My Bibliography

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Mellén M, Ayata P, Dewell S, Kriaucionis S, Heintz N. MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell. 2012 Dec 21;151(7):1417-30. doi: 10.1016/j.cell.2012.11.022. PubMed PMID: 23260135; PubMed Central PMCID: PMC3653293.

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Sullivan JM, Badimon A, Schaefer U, Ayata P, Gray J, Chung CW, von Schimmelmann M, Zhang F, Garton N, Smithers N, Lewis H, Tarakhovsky A, Prinjha RK, Schaefer A. Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice. J Exp Med. 2015 Oct 19;212(11):1771-81. doi: 10.1084/jem.20151271. Epub 2015 Sep 21. PubMed PMID: 26392221; PubMed Central PMCID: PMC4612093.

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Mellén M, Ayata P, Heintz N. 5-hydroxymethylcytosine accumulation in postmitotic neurons results in functional demethylation of expressed genes. Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7812-E7821. doi: 10.1073/pnas.1708044114. Epub 2017 Aug 28. PubMed PMID: 28847947; PubMed Central PMCID: PMC5604027.

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Ayata P, Badimon A, Strasburger HJ, Duff MK, Montgomery SE, Loh YE, Ebert A, Pimenova AA, Ramirez BR, Chan AT, Sullivan JM, Purushothaman I, Scarpa JR, Goate AM, Busslinger M, Shen L, Losic B, Schaefer A. Epigenetic regulation of brain region-specific microglia clearance activity. Nat Neurosci. 2018 Aug;21(8):1049-1060. doi: 10.1038/s41593-018-0192-3. Epub 2018 Jul 23. PubMed PMID: 30038282; PubMed Central PMCID: PMC6090564.

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Gunner G, Cheadle L, Johnson KM, Ayata P, Badimon A, Mondo E, Nagy MA, Liu L, Bemiller SM, Kim KW, Lira SA, Lamb BT, Tapper AR, Ransohoff RM, Greenberg ME, Schaefer A, Schafer DP. Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling. Nat Neurosci. 2019 Jul;22(7):1075-1088. doi: 10.1038/s41593-019-0419-y. Epub 2019 Jun 17. PubMed PMID: 31209379; PubMed Central PMCID: PMC6596419.

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Kana V, Desland FA, Casanova-Acebes M, Ayata P, Badimon A, Nabel E, Yamamuro K, Sneeboer M, Tan IL, Flanigan ME, Rose SA, Chang C, Leader A, Le Bourhis H, Sweet ES, Tung N, Wroblewska A, Lavin Y, See P, Baccarini A, Ginhoux F, Chitu V, Stanley ER, Russo SJ, Yue Z, Brown BD, Joyner AL, De Witte LD, Morishita H, Schaefer A, Merad M. CSF-1 controls cerebellar microglia and is required for motor function and social interaction. J Exp Med. 2019 Oct 7;216(10):2265-2281. doi: 10.1084/jem.20182037. Epub 2019 Jul 26. PubMed PMID: 31350310; PubMed Central PMCID: PMC6781012.

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Shrestha P, Ayata P, Herrero-Vidal P, Longo F, Gastone A, LeDoux JE, Heintz N, Klann E. Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation. Nat Neurosci. 2020 Feb;23(2):281-292. doi: 10.1038/s41593-019-0568-z. Epub 2020 Jan 20. PubMed PMID: 31959934; PubMed Central PMCID: PMC7147976.

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Ayata P, Schaefer A. Innate sensing of mechanical properties of brain tissue by microglia. Curr Opin Immunol. 2020 Feb;62:123-130. doi: 10.1016/j.coi.2020.01.003. Epub 2020 Feb 10. Review. PubMed PMID: 32058296; PubMed Central PMCID: PMC7067639.

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Lim SL, Rodriguez-Ortiz CJ, Hsu HW, Wu J, Zumkehr J, Kilian J, Vidal J, Ayata P, Kitazawa M. Chronic copper exposure directs microglia towards degenerative expression signatures in wild-type and J20 mouse model of Alzheimer's disease. J Trace Elem Med Biol. 2020 Dec;62:126578. doi: 10.1016/j.jtemb.2020.126578. Epub 2020 Jun 20. PubMed PMID: 32599538; PubMed Central PMCID: PMC7655674.

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Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru JO, Ledderose C, Kutlu MG, Wheeler MA, Kahan A, Ishikawa M, Wang YC, Loh YE, Jiang JX, Surmeier DJ, Robson SC, Junger WG, Sebra R, Calipari ES, Kenny PJ, Eyo UB, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A. Negative feedback control of neuronal activity by microglia. Nature. 2020 Oct;586(7829):417-423. doi: 10.1038/s41586-020-2777-8. Epub 2020 Sep 30. PubMed PMID: 32999463; PubMed Central PMCID: PMC7577179.

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Ayata P, Amit I, Cuda CM. Editorial: Microglia in neuroinflammation. Front Immunol. 2023;14:1227095. doi: 10.3389/fimmu.2023.1227095. eCollection 2023. PubMed PMID: 37398652; PubMed Central PMCID: PMC10311352.

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Ralvenius WT, Mungenast AE, Woolf H, Huston MM, Gillingham TZ, Godin SK, Penney J, Cam HP, Gao F, Fernandez CG, Czako B, Lightfoot Y, Ray WJ, Beckmann A, Goate AM, Marcora E, Romero-Molina C, Ayata P, Schaefer A, Gjoneska E, Tsai LH. A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation. J Exp Med. 2023 Nov 6;220(11). doi: 10.1084/jem.20222105. Epub 2023 Aug 29. PubMed PMID: 37642942; PubMed Central PMCID: PMC10465325.

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Faust TE, Lee YH, O'Connor CD, Boyle MA, Gunner G, Badimon A, Ayata P, Schaefer A, Schafer DP. Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling. bioRxiv. 2024 Feb 9;. doi: 10.1101/2024.02.08.579178. PubMed PMID: 38370645; PubMed Central PMCID: PMC10871360.

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Flury A, Aljayousi L, Park HJ, Khakpour M, Mechler J, Aziz S, McGrath JD, Deme P, Sandberg C, González Ibáñez F, Braniff O, Ngo T, Smith S, Velez M, Ramirez DM, Avnon-Klein D, Murray JW, Liu J, Parent M, Mingote S, Haughey NJ, Werneburg S, Tremblay MÈ, Ayata P. A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion. Neuron. 2025 Feb 19;113(4):554-571.e14. doi: 10.1016/j.neuron.2024.11.018. Epub 2024 Dec 23. PubMed PMID: 39719704; PubMed Central PMCID: PMC12481204.

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Faust TE, Lee YH, O'Connor CD, Boyle MA, Gunner G, Durán-Laforet V, Ferrari LL, Murphy RE, Badimon A, Sakers K, Eroglu C, Ayata P, Schaefer A, Schafer DP. Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling. Cell. 2025 Sep 18;188(19):5212-5230.e21. doi: 10.1016/j.cell.2025.08.023. Epub 2025 Sep 10. PubMed PMID: 40934914; PubMed Central PMCID: PMC12489809.

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Iyer AK, Moutinho M, Ayata P, Karahan H. Editorial: Myeloid cells as active players in human neurodegenerative diseases. Front Neurosci. 2025;19:1712394. doi: 10.3389/fnins.2025.1712394. eCollection 2025. PubMed PMID: 41200514; PubMed Central PMCID: PMC12586100.

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Ayata P, Crowley JM, Challman MF, Sahasrabuddhe V, Gratuze M, Werneburg S, Ribeiro D, Hays EC, Durán-Laforet V, Faust TE, Hwang P, Mendes Lopes F, Nikopoulou C, Buchholz S, Murphy RE, Mei T, Pimenova AA, Romero-Molina C, Garretti F, Patel TA, De Sanctis C, Ramirez Jimenez AV, Crow M, Weiss FD, Ulrich JD, Marcora E, Murray JW, Meissner F, Beyer A, Hasson D, Crary JF, Schafer DP, Holtzman DM, Goate AM, Tarakhovsky A, Schaefer A. Lymphoid gene expression supports neuroprotective microglia function. Nature. 2025 Dec;648(8092):157-165. doi: 10.1038/s41586-025-09662-z. Epub 2025 Nov 5. PubMed PMID: 41193812; PubMed Central PMCID: PMC12675299.

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Flury A, St-Pierre MK, Ayata P, Tremblay MÈ. Evolving insights into the identity and function of dark microglia. Trends Neurosci. 2026 Jan;49(1):20-34. doi: 10.1016/j.tins.2025.11.002. Epub 2025 Dec 6. Review. PubMed PMID: 41354574; PubMed Central PMCID: PMC12695070.