My Bibliography

select

Flores-Ramirez FJ, Martin-Fardon R. Functional interaction between orexin/CRF and orexin/dynorphin transmission in the infralimbic cortex modulates the stress-induced reinstatement of alcohol-seeking behavior in male and female Wistar rats. Neuropharmacology. 2026 Jun 1;290:110895. doi: 10.1016/j.neuropharm.2026.110895. Epub 2026 Feb 27. PubMed PMID: 41765280; PubMed Central PMCID: PMC13318409.

select

Holguin G, Martin-Fardon R. Modulatory effects of orexin and dynorphin on stress-related alcohol seeking and relapse: pivotal role of the posterior paraventricular nucleus of the thalamus. Front Pharmacol. 2026;17:1729040. doi: 10.3389/fphar.2026.1729040. eCollection 2026. Review. PubMed PMID: 41669681; PubMed Central PMCID: PMC12883789.

select

Flores-Ramirez FJ, Pascasio G, Martin-Fardon R. Functional interaction between orexin/dynorphin transmission in the posterior paraventricular nucleus of the thalamus following alcohol dependence: mediation of alcohol-seeking behavior. Front Pharmacol. 2025;16:1718540. doi: 10.3389/fphar.2025.1718540. eCollection 2025. PubMed PMID: 41394154; PubMed Central PMCID: PMC12695742.

select

Porras-Perales O, Sánchez-Marín L, Medina-Vera D, Flores-López M, Martín-Chaves L, Boccalon M, Requena-Ocaña N, García-Marchena N, Reviriego R, Santín LJ, Martin-Fardon R, Jiménez-Navarro M, Rodríguez de Fonseca F, Serrano A, Pavón-Morón FJ. Sex-specific dysregulation of the CX(3)CL1/CX(3)CR1 Axis following cocaine exposure: Translational evidence for a potential biomarker of abstinence. Prog Neuropsychopharmacol Biol Psychiatry. 2025 Aug 30;141:111482. doi: 10.1016/j.pnpbp.2025.111482. Epub 2025 Aug 31. PubMed PMID: 40897230; PubMed Central PMCID: PMC12862095.

select

Oasa S, Stoyanov B, Hamada Y, Nikolić SN, Krmpot AJ, Kitamura A, Vukojević V. Celebrating 50 years of fluorescence correlation spectroscopy (FCS): Advancing live-cell massively parallel FCS studies with photostable GFPs, mStayGold and StayGold/E138D. Biochim Biophys Acta Gen Subj. 2025 Jun;1869(7):130809. doi: 10.1016/j.bbagen.2025.130809. Epub 2025 Apr 17. PubMed PMID: 40252740; PubMed Central PMCID: PMC13276660.

select

Anjos-Santos A, Erikson CM, Flores-Ramirez FJ, Rodriguez L, Barchiesi R, Vozella V, Borgonetti V, Cruz B, Zalfa C, Hughes K, Gandhi P, Bajo M, Vlkolinsky R, Mayfield RD, Martin-Fardon R, Roberto M. Noradrenaline Modulates Central Amygdala GABA Transmission and Alcohol Drinking in Female Rats. Biol Psychiatry. 2026 Jan 1;99(1):21-33. doi: 10.1016/j.biopsych.2025.03.024. Epub 2025 Apr 5. PubMed PMID: 40194754; PubMed Central PMCID: PMC12369889.

select

Oasa S, Sezgin E, Ma Y, Horne DA, Radmilović MD, Jovanović-Talisman T, Martin-Fardon R, Vukojević V, Terenius L. Naltrexone blocks alcohol-induced effects on kappa-opioid receptors in the plasma membrane. Transl Psychiatry. 2024 Nov 24;14(1):477. doi: 10.1038/s41398-024-03172-8. PubMed PMID: 39582064; PubMed Central PMCID: PMC11586411.

select

Flores-Ramirez FJ, Illenberger JM, Martin-Fardon R. Interaction between corticotropin-releasing factor, orexin, and dynorphin in the infralimbic cortex may mediate exacerbated alcohol-seeking behavior. Neurobiol Stress. 2024 Nov;33:100695. doi: 10.1016/j.ynstr.2024.100695. eCollection 2024 Nov. PubMed PMID: 39640001; PubMed Central PMCID: PMC11617300.

select

Illenberger JM, Flores-Ramirez FJ, Pascasio G, Franco M, Mendonsa B, Martin-Fardon R. Pivotal role of orexin signaling in the posterior paraventricular nucleus of the thalamus during the stress-induced reinstatement of oxycodone-seeking behavior. J Psychopharmacol. 2024 Jul;38(7):647-660. doi: 10.1177/02698811241260989. Epub 2024 Jun 18. PubMed PMID: 38888086; PubMed Central PMCID: PMC11407285.

select

Flores-Ramirez FJ, Illenberger JM, Pascasio G, Terenius L, Martin-Fardon R. LY2444296, a κ-opioid receptor antagonist, selectively reduces alcohol drinking in male and female Wistar rats with a history of alcohol dependence. Sci Rep. 2024 Mar 9;14(1):5804. doi: 10.1038/s41598-024-56500-9. PubMed PMID: 38461355; PubMed Central PMCID: PMC10925033.

select

Matzeu A, Flores-Ramirez F, Martin-Fardon R. Thalamic circuits. In: Gilpin N, editor. Neurocircuitry of Addiction [Internet] London: Academic Press; 2023. p.209-246. Available from: doi: 10.1016/B978-0-12-823453-2.00012-6.

select

Illenberger JM, Flores-Ramirez FJ, Pascasio G, Matzeu A, Martin-Fardon R. Daily treatment with the dual orexin receptor antagonist DORA-12 during oxycodone abstinence decreases oxycodone conditioned reinstatement. Neuropharmacology. 2023 Nov 15;239:109685. doi: 10.1016/j.neuropharm.2023.109685. Epub 2023 Aug 12. PubMed PMID: 37579870; PubMed Central PMCID: PMC10529002.

select

Terenius L, Oasa S, Sezgin E, Ma Y, Horne D, Radmiković M, Jovanović-Talisman T, Martin-Fardon R, Vukojevic V. Naltrexone blocks alcohol-induced effects on kappa-opioid receptors in the plasma membrane. Res Sq. 2023 Jul 21;. doi: 10.21203/rs.3.rs-3091960/v1. PubMed PMID: 37503185; PubMed Central PMCID: PMC10371157.

select

Illenberger JM, Flores-Ramirez FJ, Matzeu A, Lütjens R, Martin-Fardon R. ADX106772, an mGlu2 receptor positive allosteric modulator, selectively attenuates oxycodone taking and seeking. Neuropharmacology. 2023 Nov 1;238:109666. doi: 10.1016/j.neuropharm.2023.109666. Epub 2023 Jul 16. PubMed PMID: 37463637; PubMed Central PMCID: PMC10529136.

select

Doyle MR, Martinez AR, Qiao R, Dirik S, Di Ottavio F, Pascasio G, Martin-Fardon R, Benner C, George O, Telese F, de Guglielmo G. Strain and sex-related behavioral variability of oxycodone dependence in rats. Neuropharmacology. 2023 Oct 1;237:109635. doi: 10.1016/j.neuropharm.2023.109635. Epub 2023 Jun 15. PubMed PMID: 37327971; PubMed Central PMCID: PMC10353778.

select

McGregor R, Matzeu A, Thannickal TC, Wu F, Cornford M, Martin-Fardon R, Siegel JM. Sensitivity of Hypocretin System to Chronic Alcohol Exposure: A Human and Animal Study. Neuroscience. 2023 Jul 1;522:1-10. doi: 10.1016/j.neuroscience.2023.04.018. Epub 2023 Apr 28. PubMed PMID: 37121379; PubMed Central PMCID: PMC10681027.

select

Illenberger JM, Flores-Ramirez FJ, Matzeu A, Mason BJ, Martin-Fardon R. Suvorexant, an FDA-approved dual orexin receptor antagonist, reduces oxycodone self-administration and conditioned reinstatement in male and female rats. Front Pharmacol. 2023;14:1127735. doi: 10.3389/fphar.2023.1127735. eCollection 2023. PubMed PMID: 37180716; PubMed Central PMCID: PMC10172671.

select

Flores-Ramirez FJ, Varodayan FP, Patel RR, Illenberger JM, Di Ottavio F, Roberto M, Martin-Fardon R. Blockade of orexin receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol-seeking behaviour in alcohol-dependent rats. Br J Pharmacol. 2023 Jun;180(11):1500-1515. doi: 10.1111/bph.16015. Epub 2023 Jan 16. PubMed PMID: 36537731; PubMed Central PMCID: PMC10577928.

select

Matzeu A, Martin-Fardon R. The orexin system, prescription opioid use disorder, and orexin receptors blockade. In: Preedy V, Patel V, editors. Handbook of Substance Misuse and Addictions; From Biology to Public Health. [Internet] Basel: Springer Nature; 2022. p.1769-1804. Available from: doi: 10.1007/978-3-030-67928-6_91-1.

select

Flores-Ramirez FJ, Illenberger JM, Pascasio GE, Matzeu A, Mason BJ, Martin-Fardon R. Alternative use of suvorexant (Belsomra(®)) for the prevention of alcohol drinking and seeking in rats with a history of alcohol dependence. Front Behav Neurosci. 2022;16:1085882. doi: 10.3389/fnbeh.2022.1085882. eCollection 2022. PubMed PMID: 36620860; PubMed Central PMCID: PMC9813433.

select

Varodayan FP, Patel RR, Matzeu A, Wolfe SA, Curley DE, Khom S, Gandhi PJ, Rodriguez L, Bajo M, D'Ambrosio S, Sun H, Kerr TM, Gonzales RA, Leggio L, Natividad LA, Haass-Koffler CL, Martin-Fardon R, Roberto M. The Amygdala Noradrenergic System Is Compromised With Alcohol Use Disorder. Biol Psychiatry. 2022 Jun 15;91(12):1008-1018. doi: 10.1016/j.biopsych.2022.02.006. Epub 2022 Apr 13. PubMed PMID: 35430085; PubMed Central PMCID: PMC9167785.

select

Flores-Ramirez FJ, Matzeu A, Sánchez-Marín L, Martin-Fardon R. Blockade of corticotropin-releasing factor-1 receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol seeking in male Wistar rats: Evidence of interaction between CRF(1) and orexin receptor signaling. Neuropharmacology. 2022 Jun 1;210:109046. doi: 10.1016/j.neuropharm.2022.109046. Epub 2022 Mar 25. PubMed PMID: 35341789; PubMed Central PMCID: PMC9176217.

select

Laque A, Wagner GE, Matzeu A, De Ness GL, Kerr TM, Carroll AM, de Guglielmo G, Nedelescu H, Buczynski MW, Gregus AM, Jhou TC, Zorrilla EP, Martin-Fardon R, Koya E, Ritter RC, Weiss F, Suto N. Linking drug and food addiction via compulsive appetite. Br J Pharmacol. 2022 Jun;179(11):2589-2609. doi: 10.1111/bph.15797. Epub 2022 Mar 7. PubMed PMID: 35023154; PubMed Central PMCID: PMC9081129.

select

Matzeu A, Martin-Fardon R. Understanding the Role of Orexin Neuropeptides in Drug Addiction: Preclinical Studies and Translational Value. Front Behav Neurosci. 2021;15:787595. doi: 10.3389/fnbeh.2021.787595. eCollection 2021. Review. PubMed PMID: 35126069; PubMed Central PMCID: PMC8811192.

select

Matzeu A, Martin-Fardon R. Blockade of corticotropin-releasing factor receptor 1 in the central amygdala prevents cocaine-seeking behaviour induced by orexin-A administered to the posterior paraventricular nucleus of the thalamus in male rats. J Psychiatry Neurosci. 2021 Jul 28;46(4):E459-E471. doi: 10.1503/jpn.200213. PubMed PMID: 34318655; PubMed Central PMCID: PMC8519495.

select

Matzeu A, Martin-Fardon R. Cocaine-Seeking Behavior Induced by Orexin A Administration in the Posterior Paraventricular Nucleus of the Thalamus Is Not Long-Lasting: Neuroadaptation of the Orexin System During Cocaine Abstinence. Front Behav Neurosci. 2021;15:620868. doi: 10.3389/fnbeh.2021.620868. eCollection 2021. PubMed PMID: 33708078; PubMed Central PMCID: PMC7940839.

select

Pavón FJ, Polis IY, Stouffer DG, Cravatt BF, Roberto M, Martin-Fardon R, Rodríguez de Fonseca F, Parsons LH, Serrano A. Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex. Neurobiol Stress. 2021 May;14:100293. doi: 10.1016/j.ynstr.2021.100293. eCollection 2021 May. PubMed PMID: 33490317; PubMed Central PMCID: PMC7809503.

select

Matzeu A, Martin-Fardon R. Blockade of Orexin Receptors in the Posterior Paraventricular Nucleus of the Thalamus Prevents Stress-Induced Reinstatement of Reward-Seeking Behavior in Rats With a History of Ethanol Dependence. Front Integr Neurosci. 2020;14:599710. doi: 10.3389/fnint.2020.599710. eCollection 2020. PubMed PMID: 33240054; PubMed Central PMCID: PMC7683390.

select

Pavon FJ, Polis I, Stouffer DG, Roberto M, Martin-Fardon R, Rodriguez de Fonseca F, Parsons LH, Serrano A. COX-2 Inhibition Antagonizes Intra-Accumbens 2-Arachidonoylglycerol-Mediated Reduction in Ethanol Self-Administration in Rats. Alcohol Clin Exp Res. 2020 Nov;44(11):2158-2165. doi: 10.1111/acer.14456. Epub 2020 Oct 3. PubMed PMID: 32944989; PubMed Central PMCID: PMC7680444.

select

Matzeu A, Martin-Fardon R. Targeting the Orexin System for Prescription Opioid Use Disorder. Brain Sci. 2020 Apr 10;10(4). doi: 10.3390/brainsci10040226. Review. PubMed PMID: 32290110; PubMed Central PMCID: PMC7225970.

select

Kim JS, Martin-Fardon R. Possible Role of CRF-Hcrt Interaction in the Infralimbic Cortex in the Emergence and Maintenance of Compulsive Alcohol-Seeking Behavior. Alcohol Clin Exp Res. 2020 Feb;44(2):354-367. doi: 10.1111/acer.14264. Epub 2020 Jan 2. Review. PubMed PMID: 31840823; PubMed Central PMCID: PMC7018591.

select

Matzeu A, Martin-Fardon R. Orexin and cocaine addiction. In: Fadel JR, Burk JA, editors. The Orexin/Hypocretin System: Functional Roles and Its Therapeutic Potential [Internet] London: Academic Press; 2019. p.121-137. Available from: doi: 10.1016/B978-0-12-813751-2.00006-1.

select

Matzeu A, Martin-Fardon R. Targeting the orexin system for prescription opioid use disorder: Orexin-1 receptor blockade prevents oxycodone taking and seeking in rats. Neuropharmacology. 2020 Mar 1;164:107906. doi: 10.1016/j.neuropharm.2019.107906. Epub 2019 Dec 4. PubMed PMID: 31841797; PubMed Central PMCID: PMC6954966.

select

Suárez J, Khom S, Alén F, Natividad LA, Varodayan FP, Patel RR, Kirson D, Arco R, Ballesta A, Bajo M, Rubio L, Martin-Fardon R, Rodríguez de Fonseca F, Roberto M. Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala. Addict Biol. 2020 Sep;25(5):e12813. doi: 10.1111/adb.12813. Epub 2019 Jul 24. PubMed PMID: 31339221; PubMed Central PMCID: PMC8050940.

select

Pavón FJ, Serrano A, Stouffer DG, Polis I, Roberto M, Cravatt BF, Martin-Fardon R, Rodríguez de Fonseca F, Parsons LH. Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice. Addict Biol. 2019 Nov;24(6):1204-1215. doi: 10.1111/adb.12695. Epub 2018 Nov 13. PubMed PMID: 30421483; PubMed Central PMCID: PMC6551299.

select

Matzeu A, Terenius L, Martin-Fardon R. Exploring Sex Differences in the Attenuation of Ethanol Drinking by Naltrexone in Dependent Rats During Early and Protracted Abstinence. Alcohol Clin Exp Res. 2018 Dec;42(12):2466-2478. doi: 10.1111/acer.13898. Epub 2018 Oct 28. PubMed PMID: 30320880; PubMed Central PMCID: PMC6286204.

select

Matzeu A, Martin-Fardon R. Drug Seeking and Relapse: New Evidence of a Role for Orexin and Dynorphin Co-transmission in the Paraventricular Nucleus of the Thalamus. Front Neurol. 2018;9:720. doi: 10.3389/fneur.2018.00720. eCollection 2018. Review. PubMed PMID: 30210441; PubMed Central PMCID: PMC6121102.

select

Schmeichel BE, Matzeu A, Koebel P, Vendruscolo LF, Sidhu H, Shahryari R, Kieffer BL, Koob GF, Martin-Fardon R, Contet C. Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats. Neuropsychopharmacology. 2018 Nov;43(12):2373-2382. doi: 10.1038/s41386-018-0054-4. Epub 2018 Apr 6. PubMed PMID: 29703996; PubMed Central PMCID: PMC6180106.

select

Serrano A, Pavon FJ, Buczynski MW, Schlosburg J, Natividad LA, Polis IY, Stouffer DG, Zorrilla EP, Roberto M, Cravatt BF, Martin-Fardon R, Rodriguez de Fonseca F, Parsons LH. Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake. Neuropsychopharmacology. 2018 Aug;43(9):1840-1850. doi: 10.1038/s41386-018-0055-3. Epub 2018 Apr 5. PubMed PMID: 29748627; PubMed Central PMCID: PMC6046053.

select

Gonzalez-Cuevas G, Martin-Fardon R, Kerr TM, Stouffer DG, Parsons LH, Hammell DC, Banks SL, Stinchcomb AL, Weiss F. Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle. Neuropsychopharmacology. 2018 Sep;43(10):2036-2045. doi: 10.1038/s41386-018-0050-8. Epub 2018 Mar 22. PubMed PMID: 29686308; PubMed Central PMCID: PMC6098033.

select

Matzeu A, Kallupi M, George O, Schweitzer P, Martin-Fardon R. Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence. Neuropsychopharmacology. 2018 Apr;43(5):1010-1020. doi: 10.1038/npp.2017.250. Epub 2017 Oct 20. PubMed PMID: 29052613; PubMed Central PMCID: PMC5854806.

select

Natividad LA, Steinman MQ, Laredo SA, Irimia C, Polis IY, Lintz R, Buczynski MW, Martin-Fardon R, Roberto M, Parsons LH. Phosphorylation of calcium/calmodulin-dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol-induced cognitive inflexibility. Addict Biol. 2018 Sep;23(5):1117-1129. doi: 10.1111/adb.12568. Epub 2017 Sep 22. PubMed PMID: 28940879; PubMed Central PMCID: PMC5862723.

select

Pavon FJ, Serrano A, Sidhpura N, Polis I, Stouffer D, de Fonseca FR, Cravatt BF, Martin-Fardon R, Parsons LH. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addict Biol. 2018 Mar;23(2):723-734. doi: 10.1111/adb.12531. Epub 2017 Jun 29. PubMed PMID: 28660730; PubMed Central PMCID: PMC5747548.

select

de Guglielmo G, Matzeu A, Kononoff J, Mattioni J, Martin-Fardon R, George O. Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats. J Pharmacol Exp Ther. 2017 Sep;362(3):378-384. doi: 10.1124/jpet.117.241042. Epub 2017 Jun 23. PubMed PMID: 28645915; PubMed Central PMCID: PMC5539589.

select

Matzeu A, Martin-Fardon R. The orexin/hypocretin system and drug addiction. In: Preedy VR, editor. Neuropathology of Drug Addictions and Substance Misuse: Volume 3. General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addiction [Internet] Amsterdam: Academic Press; 2016. p.144-164. Available from: doi: 10.1016/B978-0-12-800634-4.00015-9.

select

Martin-Fardon R, Cauvi G, Kerr TM, Weiss F. Differential role of hypothalamic orexin/hypocretin neurons in reward seeking motivated by cocaine versus palatable food. Addict Biol. 2018 Jan;23(1):6-15. doi: 10.1111/adb.12441. Epub 2016 Aug 24. PubMed PMID: 27558790; PubMed Central PMCID: PMC5325827.

select

Matzeu A, Kerr TM, Weiss F, Martin-Fardon R. Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2. J Pharmacol Exp Ther. 2016 Nov;359(2):273-279. doi: 10.1124/jpet.116.235945. Epub 2016 Aug 18. PubMed PMID: 27540003; PubMed Central PMCID: PMC5074483.

select

Martin-Fardon R, Weiss F. Perseveration of craving: effects of stimuli conditioned to drugs of abuse versus conventional reinforcers differing in demand. Addict Biol. 2017 Jul;22(4):923-932. doi: 10.1111/adb.12374. Epub 2016 Feb 10. PubMed PMID: 26864474; PubMed Central PMCID: PMC4980277.

select

Matzeu A, Weiss F, Martin-Fardon R. Transient inactivation of the posterior paraventricular nucleus of the thalamus blocks cocaine-seeking behavior. Neurosci Lett. 2015 Nov 3;608:34-9. doi: 10.1016/j.neulet.2015.10.016. Epub 2015 Oct 9. PubMed PMID: 26455867; PubMed Central PMCID: PMC4639449.

select

Matzeu A, Cauvi G, Kerr TM, Weiss F, Martin-Fardon R. The paraventricular nucleus of the thalamus is differentially recruited by stimuli conditioned to the availability of cocaine versus palatable food. Addict Biol. 2017 Jan;22(1):70-77. doi: 10.1111/adb.12280. Epub 2015 Jun 19. PubMed PMID: 26096647; PubMed Central PMCID: PMC4788574.