec;138(Pt 12):3520-36. doi: 10.1093/brain/awv284. Epub 2015 Oct 27. PubMed PMID: 26510954; PubMed Central PMCID: PMC4668921.
Kraushar ML, Viljetic B, Wijeratne HR, Thompson K, Jiao X, Pike JW, Medvedeva V, Groszer M, Kiledjian M, Hart RP, Rasin MR. Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes. J Neurosci. 2015 Aug 5;35(31):10911-26. doi: 10.1523/JNEUROSCI.0601-15.2015. PubMed PMID: 26245956; PubMed Central PMCID: PMC4524969.
Carmel JB, Young W, Hart RP. Flipping the transcriptional switch from myelin inhibition to axon growth in the CNS. Front Mol Neurosci. 2015;8:34. doi: 10.3389/fnmol.2015.00034. eCollection 2015. PubMed PMID: 26236189; PubMed Central PMCID: PMC4505142.
Siddiq MM, Hannila SS, Carmel JB, Bryson JB, Hou J, Nikulina E, Willis MR, Mellado W, Richman EL, Hilaire M, Hart RP, Filbin MT. Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System. J Biol Chem. 2015 Jun 26;290(26):16343-56. doi: 10.1074/jbc.M114.630574. Epub 2015 May 6. PubMed PMID: 25947372; PubMed Central PMCID: PMC4481232.
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