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Ping P, Johnson PC. Mechanism of enhanced myogenic response in arterioles during sympathetic nerve stimulation. Am J Physiol. 1992 Oct;263(4 Pt 2):H1185-9. doi: 10.1152/ajpheart.1992.263.4.H1185. PubMed PMID: 1384361.
Ping P, Johnson PC. Role of myogenic response in enhancing autoregulation of flow during sympathetic nerve stimulation. Am J Physiol. 1992 Oct;263(4 Pt 2):H1177-84. doi: 10.1152/ajpheart.1992.263.4.H1177. PubMed PMID: 1415767.
Ping P, Faber JE. Characterization of alpha-adrenoceptor gene expression in arterial and venous smooth muscle. Am J Physiol. 1993 Nov;265(5 Pt 2):H1501-9. doi: 10.1152/ajpheart.1993.265.5.H1501. PubMed PMID: 8238561.
Hammond HK, Roth DA, McKirnan MD, Ping P. Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of chronic episodic myocardial ischemia. J Clin Invest. 1993 Dec;92(6):2644-52. doi: 10.1172/JCI116880. PubMed PMID: 8254020; PubMed Central PMCID: PMC288461.
Ping P, Johnson PC. Arteriolar network response to pressure reduction during sympathetic nerve stimulation in cat skeletal muscle. Am J Physiol. 1994 Mar;266(3 Pt 2):H1251-9. doi: 10.1152/ajpheart.1994.266.3.H1251. PubMed PMID: 8160830.
Ping P, Hammond HK. Diverse G protein and beta-adrenergic receptor mRNA expression in normal and failing porcine hearts. Am J Physiol. 1994 Nov;267(5 Pt 2):H2079-85. doi: 10.1152/ajpheart.1994.267.5.H2079. PubMed PMID: 7977840.
Ping P, Gelzer-Bell R, Roth DA, Kiel D, Insel PA, Hammond HK. Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart. J Clin Invest. 1995 Mar;95(3):1271-80. doi: 10.1172/JCI117777. PubMed PMID: 7883975; PubMed Central PMCID: PMC441466.
Giordano FJ, Ping P, McKirnan MD, Nozaki S, DeMaria AN, Dillmann WH, Mathieu-Costello O, Hammond HK. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nat Med. 1996 May;2(5):534-9. doi: 10.1038/nm0596-534. PubMed PMID: 8616711.
Ping P, Yang Q, Hammond HK. Altered beta-adrenergic receptor signaling in heart failure, in vivo gene transfer via adeno and adeno-associated virus. Microcirculation. 1996 Jun;3(2):225-8. doi: 10.3109/10739689609148292. PubMed PMID: 8839444.
Ping P, Anzai T, Gao M, Hammond HK. Adenylyl cyclase and G protein receptor kinase expression during development of heart failure. Am J Physiol. 1997 Aug;273(2 Pt 2):H707-17. doi: 10.1152/ajpheart.1997.273.2.H707. PubMed PMID: 9277487.
Ping P, Zhang J, Qiu Y, Tang XL, Manchikalapudi S, Cao X, Bolli R. Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity. Circ Res. 1997 Sep;81(3):404-14. doi: 10.1161/01.res.81.3.404. PubMed PMID: 9285643.
Hammond HK, Ping P, Insel PA. Cardiac G-protein receptor kinase activity: effect of a beta-adrenergic receptor antagonist. Adv Pharmacol. 1998;42:507-10. doi: 10.1016/s1054-3589(08)60800-5. PubMed PMID: 9327951.
Pál M, Tóth A, Ping P, Johnson PC. Capillary blood flow and tissue metabolism in skeletal muscle during sympathetic trunk stimulation. Am J Physiol. 1998 Feb;274(2):H430-40. doi: 10.1152/ajpheart.1998.274.2.H430. PubMed PMID: 9486245.
Gao M, Ping P, Post S, Insel PA, Tang R, Hammond HK. Increased expression of adenylylcyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1038-43. doi: 10.1073/pnas.95.3.1038. PubMed PMID: 9448281; PubMed Central PMCID: PMC18663.
Qiu Y, Ping P, Tang XL, Manchikalapudi S, Rizvi A, Zhang J, Takano H, Wu WJ, Teschner S, Bolli R. Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that epsilon is the isoform involved. J Clin Invest. 1998 May 15;101(10):2182-98. doi: 10.1172/JCI1258. PubMed PMID: 9593774; PubMed Central PMCID: PMC508806.
Bolli R, Dawn B, Tang XL, Qiu Y, Ping P, Xuan YT, Jones WK, Takano H, Guo Y, Zhang J. The nitric oxide hypothesis of late preconditioning. Basic Res Cardiol. 1998 Oct;93(5):325-38. doi: 10.1007/s003950050101. Review. PubMed PMID: 9833145; PubMed Central PMCID: PMC3701309.
Ping P, Takano H, Zhang J, Tang XL, Qiu Y, Li RC, Banerjee S, Dawn B, Balafonova Z, Bolli R. Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits: a signaling mechanism for both nitric oxide-induced and ischemia-induced preconditioning. Circ Res. 1999 Mar 19;84(5):587-604. doi: 10.1161/01.res.84.5.587. PubMed PMID: 10082480.
Ping P, Zhang J, Cao X, Li RC, Kong D, Tang XL, Qiu Y, Manchikalapudi S, Auchampach JA, Black RG, Bolli R. PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits. Am J Physiol. 1999 May;276(5):H1468-81. doi: 10.1152/ajpheart.1999.276.5.H1468. PubMed PMID: 10330229.
Ping P, Zhang J, Zheng YT, Li RC, Dawn B, Tang XL, Takano H, Balafanova Z, Bolli R. Demonstration of selective protein kinase C-dependent activation of Src and Lck tyrosine kinases during ischemic preconditioning in conscious rabbits. Circ Res. 1999 Sep 17;85(6):542-50. doi: 10.1161/01.res.85.6.542. PubMed PMID: 10488057.
Guo Y, Jones WK, Xuan YT, Tang XL, Bao W, Wu WJ, Han H, Laubach VE, Ping P, Yang Z, Qiu Y, Bolli R. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11507-12. doi: 10.1073/pnas.96.20.11507. PubMed PMID: 10500207; PubMed Central PMCID: PMC18064.
Ping P, Zhang J, Huang S, Cao X, Tang XL, Li RC, Zheng YT, Qiu Y, Clerk A, Sugden P, Han J, Bolli R. PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits. Am J Physiol. 1999 Nov;277(5):H1771-85. doi: 10.1152/ajpheart.1999.277.5.H1771. PubMed PMID: 10564130.
Dawn B, Xuan YT, Qiu Y, Takano H, Tang XL, Ping P, Banerjee S, Hill M, Bolli R. Bifunctional role of protein tyrosine kinases in late preconditioning against myocardial stunning in conscious rabbits. Circ Res. 1999 Dec 3-17;85(12):1154-63. doi: 10.1161/01.res.85.12.1154. PubMed PMID: 10590242.
Doble BW, Ping P, Kardami E. The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation. Circ Res. 2000 Feb 18;86(3):293-301. doi: 10.1161/01.res.86.3.293. PubMed PMID: 10679481.
Ping P, Murphy E. Role of p38 mitogen-activated protein kinases in preconditioning: a detrimental factor or a protective kinase?. Circ Res. 2000 May 12;86(9):921-2. doi: 10.1161/01.res.86.9.921. Review. PubMed PMID: 10807861.
Takeishi Y, Ping P, Bolli R, Kirkpatrick DL, Hoit BD, Walsh RA. Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy. Circ Res. 2000 Jun 23;86(12):1218-23. doi: 10.1161/01.res.86.12.1218. PubMed PMID: 10864911.
Li RC, Ping P, Zhang J, Wead WB, Cao X, Gao J, Zheng Y, Huang S, Han J, Bolli R. PKCepsilon modulates NF-kappaB and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes. Am J Physiol Heart Circ Physiol. 2000 Oct;279(4):H1679-89. doi: 10.1152/ajpheart.2000.279.4.H1679. PubMed PMID: 11009455.
Doble BW, Ping P, Fandrich RR, Cattini PA, Kardami E. Protein kinase C-epsilon mediates phorbol ester-induced phosphorylation of connexin-43. Cell Commun Adhes. 2001;8(4-6):253-6. doi: 10.3109/15419060109080733. PubMed PMID: 12064598.
Ping P, Zhang J, Pierce WM Jr, Bolli R. Functional proteomic analysis of protein kinase C epsilon signaling complexes in the normal heart and during cardioprotection. Circ Res. 2001 Jan 19;88(1):59-62. doi: 10.1161/01.res.88.1.59. PubMed PMID: 11139474.
Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P, McLeish KR. p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. J Biol Chem. 2001 Feb 2;276(5):3517-23. doi: 10.1074/jbc.M005953200. Epub 2000 Oct 20. PubMed PMID: 11042204.
Pass JM, Zheng Y, Wead WB, Zhang J, Li RC, Bolli R, Ping P. PKCepsilon activation induces dichotomous cardiac phenotypes and modulates PKCepsilon-RACK interactions and RACK expression. Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H946-55. doi: 10.1152/ajpheart.2001.280.3.H946. PubMed PMID: 11179034.
Vondriska TM, Klein JB, Ping P. Use of functional proteomics to investigate PKC epsilon-mediated cardioprotection: the signaling module hypothesis. Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1434-41. doi: 10.1152/ajpheart.2001.280.4.H1434. Review. PubMed PMID: 11247751.
Baines CP, Pass JM, Ping P. Protein kinases and kinase-modulated effectors in the late phase of ischemic preconditioning. Basic Res Cardiol. 2001 May-Jun;96(3):207-18. doi: 10.1007/s003950170051. Review. PubMed PMID: 11403414.
Pass JM, Gao J, Jones WK, Wead WB, Wu X, Zhang J, Baines CP, Bolli R, Zheng YT, Joshua IG, Ping P. Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1. Am J Physiol Heart Circ Physiol. 2001 Dec;281(6):H2500-10. doi: 10.1152/ajpheart.2001.281.6.H2500. PubMed PMID: 11709417.
Wang JF, Yang Y, Wang G, Min J, Sullivan MF, Ping P, Xiao YF, Morgan JP. Embryonic stem cells attenuate viral myocarditis in murine model. Cell Transplant. 2002;11(8):753-8. PubMed PMID: 12588107.
Ping P, Song C, Zhang J, Guo Y, Cao X, Li RC, Wu W, Vondriska TM, Pass JM, Tang XL, Pierce WM, Bolli R. Formation of protein kinase C(epsilon)-Lck signaling modules confers cardioprotection. J Clin Invest. 2002 Feb;109(4):499-507. doi: 10.1172/JCI13200. PubMed PMID: 11854322; PubMed Central PMCID: PMC150872.
Cross HR, Murphy E, Bolli R, Ping P, Steenbergen C. Expression of activated PKC epsilon (PKC epsilon) protects the ischemic heart, without attenuating ischemic H(+) production. J Mol Cell Cardiol. 2002 Mar;34(3):361-7. doi: 10.1006/jmcc.2001.1518. PubMed PMID: 11945027.
Song C, Vondriska TM, Wang GW, Klein JB, Cao X, Zhang J, Kang YJ, D'Souza S, Ping P. Molecular conformation dictates signaling module formation: example of PKCepsilon and Src tyrosine kinase. Am J Physiol Heart Circ Physiol. 2002 Mar;282(3):H1166-71. doi: 10.1152/ajpheart.00830.2001. PubMed PMID: 11834516.
Baines CP, Zhang J, Wang GW, Zheng YT, Xiu JX, Cardwell EM, Bolli R, Ping P. Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection. Circ Res. 2002 Mar 8;90(4):390-7. doi: 10.1161/01.res.0000012702.90501.8d. PubMed PMID: 11884367.
Balafanova Z, Bolli R, Zhang J, Zheng Y, Pass JM, Bhatnagar A, Tang XL, Wang O, Cardwell E, Ping P. Nitric oxide (NO) induces nitration of protein kinase Cepsilon (PKCepsilon ), facilitating PKCepsilon translocation via enhanced PKCepsilon -RACK2 interactions: a novel mechanism of no-triggered activation of PKCepsilon. J Biol Chem. 2002 Apr 26;277(17):15021-7. doi: 10.1074/jbc.M112451200. Epub 2002 Feb 11. PubMed PMID: 11839754.
Edmondson RD, Vondriska TM, Biederman KJ, Zhang J, Jones RC, Zheng Y, Allen DL, Xiu JX, Cardwell EM, Pisano MR, Ping P. Protein kinase C epsilon signaling complexes include metabolism- and transcription/translation-related proteins: complimentary separation techniques with LC/MS/MS. Mol Cell Proteomics. 2002 Jun;1(6):421-33. doi: 10.1074/mcp.m100036-mcp200. PubMed PMID: 12169683.
Vondriska TM, Ping P. Functional proteomics to study protection of the ischaemic myocardium. Expert Opin Ther Targets. 2002 Oct;6(5):563-70. doi: 10.1517/14728222.6.5.563. Review. PubMed PMID: 12387680.
Pass JM, Zhang J, Vondriska TM, Ping P. Functional proteomic analysis of the protein kinase C signaling system. Methods Mol Biol. 2003;233:369-85. doi: 10.1385/1-59259-397-6:369. PubMed PMID: 12840523.
Ping P, Baines CP, Gu Y, Prabhu SD, Zhang J, Tsai LL, Cardwell E, Zong NC, Vondriska TM, Korge P, Bhatnagar A, Wang GW. Cardiac toxic effects of trans-2-hexenal are mediated by induction of cardiomyocyte apoptotic pathways. Cardiovasc Toxicol. 2003;3(4):341-51. doi: 10.1385/ct:3:4:341. PubMed PMID: 14734831.
Tang XL, Kodani E, Takano H, Hill M, Shinmura K, Vondriska TM, Ping P, Bolli R. Protein tyrosine kinase signaling is necessary for NO donor-induced late preconditioning against myocardial stunning. Am J Physiol Heart Circ Physiol. 2003 Apr;284(4):H1441-8. doi: 10.1152/ajpheart.00789.2002. Epub 2002 Dec 12. PubMed PMID: 12531734.
Prabhu SD, Wang G, Luo J, Gu Y, Ping P, Chandrasekar B. Beta-adrenergic receptor blockade modulates Bcl-X(S) expression and reduces apoptosis in failing myocardium. J Mol Cell Cardiol. 2003 May;35(5):483-93. doi: 10.1016/s0022-2828(03)00052-x. PubMed PMID: 12738230.
Baines CP, Song CX, Zheng YT, Wang GW, Zhang J, Wang OL, Guo Y, Bolli R, Cardwell EM, Ping P. Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria. Circ Res. 2003 May 2;92(8):873-80. doi: 10.1161/01.RES.0000069215.36389.8D. Epub 2003 Mar 27. PubMed PMID: 12663490; PubMed Central PMCID: PMC3691672.
Weiss JN, Korge P, Honda HM, Ping P. Role of the mitochondrial permeability transition in myocardial disease. Circ Res. 2003 Aug 22;93(4):292-301. doi: 10.1161/01.RES.0000087542.26971.D4. Review. PubMed PMID: 12933700.
Vondriska TM, Ping P. Multiprotein signaling complexes and regulation of cardiac phenotype. J Mol Cell Cardiol. 2003 Sep;35(9):1027-33. doi: 10.1016/s0022-2828(03)00175-5. Review. PubMed PMID: 12967625.
Zhang J, Ping P, Vondriska TM, Tang XL, Wang GW, Cardwell EM, Bolli R. Cardioprotection involves activation of NF-kappa B via PKC-dependent tyrosine and serine phosphorylation of I kappa B-alpha. Am J Physiol Heart Circ Physiol. 2003 Oct;285(4):H1753-8. doi: 10.1152/ajpheart.00416.2003. Epub 2003 Jun 26. PubMed PMID: 12829431.
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