My Bibliography

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Jones BO, Spencer HF, Cruz AM, Paladino MS, Handel SN, Smith RJ. Random interval schedule of reinforcement influences punishment resistance for cocaine in rats. Neurobiol Learn Mem. 2024 Sep;213:107961. doi: 10.1016/j.nlm.2024.107961. Epub 2024 Jul 16. PubMed PMID: 39025429.

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Jones BO, Paladino MS, Cruz AM, Spencer HF, Kahanek PL, Scarborough LN, Georges SF, Smith RJ. Punishment resistance for cocaine is associated with inflexible habits in rats. Addict Neurosci. 2024 Jun;11. doi: 10.1016/j.addicn.2024.100148. Epub 2024 Jan 27. PubMed PMID: 38859977; PubMed Central PMCID: PMC11164474.

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Handel SN, Smith RJ. Making and breaking habits: Revisiting the definitions and behavioral factors that influence habits in animals. J Exp Anal Behav. 2024 Jan;121(1):8-26. doi: 10.1002/jeab.889. Epub 2023 Nov 27. Review. PubMed PMID: 38010353; PubMed Central PMCID: PMC10842199.

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Gangal H, Xie X, Huang Z, Cheng Y, Wang X, Lu J, Zhuang X, Essoh A, Huang Y, Chen R, Smith LN, Smith RJ, Wang J. Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons. Nat Commun. 2023 Jun 30;14(1):3886. doi: 10.1038/s41467-023-39623-x. PubMed PMID: 37391566; PubMed Central PMCID: PMC10313783.

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Jones BO, Paladino MS, Cruz AM, Spencer HF, Kahanek PL, Scarborough LN, Georges SF, Smith RJ. Punishment resistance for cocaine is associated with inflexible habits in rats. bioRxiv. 2023 Jun 9;. doi: 10.1101/2023.06.08.544242. PubMed PMID: 37333299; PubMed Central PMCID: PMC10274925.

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Jones BO, Cruz AM, Kim TH, Spencer HF, Smith RJ. Discriminating goal-directed and habitual cocaine seeking in rats using a novel outcome devaluation procedure. Learn Mem. 2022 Dec;29(12):447-457. doi: 10.1101/lm.053621.122. Print 2022 Dec. PubMed PMID: 36621907; PubMed Central PMCID: PMC9749853.

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Ma T, Huang Z, Xie X, Cheng Y, Zhuang X, Childs MJ, Gangal H, Wang X, Smith LN, Smith RJ, Zhou Y, Wang J. Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility. J Clin Invest. 2022 Feb 15;132(4). doi: 10.1172/JCI154969. PubMed PMID: 34941575; PubMed Central PMCID: PMC8843706.

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Brown RM, Dayas CV, James MH, Smith RJ. New directions in modelling dysregulated reward seeking for food and drugs. Neurosci Biobehav Rev. 2022 Jan;132:1037-1048. doi: 10.1016/j.neubiorev.2021.10.043. Epub 2021 Nov 2. Review. PubMed PMID: 34736883; PubMed Central PMCID: PMC8816817.

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Cruz AM, Spencer HF, Kim TH, Jhou TC, Smith RJ. Prelimbic cortical projections to rostromedial tegmental nucleus play a suppressive role in cue-induced reinstatement of cocaine seeking. Neuropsychopharmacology. 2021 Jul;46(8):1399-1406. doi: 10.1038/s41386-020-00909-z. Epub 2020 Nov 23. PubMed PMID: 33230269; PubMed Central PMCID: PMC8209220.

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Cruz AM, Kim TH, Smith RJ. Monosynaptic Retrograde Tracing From Prelimbic Neuron Subpopulations Projecting to Either Nucleus Accumbens Core or Rostromedial Tegmental Nucleus. Front Neural Circuits. 2021;15:639733. doi: 10.3389/fncir.2021.639733. eCollection 2021. PubMed PMID: 33732114; PubMed Central PMCID: PMC7959753.

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Smith RJ, Anderson RI, Haun HL, Mulholland PJ, Griffin WC 3rd, Lopez MF, Becker HC. Dynamic c-Fos changes in mouse brain during acute and protracted withdrawal from chronic intermittent ethanol exposure and relapse drinking. Addict Biol. 2020 Nov;25(6):e12804. doi: 10.1111/adb.12804. Epub 2019 Jul 9. PubMed PMID: 31288295; PubMed Central PMCID: PMC7579841.

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Smith RJ, Vento PJ, Chao YS, Good CH, Jhou TC. Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and mice. Brain Struct Funct. 2019 Jan;224(1):219-238. doi: 10.1007/s00429-018-1761-7. Epub 2018 Oct 9. PubMed PMID: 30302539; PubMed Central PMCID: PMC6467516.

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Smith RJ, Laiks LS. Behavioral and neural mechanisms underlying habitual and compulsive drug seeking. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Dec 20;87(Pt A):11-21. doi: 10.1016/j.pnpbp.2017.09.003. Epub 2017 Sep 5. Review. PubMed PMID: 28887182; PubMed Central PMCID: PMC5837910.

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Smith ACW, Scofield MD, Heinsbroek JA, Gipson CD, Neuhofer D, Roberts-Wolfe DJ, Spencer S, Garcia-Keller C, Stankeviciute NM, Smith RJ, Allen NP, Lorang MR, Griffin WC 3rd, Boger HA, Kalivas PW. Accumbens nNOS Interneurons Regulate Cocaine Relapse. J Neurosci. 2017 Jan 25;37(4):742-756. doi: 10.1523/JNEUROSCI.2673-16.2016. PubMed PMID: 28123012; PubMed Central PMCID: PMC5296777.

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Beckley JT, Randall PK, Smith RJ, Hughes BA, Kalivas PW, Woodward JJ. Phenotype-dependent inhibition of glutamatergic transmission on nucleus accumbens medium spiny neurons by the abused inhalant toluene. Addict Biol. 2016 May;21(3):530-46. doi: 10.1111/adb.12235. Epub 2015 Mar 6. PubMed PMID: 25752326; PubMed Central PMCID: PMC4561223.

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Scofield MD, Boger HA, Smith RJ, Li H, Haydon PG, Kalivas PW. Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking. Biol Psychiatry. 2015 Oct 1;78(7):441-51. doi: 10.1016/j.biopsych.2015.02.016. Epub 2015 Feb 24. PubMed PMID: 25861696; PubMed Central PMCID: PMC4547911.

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Mahler SV, Moorman DE, Smith RJ, James MH, Aston-Jones G. Motivational activation: a unifying hypothesis of orexin/hypocretin function. Nat Neurosci. 2014 Oct;17(10):1298-303. doi: 10.1038/nn.3810. Epub 2014 Sep 25. Review. PubMed PMID: 25254979; PubMed Central PMCID: PMC4335648.

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Smith RJ, Aston-Jones G. Incentive learning for morphine-associated stimuli during protracted abstinence increases conditioned drug preference. Neuropsychopharmacology. 2014 Jan;39(2):373-9. doi: 10.1038/npp.2013.200. Epub 2013 Aug 14. PubMed PMID: 23942418; PubMed Central PMCID: PMC3870770.

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Smith RJ, Lobo MK, Spencer S, Kalivas PW. Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways). Curr Opin Neurobiol. 2013 Aug;23(4):546-52. doi: 10.1016/j.conb.2013.01.026. Epub 2013 Feb 18. PubMed PMID: 23428656; PubMed Central PMCID: PMC3681928.

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Mahler SV, Smith RJ, Aston-Jones G. Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl). 2013 Apr;226(4):687-98. doi: 10.1007/s00213-012-2681-5. Epub 2012 Mar 13. PubMed PMID: 22411428; PubMed Central PMCID: PMC3649073.

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Zhou L, Smith RJ, Do PH, Aston-Jones G, See RE. Repeated orexin 1 receptor antagonism effects on cocaine seeking in rats. Neuropharmacology. 2012 Dec;63(7):1201-7. doi: 10.1016/j.neuropharm.2012.07.044. Epub 2012 Aug 7. PubMed PMID: 22971541; PubMed Central PMCID: PMC3442258.

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Smith RJ, Aston-Jones G. Orexin / hypocretin 1 receptor antagonist reduces heroin self-administration and cue-induced heroin seeking. Eur J Neurosci. 2012 Mar;35(5):798-804. doi: 10.1111/j.1460-9568.2012.08013.x. Epub 2012 Feb 22. PubMed PMID: 22356621; PubMed Central PMCID: PMC3295925.

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Mahler SV, Smith RJ, Moorman DE, Sartor GC, Aston-Jones G. Multiple roles for orexin/hypocretin in addiction. Prog Brain Res. 2012;198:79-121. doi: 10.1016/B978-0-444-59489-1.00007-0. Review. PubMed PMID: 22813971; PubMed Central PMCID: PMC3643893.

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Wiggins A, Smith RJ, Shen HW, Kalivas PW. Integrins modulate relapse to cocaine-seeking. J Neurosci. 2011 Nov 9;31(45):16177-84. doi: 10.1523/JNEUROSCI.3816-11.2011. PubMed PMID: 22072669; PubMed Central PMCID: PMC3280336.

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Smith RJ, Aston-Jones G. α(2) Adrenergic and imidazoline receptor agonists prevent cue-induced cocaine seeking. Biol Psychiatry. 2011 Oct 15;70(8):712-719. doi: 10.1016/j.biopsych.2011.06.010. Epub 2011 Jul 23. PubMed PMID: 21783176; PubMed Central PMCID: PMC3186828.

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Cason AM, Smith RJ, Tahsili-Fahadan P, Moorman DE, Sartor GC, Aston-Jones G. Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity. Physiol Behav. 2010 Jul 14;100(5):419-28. doi: 10.1016/j.physbeh.2010.03.009. Epub 2010 Mar 23. Review. PubMed PMID: 20338186; PubMed Central PMCID: PMC2886173.

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Aston-Jones G, Smith RJ, Sartor GC, Moorman DE, Massi L, Tahsili-Fahadan P, Richardson KA. Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction. Brain Res. 2010 Feb 16;1314:74-90. doi: 10.1016/j.brainres.2009.09.106. Epub 2009 Oct 6. Review. PubMed PMID: 19815001; PubMed Central PMCID: PMC2819557.

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Smith RJ, Tahsili-Fahadan P, Aston-Jones G. Orexin/hypocretin is necessary for context-driven cocaine-seeking. Neuropharmacology. 2010 Jan;58(1):179-84. doi: 10.1016/j.neuropharm.2009.06.042. Epub 2009 Jul 8. PubMed PMID: 19591850; PubMed Central PMCID: PMC2783559.

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Smith RJ, Aston-Jones G. Inactivating the activated: identifying functions of specific neural networks. Nat Neurosci. 2009 Aug;12(8):965-6. doi: 10.1038/nn0809-965. PubMed PMID: 19636350.

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Smith RJ, See RE, Aston-Jones G. Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking. Eur J Neurosci. 2009 Aug;30(3):493-503. doi: 10.1111/j.1460-9568.2009.06844.x. Epub 2009 Jul 28. PubMed PMID: 19656173; PubMed Central PMCID: PMC2771107.

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Aston-Jones G, Smith RJ, Moorman DE, Richardson KA. Role of lateral hypothalamic orexin neurons in reward processing and addiction. Neuropharmacology. 2009;56 Suppl 1(Suppl 1):112-21. doi: 10.1016/j.neuropharm.2008.06.060. Epub 2008 Jul 4. Review. PubMed PMID: 18655797; PubMed Central PMCID: PMC2635332.

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Smith RJ, Aston-Jones G. Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence. Brain Struct Funct. 2008 Sep;213(1-2):43-61. doi: 10.1007/s00429-008-0191-3. Epub 2008 Jul 24. Review. PubMed PMID: 18651175; PubMed Central PMCID: PMC3632504.

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Smith RJ, Doyle GA, Han AM, Crowley JJ, Oslin DW, Patkar AA, Mannelli P, Demaria PA Jr, O'brien CP, Berrettini WH. Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence. Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5;133B(1):105-9. doi: 10.1002/ajmg.b.30105. PubMed PMID: 15558714.

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Talbot K, Eidem WL, Tinsley CL, Benson MA, Thompson EW, Smith RJ, Hahn CG, Siegel SJ, Trojanowski JQ, Gur RE, Blake DJ, Arnold SE. Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. J Clin Invest. 2004 May;113(9):1353-63. doi: 10.1172/JCI20425. PubMed PMID: 15124027; PubMed Central PMCID: PMC398430.