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Huang Y, Wang M, Ni H, Zhang J, Li A, Hu B, Junqueira Alves C, Wahane S, Mitzy Rios de Anda M, Ho L, Li Y, Kang S, Neff R, Kostic A, Buxbaum JD, Crary JF, Brennand KJ, Zhang B, Zou H, Friedel RH. Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease. Nature Neuroscience. Forthcoming.
Marallano VJ, Ughetta ME, Tejero R, Nanda S, Ramalingam R, Stalbow L, Sattiraju A, Huang Y, Ramakrishnan A, Shen L, Wojcinski A, Kesari S, Zou H, Tsankov AM, Friedel RH. Hypoxia drives shared and distinct transcriptomic changes in two invasive glioma stem cell lines. Sci Rep. 2024 Mar 27;14(1):7246. doi: 10.1038/s41598-024-56102-5. PubMed PMID: 38538643; PubMed Central PMCID: PMC10973515.
Halawani D, Wang Y, Ramakrishnan A, Estill M, He X, Shen L, Friedel RH, Zou H. Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons. Nat Commun. 2023 Aug 24;14(1):5165. doi: 10.1038/s41467-023-40816-7. PubMed PMID: 37620297; PubMed Central PMCID: PMC10449865.
Sattiraju A, Kang S, Giotti B, Chen Z, Marallano VJ, Brusco C, Ramakrishnan A, Shen L, Tsankov AM, Hambardzumyan D, Friedel RH, Zou H. Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression. Immunity. 2023 Aug 8;56(8):1825-1843.e6. doi: 10.1016/j.immuni.2023.06.017. Epub 2023 Jul 13. PubMed PMID: 37451265; PubMed Central PMCID: PMC10527169.
Li Y, Kang S, Halawani D, Wang Y, Junqueira Alves C, Ramakrishnan A, Estill M, Shen L, Li F, He X, Friedel RH, Zou H. Macrophages facilitate peripheral nerve regeneration by organizing regeneration tracks through Plexin-B2. Genes Dev. 2022 Feb 1;36(3-4):133-148. doi: 10.1101/gad.349063.121. Epub 2022 Jan 27. PubMed PMID: 35086862; PubMed Central PMCID: PMC8887133.
Junqueira Alves C, Dariolli R, Haydak J, Kang S, Hannah T, Wiener RJ, DeFronzo S, Tejero R, Gusella GL, Ramakrishnan A, Alves Dias R, Wojcinski A, Kesari S, Shen L, Sobie EA, Rodrigues Furtado de Mendonça JP, Azeloglu EU, Zou H, Friedel RH. Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion. Nat Commun. 2021 Oct 14;12(1):6019. doi: 10.1038/s41467-021-26296-7. PubMed PMID: 34650052; PubMed Central PMCID: PMC8517024.
Vitic Z, Safory H, Jovanovic VM, Sarusi Y, Stavsky A, Kahn J, Kuzmina A, Toker L, Gitler D, Taube R, Friedel RH, Engelender S, Brodski C. BMP5/7 protect dopaminergic neurons in an α-synuclein mouse model of Parkinson's disease. Brain. 2021 Mar 3;144(2):e15. doi: 10.1093/brain/awaa368. PubMed PMID: 33253359; PubMed Central PMCID: PMC7940172.
Junqueira Alves C, Silva Ladeira J, Hannah T, Pedroso Dias RJ, Zabala Capriles PV, Yotoko K, Zou H, Friedel RH. Evolution and Diversity of Semaphorins and Plexins in Choanoflagellates. Genome Biol Evol. 2021 Mar 1;13(3). doi: 10.1093/gbe/evab035. PubMed PMID: 33624753; PubMed Central PMCID: PMC8011033.
Wahane S, Zhou X, Zhou X, Guo L, Friedl MS, Kluge M, Ramakrishnan A, Shen L, Friedel CC, Zhang B, Friedel RH, Zou H. Diversified transcriptional responses of myeloid and glial cells in spinal cord injury shaped by HDAC3 activity. Sci Adv. 2021 Feb;7(9). doi: 10.1126/sciadv.abd8811. Print 2021 Feb. PubMed PMID: 33637528; PubMed Central PMCID: PMC7909890.
Huang Y, Tejero R, Lee VK, Brusco C, Hannah T, Bertucci TB, Junqueira Alves C, Katsyv I, Kluge M, Foty R, Zhang B, Friedel CC, Dai G, Zou H, Friedel RH. Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics. Commun Biol. 2021 Jan 29;4(1):145. doi: 10.1038/s42003-021-01667-4. PubMed PMID: 33514835; PubMed Central PMCID: PMC7846610.
Bozec D, Sattiraju A, Bouras A, Jesu Raj JG, Rivera D, Huang Y, Junqueira Alves C, Tejero R, Tsankova NM, Zou H, Hadjipanayis C, Friedel RH. Akaluc bioluminescence offers superior sensitivity to track in vivo glioma expansion. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa134. doi: 10.1093/noajnl/vdaa134. eCollection 2020 Jan-Dec. PubMed PMID: 33241215; PubMed Central PMCID: PMC7680182.
Carminucci A, Tejero R, Huang Y, Danish S, Friedel RH, Foty R. Teaching an Old Drug New Tricks: Dexamethasone as an In Vivo Inhibitor of Glioblastoma Dispersal. Cureus. 2020 Apr 20;12(4):e7749. doi: 10.7759/cureus.7749. PubMed PMID: 32455066; PubMed Central PMCID: PMC7243068.
Ozturk MS, Lee VK, Zou H, Friedel RH, Intes X, Dai G. High-resolution tomographic analysis of in vitro 3D glioblastoma tumor model under long-term drug treatment. Sci Adv. 2020 Mar;6(10):eaay7513. doi: 10.1126/sciadv.aay7513. eCollection 2020 Mar. PubMed PMID: 32181351; PubMed Central PMCID: PMC7060061.
Zhou X, Wahane S, Friedl MS, Kluge M, Friedel CC, Avrampou K, Zachariou V, Guo L, Zhang B, He X, Friedel RH, Zou H. Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2. Nat Neurosci. 2020 Mar;23(3):337-350. doi: 10.1038/s41593-020-0597-7. PubMed PMID: 32112058; PubMed Central PMCID: PMC7412870.
Daviaud N, Chevalier C, Friedel RH, Zou H. Distinct Vulnerability and Resilience of Human Neuroprogenitor Subtypes in Cerebral Organoid Model of Prenatal Hypoxic Injury. Front Cell Neurosci. 2019;13:336. doi: 10.3389/fncel.2019.00336. eCollection 2019. PubMed PMID: 31417360; PubMed Central PMCID: PMC6682705.
Tejero R, Huang Y, Katsyv I, Kluge M, Lin JY, Tome-Garcia J, Daviaud N, Wang Y, Zhang B, Tsankova NM, Friedel CC, Zou H, Friedel RH. Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment. EBioMedicine. 2019 Apr;42:252-269. doi: 10.1016/j.ebiom.2019.03.064. Epub 2019 Apr 3. PubMed PMID: 30952620; PubMed Central PMCID: PMC6491796.
Junqueira Alves C, Yotoko K, Zou H, Friedel RH. Origin and evolution of plexins, semaphorins, and Met receptor tyrosine kinases. Sci Rep. 2019 Feb 13;9(1):1970. doi: 10.1038/s41598-019-38512-y. PubMed PMID: 30760850; PubMed Central PMCID: PMC6374515.
Daviaud N, Friedel RH, Zou H. Vascularization and Engraftment of Transplanted Human Cerebral Organoids in Mouse Cortex. eNeuro. 2018 Nov-Dec;5(6). doi: 10.1523/ENEURO.0219-18.2018. eCollection 2018 Nov-Dec. PubMed PMID: 30460331; PubMed Central PMCID: PMC6243198.
Tome-Garcia J, Erfani P, Nudelman G, Tsankov AM, Katsyv I, Tejero R, Bin Zhang, Walsh M, Friedel RH, Zaslavsky E, Tsankova NM. Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma. Nat Commun. 2018 Oct 1;9(1):4020. doi: 10.1038/s41467-018-06258-2. PubMed PMID: 30275445; PubMed Central PMCID: PMC6167382.
Jovanovic VM, Salti A, Tilleman H, Zega K, Jukic MM, Zou H, Friedel RH, Prakash N, Blaess S, Edenhofer F, Brodski C. BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells. J Neurosci. 2018 Feb 14;38(7):1662-1676. doi: 10.1523/JNEUROSCI.1540-17.2018. Epub 2018 Jan 10. PubMed PMID: 29321139; PubMed Central PMCID: PMC5815451.
Zega K, Jovanovic VM, Vitic Z, Niedzielska M, Knaapi L, Jukic MM, Partanen J, Friedel RH, Lang R, Brodski C. Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool. Front Mol Neurosci. 2017;10:372. doi: 10.3389/fnmol.2017.00372. eCollection 2017. PubMed PMID: 29170629; PubMed Central PMCID: PMC5684737.
Yu W, Goncalves KA, Li S, Kishikawa H, Sun G, Yang H, Vanli N, Wu Y, Jiang Y, Hu MG, Friedel RH, Hu GF. Plexin-B2 Mediates Physiologic and Pathologic Functions of Angiogenin. Cell. 2017 Nov 2;171(4):849-864.e25. doi: 10.1016/j.cell.2017.10.005. PubMed PMID: 29100074; PubMed Central PMCID: PMC5847377.
Kuboyama T, Wahane S, Huang Y, Zhou X, Wong JK, Koemeter-Cox A, Martini M, Friedel RH, Zou H. HDAC3 inhibition ameliorates spinal cord injury by immunomodulation. Sci Rep. 2017 Aug 17;7(1):8641. doi: 10.1038/s41598-017-08535-4. PubMed PMID: 28819194; PubMed Central PMCID: PMC5561061.
Tome-Garcia J, Tejero R, Nudelman G, Yong RL, Sebra R, Wang H, Fowkes M, Magid M, Walsh M, Silva-Vargas V, Zaslavsky E, Friedel RH, Doetsch F, Tsankova NM. Prospective Isolation and Comparison of Human Germinal Matrix and Glioblastoma EGFR(+) Populations with Stem Cell Properties. Stem Cell Reports. 2017 May 9;8(5):1421-1429. doi: 10.1016/j.stemcr.2017.03.019. Epub 2017 Apr 20. PubMed PMID: 28434940; PubMed Central PMCID: PMC5425658.
Yan H, Wu L, Shih C, Hou S, Shi J, Mao T, Chen W, Melvin B, Rigby RJ, Chen Y, Jiang H, Friedel RH, Vinuesa CG, Qi H. Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center. Cell Rep. 2017 May 2;19(5):995-1007. doi: 10.1016/j.celrep.2017.04.022. PubMed PMID: 28467912.
Loh YE, Koemeter-Cox A, Finelli MJ, Shen L, Friedel RH, Zou H. Comprehensive mapping of 5-hydroxymethylcytosine epigenetic dynamics in axon regeneration. Epigenetics. 2017 Feb;12(2):77-92. doi: 10.1080/15592294.2016.1264560. Epub 2016 Dec 5. PubMed PMID: 27918235; PubMed Central PMCID: PMC5330438.
Xue D, Kaufman GN, Dembele M, Beland M, Massoud AH, Mindt BC, Fiter R, Fixman ED, Martin JG, Friedel RH, Divangahi M, Fritz JH, Mazer BD. Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells. J Immunol. 2017 Jan 1;198(1):71-81. doi: 10.4049/jimmunol.1600831. Epub 2016 Nov 23. PubMed PMID: 27881703.
Xue D, Desjardins M, Kaufman GN, Béland M, Al-Tamemi S, Ahmed E, Tao S, Friedel RH, Mourad W, Mazer BD. Semaphorin 4C: A Novel Component of B-Cell Polarization in Th2-Driven Immune Responses. Front Immunol. 2016;7:558. doi: 10.3389/fimmu.2016.00558. eCollection 2016. PubMed PMID: 28003812; PubMed Central PMCID: PMC5141245.
Daviaud N, Chen K, Huang Y, Friedel RH, Zou H. Impaired cortical neurogenesis in plexin-B1 and -B2 double deletion mutant. Dev Neurobiol. 2016 Aug;76(8):882-99. doi: 10.1002/dneu.22364. Epub 2015 Dec 1. PubMed PMID: 26579598.
Wong JK, Chen L, Huang Y, Sehba FA, Friedel RH, Zou H. Attenuation of Cerebral Ischemic Injury in Smad1 Deficient Mice. PLoS One. 2015;10(8):e0136967. doi: 10.1371/journal.pone.0136967. eCollection 2015. PubMed PMID: 26317208; PubMed Central PMCID: PMC4552810.
Xia J, Swiercz JM, Bañón-Rodríguez I, Matković I, Federico G, Sun T, Franz T, Brakebusch CH, Kumanogoh A, Friedel RH, Martín-Belmonte F, Gröne HJ, Offermanns S, Worzfeld T. Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair. Dev Cell. 2015 May 4;33(3):299-313. doi: 10.1016/j.devcel.2015.02.001. Epub 2015 Apr 16. PubMed PMID: 25892012.
Le AP, Huang Y, Pingle SC, Kesari S, Wang H, Yong RL, Zou H, Friedel RH. Plexin-B2 promotes invasive growth of malignant glioma. Oncotarget. 2015 Mar 30;6(9):7293-304. doi: 10.18632/oncotarget.3421. PubMed PMID: 25762646; PubMed Central PMCID: PMC4466685.
Zou H, Feng R, Huang Y, Tripodi J, Najfeld V, Tsankova NM, Jahanshahi M, Olson LE, Soriano P, Friedel RH. Double minute amplification of mutant PDGF receptor α in a mouse glioma model. Sci Rep. 2015 Feb 16;5:8468. doi: 10.1038/srep08468. PubMed PMID: 25683249; PubMed Central PMCID: PMC4329559.
Azzarelli R, Pacary E, Garg R, Garcez P, van den Berg D, Riou P, Ridley AJ, Friedel RH, Parsons M, Guillemot F. An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration. Nat Commun. 2014 Feb 27;5:3405. doi: 10.1038/ncomms4405. PubMed PMID: 24572910; PubMed Central PMCID: PMC3939360.
Friedel RH, Friedel CC, Bonfert T, Shi R, Rad R, Soriano P. Clonal expansion analysis of transposon insertions by high-throughput sequencing identifies candidate cancer genes in a PiggyBac mutagenesis screen. PLoS One. 2013;8(8):e72338. doi: 10.1371/journal.pone.0072338. Print 2013. PubMed PMID: 23940809; PubMed Central PMCID: PMC3733837.
Kuzirian MS, Moore AR, Staudenmaier EK, Friedel RH, Paradis S. The class 4 semaphorin Sema4D promotes the rapid assembly of GABAergic synapses in rodent hippocampus. J Neurosci. 2013 May 22;33(21):8961-73. doi: 10.1523/JNEUROSCI.0989-13.2013. PubMed PMID: 23699507; PubMed Central PMCID: PMC3713781.
Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Stewart AF, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W. The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome. 2012 Oct;23(9-10):580-6. doi: 10.1007/s00335-012-9422-2. Epub 2012 Sep 12. PubMed PMID: 22968824; PubMed Central PMCID: PMC3463800.
Negishi-Koga T, Shinohara M, Komatsu N, Bito H, Kodama T, Friedel RH, Takayanagi H. Suppression of bone formation by osteoclastic expression of semaphorin 4D. Nat Med. 2011 Oct 23;17(11):1473-80. doi: 10.1038/nm.2489. PubMed PMID: 22019888.
Leslie JR, Imai F, Fukuhara K, Takegahara N, Rizvi TA, Friedel RH, Wang F, Kumanogoh A, Yoshida Y. Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation. Development. 2011 Sep;138(18):4085-95. doi: 10.1242/dev.066076. Epub 2011 Aug 10. PubMed PMID: 21831918; PubMed Central PMCID: PMC3160102.
Maier V, Jolicoeur C, Rayburn H, Takegahara N, Kumanogoh A, Kikutani H, Tessier-Lavigne M, Wurst W, Friedel RH. Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development. Mol Cell Neurosci. 2011 Feb;46(2):419-31. doi: 10.1016/j.mcn.2010.11.005. Epub 2010 Nov 29. PubMed PMID: 21122816; PubMed Central PMCID: PMC3030677.
Friedel RH, Wurst W, Wefers B, Kühn R. Generating conditional knockout mice. Methods Mol Biol. 2011;693:205-31. doi: 10.1007/978-1-60761-974-1_12. PubMed PMID: 21080282.
Zielonka M, Xia J, Friedel RH, Offermanns S, Worzfeld T. A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system. Exp Cell Res. 2010 Sep 10;316(15):2477-86. doi: 10.1016/j.yexcr.2010.05.007. Epub 2010 May 15. PubMed PMID: 20478304.
Takamatsu H, Takegahara N, Nakagawa Y, Tomura M, Taniguchi M, Friedel RH, Rayburn H, Tessier-Lavigne M, Yoshida Y, Okuno T, Mizui M, Kang S, Nojima S, Tsujimura T, Nakatsuji Y, Katayama I, Toyofuku T, Kikutani H, Kumanogoh A. Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II. Nat Immunol. 2010 Jul;11(7):594-600. doi: 10.1038/ni.1885. Epub 2010 May 30. PubMed PMID: 20512151; PubMed Central PMCID: PMC3045806.
Okuno T, Nakatsuji Y, Moriya M, Takamatsu H, Nojima S, Takegahara N, Toyofuku T, Nakagawa Y, Kang S, Friedel RH, Sakoda S, Kikutani H, Kumanogoh A. Roles of Sema4D-plexin-B1 interactions in the central nervous system for pathogenesis of experimental autoimmune encephalomyelitis. J Immunol. 2010 Feb 1;184(3):1499-506. doi: 10.4049/jimmunol.0903302. Epub 2009 Dec 28. PubMed PMID: 20038643.
Friedel RH, Soriano P. Gene trap mutagenesis in the mouse. Methods Enzymol. 2010;477:243-69. doi: 10.1016/S0076-6879(10)77013-0. PubMed PMID: 20699145; PubMed Central PMCID: PMC5659187.
Friedel RH. Targeting embryonic stem cells. Methods Mol Biol. 2009;561:185-97. doi: 10.1007/978-1-60327-019-9_12. PubMed PMID: 19504072.
Korostylev A, Worzfeld T, Deng S, Friedel RH, Swiercz JM, Vodrazka P, Maier V, Hirschberg A, Ohoka Y, Inagaki S, Offermanns S, Kuner R. A functional role for semaphorin 4D/plexin B1 interactions in epithelial branching morphogenesis during organogenesis. Development. 2008 Oct;135(20):3333-43. doi: 10.1242/dev.019760. Epub 2008 Sep 17. PubMed PMID: 18799546.
Friedel RH, Seisenberger C, Kaloff C, Wurst W. EUCOMM--the European conditional mouse mutagenesis program. Brief Funct Genomic Proteomic. 2007 Sep;6(3):180-5. doi: 10.1093/bfgp/elm022. Epub 2007 Oct 29. PubMed PMID: 17967808.
Friedel RH, Kerjan G, Rayburn H, Schüller U, Sotelo C, Tessier-Lavigne M, Chédotal A. Plexin-B2 controls the development of cerebellar granule cells. J Neurosci. 2007 Apr 4;27(14):3921-32. doi: 10.1523/JNEUROSCI.4710-06.2007. PubMed PMID: 17409257; PubMed Central PMCID: PMC6672405.
Miller SF, Summerhurst K, Rünker AE, Kerjan G, Friedel RH, Chédotal A, Murphy P, Mitchell KJ. Expression of Plxdc2/TEM7R in the developing nervous system of the mouse. Gene Expr Patterns. 2007 Apr;7(5):635-44. doi: 10.1016/j.modgep.2006.12.002. Epub 2006 Dec 16. PubMed PMID: 17280871.
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