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The ubiquitin proteasome system as a potential therapeutic target for systemic sclerosis. Translational research : the journal of laboratory and clinical medicine. . NIHMSID: NIHMS1899726.
The deubiquitinase STAMBP modulates cytokine secretion through the NLRP3 inflammasome. Cellular signalling. . NIHMSID: NIHMS1899734.
Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells. Translational research : the journal of laboratory and clinical medicine. . NIHMSID: NIHMS1899743.
Sensory Nerves Impede the Formation of Tertiary Lymphoid Structures and Development of Protective Antimelanoma Immune Responses. Cancer immunology research. . NIHMSID: NIHMS1909502.
Mallampalli R, Pentel PR, Anderson DC. Nonreactive pupils due to monoamine oxidase inhibitor overdose. Crit Care Med. 1987 May;15(5):536-7. doi: 10.1097/00003246-198705000-00019. PubMed PMID: 3568718.
Mallampalli RK, Floerchinger CS, Hunninghake GW. Isolation and immortalization of rat pre-type II cell lines. In Vitro Cell Dev Biol. 1992 Mar;28A(3 Pt 1):181-7. doi: 10.1007/BF02631089. PubMed PMID: 1316350.
Mallampalli RK, Salome RG, Hunninghake GW. Lung CTP:choline-phosphate cytidylyltransferase: activation of cytosolic species by unsaturated fatty acid. Am J Physiol. 1993 Aug;265(2 Pt 1):L158-63. doi: 10.1152/ajplung.1993.265.2.L158. PubMed PMID: 8396337.
Mallampalli RK, Hunninghake GW. Expression of immunoreactive cytidine 5'-triphosphate: cholinephosphate cytidylyltransferase in developing rat lung. Pediatr Res. 1993 Oct;34(4):502-11. doi: 10.1203/00006450-199310000-00024. PubMed PMID: 8255685.
Mallampalli RK, Salome RG, Hunninghake GW. Epidermal growth factor is a positive in vivo regulator of CTP:cholinephosphate cytidylyltransferase. Exp Lung Res. 1994 Jan-Feb;20(1):1-11. doi: 10.3109/01902149409064369. PubMed PMID: 8181450.
Mallampalli RK, Walter ME, Peterson MW, Hunninghake GW. Betamethasone activation of CTP:cholinephosphate cytidylyltransferase in vivo is lipid dependent. Am J Respir Cell Mol Biol. 1994 Jan;10(1):48-57. doi: 10.1165/ajrcmb.10.1.8292380. PubMed PMID: 8292380.
Mallampalli RK, Salome RG, Spector AA. Regulation of CTP:choline-phosphate cytidylyltransferase by polyunsaturated n-3 fatty acids. Am J Physiol. 1994 Dec;267(6 Pt 1):L641-8. doi: 10.1152/ajplung.1994.267.6.L641. PubMed PMID: 7810669.
Mallampalli RK, Salome RG, Li CH, VanRollins M, Hunninghake GW. Betamethasone activation of CTP:cholinephosphate cytidylyltransferase is mediated by fatty acids. J Cell Physiol. 1995 Mar;162(3):410-21. doi: 10.1002/jcp.1041620313. PubMed PMID: 7860648.
Acarregui MJ, Brown JJ, Mallampalli RK. Oxygen modulates surfactant protein mRNA expression and phospholipid production in human fetal lung in vitro. Am J Physiol. 1995 May;268(5 Pt 1):L818-25. doi: 10.1152/ajplung.1995.268.5.L818. PubMed PMID: 7762683.
Stefansson S, Kounnas MZ, Henkin J, Mallampalli RK, Chappell DA, Strickland DK, Argraves WS. gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complex. J Cell Sci. 1995 Jun;108 ( Pt 6):2361-8. doi: 10.1242/jcs.108.6.2361. PubMed PMID: 7673355.
Mallampalli RK, Mathur SN, Warnock LJ, Salome RG, Hunninghake GW, Field FJ. Betamethasone modulation of sphingomyelin hydrolysis up-regulates CTP:cholinephosphate cytidylyltransferase activity in adult rat lung. Biochem J. 1996 Aug 15;318 ( Pt 1)(Pt 1):333-41. doi: 10.1042/bj3180333. PubMed PMID: 8761490; PubMed Central PMCID: PMC1217626.
Mallampalli RK, Salome RG, Bowen SL, Chappell DA. Very low density lipoproteins stimulate surfactant lipid synthesis in vitro. J Clin Invest. 1997 Apr 15;99(8):2020-9. doi: 10.1172/JCI119370. PubMed PMID: 9109447; PubMed Central PMCID: PMC508027.
Longo CA, Tyler D, Mallampalli RK. Sphingomyelin metabolism is developmentally regulated in rat lung. Am J Respir Cell Mol Biol. 1997 May;16(5):605-12. doi: 10.1165/ajrcmb.16.5.9160843. PubMed PMID: 9160843.
Jiang XC, D'Armiento J, Mallampalli RK, Mar J, Yan SF, Lin M. Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia. J Biol Chem. 1998 Jun 19;273(25):15714-8. doi: 10.1074/jbc.273.25.15714. PubMed PMID: 9624168.
Mallampalli RK, Peterson EJ, Carter AB, Salome RG, Mathur SN, Koretzky GA. TNF-alpha increases ceramide without inducing apoptosis in alveolar type II epithelial cells. Am J Physiol. 1999 Mar;276(3):L481-90. doi: 10.1152/ajplung.1999.276.3.L481. PubMed PMID: 10070113.
Monick MM, Carter AB, Gudmundsson G, Mallampalli R, Powers LS, Hunninghake GW. A phosphatidylcholine-specific phospholipase C regulates activation of p42/44 mitogen-activated protein kinases in lipopolysaccharide-stimulated human alveolar macrophages. J Immunol. 1999 Mar 1;162(5):3005-12. PubMed PMID: 10072552.
Jia HP, Mills JN, Barahmand-Pour F, Nishimura D, Mallampali RK, Wang G, Wiles K, Tack BF, Bevins CL, McCray PB Jr. Molecular cloning and characterization of rat genes encoding homologues of human beta-defensins. Infect Immun. 1999 Sep;67(9):4827-33. doi: 10.1128/IAI.67.9.4827-4833.1999. PubMed PMID: 10456937; PubMed Central PMCID: PMC96815.
McCoy DM, Salome RG, Kusner DJ, Iyar SS, Mallampalli RK. Identification of sex-specific differences in surfactant synthesis in rat lung. Pediatr Res. 1999 Dec;46(6):722-30. doi: 10.1203/00006450-199912000-00003. PubMed PMID: 10590030.
Salome RG, McCoy DM, Ryan AJ, Mallampalli RK. Effects of intratracheal instillation of TNF-alpha on surfactant metabolism. J Appl Physiol (1985). 2000 Jan;88(1):10-6. doi: 10.1152/jappl.2000.88.1.10. PubMed PMID: 10642356.
Mallampalli RK, Ryan AJ, Salome RG, Jackowski S. Tumor necrosis factor-alpha inhibits expression of CTP:phosphocholine cytidylyltransferase. J Biol Chem. 2000 Mar 31;275(13):9699-708. doi: 10.1074/jbc.275.13.9699. PubMed PMID: 10734122.
Ryan AJ, McCoy DM, Mathur SN, Field FJ, Mallampalli RK. Lipoprotein deprivation stimulates transcription of the CTP:phosphocholine cytidylyltransferase gene. J Lipid Res. 2000 Aug;41(8):1268-77. PubMed PMID: 10946015.
Monick MM, Mallampalli RK, Carter AB, Flaherty DM, McCoy D, Robeff PK, Peterson MW, Hunninghake GW. Ceramide regulates lipopolysaccharide-induced phosphatidylinositol 3-kinase and Akt activity in human alveolar macrophages. J Immunol. 2001 Nov 15;167(10):5977-85. doi: 10.4049/jimmunol.167.10.5977. PubMed PMID: 11698477.
Mallampalli RK, Ryan AJ, Carroll JL, Osborne TF, Thomas CP. Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoter. Biochem J. 2002 Feb 15;362(Pt 1):81-8. doi: 10.1042/0264-6021:3620081. PubMed PMID: 11829742; PubMed Central PMCID: PMC1222362.
Carroll JL Jr, McCoy DM, McGowan SE, Salome RG, Ryan AJ, Mallampalli RK. Pulmonary-specific expression of tumor necrosis factor-alpha alters surfactant lipid metabolism. Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L735-42. doi: 10.1152/ajplung.00120.2001. PubMed PMID: 11880299.
Ryan AJ, Medh JD, McCoy DM, Salome RG, Mallampalli RK. Maternal loading with very low-density lipoproteins stimulates fetal surfactant synthesis. Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L310-8. doi: 10.1152/ajplung.00021.2002. PubMed PMID: 12114192; PubMed Central PMCID: PMC2768472.
Ryan AJ, McCoy DM, McGowan SE, Salome RG, Mallampalli RK. Alveolar sphingolipids generated in response to TNF-alpha modifies surfactant biophysical activity. J Appl Physiol (1985). 2003 Jan;94(1):253-8. doi: 10.1152/japplphysiol.00184.2002. Epub 2002 Oct 4. PubMed PMID: 12391098.
Zhou J, Ryan AJ, Medh J, Mallampalli RK. Oxidized lipoproteins inhibit surfactant phosphatidylcholine synthesis via calpain-mediated cleavage of CTP:phosphocholine cytidylyltransferase. J Biol Chem. 2003 Sep 26;278(39):37032-40. doi: 10.1074/jbc.M304316200. Epub 2003 Jul 11. PubMed PMID: 12857760; PubMed Central PMCID: PMC2768468.
Zhou J, You Y, Zabner J, Ryan AJ, Mallampalli RK. The CCT promoter directs high-level transgene expression in distal lung epithelial cell lines. Am J Respir Cell Mol Biol. 2004 Jan;30(1):61-8. doi: 10.1165/rcmb.2003-0020OC. Epub 2003 Jun 26. PubMed PMID: 12829450.
Monick MM, Cameron K, Powers LS, Butler NS, McCoy D, Mallampalli RK, Hunninghake GW. Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. Am J Respir Cell Mol Biol. 2004 Jun;30(6):844-52. doi: 10.1165/rcmb.2003-0424OC. Epub 2004 Jan 23. PubMed PMID: 14742298.
Monick MM, Mallampalli RK, Bradford M, McCoy D, Gross TJ, Flaherty DM, Powers LS, Cameron K, Kelly S, Merrill AH Jr, Hunninghake GW. Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity. J Immunol. 2004 Jul 1;173(1):123-35. doi: 10.4049/jimmunol.173.1.123. PubMed PMID: 15210766.
Agassandian M, Mathur SN, Zhou J, Field FJ, Mallampalli RK. Oxysterols trigger ABCA1-mediated basolateral surfactant efflux. Am J Respir Cell Mol Biol. 2004 Aug;31(2):227-33. doi: 10.1165/rcmb.2004-0038OC. Epub 2004 Mar 23. PubMed PMID: 15039140.
Ryan AJ, Fisher K, Thomas CP, Mallampalli RK. Transcriptional repression of the CTP:phosphocholine cytidylyltransferase gene by sphingosine. Biochem J. 2004 Sep 1;382(Pt 2):741-50. doi: 10.1042/BJ20040105. PubMed PMID: 15139854; PubMed Central PMCID: PMC1133833.
Zhou J, You Y, Ryan AJ, Mallampalli RK. Upregulation of surfactant synthesis triggers ABCA1-mediated basolateral phospholipid efflux. J Lipid Res. 2004 Sep;45(9):1758-67. doi: 10.1194/jlr.M400179-JLR200. Epub 2004 Jun 21. PubMed PMID: 15210848.
Miakotina OL, Agassandian M, Shi L, Look DC, Mallampalli RK. Adenovirus stimulates choline efflux by increasing expression of organic cation transporter-2. Am J Physiol Lung Cell Mol Physiol. 2005 Jan;288(1):L93-102. doi: 10.1152/ajplung.00184.2004. Epub 2004 Sep 17. PubMed PMID: 15377492.
Sinn PL, Penisten AK, Burnight ER, Hickey MA, Williams G, McCoy DM, Mallampalli RK, McCray PB. Gene transfer to respiratory epithelia with lentivirus pseudotyped with Jaagsiekte sheep retrovirus envelope glycoprotein. Hum Gene Ther. 2005 Apr;16(4):479-88. doi: 10.1089/hum.2005.16.479. PubMed PMID: 15871679.
Xu Z, Zhou J, McCoy DM, Mallampalli RK. LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia. J Lipid Res. 2005 Jun;46(6):1229-38. doi: 10.1194/jlr.M500001-JLR200. Epub 2005 Mar 16. PubMed PMID: 15772421.
Agassandian M, Zhou J, Tephly LA, Ryan AJ, Carter AB, Mallampalli RK. Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase. J Biol Chem. 2005 Jun 3;280(22):21577-87. doi: 10.1074/jbc.M412409200. Epub 2005 Mar 23. PubMed PMID: 15788406.
Labra A, Brann JH, Fadool DA. Heterogeneity of voltage- and chemosignal-activated response profiles in vomeronasal sensory neurons. J Neurophysiol. 2005 Oct;94(4):2535-48. doi: 10.1152/jn.00490.2005. Epub 2005 Jun 22. PubMed PMID: 15972830; PubMed Central PMCID: PMC2685031.
Ryan AJ, Andrews M, Zhou J, Mallampalli RK. c-Jun N-terminal kinase regulates CTP:phosphocholine cytidylyltransferase. Arch Biochem Biophys. 2006 Mar 1;447(1):23-33. doi: 10.1016/ Epub 2006 Jan 24. PubMed PMID: 16466687.
Zhou J, Wu Y, Henderson F, McCoy DM, Salome RG, McGowan SE, Mallampalli RK. Adenoviral gene transfer of a mutant surfactant enzyme ameliorates pseudomonas-induced lung injury. Gene Ther. 2006 Jun;13(12):974-85. doi: 10.1038/ Epub 2006 Mar 2. PubMed PMID: 16511521.
McCoy DM, Fisher K, Robichaud J, Ryan AJ, Mallampalli RK. Transcriptional regulation of lung cytidylyltransferase in developing transgenic mice. Am J Respir Cell Mol Biol. 2006 Sep;35(3):394-402. doi: 10.1165/rcmb.2005-0401OC. Epub 2006 Apr 27. PubMed PMID: 16645180; PubMed Central PMCID: PMC2643291.
Henderson FC, Miakotina OL, Mallampalli RK. Proapoptotic effects of P. aeruginosa involve inhibition of surfactant phosphatidylcholine synthesis. J Lipid Res. 2006 Oct;47(10):2314-24. doi: 10.1194/jlr.M600284-JLR200. Epub 2006 Jul 25. PubMed PMID: 16868337.
Wu Y, Xu Z, Henderson FC, Ryan AJ, Yahr TL, Mallampalli RK. Chronic Pseudomonas aeruginosa infection reduces surfactant levels by inhibiting its biosynthesis. Cell Microbiol. 2007 Apr;9(4):1062-72. doi: 10.1111/j.1462-5822.2006.00852.x. Epub 2006 Dec 12. PubMed PMID: 17166234.
Agassandian M, Miakotina OL, Andrews M, Mathur SN, Mallampalli RK. Pseudomonas aeruginosa and sPLA2 IB stimulate ABCA1-mediated phospholipid efflux via ERK-activation of PPARalpha-RXR. Biochem J. 2007 May 1;403(3):409-20. doi: 10.1042/BJ20061364. PubMed PMID: 17223797; PubMed Central PMCID: PMC1876365.
Chen BB, Mallampalli RK. Calmodulin binds and stabilizes the regulatory enzyme, CTP: phosphocholine cytidylyltransferase. J Biol Chem. 2007 Nov 16;282(46):33494-33506. doi: 10.1074/jbc.M706472200. Epub 2007 Sep 5. PubMed PMID: 17804406.
Miakotina OL, McCoy DM, Shi L, Look DC, Mallampalli RK. Human adenovirus modulates surfactant phospholipid trafficking. Traffic. 2007 Dec;8(12):1765-1777. doi: 10.1111/j.1600-0854.2007.00641.x. Epub 2007 Sep 26. PubMed PMID: 17897321.
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