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Meng W, Sjöholm LK, Kononenko O, Tay N, Zhang D, Sarkisyan D, Geske JR, Ing A, Qiu W, Watanabe H, Almamoun R, Frieling H, Bleich S, Cui D, Biernacka JM, Mayfield RD, Dang Y, Karpyak VM, Schumann G, Bakalkin G, Ekström TJ, Rüegg J, Liu Y. Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence. Mol Psychiatry. 2021 Aug;26(8):4367-4382. doi: 10.1038/s41380-019-0588-9. Epub 2019 Nov 19. PubMed PMID: 31745236.
Rao X, Thapa KS, Chen AB, Lin H, Gao H, Reiter JL, Hargreaves KA, Ipe J, Lai D, Xuei X, Wang Y, Gu H, Kapoor M, Farris SP, Tischfield J, Foroud T, Goate AM, Skaar TC, Mayfield RD, Edenberg HJ, Liu Y. Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders. Mol Psychiatry. 2021 Apr;26(4):1142-1151. doi: 10.1038/s41380-019-0508-z. Epub 2019 Sep 2. PubMed PMID: 31477794; PubMed Central PMCID: PMC7050407.
Warden AS, Triplett TA, Lyu A, Grantham EK, Azzam MM, DaCosta A, Mason S, Blednov YA, Ehrlich LIR, Mayfield RD, Harris RA. Microglia depletion and alcohol: Transcriptome and behavioral profiles. Addict Biol. 2021 Mar;26(2):e12889. doi: 10.1111/adb.12889. Epub 2020 Mar 16. PubMed PMID: 32176824; PubMed Central PMCID: PMC8510547.
Erickson EK, DaCosta AJ, Mason SC, Blednov YA, Mayfield RD, Harris RA. Cortical astrocytes regulate ethanol consumption and intoxication in mice. Neuropsychopharmacology. 2021 Feb;46(3):500-508. doi: 10.1038/s41386-020-0721-0. Epub 2020 May 28. PubMed PMID: 32464636; PubMed Central PMCID: PMC8027025.
Warden AS, Wolfe SA, Khom S, Varodayan FP, Patel RR, Steinman MQ, Bajo M, Montgomery SE, Vlkolinsky R, Nadav T, Polis I, Roberts AJ, Mayfield RD, Harris RA, Roberto M. Microglia Control Escalation of Drinking in Alcohol-Dependent Mice: Genomic and Synaptic Drivers. Biol Psychiatry. 2020 Dec 15;88(12):910-921. doi: 10.1016/j.biopsych.2020.05.011. Epub 2020 May 19. PubMed PMID: 32680583; PubMed Central PMCID: PMC7674270.
Blednov YA, Borghese CM, Dugan MP, Pradhan S, Thodati TM, Kichili NR, Harris RA, Messing RO. Apremilast regulates acute effects of ethanol and other GABAergic drugs via protein kinase A-dependent signaling. Neuropharmacology. 2020 Nov 1;178:108220. doi: 10.1016/j.neuropharm.2020.108220. Epub 2020 Jul 29. PubMed PMID: 32736086; PubMed Central PMCID: PMC7544627.
Grantham EK, Warden AS, McCarthy GS, DaCosta A, Mason S, Blednov Y, Mayfield RD, Harris RA. Role of toll-like receptor 7 (TLR7) in voluntary alcohol consumption. Brain Behav Immun. 2020 Oct;89:423-432. doi: 10.1016/j.bbi.2020.07.029. Epub 2020 Jul 26. PubMed PMID: 32726684; PubMed Central PMCID: PMC7572874.
Warden AS, DaCosta A, Mason S, Blednov YA, Mayfield RD, Harris RA. Inbred Substrain Differences Influence Neuroimmune Response and Drinking Behavior. Alcohol Clin Exp Res. 2020 Sep;44(9):1760-1768. doi: 10.1111/acer.14410. Epub 2020 Aug 2. PubMed PMID: 32640038; PubMed Central PMCID: PMC7722067.
Brenner E, Tiwari GR, Kapoor M, Liu Y, Brock A, Mayfield RD. Single cell transcriptome profiling of the human alcohol-dependent brain. Hum Mol Genet. 2020 May 8;29(7):1144-1153. doi: 10.1093/hmg/ddaa038. PubMed PMID: 32142123; PubMed Central PMCID: PMC7206851.
Farris SP, Tiwari GR, Ponomareva O, Lopez MF, Mayfield RD, Becker HC. Transcriptome Analysis of Alcohol Drinking in Non-Dependent and Dependent Mice Following Repeated Cycles of Forced Swim Stress Exposure. Brain Sci. 2020 May 2;10(5). doi: 10.3390/brainsci10050275. PubMed PMID: 32370184; PubMed Central PMCID: PMC7288165.
Lai D, Wetherill L, Kapoor M, Johnson EC, Schwandt M, Ramchandani VA, Goldman D, Joslyn G, Rao X, Liu Y, Farris S, Mayfield RD, Dick D, Hesselbrock V, Kramer J, McCutcheon VV, Nurnberger J, Tischfield J, Goate A, Edenberg HJ, Porjesz B, Agrawal A, Foroud T, Schuckit M. Genome-wide association studies of the self-rating of effects of ethanol (SRE). Addict Biol. 2020 Mar;25(2):e12800. doi: 10.1111/adb.12800. Epub 2019 Jul 3. PubMed PMID: 31270906; PubMed Central PMCID: PMC6940552.
Ferguson LB, Patil S, Moskowitz BA, Ponomarev I, Harris RA, Mayfield RD, Messing RO. A Pathway-Based Genomic Approach to Identify Medications: Application to Alcohol Use Disorder. Brain Sci. 2019 Dec 16;9(12). doi: 10.3390/brainsci9120381. PubMed PMID: 31888299; PubMed Central PMCID: PMC6956180.
Erickson EK, Blednov YA, Harris RA, Mayfield RD. Glial gene networks associated with alcohol dependence. Sci Rep. 2019 Jul 29;9(1):10949. doi: 10.1038/s41598-019-47454-4. PubMed PMID: 31358844; PubMed Central PMCID: PMC6662804.
Most D, Salem NA, Tiwari GR, Blednov YA, Mayfield RD, Harris RA. Silencing synaptic MicroRNA-411 reduces voluntary alcohol consumption in mice. Addict Biol. 2019 Jul;24(4):604-616. doi: 10.1111/adb.12625. Epub 2018 Apr 17. PubMed PMID: 29665166; PubMed Central PMCID: PMC6192878.
Ferguson LB, Zhang L, Kircher D, Wang S, Mayfield RD, Crabbe JC, Morrisett RA, Harris RA, Ponomarev I. Dissecting Brain Networks Underlying Alcohol Binge Drinking Using a Systems Genomics Approach. Mol Neurobiol. 2019 Apr;56(4):2791-2810. doi: 10.1007/s12035-018-1252-0. Epub 2018 Jul 30. PubMed PMID: 30062672; PubMed Central PMCID: PMC6459809.
Wolfe SA, Farris SP, Mayfield JE, Heaney CF, Erickson EK, Harris RA, Mayfield RD, Raab-Graham KF. Ethanol and a rapid-acting antidepressant produce overlapping changes in exon expression in the synaptic transcriptome. Neuropharmacology. 2019 Mar 1;146:289-299. doi: 10.1016/j.neuropharm.2018.11.007. Epub 2018 Nov 9. PubMed PMID: 30419244; PubMed Central PMCID: PMC6778957.
Warden AS, Azzam M, DaCosta A, Mason S, Blednov YA, Messing RO, Mayfield RD, Harris RA. Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male mice. Brain Behav Immun. 2019 Mar;77:55-65. doi: 10.1016/j.bbi.2018.12.004. Epub 2018 Dec 11. PubMed PMID: 30550931; PubMed Central PMCID: PMC6399060.
Warden AS, Azzam M, DaCosta A, Mason S, Blednov YA, Messing RO, Mayfield RD, Harris RA. Toll-like receptor 3 dynamics in female C57BL/6J mice: Regulation of alcohol intake. Brain Behav Immun. 2019 Mar;77:66-76. doi: 10.1016/j.bbi.2018.12.006. Epub 2018 Dec 11. PubMed PMID: 30550930; PubMed Central PMCID: PMC6399033.
Kapoor M, Wang JC, Farris SP, Liu Y, McClintick J, Gupta I, Meyers JL, Bertelsen S, Chao M, Nurnberger J, Tischfield J, Harari O, Zeran L, Hesselbrock V, Bauer L, Raj T, Porjesz B, Agrawal A, Foroud T, Edenberg HJ, Mayfield RD, Goate A. Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism. Transl Psychiatry. 2019 Feb 14;9(1):89. doi: 10.1038/s41398-019-0384-y. PubMed PMID: 30765688; PubMed Central PMCID: PMC6376002.
Erickson EK, Grantham EK, Warden AS, Harris RA. Neuroimmune signaling in alcohol use disorder. Pharmacol Biochem Behav. 2019 Feb;177:34-60. doi: 10.1016/j.pbb.2018.12.007. Epub 2018 Dec 24. Review. PubMed PMID: 30590091; PubMed Central PMCID: PMC6946054.
Mayfield RD, Harris RA. Persistence of Drug Memories: Melting Transcriptomes. Biol Psychiatry. 2018 Dec 15;84(12):860-861. doi: 10.1016/j.biopsych.2018.09.023. PubMed PMID: 30466505; PubMed Central PMCID: PMC6338210.
Farris SP, Riley BP, Williams RW, Mulligan MK, Miles MF, Lopez MF, Hitzemann R, Iancu OD, Colville A, Walter NAR, Darakjian P, Oberbeck DL, Daunais JB, Zheng CL, Searles RP, McWeeney SK, Grant KA, Mayfield RD. Cross-species molecular dissection across alcohol behavioral domains. Alcohol. 2018 Nov;72:19-31. doi: 10.1016/j.alcohol.2017.11.036. Epub 2017 Dec 6. Review. PubMed PMID: 30213503; PubMed Central PMCID: PMC6309876.
Erickson EK, Farris SP, Blednov YA, Mayfield RD, Harris RA. Astrocyte-specific transcriptome responses to chronic ethanol consumption. Pharmacogenomics J. 2018 Jul;18(4):578-589. doi: 10.1038/s41397-017-0012-2. Epub 2018 Jan 5. PubMed PMID: 29305589; PubMed Central PMCID: PMC6033697.
Augier E, Barbier E, Dulman RS, Licheri V, Augier G, Domi E, Barchiesi R, Farris S, Nätt D, Mayfield RD, Adermark L, Heilig M. A molecular mechanism for choosing alcohol over an alternative reward. Science. 2018 Jun 22;360(6395):1321-1326. doi: 10.1126/science.aao1157. PubMed PMID: 29930131.
Ferguson LB, Harris RA, Mayfield RD. From gene networks to drugs: systems pharmacology approaches for AUD. Psychopharmacology (Berl). 2018 Jun;235(6):1635-1662. doi: 10.1007/s00213-018-4855-2. Epub 2018 Mar 1. Review. PubMed PMID: 29497781; PubMed Central PMCID: PMC6298603.
Ferguson LB, Ozburn AR, Ponomarev I, Metten P, Reilly M, Crabbe JC, Harris RA, Mayfield RD. Genome-Wide Expression Profiles Drive Discovery of Novel Compounds that Reduce Binge Drinking in Mice. Neuropsychopharmacology. 2018 May;43(6):1257-1266. doi: 10.1038/npp.2017.301. Epub 2017 Dec 18. PubMed PMID: 29251283; PubMed Central PMCID: PMC5916369.
Osterndorff-Kahanek EA, Tiwari GR, Lopez MF, Becker HC, Harris RA, Mayfield RD. Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain. PLoS One. 2018;13(1):e0190841. doi: 10.1371/journal.pone.0190841. eCollection 2018. PubMed PMID: 29315347; PubMed Central PMCID: PMC5760035.
McCarthy GM, Farris SP, Blednov YA, Harris RA, Mayfield RD. Microglial-specific transcriptome changes following chronic alcohol consumption. Neuropharmacology. 2018 Jan;128:416-424. doi: 10.1016/j.neuropharm.2017.10.035. Epub 2017 Oct 31. PubMed PMID: 29101021; PubMed Central PMCID: PMC5990017.
Warden AS, Mayfield RD. Gene expression profiling in the human alcoholic brain. Neuropharmacology. 2017 Aug 1;122:161-174. doi: 10.1016/j.neuropharm.2017.02.017. Epub 2017 Mar 15. Review. PubMed PMID: 28254370; PubMed Central PMCID: PMC5479716.
Mayfield RD. Emerging roles for ncRNAs in alcohol use disorders. Alcohol. 2017 May;60:31-39. doi: 10.1016/j.alcohol.2017.01.004. Epub 2017 Apr 15. Review. PubMed PMID: 28438526; PubMed Central PMCID: PMC5504532.
Ponomarev I, Stelly CE, Morikawa H, Blednov YA, Mayfield RD, Harris RA. Mechanistic insights into epigenetic modulation of ethanol consumption. Alcohol. 2017 May;60:95-101. doi: 10.1016/j.alcohol.2017.01.016. Epub 2017 Mar 12. PubMed PMID: 28433417; PubMed Central PMCID: PMC5550096.
Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents. J Neurosci. 2017 Feb 1;37(5):1139-1155. doi: 10.1523/JNEUROSCI.2002-16.2016. Epub 2016 Dec 16. PubMed PMID: 27986929; PubMed Central PMCID: PMC5296793.
Warden A, Erickson E, Robinson G, Harris RA, Mayfield RD. The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies. Pharmacogenomics. 2016 Dec;17(18):2081-2096. doi: 10.2217/pgs-2016-0062. Epub 2016 Dec 5. Review. PubMed PMID: 27918243; PubMed Central PMCID: PMC5618934.
Truitt JM, Blednov YA, Benavidez JM, Black M, Ponomareva O, Law J, Merriman M, Horani S, Jameson K, Lasek AW, Harris RA, Mayfield RD. Inhibition of IKKβ Reduces Ethanol Consumption in C57BL/6J Mice. eNeuro. 2016 Sep-Oct;3(5). doi: 10.1523/ENEURO.0256-16.2016. eCollection 2016 Sep-Oct. PubMed PMID: 27822501; PubMed Central PMCID: PMC5086799.
McCracken ML, Gorini G, McCracken LM, Mayfield RD, Harris RA, Trudell JR. Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor. Front Mol Neurosci. 2016;9:45. doi: 10.3389/fnmol.2016.00045. eCollection 2016. PubMed PMID: 27378846; PubMed Central PMCID: PMC4906044.
Warden A, Truitt J, Merriman M, Ponomareva O, Jameson K, Ferguson LB, Mayfield RD, Harris RA. Localization of PPAR isotypes in the adult mouse and human brain. Sci Rep. 2016 Jun 10;6:27618. doi: 10.1038/srep27618. PubMed PMID: 27283430; PubMed Central PMCID: PMC4901333.
Most D, Leiter C, Blednov YA, Harris RA, Mayfield RD. Synaptic microRNAs Coordinately Regulate Synaptic mRNAs: Perturbation by Chronic Alcohol Consumption. Neuropsychopharmacology. 2016 Jan;41(2):538-48. doi: 10.1038/npp.2015.179. Epub 2015 Jun 24. PubMed PMID: 26105134; PubMed Central PMCID: PMC5130129.
Mayfield J, Arends MA, Harris RA, Blednov YA. Genes and Alcohol Consumption: Studies with Mutant Mice. Int Rev Neurobiol. 2016;126:293-355. doi: 10.1016/bs.irn.2016.02.014. Review. PubMed PMID: 27055617; PubMed Central PMCID: PMC5302130.
Farris SP, Pietrzykowski AZ, Miles MF, O'Brien MA, Sanna PP, Zakhari S, Mayfield RD, Harris RA. Applying the new genomics to alcohol dependence. Alcohol. 2015 Dec;49(8):825-36. doi: 10.1016/j.alcohol.2015.03.001. Epub 2015 Mar 28. Review. PubMed PMID: 25896098; PubMed Central PMCID: PMC4586299.
Farris SP, Arasappan D, Hunicke-Smith S, Harris RA, Mayfield RD. Transcriptome organization for chronic alcohol abuse in human brain. Mol Psychiatry. 2015 Nov;20(11):1438-47. doi: 10.1038/mp.2014.159. Epub 2014 Dec 2. PubMed PMID: 25450227; PubMed Central PMCID: PMC4452464.
Mayfield J, Blednov YA, Harris RA. Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction. Int Rev Neurobiol. 2015;123:279-313. doi: 10.1016/bs.irn.2015.05.016. Epub 2015 Jun 22. Review. PubMed PMID: 26422988; PubMed Central PMCID: PMC4769645.
Most D, Ferguson L, Blednov Y, Mayfield RD, Harris RA. The synaptoneurosome transcriptome: a model for profiling the emolecular effects of alcohol. Pharmacogenomics J. 2015 Apr;15(2):177-88. doi: 10.1038/tpj.2014.43. Epub 2014 Aug 19. PubMed PMID: 25135349; PubMed Central PMCID: PMC4334750.
Osterndorff-Kahanek EA, Becker HC, Lopez MF, Farris SP, Tiwari GR, Nunez YO, Harris RA, Mayfield RD. Chronic ethanol exposure produces time- and brain region-dependent changes in gene coexpression networks. PLoS One. 2015;10(3):e0121522. doi: 10.1371/journal.pone.0121522. eCollection 2015. PubMed PMID: 25803291; PubMed Central PMCID: PMC4372440.
Lee C, Mayfield RD, Harris RA. Altered gamma-aminobutyric acid type B receptor subunit 1 splicing in alcoholics. Biol Psychiatry. 2014 May 15;75(10):765-73. doi: 10.1016/j.biopsych.2013.08.028. Epub 2013 Oct 24. PubMed PMID: 24209778; PubMed Central PMCID: PMC3999301.
Farris SP, Mayfield RD. RNA-Seq reveals novel transcriptional reorganization in human alcoholic brain. Int Rev Neurobiol. 2014;116:275-300. doi: 10.1016/B978-0-12-801105-8.00011-4. Review. PubMed PMID: 25172479; PubMed Central PMCID: PMC4267562.
Marballi K, Ponomarev I, Mayfield D, Harris A. Alcohol and the brain: an epigenetic viewpoint. In: Noronha A, Cui C, Harris A, Crabbe J, editors. Neurobiology of Alcohol Dependence First ed. United States: Academic Press, Elsevier; 2014. Chapter 17; p.349-358. 560p.
Gorini G, Harris RA, Mayfield RD. Proteomic approaches and identification of novel therapeutic targets for alcoholism. Neuropsychopharmacology. 2014 Jan;39(1):104-30. doi: 10.1038/npp.2013.182. Epub 2013 Jul 31. Review. PubMed PMID: 23900301; PubMed Central PMCID: PMC3857647.
Gorini G, Roberts AJ, Mayfield RD. Neurobiological signatures of alcohol dependence revealed by protein profiling. PLoS One. 2013;8(12):e82656. doi: 10.1371/journal.pone.0082656. eCollection 2013. PubMed PMID: 24358215; PubMed Central PMCID: PMC3865151.
Gorini G, Nunez YO, Mayfield RD. Integration of miRNA and protein profiling reveals coordinated neuroadaptations in the alcohol-dependent mouse brain. PLoS One. 2013;8(12):e82565. doi: 10.1371/journal.pone.0082565. eCollection 2013. PubMed PMID: 24358208; PubMed Central PMCID: PMC3865091.
Nunez YO, Truitt JM, Gorini G, Ponomareva ON, Blednov YA, Harris RA, Mayfield RD. Positively correlated miRNA-mRNA regulatory networks in mouse frontal cortex during early stages of alcohol dependence. BMC Genomics. 2013 Oct 22;14:725. doi: 10.1186/1471-2164-14-725. PubMed PMID: 24148570; PubMed Central PMCID: PMC3924350.
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