My Bibliography

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Cook JR, Kohan AB, Haeusler RA. An Updated Perspective on the Dual-Track Model of Enterocyte Fat Metabolism. J Lipid Res. 2022 Nov;63(11):100278. doi: 10.1016/j.jlr.2022.100278. Epub 2022 Sep 10. Review. PubMed PMID: 36100090; PubMed Central PMCID: PMC9593242.

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Bini S, D'Erasmo L, Astiarraga B, Minicocci I, Palumbo M, Pecce V, Polito L, Di Costanzo A, Haeusler RA, Arca M, Ferrannini E, Camastra S. Differential effects of bariatric surgery on plasma levels of ANGPTL3 and ANGPTL4. Nutr Metab Cardiovasc Dis. 2022 Nov;32(11):2647-2654. doi: 10.1016/j.numecd.2022.08.019. Epub 2022 Sep 1. PubMed PMID: 36163215; PubMed Central PMCID: PMC10018753.

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Gamarra JR, Haeusler RA. Hepatocentric Leptin Signaling Modulates Gluconeogenesis via MKP-3. Cell Mol Gastroenterol Hepatol. 2022;14(5):1166-1167. doi: 10.1016/j.jcmgh.2022.08.006. Epub 2022 Sep 8. PubMed PMID: 36088958; PubMed Central PMCID: PMC9606795.

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Emiliano AB, Lopatinsky NR, Kraljević M, Higuchi S, He Y, Haeusler RA, Schwartz GJ. Sex-specific differences in metabolic outcomes after sleeve gastrectomy and intermittent fasting in obese middle-aged mice. Am J Physiol Endocrinol Metab. 2022 Jul 1;323(1):E107-E121. doi: 10.1152/ajpendo.00017.2022. Epub 2022 Jun 6. PubMed PMID: 35658544; PubMed Central PMCID: PMC9273270.

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McKimpson WM, Kuo T, Kitamoto T, Higuchi S, Mills JC, Haeusler RA, Accili D. FOXO1 Is Present in Stomach Epithelium and Determines Gastric Cell Distribution. Gastro Hep Adv. 2022;1(5):733-745. doi: 10.1016/j.gastha.2022.05.005. Epub 2022 May 14. PubMed PMID: 36117550; PubMed Central PMCID: PMC9481069.

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Izquierdo MC, Shanmugarajah N, Lee SX, Kraakman MJ, Westerterp M, Kitamoto T, Harris M, Cook JR, Gusarova GA, Zhong K, Marbuary E, O-Sullivan I, Rasmus N, Camastra S, Unterman TG, Ferrannini E, Hurwitz BE, Haeusler RA. Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathway. J Clin Invest. 2022 Apr 1;132(7). doi: 10.1172/JCI146219. PubMed PMID: 35104242; PubMed Central PMCID: PMC8970673.

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Oteng AB, Higuchi S, Banks AS, Haeusler RA. Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage. Mol Metab. 2021 Nov;53:101326. doi: 10.1016/j.molmet.2021.101326. Epub 2021 Aug 24. PubMed PMID: 34438105; PubMed Central PMCID: PMC8449133.

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Higuchi S, Ahmad TR, Argueta DA, Perez PA, Zhao C, Schwartz GJ, DiPatrizio NV, Haeusler RA. Bile acid composition regulates GPR119-dependent intestinal lipid sensing and food intake regulation in mice. Gut. 2020 Sep;69(9):1620-1628. doi: 10.1136/gutjnl-2019-319693. Epub 2020 Feb 28. PubMed PMID: 32111630; PubMed Central PMCID: PMC7423635.

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Ahmad TR, Higuchi S, Bertaggia E, Hung A, Shanmugarajah N, Guilz NC, Gamarra JR, Haeusler RA. Bile acid composition regulates the manganese transporter Slc30a10 in intestine. J Biol Chem. 2020 Aug 28;295(35):12545-12558. doi: 10.1074/jbc.RA120.012792. Epub 2020 Jul 20. PubMed PMID: 32690612; PubMed Central PMCID: PMC7458818.

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Liu Q, Yu J, Wang L, Tang Y, Zhou Q, Ji S, Wang Y, Santos L, Haeusler RA, Que J, Rajbhandari P, Lei X, Valenti L, Pajvani UB, Qin J, Qiang L. Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitis. J Hepatol. 2020 Aug;73(2):361-370. doi: 10.1016/j.jhep.2020.02.025. Epub 2020 Mar 3. PubMed PMID: 32135178.

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Manuel CR, Haeusler RA. Insulin-stimulated lipogenesis gets an epigenetic makeover. J Clin Invest. 2020 Jun 1;130(6):2809-2810. doi: 10.1172/JCI137050. PubMed PMID: 32364539; PubMed Central PMCID: PMC7260037.

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Hoogerland JA, Lei Y, Wolters JC, de Boer JF, Bos T, Bleeker A, Mulder NL, van Dijk TH, Kuivenhoven JA, Rajas F, Mithieux G, Haeusler RA, Verkade HJ, Bloks VW, Kuipers F, Oosterveer MH. Glucose-6-Phosphate Regulates Hepatic Bile Acid Synthesis in Mice. Hepatology. 2019 Dec;70(6):2171-2184. doi: 10.1002/hep.30778. Epub 2019 Jun 24. PubMed PMID: 31102537; PubMed Central PMCID: PMC6859192.

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Ahmad TR, Haeusler RA. Bile acids in glucose metabolism and insulin signalling - mechanisms and research needs. Nat Rev Endocrinol. 2019 Dec;15(12):701-712. doi: 10.1038/s41574-019-0266-7. Epub 2019 Oct 15. Review. PubMed PMID: 31616073; PubMed Central PMCID: PMC6918475.

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Kanter JE, Shao B, Kramer F, Barnhart S, Shimizu-Albergine M, Vaisar T, Graham MJ, Crooke RM, Manuel CR, Haeusler RA, Mar D, Bomsztyk K, Hokanson JE, Kinney GL, Snell-Bergeon JK, Heinecke JW, Bornfeldt KE. Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes. J Clin Invest. 2019 Jul 11;129(10):4165-4179. doi: 10.1172/JCI127308. PubMed PMID: 31295146; PubMed Central PMCID: PMC6763229.

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Langlet F, Tarbier M, Haeusler RA, Camastra S, Ferrannini E, Friedländer MR, Accili D. microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function. Mol Metab. 2018 Nov;17:49-60. doi: 10.1016/j.molmet.2018.08.003. Epub 2018 Aug 11. PubMed PMID: 30174230; PubMed Central PMCID: PMC6197154.

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Molusky MM, Hsieh J, Lee SX, Ramakrishnan R, Tascau L, Haeusler RA, Accili D, Tall AR. Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences. Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1493-1503. doi: 10.1161/ATVBAHA.118.311212. Epub 2018 May 31. PubMed PMID: 29853564; PubMed Central PMCID: PMC6039406.

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Higuchi S, Izquierdo MC, Haeusler RA. Unexplained reciprocal regulation of diabetes and lipoproteins. Curr Opin Lipidol. 2018 Jun;29(3):186-193. doi: 10.1097/MOL.0000000000000521. Review. PubMed PMID: 29708925; PubMed Central PMCID: PMC6150711.

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Kim K, Goldberg IJ, Graham MJ, Sundaram M, Bertaggia E, Lee SX, Qiang L, Haeusler RA, Metzger D, Chambon P, Yao Z, Ginsberg HN, Pajvani UB. γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor. Cell Metab. 2018 Apr 3;27(4):816-827.e4. doi: 10.1016/j.cmet.2018.02.010. Epub 2018 Mar 22. PubMed PMID: 29576536; PubMed Central PMCID: PMC5884729.

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Lee SX, Heine M, Schlein C, Ramakrishnan R, Liu J, Belnavis G, Haimi I, Fischer AW, Ginsberg HN, Heeren J, Rinninger F, Haeusler RA. FoxO transcription factors are required for hepatic HDL cholesterol clearance. J Clin Invest. 2018 Apr 2;128(4):1615-1626. doi: 10.1172/JCI94230. Epub 2018 Mar 19. PubMed PMID: 29408809; PubMed Central PMCID: PMC5873864.

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Haeusler RA, McGraw TE, Accili D. Biochemical and cellular properties of insulin receptor signalling. Nat Rev Mol Cell Biol. 2018 Jan;19(1):31-44. doi: 10.1038/nrm.2017.89. Epub 2017 Oct 4. Review. PubMed PMID: 28974775; PubMed Central PMCID: PMC5894887.

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Langlet F, Haeusler RA, Lindén D, Ericson E, Norris T, Johansson A, Cook JR, Aizawa K, Wang L, Buettner C, Accili D. Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling. Cell. 2017 Nov 2;171(4):824-835.e18. doi: 10.1016/j.cell.2017.09.045. Epub 2017 Oct 19. PubMed PMID: 29056338; PubMed Central PMCID: PMC5687849.

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Bertaggia E, Jensen KK, Castro-Perez J, Xu Y, Di Paolo G, Chan RB, Wang L, Haeusler RA. Cyp8b1 ablation prevents Western diet-induced weight gain and hepatic steatosis because of impaired fat absorption. Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E121-E133. doi: 10.1152/ajpendo.00409.2016. Epub 2017 Apr 4. PubMed PMID: 28377401; PubMed Central PMCID: PMC5582885.

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Haeusler RA, Camastra S, Nannipieri M, Astiarraga B, Castro-Perez J, Xie D, Wang L, Chakravarthy M, Ferrannini E. Increased Bile Acid Synthesis and Impaired Bile Acid Transport in Human Obesity. J Clin Endocrinol Metab. 2016 May;101(5):1935-44. doi: 10.1210/jc.2015-2583. Epub 2015 Dec 18. PubMed PMID: 26684275; PubMed Central PMCID: PMC4870845.

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Ferrannini E, Camastra S, Astiarraga B, Nannipieri M, Castro-Perez J, Xie D, Wang L, Chakravarthy M, Haeusler RA. Increased Bile Acid Synthesis and Deconjugation After Biliopancreatic Diversion. Diabetes. 2015 Oct;64(10):3377-85. doi: 10.2337/db15-0214. Epub 2015 May 26. PubMed PMID: 26015549; PubMed Central PMCID: PMC4587641.

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Dutia R, Embrey M, O'Brien CS, Haeusler RA, Agénor KK, Homel P, McGinty J, Vincent RP, Alaghband-Zadeh J, Staels B, le Roux CW, Yu J, Laferrère B. Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes. Int J Obes (Lond). 2015 May;39(5):806-13. doi: 10.1038/ijo.2015.1. Epub 2015 Jan 20. PubMed PMID: 25599611; PubMed Central PMCID: PMC4422767.

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Haeusler RA, Camastra S, Astiarraga B, Nannipieri M, Anselmino M, Ferrannini E. Decreased expression of hepatic glucokinase in type 2 diabetes. Mol Metab. 2015 Mar;4(3):222-6. doi: 10.1016/j.molmet.2014.12.007. eCollection 2015 Mar. PubMed PMID: 25737948; PubMed Central PMCID: PMC4338311.

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Haeusler RA, Hartil K, Vaitheesvaran B, Arrieta-Cruz I, Knight CM, Cook JR, Kammoun HL, Febbraio MA, Gutierrez-Juarez R, Kurland IJ, Accili D. Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors. Nat Commun. 2014 Oct 13;5:5190. doi: 10.1038/ncomms6190. PubMed PMID: 25307742; PubMed Central PMCID: PMC4197140.

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Haeusler RA, Astiarraga B, Camastra S, Accili D, Ferrannini E. Human insulin resistance is associated with increased plasma levels of 12α-hydroxylated bile acids. Diabetes. 2013 Dec;62(12):4184-91. doi: 10.2337/db13-0639. Epub 2013 Jul 24. PubMed PMID: 23884887; PubMed Central PMCID: PMC3837033.

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Pratt-Hyatt M, Pai DA, Haeusler RA, Wozniak GG, Good PD, Miller EL, McLeod IX, Yates JR 3rd, Hopper AK, Engelke DR. Mod5 protein binds to tRNA gene complexes and affects local transcriptional silencing. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):E3081-9. doi: 10.1073/pnas.1219946110. Epub 2013 Jul 29. PubMed PMID: 23898186; PubMed Central PMCID: PMC3746885.

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Ai D, Chen C, Han S, Ganda A, Murphy AJ, Haeusler R, Thorp E, Accili D, Horton JD, Tall AR. Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice. J Clin Invest. 2012 Apr;122(4):1262-70. doi: 10.1172/JCI61919. Epub 2012 Mar 19. PubMed PMID: 22426206; PubMed Central PMCID: PMC3314476.

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Haeusler RA, Pratt-Hyatt M, Welch CL, Klaassen CD, Accili D. Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metab. 2012 Jan 4;15(1):65-74. doi: 10.1016/j.cmet.2011.11.010. Epub 2011 Dec 22. PubMed PMID: 22197325; PubMed Central PMCID: PMC3253887.

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Banks AS, Kim-Muller JY, Mastracci TL, Kofler NM, Qiang L, Haeusler RA, Jurczak MJ, Laznik D, Heinrich G, Samuel VT, Shulman GI, Papaioannou VE, Accili D. Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metab. 2011 Nov 2;14(5):587-97. doi: 10.1016/j.cmet.2011.09.012. PubMed PMID: 22055502; PubMed Central PMCID: PMC3221516.

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Haeusler RA, Kaestner KH, Accili D. FoxOs function synergistically to promote glucose production. J Biol Chem. 2010 Nov 12;285(46):35245-8. doi: 10.1074/jbc.C110.175851. Epub 2010 Sep 29. PubMed PMID: 20880840; PubMed Central PMCID: PMC2975147.

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Haeusler RA, Han S, Accili D. Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemia. J Biol Chem. 2010 Aug 27;285(35):26861-26868. doi: 10.1074/jbc.M110.134023. Epub 2010 Jun 23. PubMed PMID: 20573950; PubMed Central PMCID: PMC2930685.

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Haeusler RA, Pratt-Hyatt M, Good PD, Gipson TA, Engelke DR. Clustering of yeast tRNA genes is mediated by specific association of condensin with tRNA gene transcription complexes. Genes Dev. 2008 Aug 15;22(16):2204-14. doi: 10.1101/gad.1675908. PubMed PMID: 18708579; PubMed Central PMCID: PMC2518813.

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Haeusler RA, Accili D. The double life of Irs. Cell Metab. 2008 Jul;8(1):7-9. doi: 10.1016/j.cmet.2008.06.010. Review. PubMed PMID: 18590687; PubMed Central PMCID: PMC2712626.

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Moir RD, Lee J, Haeusler RA, Desai N, Engelke DR, Willis IM. Protein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15044-9. doi: 10.1073/pnas.0607129103. Epub 2006 Sep 27. PubMed PMID: 17005718; PubMed Central PMCID: PMC1622776.

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Haeusler RA, Engelke DR. Spatial organization of transcription by RNA polymerase III. Nucleic Acids Res. 2006;34(17):4826-36. doi: 10.1093/nar/gkl656. Epub 2006 Sep 13. Review. PubMed PMID: 16971453; PubMed Central PMCID: PMC1635290.

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Wang L, Haeusler RA, Good PD, Thompson M, Nagar S, Engelke DR. Silencing near tRNA genes requires nucleolar localization. J Biol Chem. 2005 Mar 11;280(10):8637-9. doi: 10.1074/jbc.C500017200. Epub 2005 Jan 15. PubMed PMID: 15654076; PubMed Central PMCID: PMC3761214.

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Chan EY, Goncalves NM, Haeusler RA, Hatch AJ, Larson JW, Maletta AM, Yantz GR, Carstea ED, Fuchs M, Wong GG, Gullans SR, Gilmanshin R. DNA mapping using microfluidic stretching and single-molecule detection of fluorescent site-specific tags. Genome Res. 2004 Jun;14(6):1137-46. doi: 10.1101/gr.1635204. PubMed PMID: 15173119; PubMed Central PMCID: PMC419792.

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Haeusler RA, Engelke DR. Genome organization in three dimensions: thinking outside the line. Cell Cycle. 2004 Mar;3(3):273-5. Epub 2004 Mar 1. PubMed PMID: 14726665; PubMed Central PMCID: PMC3746017.

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Thompson M, Haeusler RA, Good PD, Engelke DR. Nucleolar clustering of dispersed tRNA genes. Science. 2003 Nov 21;302(5649):1399-401. doi: 10.1126/science.1089814. PubMed PMID: 14631041; PubMed Central PMCID: PMC3783965.