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Paez PM, Marta CB, Moreno MB, Soto EF, Pasquini JM. Apotransferrin decreases migration and enhances differentiation of oligodendroglial progenitor cells in an in vitro system. Dev Neurosci. 2002;24(1):47-58. doi: 10.1159/000064945. PubMed PMID: 12145410.
Marta CB, Paez P, Lopez M, Pellegrino de Iraldi A, Soto EF, Pasquini JM. Morphological changes of myelin sheaths in rats intracranially injected with apotransferrin. Neurochem Res. 2003 Jan;28(1):101-10. doi: 10.1023/a:1021604413737. PubMed PMID: 12587668.
García CI, Paez P, Soto EF, Pasquini JM. Differential effects of apotransferrin on two populations of oligodendroglial cells. Glia. 2003 Jun;42(4):406-16. doi: 10.1002/glia.10227. PubMed PMID: 12730961.
Pasquini LA, Paez PM, Moreno MA, Pasquini JM, Soto EF. Inhibition of the proteasome by lactacystin enhances oligodendroglial cell differentiation. J Neurosci. 2003 Jun 1;23(11):4635-44. doi: 10.1523/JNEUROSCI.23-11-04635.2003. PubMed PMID: 12805303; PubMed Central PMCID: PMC6740787.
Paez PM, García CI, Davio C, Campagnoni AT, Soto EF, Pasquini JM. Apotransferrin promotes the differentiation of two oligodendroglial cell lines. Glia. 2004 Apr 15;46(2):207-17. doi: 10.1002/glia.20001. PubMed PMID: 15042587.
Garcia C, Paez P, Davio C, Soto EF, Pasquini JM. Apotransferrin induces cAMP/CREB pathway and cell cycle exit in immature oligodendroglial cells. J Neurosci Res. 2004 Nov 1;78(3):338-46. doi: 10.1002/jnr.20254. PubMed PMID: 15389838.
Paez PM, García CI, Campagnoni AT, Soto EF, Pasquini JM. Overexpression of human transferrin in two oligodendroglial cell lines enhances their differentiation. Glia. 2005 Oct;52(1):1-15. doi: 10.1002/glia.20214. PubMed PMID: 15892129.
Paez PM, García CI, Pasquini JM. Expression of myelin basic protein in two oligodendroglial cell lines is modulated by apotransferrin through different transcription factors. J Neurosci Res. 2006 Mar;83(4):606-18. doi: 10.1002/jnr.20750. PubMed PMID: 16435391.
Adamo AM, Paez PM, Escobar Cabrera OE, Wolfson M, Franco PG, Pasquini JM, Soto EF. Remyelination after cuprizone-induced demyelination in the rat is stimulated by apotransferrin. Exp Neurol. 2006 Apr;198(2):519-29. doi: 10.1016/j.expneurol.2005.12.027. Epub 2006 Feb 14. PubMed PMID: 16480980.
Paez PM, Garcia CI, Soto EF, Pasquini JM. Apotransferrin decreases the response of oligodendrocyte progenitors to PDGF and inhibits the progression of the cell cycle. Neurochem Int. 2006 Sep;49(4):359-71. doi: 10.1016/j.neuint.2006.02.009. Epub 2006 Apr 18. PubMed PMID: 16621163.
García CI, Paez PM, Soto EF, Pasquini JM. Differential gene expression during development in two oligodendroglial cell lines overexpressing transferrin: a cDNA array analysis. Dev Neurosci. 2007;29(6):413-26. doi: 10.1159/000097317. PubMed PMID: 17119318.
Paez PM, Spreuer V, Handley V, Feng JM, Campagnoni C, Campagnoni AT. Increased expression of golli myelin basic proteins enhances calcium influx into oligodendroglial cells. J Neurosci. 2007 Nov 14;27(46):12690-9. doi: 10.1523/JNEUROSCI.2381-07.2007. PubMed PMID: 18003849; PubMed Central PMCID: PMC6673339.
Calatayud CA, García CI, Paez PM, Pasquini JM, Soto EF, Pasquini LA. Partial inhibition of the proteasome enhances the activity of the myelin basic protein promoter. Dev Neurosci. 2009;31(3):169-80. doi: 10.1159/000193393. Epub 2009 Jan 15. PubMed PMID: 19145069.
Todorich B, Pasquini JM, Garcia CI, Paez PM, Connor JR. Oligodendrocytes and myelination: the role of iron. Glia. 2009 Apr 1;57(5):467-78. doi: 10.1002/glia.20784. Review. PubMed PMID: 18837051.
Paez PM, Fulton DJ, Spreuer V, Handley V, Campagnoni CW, Campagnoni AT. Regulation of store-operated and voltage-operated Ca2+ channels in the proliferation and death of oligodendrocyte precursor cells by golli proteins. ASN Neuro. 2009 Apr 14;1(1). doi: 10.1042/AN20090003. PubMed PMID: 19570024; PubMed Central PMCID: PMC2695580.
Paez PM, Fulton DJ, Spreuer V, Handley V, Campagnoni CW, Macklin WB, Colwell C, Campagnoni AT. Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca2+ influx. J Neurosci. 2009 May 20;29(20):6663-76. doi: 10.1523/JNEUROSCI.5806-08.2009. PubMed PMID: 19458236; PubMed Central PMCID: PMC2739626.
Paez PM, Fulton D, Colwell CS, Campagnoni AT. Voltage-operated Ca(2+) and Na(+) channels in the oligodendrocyte lineage. J Neurosci Res. 2009 Nov 15;87(15):3259-66. doi: 10.1002/jnr.21938. Review. PubMed PMID: 19021296.
Mendeluk GR, Sardi-Segovia LM, Chenlo PH, Pugliese MN, Repetto H, Curi S, Ariagno J, Prentki Santos E, Paez P, Passanante EG, Palaoro LA. Assessment of human sperm protein tyrosine phosphorylation by immunocytochemistry in a clinical andrology laboratory. Preliminary data. Biotech Histochem. 2009 Dec;84(6):321-8. doi: 10.3109/10520290903126875. PubMed PMID: 19634066.
Fulton D, Paez PM, Campagnoni AT. The multiple roles of myelin protein genes during the development of the oligodendrocyte. ASN Neuro. 2010 Feb 1;2(1):e00027. doi: 10.1042/AN20090051. Review. PubMed PMID: 20017732; PubMed Central PMCID: PMC2814326.
Paez PM, Fulton DJ, Spreur V, Handley V, Campagnoni AT. Multiple kinase pathways regulate voltage-dependent Ca2+ influx and migration in oligodendrocyte precursor cells. J Neurosci. 2010 May 5;30(18):6422-33. doi: 10.1523/JNEUROSCI.5086-09.2010. PubMed PMID: 20445068; PubMed Central PMCID: PMC2887321.
Fulton D, Paez PM, Fisher R, Handley V, Colwell CS, Campagnoni AT. Regulation of L-type Ca++ currents and process morphology in white matter oligodendrocyte precursor cells by golli-myelin proteins. Glia. 2010 Aug 15;58(11):1292-303. doi: 10.1002/glia.21008. PubMed PMID: 20607717.
Paez PM, Fulton D, Spreuer V, Handley V, Campagnoni AT. Modulation of canonical transient receptor potential channel 1 in the proliferation of oligodendrocyte precursor cells by the golli products of the myelin basic protein gene. J Neurosci. 2011 Mar 9;31(10):3625-37. doi: 10.1523/JNEUROSCI.4424-10.2011. PubMed PMID: 21389218; PubMed Central PMCID: PMC3076512.
Smith GS, Paez PM, Spreuer V, Campagnoni CW, Boggs JM, Campagnoni AT, Harauz G. Classical 18.5-and 21.5-kDa isoforms of myelin basic protein inhibit calcium influx into oligodendroglial cells, in contrast to golli isoforms. J Neurosci Res. 2011 Apr;89(4):467-80. doi: 10.1002/jnr.22570. Epub 2011 Jan 13. PubMed PMID: 21312222; PubMed Central PMCID: PMC3605075.
Fulton D, Paez P, Spreur V, Handley V, Colwell CS, Campagnoni A, Fisher R. Developmental activation of the proteolipid protein promoter transgene in neuronal and oligodendroglial cells of neostriatum in mice. Dev Neurosci. 2011;33(2):170-84. doi: 10.1159/000330321. Epub 2011 Sep 1. PubMed PMID: 21912090; PubMed Central PMCID: PMC3221275.
Smith GS, De Avila M, Paez PM, Spreuer V, Wills MK, Jones N, Boggs JM, Harauz G. Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and protein localization in oligodendrocytes. J Neurosci Res. 2012 Jan;90(1):28-47. doi: 10.1002/jnr.22733. Epub 2011 Sep 1. PubMed PMID: 21887699; PubMed Central PMCID: PMC3527418.
Paez PM, Cheli VT, Ghiani CA, Spreuer V, Handley VW, Campagnoni AT. Golli myelin basic proteins stimulate oligodendrocyte progenitor cell proliferation and differentiation in remyelinating adult mouse brain. Glia. 2012 Jul;60(7):1078-93. doi: 10.1002/glia.22336. Epub 2012 Mar 23. PubMed PMID: 22447683.
Guardia Clausi M, Paez PM, Campagnoni AT, Pasquini LA, Pasquini JM. Intranasal administration of aTf protects and repairs the neonatal white matter after a cerebral hypoxic-ischemic event. Glia. 2012 Oct;60(10):1540-54. doi: 10.1002/glia.22374. Epub 2012 Jun 26. PubMed PMID: 22736466.
Nobuta H, Ghiani CA, Paez PM, Spreuer V, Dong H, Korsak RA, Manukyan A, Li J, Vinters HV, Huang EJ, Rowitch DH, Sofroniew MV, Campagnoni AT, de Vellis J, Waschek JA. STAT3-mediated astrogliosis protects myelin development in neonatal brain injury. Ann Neurol. 2012 Nov;72(5):750-65. doi: 10.1002/ana.23670. Epub 2012 Aug 31. PubMed PMID: 22941903; PubMed Central PMCID: PMC3514566.
Espinosa-Jeffrey A, Paez PM, Cheli VT, Spreuer V, Wanner I, de Vellis J. Impact of simulated microgravity on oligodendrocyte development: implications for central nervous system repair. PLoS One. 2013;8(12):e76963. doi: 10.1371/journal.pone.0076963. eCollection 2013. PubMed PMID: 24324574; PubMed Central PMCID: PMC3850904.
Cheli VT, Santiago González DA, Spreuer V, Paez PM. Voltage-gated Ca2+ entry promotes oligodendrocyte progenitor cell maturation and myelination in vitro. Exp Neurol. 2015 Mar;265:69-83. doi: 10.1016/j.expneurol.2014.12.012. Epub 2014 Dec 24. PubMed PMID: 25542980; PubMed Central PMCID: PMC4711374.
Levine J, Kwon E, Paez P, Yan W, Czerwieniec G, Loo JA, Sofroniew MV, Wanner IB. Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival. Glia. 2016 May;64(5):668-94. doi: 10.1002/glia.22953. Epub 2015 Dec 19. PubMed PMID: 26683444; PubMed Central PMCID: PMC4805454.
Guardia Clausi M, Paez PM, Pasquini LA, Pasquini JM. Inhalation of growth factors and apo-transferrin to protect and repair the hypoxic-ischemic brain. Pharmacol Res. 2016 Jul;109:81-5. doi: 10.1016/j.phrs.2016.01.010. Epub 2016 Jan 22. Review. PubMed PMID: 26804249.
Cheli VT, Santiago González DA, Smith J, Spreuer V, Murphy GG, Paez PM. L-type voltage-operated calcium channels contribute to astrocyte activation In vitro. Glia. 2016 Aug;64(8):1396-415. doi: 10.1002/glia.23013. Epub 2016 Jun 1. PubMed PMID: 27247164; PubMed Central PMCID: PMC5289280.
Cheli VT, Santiago González DA, Spreuer V, Handley V, Campagnoni AT, Paez PM. Golli Myelin Basic Proteins Modulate Voltage-Operated Ca(++) Influx and Development in Cortical and Hippocampal Neurons. Mol Neurobiol. 2016 Oct;53(8):5749-71. doi: 10.1007/s12035-015-9499-1. Epub 2015 Oct 26. PubMed PMID: 26497031; PubMed Central PMCID: PMC4882270.
Cheli VT, Santiago González DA, Namgyal Lama T, Spreuer V, Handley V, Murphy GG, Paez PM. Conditional Deletion of the L-Type Calcium Channel Cav1.2 in Oligodendrocyte Progenitor Cells Affects Postnatal Myelination in Mice. J Neurosci. 2016 Oct 19;36(42):10853-10869. doi: 10.1523/JNEUROSCI.1770-16.2016. PubMed PMID: 27798140; PubMed Central PMCID: PMC5083013.
Cheli VT, Santiago González DA, Spreuer V, Handley V, Campagnoni AT, Paez PM. Erratum to: Golli Myelin Basic Proteins Modulate Voltage-Operated Ca++ Influx and Development in Cortical and Hippocampal Neurons. Mol Neurobiol. 2017 Jan;54(1):817. doi: 10.1007/s12035-016-0264-x. PubMed PMID: 27815835.
Santiago González DA, Cheli VT, Zamora NN, Lama TN, Spreuer V, Murphy GG, Paez PM. Conditional Deletion of the L-Type Calcium Channel Cav1.2 in NG2-Positive Cells Impairs Remyelination in Mice. J Neurosci. 2017 Oct 18;37(42):10038-10051. doi: 10.1523/JNEUROSCI.1787-17.2017. Epub 2017 Sep 12. PubMed PMID: 28899915; PubMed Central PMCID: PMC5647766.
Siemian JN, LaMacchia ZM, Spreuer V, Tian J, Ignatowski TA, Paez PM, Zhang Y, Li JX. The imidazoline I(2) receptor agonist 2-BFI attenuates hypersensitivity and spinal neuroinflammation in a rat model of neuropathic pain. Biochem Pharmacol. 2018 Jul;153:260-268. doi: 10.1016/j.bcp.2018.01.032. Epub 2018 Jan 31. PubMed PMID: 29366977; PubMed Central PMCID: PMC5959749.
Welliver RR, Polanco JJ, Seidman RA, Sinha AK, O'Bara MA, Khaku ZM, Santiago González DA, Nishiyama A, Wess J, Feltri ML, Paez PM, Sim FJ. Muscarinic Receptor M(3)R Signaling Prevents Efficient Remyelination by Human and Mouse Oligodendrocyte Progenitor Cells. J Neurosci. 2018 Aug 1;38(31):6921-6932. doi: 10.1523/JNEUROSCI.1862-17.2018. Epub 2018 Jun 29. PubMed PMID: 29959237; PubMed Central PMCID: PMC6070663.
Cheli VT, Santiago González DA, Marziali LN, Zamora NN, Guitart ME, Spreuer V, Pasquini JM, Paez PM. The Divalent Metal Transporter 1 (DMT1) Is Required for Iron Uptake and Normal Development of Oligodendrocyte Progenitor Cells. J Neurosci. 2018 Oct 24;38(43):9142-9159. doi: 10.1523/JNEUROSCI.1447-18.2018. Epub 2018 Sep 6. PubMed PMID: 30190412; PubMed Central PMCID: PMC6199407.
Cheli VT, Santiago González DA, Zamora NN, Lama TN, Spreuer V, Rasmusson RL, Bett GC, Panagiotakos G, Paez PM. Enhanced oligodendrocyte maturation and myelination in a mouse model of Timothy syndrome. Glia. 2018 Nov;66(11):2324-2339. doi: 10.1002/glia.23468. Epub 2018 Aug 26. PubMed PMID: 30151840; PubMed Central PMCID: PMC6697123.
Santiago González DA, Cheli VT, Wan R, Paez PM. Iron Metabolism in the Peripheral Nervous System: The Role of DMT1, Ferritin, and Transferrin Receptor in Schwann Cell Maturation and Myelination. J Neurosci. 2019 Dec 11;39(50):9940-9953. doi: 10.1523/JNEUROSCI.1409-19.2019. Epub 2019 Nov 1. PubMed PMID: 31676601; PubMed Central PMCID: PMC6978953.
Cheli VT, Correale J, Paez PM, Pasquini JM. Iron Metabolism in Oligodendrocytes and Astrocytes, Implications for Myelination and Remyelination. ASN Neuro. 2020 Jan-Dec;12:1759091420962681. doi: 10.1177/1759091420962681. Review. PubMed PMID: 32993319; PubMed Central PMCID: PMC7545512.
Zamora NN, Cheli VT, Santiago González DA, Wan R, Paez PM. Deletion of Voltage-Gated Calcium Channels in Astrocytes during Demyelination Reduces Brain Inflammation and Promotes Myelin Regeneration in Mice. J Neurosci. 2020 Apr 22;40(17):3332-3347. doi: 10.1523/JNEUROSCI.1644-19.2020. Epub 2020 Mar 13. PubMed PMID: 32169969; PubMed Central PMCID: PMC7178909.
Paez PM, Lyons DA. Calcium Signaling in the Oligodendrocyte Lineage: Regulators and Consequences. Annu Rev Neurosci. 2020 Jul 8;43:163-186. doi: 10.1146/annurev-neuro-100719-093305. Epub 2020 Feb 19. Review. PubMed PMID: 32075518.
Wan R, Cheli VT, Santiago-González DA, Rosenblum SL, Wan Q, Paez PM. Impaired Postnatal Myelination in a Conditional Knockout Mouse for the Ferritin Heavy Chain in Oligodendroglial Cells. J Neurosci. 2020 Sep 30;40(40):7609-7624. doi: 10.1523/JNEUROSCI.1281-20.2020. Epub 2020 Aug 31. PubMed PMID: 32868463; PubMed Central PMCID: PMC7531557.
Sidoli M, Reed CB, Scapin C, Paez P, Cavener DR, Kaufman RJ, D'Antonio M, Feltri ML, Wrabetz L. Calcineurin Activity Is Increased in Charcot-Marie-Tooth 1B Demyelinating Neuropathy. J Neurosci. 2021 May 19;41(20):4536-4548. doi: 10.1523/JNEUROSCI.2384-20.2021. Epub 2021 Apr 20. PubMed PMID: 33879538; PubMed Central PMCID: PMC8152608.
Santiago González DA, Cheli VT, Rosenblum SL, Denaroso G, Paez PM. Ceruloplasmin deletion in myelinating glial cells induces myelin disruption and oxidative stress in the central and peripheral nervous systems. Redox Biol. 2021 Oct;46:102118. doi: 10.1016/j.redox.2021.102118. Epub 2021 Aug 27. PubMed PMID: 34474395; PubMed Central PMCID: PMC8408659.
Cheli VT, Santiago González DA, Wan Q, Denaroso G, Wan R, Rosenblum SL, Paez PM. H-ferritin expression in astrocytes is necessary for proper oligodendrocyte development and myelination. Glia. 2021 Dec;69(12):2981-2998. doi: 10.1002/glia.24083. Epub 2021 Aug 30. PubMed PMID: 34460113.
Dupree JL, Paez PM, Tiwari-Woodruff SK, Denton TT, Hensley K, Angeliu CG, Boullerne AI, Kalinin S, Egge S, Cheli VT, Denaroso G, Atkinson KC, Feri M, Feinstein DL. Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis. ASN Neuro. 2022 Jan-Dec;14:17590914221112352. doi: 10.1177/17590914221112352. PubMed PMID: 35791633; PubMed Central PMCID: PMC9272172.
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