My Bibliography

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Lu Z, May A, Dinh B, Lin V, Su F, Tran C, Adivikolanu H, Ehlen R, Che B, Wang Z, Shaw D, Borooah S, Shaw PX. The interplay of oxidative stress and ARMS2-HTRA1 genetic risk in neovascular AMD. Vessel Plus. 2021 January; 4(5):2-19.

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Chekuri A, Zientara-Rytter K, Soto-Hermida A, Borooah S, Voronchikhina M, Biswas P, Kumar V, Goodsell D, Hayward C, Shaw P, Stanton C, Garland D, Subramani S, Ayyagari R. Late-onset retinal degeneration pathology due to mutations in CTRP5 is mediated through HTRA1. Aging Cell. 2019 Dec;18(6):e13011. doi: 10.1111/acel.13011. Epub 2019 Aug 5. PubMed PMID: 31385385; PubMed Central PMCID: PMC6826137.

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Gong B, Zhang H, Huang L, Chen Y, Shi Y, Tam PO, Zhu X, Huang Y, Lei B, Sundaresan P, Li X, Jiang L, Yang J, Lin Y, Lu F, Chen L, Li Y, Leung CK, Guo X, Zhang S, Huang G, Wu Y, Zhou T, Shuai P, Tham CC, Weisschuh N, Krishnadas SR, Mardin C, Reis A, Yang J, Zhang L, Zhou Y, Wang Z, Qu C, Shaw PX, Pang CP, Sun X, Zhu W, Li DY, Pasutto F, Yang Z. Mutant RAMP2 causes primary open-angle glaucoma via the CRLR-cAMP axis. Genet Med. 2019 Oct;21(10):2345-2354. doi: 10.1038/s41436-019-0507-0. Epub 2019 Apr 19. PubMed PMID: 31000793.

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Lu Z, Lin V, May A, Che B, Xiao X, Shaw DH, Su F, Wang Z, Du H, Shaw PX. HTRA1 synergizes with oxidized phospholipids in promoting inflammation and macrophage infiltration essential for ocular VEGF expression. PLoS One. 2019;14(5):e0216808. doi: 10.1371/journal.pone.0216808. eCollection 2019. PubMed PMID: 31100080; PubMed Central PMCID: PMC6524793.

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Xiao X, Lu Z, Lin V, May A, Shaw DH, Wang Z, Che B, Tran K, Du H, Shaw PX. MicroRNA miR-24-3p Reduces Apoptosis and Regulates Keap1-Nrf2 Pathway in Mouse Cardiomyocytes Responding to Ischemia/Reperfusion Injury. Oxid Med Cell Longev. 2018;2018:7042105. doi: 10.1155/2018/7042105. eCollection 2018. PubMed PMID: 30622671; PubMed Central PMCID: PMC6304907.

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Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Sci Signal. 2018 Feb 13;11(517). doi: 10.1126/scisignal.aan5785. PubMed PMID: 29440509; PubMed Central PMCID: PMC5957084.

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Xiao X, Hou H, Lin V, Ho D, Tran K, Che B, May A, Zhang J, Lu Z, Lu Z, Shaw PX. Probucol Protects Rats from Cardiac Dysfunction Induced by Oxidative Stress following Cardiopulmonary Resuscitation. Oxid Med Cell Longev. 2017;2017:1284804. doi: 10.1155/2017/1284804. Epub 2017 Oct 30. PubMed PMID: 29213348; PubMed Central PMCID: PMC5682903.

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Apara A, Galvao J, Wang Y, Blackmore M, Trillo A, Iwao K, Brown DP Jr, Fernandes KA, Huang A, Nguyen T, Ashouri M, Zhang X, Shaw PX, Kunzevitzky NJ, Moore DL, Libby RT, Goldberg JL. KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS. J Neurosci. 2017 Oct 4;37(40):9632-9644. doi: 10.1523/JNEUROSCI.0643-16.2017. Epub 2017 Sep 4. PubMed PMID: 28871032; PubMed Central PMCID: PMC5628408.

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Chang KC, Hertz J, Zhang X, Jin XL, Shaw P, Derosa BA, Li JY, Venugopalan P, Valenzuela DA, Patel RD, Russano KR, Alshamekh SA, Sun C, Tenerelli K, Li C, Velmeshev D, Cheng Y, Boyce TM, Dreyfuss A, Uddin MS, Muller KJ, Dykxhoorn DM, Goldberg JL. Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development. J Neurosci. 2017 May 10;37(19):4967-4981. doi: 10.1523/JNEUROSCI.3430-13.2017. Epub 2017 Apr 14. PubMed PMID: 28411269; PubMed Central PMCID: PMC5426184.

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Shaw PX, Sang A, Wang Y, Ho D, Douglas C, Dia L, Goldberg JL. Topical administration of a Rock/Net inhibitor promotes retinal ganglion cell survival and axon regeneration after optic nerve injury. Exp Eye Res. 2017 May;158:33-42. doi: 10.1016/j.exer.2016.07.006. Epub 2016 Jul 18. PubMed PMID: 27443501; PubMed Central PMCID: PMC5821900.

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Stiles T, Du H, Xiao X, Douglas C, Ho D, Shaw PX. Understanding mechanistic interplay between oxidative stress and the complement system in AMD pathogenesis. Investigative Ophthalmology & Visual Science. 2016 September; 57(12):5810-5810.

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Shaw PX, Fang J, Sang A, Wang Y, Kapiloff MS, Goldberg JL. Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation. Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):5083-5092. doi: 10.1167/iovs.16-19465. PubMed PMID: 27679853; PubMed Central PMCID: PMC5053116.

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Shaw PX, Travis S, Douglas C, Ho D, Fan W, Du H, Xiao X. Oxidative stress, innate immunity, and age-related macular degeneration. AIMS Mol Sci.. 2016 May; 3(2):196-221.

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Shaw PX, Stiles T, Douglas C, Ho D, Fan W, Du H, Xiao X. Oxidative stress, innate immunity, and age-related macular degeneration. AIMS Mol Sci. 2016;3(2):196-221. doi: 10.3934/molsci.2016.2.196. Epub 2016 May 11. PubMed PMID: 27239555; PubMed Central PMCID: PMC4882104.

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Fang J, Shaw PX, Wang Y, Goldberg JL. Krüppel-Like Factor 4 (KLF4) Is Not Required for Retinal Cell Differentiation. eNeuro. 2016 Jan-Feb;3(1). doi: 10.1523/ENEURO.0117-15.2016. eCollection 2016 Jan-Feb. PubMed PMID: 27022622; PubMed Central PMCID: PMC4770008.

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Du H, Xiao X, Stiles T, Douglas C, Ho D, Shaw PX. Novel Mechanistic Interplay between Products of Oxidative Stress and Components of the Complement System in AMD Pathogenesis. Open J Ophthalmol. 2016 Feb;6(1):43-50. doi: 10.4236/ojoph.2016.61006. Epub 2016 Feb 26. PubMed PMID: 27668132; PubMed Central PMCID: PMC5035113.

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Fang J, Shaw PX, Wang Y, Goldberg JL. Krüppel-like factor 4 (KLF4) is not required for retinal cell differentiation. eNeuro. 2016 January. doi: 10.1523/ENEURO.0117-15.2016.

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Trakhtenberg EF, Morkin MI, Patel KH, Fernandez SG, Sang A, Shaw P, Liu X, Wang Y, Mlacker GM, Gao H, Velmeshev D, Dombrowski SM, Vitek MP, Goldberg JL. The N-terminal Set-β Protein Isoform Induces Neuronal Death. J Biol Chem. 2015 May 22;290(21):13417-26. doi: 10.1074/jbc.M114.633883. Epub 2015 Apr 1. PubMed PMID: 25833944; PubMed Central PMCID: PMC4505589.

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Shaw PX, Werstuck G, Chen Y. Oxidative stress and aging diseases. Oxid Med Cell Longev. 2014;2014:569146. doi: 10.1155/2014/569146. Epub 2014 May 12. PubMed PMID: 24959310; PubMed Central PMCID: PMC4052780.

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Luo J, Baranov P, Patel S, Ouyang H, Quach J, Wu F, Qiu A, Luo H, Hicks C, Zeng J, Zhu J, Lu J, Sfeir N, Wen C, Zhang M, Reade V, Patel S, Sinden J, Sun X, Shaw P, Young M, Zhang K. Human retinal progenitor cell transplantation preserves vision. J Biol Chem. 2014 Mar 7;289(10):6362-6371. doi: 10.1074/jbc.M113.513713. Epub 2014 Jan 9. PubMed PMID: 24407289; PubMed Central PMCID: PMC3945303.

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Xiao X, Du HJ, Hu WJ, Shaw PX. The influence of long term hydrochlorothiazide administration on the relationship between renin-angiotensin-aldosterone system activity and plasma glucose in patients with hypertension. Oxid Med Cell Longev. 2013;2013:434618. doi: 10.1155/2013/434618. Epub 2013 Nov 19. PubMed PMID: 24349612; PubMed Central PMCID: PMC3852583.

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Luo J, Zhao L, Chen AY, Zhang X, Zhu J, Zhao J, Ouyang H, Luo H, Song Y, Lee J, Patel SH, Shaw PX, Sadda S, Zhuo Y, Rosenfeld MG, Zhang K. TCF7L2 variation and proliferative diabetic retinopathy. Diabetes. 2013 Jul;62(7):2613-7. doi: 10.2337/db12-1093. Epub 2013 Feb 22. PubMed PMID: 23434931; PubMed Central PMCID: PMC3712060.

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Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2377-82. doi: 10.1073/pnas.1221729110. Epub 2013 Jan 22. PubMed PMID: 23341606; PubMed Central PMCID: PMC3568328.

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Lee J, Zeng J, Hughes G, Chen Y, Grob S, Zhao L, Lee C, Krupa M, Quach J, Luo J, Zeng J, Wei X, Zhang X, Zhu J, Duan Y, Ferreyra H, Goldbaum M, Haw W, Shaw PX, Tang L, Zhang K. Association of LIPC and advanced age-related macular degeneration. Eye (Lond). 2013 Feb;27(2):265-70; quiz 271. doi: 10.1038/eye.2012.276. Epub 2013 Jan 25. PubMed PMID: 23348725; PubMed Central PMCID: PMC3574263.

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Shaw PX, Zhang L, Zhang M, Du H, Zhao L, Lee C, Grob S, Lim SL, Hughes G, Lee J, Bedell M, Nelson MH, Lu F, Krupa M, Luo J, Ouyang H, Tu Z, Su Z, Zhu J, Wei X, Feng Z, Duan Y, Yang Z, Ferreyra H, Bartsch DU, Kozak I, Zhang L, Lin F, Sun H, Feng H, Zhang K. Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13757-62. doi: 10.1073/pnas.1121309109. Epub 2012 Aug 8. PubMed PMID: 22875704; PubMed Central PMCID: PMC3427125.

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Zhao L, Grob S, Corey R, Krupa M, Luo J, Du H, Lee C, Hughes G, Lee J, Quach J, Zhu J, Shaw PX, Kozak I, Zhang K. A novel compound heterozygous mutation in the BEST1 gene causes autosomal recessive Best vitelliform macular dystrophy. Eye (Lond). 2012 Jun;26(6):866-71. doi: 10.1038/eye.2012.27. Epub 2012 Mar 16. PubMed PMID: 22422030; PubMed Central PMCID: PMC3376281.

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Zhang L, Lim SL, Du H, Zhang M, Kozak I, Hannum G, Wang X, Ouyang H, Hughes G, Zhao L, Zhu X, Lee C, Su Z, Zhou X, Shaw R, Geum D, Wei X, Zhu J, Ideker T, Oka C, Wang N, Yang Z, Shaw PX, Zhang K. High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6. J Biol Chem. 2012 Jan 6;287(2):1520-6. doi: 10.1074/jbc.M111.275990. Epub 2011 Nov 2. PubMed PMID: 22049084; PubMed Central PMCID: PMC3256864.

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Sommer JR, Estrada JL, Collins EB, Bedell M, Alexander CA, Yang Z, Hughes G, Mir B, Gilger BC, Grob S, Wei X, Piedrahita JA, Shaw PX, Petters RM, Zhang K. Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration. Br J Ophthalmol. 2011 Dec;95(12):1749-54. doi: 10.1136/bjophthalmol-2011-300417. Epub 2011 Aug 26. PubMed PMID: 21873315.

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Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, Banka CL, Witztum JL. Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression. J Am Coll Cardiol. 2011 Oct 11;58(16):1715-27. doi: 10.1016/j.jacc.2011.07.017. PubMed PMID: 21982317; PubMed Central PMCID: PMC3230644.

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Zhang K, Harada Y, Wei X, Shukla D, Rajendran A, Tawansy K, Bedell M, Lim S, Shaw PX, He X, Yang Z. An essential role of the cysteine-rich domain of FZD4 in Norrin/Wnt signaling and familial exudative vitreoretinopathy. J Biol Chem. 2011 Mar 25;286(12):10210-5. doi: 10.1074/jbc.M110.194399. Epub 2010 Dec 22. PubMed PMID: 21177847; PubMed Central PMCID: PMC3060474.

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Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res. 2011 Jan 21;108(2):235-48. doi: 10.1161/CIRCRESAHA.110.223875. Review. PubMed PMID: 21252151; PubMed Central PMCID: PMC3075542.

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Briley-Saebo KC, Cho YS, Shaw PX, Ryu SK, Mani V, Dickson S, Izadmehr E, Green S, Fayad ZA, Tsimikas S. Targeted iron oxide particles for in vivo magnetic resonance detection of atherosclerotic lesions with antibodies directed to oxidation-specific epitopes. J Am Coll Cardiol. 2011 Jan 18;57(3):337-47. doi: 10.1016/j.jacc.2010.09.023. Epub 2010 Nov 23. PubMed PMID: 21106318; PubMed Central PMCID: PMC3095034.

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Wool GD, Cabana VG, Lukens J, Shaw PX, Binder CJ, Witztum JL, Reardon CA, Getz GS. 4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice. FASEB J. 2011 Jan;25(1):290-300. doi: 10.1096/fj.10-165670. Epub 2010 Sep 27. PubMed PMID: 20876212; PubMed Central PMCID: PMC3005429.

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Wang X, Harmon J, Zabrieskie N, Chen Y, Grob S, Williams B, Lee C, Kasuga D, Shaw PX, Buehler J, Wang N, Zhang K. Using the Utah Population Database to assess familial risk of primary open angle glaucoma. Vision Res. 2010 Nov 23;50(23):2391-5. doi: 10.1016/j.visres.2010.09.018. Epub 2010 Sep 19. PubMed PMID: 20858511; NIHMSID:NIHMS246142.

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Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum JL, Binder CJ. Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest. 2009 May;119(5):1335-49. doi: 10.1172/JCI36800. Epub 2009 Apr 13. PubMed PMID: 19363291; PubMed Central PMCID: PMC2673862.

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Hartvigsen K, Chou MY, Hansen LF, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. The role of innate immunity in atherogenesis. J Lipid Res. 2009 Apr;50 Suppl(Suppl):S388-93. doi: 10.1194/jlr.R800100-JLR200. Epub 2008 Dec 22. Review. PubMed PMID: 19106070; PubMed Central PMCID: PMC2674727.

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Briley-Saebo KC, Shaw PX, Mulder WJ, Choi SH, Vucic E, Aguinaldo JG, Witztum JL, Fuster V, Tsimikas S, Fayad ZA. Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. Circulation. 2008 Jun 24;117(25):3206-15. doi: 10.1161/CIRCULATIONAHA.107.757120. Epub 2008 Jun 9. PubMed PMID: 18541740; PubMed Central PMCID: PMC4492476.

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Chou MY, Hartvigsen K, Hansen LF, Fogelstrand L, Shaw PX, Boullier A, Binder CJ, Witztum JL. Oxidation-specific epitopes are important targets of innate immunity. J Intern Med. 2008 May;263(5):479-88. doi: 10.1111/j.1365-2796.2008.01968.x. Review. PubMed PMID: 18410591.

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Binder CJ, Chou MY, Fogelstrand L, Hartvigsen K, Shaw PX, Boullier A, Witztum JL. Natural antibodies in murine atherosclerosis. Curr Drug Targets. 2008 Mar;9(3):190-5. doi: 10.2174/138945008783755520. Review. PubMed PMID: 18336236.

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Choi SH, Chae A, Chen CH, Merki E, Shaw PX, Tsimikas S. Emerging approaches for imaging vulnerable plaques in patients. Curr Opin Biotechnol. 2007 Feb;18(1):73-82. doi: 10.1016/j.copbio.2007.01.001. Epub 2007 Jan 17. Review. PubMed PMID: 17234398.

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Binder CJ, Shaw PX, Chang MK, Boullier A, Hartvigsen K, Hörkkö S, Miller YI, Woelkers DA, Corr M, Witztum JL. The role of natural antibodies in atherogenesis. J Lipid Res. 2005 Jul;46(7):1353-63. doi: 10.1194/jlr.R500005-JLR200. Epub 2005 May 16. Review. PubMed PMID: 15897601.

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Chen Z, Mi L, Xu J, Yu J, Wang X, Jiang J, Xing J, Shang P, Qian A, Li Y, Shaw PX, Wang J, Duan S, Ding J, Fan C, Zhang Y, Yang Y, Yu X, Feng Q, Li B, Yao X, Zhang Z, Li L, Xue X, Zhu P. Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus. J Infect Dis. 2005 Mar 1;191(5):755-60. doi: 10.1086/427811. Epub 2005 Jan 25. PubMed PMID: 15688292; PubMed Central PMCID: PMC7110046.

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Torzewski M, Shaw PX, Han KR, Shortal B, Lackner KJ, Witztum JL, Palinski W, Tsimikas S. Reduced in vivo aortic uptake of radiolabeled oxidation-specific antibodies reflects changes in plaque composition consistent with plaque stabilization. Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2307-12. doi: 10.1161/01.ATV.0000149378.98458.fe. Epub 2004 Nov 4. PubMed PMID: 15528482.

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Shaw PX. Rethinking oxidized low-density lipoprotein, its role in atherogenesis and the immune responses associated with it. Arch Immunol Ther Exp (Warsz). 2004 Jul-Aug;52(4):225-39. Review. PubMed PMID: 15467487.

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Miller YI, Chang MK, Binder CJ, Shaw PX, Witztum JL. Oxidized low density lipoprotein and innate immune receptors. Curr Opin Lipidol. 2003 Oct;14(5):437-45. doi: 10.1097/00041433-200310000-00004. Review. PubMed PMID: 14501582.

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Shaw PX, Goodyear CS, Chang MK, Witztum JL, Silverman GJ. The autoreactivity of anti-phosphorylcholine antibodies for atherosclerosis-associated neo-antigens and apoptotic cells. J Immunol. 2003 Jun 15;170(12):6151-7. doi: 10.4049/jimmunol.170.12.6151. PubMed PMID: 12794145.

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Binder CJ, Hörkkö S, Dewan A, Chang MK, Kieu EP, Goodyear CS, Shaw PX, Palinski W, Witztum JL, Silverman GJ. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med. 2003 Jun;9(6):736-43. doi: 10.1038/nm876. Epub 2003 May 12. PubMed PMID: 12740573.

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Binder CJ, Chang MK, Shaw PX, Miller YI, Hartvigsen K, Dewan A, Witztum JL. Innate and acquired immunity in atherogenesis. Nat Med. 2002 Nov;8(11):1218-26. doi: 10.1038/nm1102-1218. Review. PubMed PMID: 12411948.

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Tsimikas S, Shaw PX. Non-invasive imaging of vulnerable plaques by molecular targeting of oxidized LDL with tagged oxidation-specific antibodies. J Cell Biochem Suppl. 2002;39:138-46. doi: 10.1002/jcb.10420. PubMed PMID: 12552613.

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Shaw PX, Hörkkö S, Tsimikas S, Chang MK, Palinski W, Silverman GJ, Chen PP, Witztum JL. Human-derived anti-oxidized LDL autoantibody blocks uptake of oxidized LDL by macrophages and localizes to atherosclerotic lesions in vivo. Arterioscler Thromb Vasc Biol. 2001 Aug;21(8):1333-9. doi: 10.1161/hq0801.093587. PubMed PMID: 11498462.