My Bibliography

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Chirasani VR, Patwardhan A, Yamaguchi N. Characterization of cardiac disease-associated mutations in RyR2 Ca(2+)- and caffeine-binding sites. Am J Physiol Cell Physiol. 2026 Apr 1;330(4):C807-C818. doi: 10.1152/ajpcell.00760.2025. Epub 2026 Feb 25. PubMed PMID: 41740622; PubMed Central PMCID: PMC13048304.

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Zhang XH, Donch GE, Yamaguchi N, Morad M. CPVT1 point mutations in RyR2 S5 and S6 segments and their Ca(2+) signaling consequence. Cell Calcium. 2025 Dec;132:103081. doi: 10.1016/j.ceca.2025.103081. Epub 2025 Sep 14. PubMed PMID: 40974955.

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Xia Y, Zhang XH, Yamaguchi N, Morad M. Point mutations in RyR2 Ca2+-binding residues of human cardiomyocytes cause cellular remodelling of cardiac excitation contraction-coupling. Cardiovasc Res. 2024 Feb 27;120(1):44-55. doi: 10.1093/cvr/cvad163. PubMed PMID: 37890099; PubMed Central PMCID: PMC10898933.

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Chirasani VR, Elferdink M, Kral M, Carter JS, Heitmann S, Meissner G, Yamaguchi N. Structural and functional interactions between the EF hand domain and S2-S3 loop in the type-1 ryanodine receptor ion channel. J Biol Chem. 2024 Feb;300(2):105606. doi: 10.1016/j.jbc.2023.105606. Epub 2023 Dec 28. PubMed PMID: 38159862; PubMed Central PMCID: PMC10832476.

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Yamaguchi N, Zhang XH, Morad M. CRISPR/Cas9 Gene Editing of RYR2 in Human iPSC-Derived Cardiomyocytes to Probe Ca(2+) Signaling Aberrancies of CPVT Arrhythmogenesis. Methods Mol Biol. 2022;2573:41-52. doi: 10.1007/978-1-0716-2707-5_4. PubMed PMID: 36040585.

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Yamaguchi N. Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca2+ in cardiomyocytes?. J Gen Physiol. 2022 Sep 5;154(9). doi: 10.1085/jgp.202213078. Epub 2022 May 25. PubMed PMID: 35612555; PubMed Central PMCID: PMC9136487.

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Yamaguchi N. Molecular Insights into Calcium Dependent Regulation of Ryanodine Receptor Calcium Release Channels. Adv Exp Med Biol. 2020;1131:321-336. doi: 10.1007/978-3-030-12457-1_13. Review. PubMed PMID: 31646516.

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Chirasani VR, Xu L, Addis HG, Pasek DA, Dokholyan NV, Meissner G, Yamaguchi N. A central core disease mutation in the Ca(2+)-binding site of skeletal muscle ryanodine receptor impairs single-channel regulation. Am J Physiol Cell Physiol. 2019 Aug 1;317(2):C358-C365. doi: 10.1152/ajpcell.00052.2019. Epub 2019 Jun 5. PubMed PMID: 31166712; PubMed Central PMCID: PMC6732417.

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Xu L, Chirasani VR, Carter JS, Pasek DA, Dokholyan NV, Yamaguchi N, Meissner G. Ca(2+)-mediated activation of the skeletal-muscle ryanodine receptor ion channel. J Biol Chem. 2018 Dec 14;293(50):19501-19509. doi: 10.1074/jbc.RA118.004453. Epub 2018 Oct 19. PubMed PMID: 30341173; PubMed Central PMCID: PMC6302159.

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Wei H, Zhang XH, Clift C, Yamaguchi N, Morad M. CRISPR/Cas9 Gene editing of RyR2 in human stem cell-derived cardiomyocytes provides a novel approach in investigating dysfunctional Ca(2+) signaling. Cell Calcium. 2018 Jul;73:104-111. doi: 10.1016/j.ceca.2018.04.009. Epub 2018 Apr 27. PubMed PMID: 29730419; PubMed Central PMCID: PMC5993620.

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Xu L, Gomez AC, Pasek DA, Meissner G, Yamaguchi N. Two EF-hand motifs in ryanodine receptor calcium release channels contribute to isoform-specific regulation by calmodulin. Cell Calcium. 2017 Sep;66:62-70. doi: 10.1016/j.ceca.2017.05.013. Epub 2017 Jun 6. PubMed PMID: 28807150; PubMed Central PMCID: PMC5657546.

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Gomez AC, Holford TW, Yamaguchi N. Malignant hyperthermia-associated mutations in the S2-S3 cytoplasmic loop of type 1 ryanodine receptor calcium channel impair calcium-dependent inactivation. Am J Physiol Cell Physiol. 2016 Nov 1;311(5):C749-C757. doi: 10.1152/ajpcell.00134.2016. Epub 2016 Aug 24. PubMed PMID: 27558158; PubMed Central PMCID: PMC5130589.

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Chakraborty A, Pasek DA, Huang TQ, Gomez AC, Yamaguchi N, Anderson ME, Meissner G. Inhibition of CaMKII does not attenuate cardiac hypertrophy in mice with dysfunctional ryanodine receptor. PLoS One. 2014;9(8):e104338. doi: 10.1371/journal.pone.0104338. eCollection 2014. PubMed PMID: 25093823; PubMed Central PMCID: PMC4122402.

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Gomez AC, Yamaguchi N. Two regions of the ryanodine receptor calcium channel are involved in Ca(2+)-dependent inactivation. Biochemistry. 2014 Mar 4;53(8):1373-9. doi: 10.1021/bi401586h. Epub 2014 Feb 21. PubMed PMID: 24521037; PubMed Central PMCID: PMC3985739.

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Arnáiz-Cot JJ, Damon BJ, Zhang XH, Cleemann L, Yamaguchi N, Meissner G, Morad M. Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor. J Physiol. 2013 Sep 1;591(17):4287-99. doi: 10.1113/jphysiol.2013.256123. Epub 2013 Jul 8. PubMed PMID: 23836685; PubMed Central PMCID: PMC3779117.

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Yamaguchi N, Chakraborty A, Huang TQ, Xu L, Gomez AC, Pasek DA, Meissner G. Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1. Am J Physiol Heart Circ Physiol. 2013 Jul 1;305(1):H86-94. doi: 10.1152/ajpheart.00144.2013. Epub 2013 May 10. PubMed PMID: 23666671; PubMed Central PMCID: PMC3727101.

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Rosa AO, Yamaguchi N, Morad M. Mechanical regulation of native and the recombinant calcium channel. Cell Calcium. 2013 Apr;53(4):264-74. doi: 10.1016/j.ceca.2012.12.007. Epub 2013 Jan 26. PubMed PMID: 23357406; PubMed Central PMCID: PMC3594391.

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Yamaguchi N, Chakraborty A, Pasek DA, Molkentin JD, Meissner G. Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2187-95. doi: 10.1152/ajpheart.00719.2010. Epub 2011 Mar 18. PubMed PMID: 21421818; PubMed Central PMCID: PMC3119098.

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Yamaguchi N, Prosser BL, Ghassemi F, Xu L, Pasek DA, Eu JP, Hernández-Ochoa EO, Cannon BR, Wilder PT, Lovering RM, Weber D, Melzer W, Schneider MF, Meissner G. Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1. Am J Physiol Cell Physiol. 2011 May;300(5):C998-C1012. doi: 10.1152/ajpcell.00370.2010. Epub 2011 Feb 2. PubMed PMID: 21289290; PubMed Central PMCID: PMC3093939.

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Petrotchenko EV, Yamaguchi N, Pasek DA, Borchers CH, Meissner G. Mass spectrometric analysis and mutagenesis predict involvement of multiple cysteines in redox regulation of the skeletal muscle ryanodine receptor ion channel complex. Res Rep Biol. 2011 Jan;2011(2):13-21. doi: 10.2147/RRB.S15776. PubMed PMID: 21603587; PubMed Central PMCID: PMC3095966.

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Meissner G, Pasek DA, Yamaguchi N, Ramachandran S, Dokholyan NV, Tripathy A. Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels. Proteins. 2009 Jan;74(1):207-11. doi: 10.1002/prot.22148. PubMed PMID: 18618700; PubMed Central PMCID: PMC2605178.

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Sun J, Yamaguchi N, Xu L, Eu JP, Stamler JS, Meissner G. Regulation of the cardiac muscle ryanodine receptor by O(2) tension and S-nitrosoglutathione. Biochemistry. 2008 Dec 30;47(52):13985-90. doi: 10.1021/bi8012627. PubMed PMID: 19053230; PubMed Central PMCID: PMC2636679.

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Stiber JA, Zhang ZS, Burch J, Eu JP, Zhang S, Truskey GA, Seth M, Yamaguchi N, Meissner G, Shah R, Worley PF, Williams RS, Rosenberg PB. Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity. Mol Cell Biol. 2008 Apr;28(8):2637-47. doi: 10.1128/MCB.01601-07. Epub 2008 Feb 11. PubMed PMID: 18268005; PubMed Central PMCID: PMC2293116.

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Xu L, Wang Y, Yamaguchi N, Pasek DA, Meissner G. Single channel properties of heterotetrameric mutant RyR1 ion channels linked to core myopathies. J Biol Chem. 2008 Mar 7;283(10):6321-9. doi: 10.1074/jbc.M707353200. Epub 2008 Jan 1. PubMed PMID: 18171678; PubMed Central PMCID: PMC2956488.

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Yamaguchi N, Takahashi N, Xu L, Smithies O, Meissner G. Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel. J Clin Invest. 2007 May;117(5):1344-53. doi: 10.1172/JCI29515. Epub 2007 Apr 12. PubMed PMID: 17431507; PubMed Central PMCID: PMC1847534.

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Yamaguchi N, Meissner G. Does Ca2+/calmodulin-dependent protein kinase deltac activate or inhibit the cardiac ryanodine receptor ion channel?. Circ Res. 2007 Feb 16;100(3):293-5. doi: 10.1161/01.RES.0000259327.56377.55. PubMed PMID: 17307966.

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Zhou H, Yamaguchi N, Xu L, Wang Y, Sewry C, Jungbluth H, Zorzato F, Bertini E, Muntoni F, Meissner G, Treves S. Characterization of recessive RYR1 mutations in core myopathies. Hum Mol Genet. 2006 Sep 15;15(18):2791-803. doi: 10.1093/hmg/ddl221. Epub 2006 Aug 29. PubMed PMID: 16940308.

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Yamaguchi N, Xu L, Pasek DA, Evans KE, Chen SR, Meissner G. Calmodulin regulation and identification of calmodulin binding region of type-3 ryanodine receptor calcium release channel. Biochemistry. 2005 Nov 15;44(45):15074-81. doi: 10.1021/bi051251t. PubMed PMID: 16274254.

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Yamaguchi N, Xu L, Evans KE, Pasek DA, Meissner G. Different regions in skeletal and cardiac muscle ryanodine receptors are involved in transducing the functional effects of calmodulin. J Biol Chem. 2004 Aug 27;279(35):36433-9. doi: 10.1074/jbc.M405834200. Epub 2004 Jun 23. PubMed PMID: 15215235.

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Stange M, Xu L, Balshaw D, Yamaguchi N, Meissner G. Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants. J Biol Chem. 2003 Dec 19;278(51):51693-702. doi: 10.1074/jbc.M310406200. Epub 2003 Oct 7. PubMed PMID: 14532276.

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Yamaguchi N, Xu L, Pasek DA, Evans KE, Meissner G. Molecular basis of calmodulin binding to cardiac muscle Ca(2+) release channel (ryanodine receptor). J Biol Chem. 2003 Jun 27;278(26):23480-6. doi: 10.1074/jbc.M301125200. Epub 2003 Apr 21. PubMed PMID: 12707260.

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Zorzato F, Yamaguchi N, Xu L, Meissner G, Müller CR, Pouliquin P, Muntoni F, Sewry C, Girard T, Treves S. Clinical and functional effects of a deletion in a COOH-terminal lumenal loop of the skeletal muscle ryanodine receptor. Hum Mol Genet. 2003 Feb 15;12(4):379-88. doi: 10.1093/hmg/ddg032. PubMed PMID: 12566385.

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O'Connell KM, Yamaguchi N, Meissner G, Dirksen RT. Calmodulin binding to the 3614-3643 region of RyR1 is not essential for excitation-contraction coupling in skeletal myotubes. J Gen Physiol. 2002 Sep;120(3):337-47. doi: 10.1085/jgp.20028617. PubMed PMID: 12198090; PubMed Central PMCID: PMC2229515.

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Balshaw DM, Yamaguchi N, Meissner G. Modulation of intracellular calcium-release channels by calmodulin. J Membr Biol. 2002 Jan 1;185(1):1-8. doi: 10.1007/s00232-001-0111-4. Epub 2002 Feb 5. Review. PubMed PMID: 11891559.

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Yamaguchi N, Xin C, Meissner G. Identification of apocalmodulin and Ca2+-calmodulin regulatory domain in skeletal muscle Ca2+ release channel, ryanodine receptor. J Biol Chem. 2001 Jun 22;276(25):22579-85. doi: 10.1074/jbc.M102729200. Epub 2001 Apr 16. PubMed PMID: 11306590.

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Balshaw DM, Xu L, Yamaguchi N, Pasek DA, Meissner G. Calmodulin binding and inhibition of cardiac muscle calcium release channel (ryanodine receptor). J Biol Chem. 2001 Jun 8;276(23):20144-53. doi: 10.1074/jbc.M010771200. Epub 2001 Mar 27. PubMed PMID: 11274202.

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Kasai M, Kawasaki T, Yamaguchi N. Regulation of the ryanodine receptor calcium release channel: a molecular complex system. Biophys Chem. 1999 Dec 13;82(2-3):173-81. doi: 10.1016/s0301-4622(99)00117-9. PubMed PMID: 17030344.

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Yamaguchi N, Kagari T, Kasai M. Inhibition of the ryanodine receptor calcium channel in the sarcoplasmic reticulum of skeletal muscle by an ADP/ATP translocase inhibitor, atractyloside. Biochem Biophys Res Commun. 1999 May 10;258(2):247-51. doi: 10.1006/bbrc.1999.0626. PubMed PMID: 10329372.

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Igami K, Yamaguchi N, Kasai M. Regulation of depolarization-induced calcium release from skeletal muscle triads by cyclic AMP-dependent protein kinase. Jpn J Physiol. 1999 Feb;49(1):81-7. doi: 10.2170/jjphysiol.49.81. PubMed PMID: 10219112.

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Yamaguchi N, Kasai M. Identification of 30 kDa calsequestrin-binding protein, which regulates calcium release from sarcoplasmic reticulum of rabbit skeletal muscle. Biochem J. 1998 Nov 1;335 ( Pt 3)(Pt 3):541-7. doi: 10.1042/bj3350541. PubMed PMID: 9794793; PubMed Central PMCID: PMC1219814.

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Yamaguchi N, Kasai M. Potentiation of depolarization-induced calcium release from skeletal muscle triads by cyclic ADP-ribose and inositol 1,4,5-trisphosphate. Biochem Biophys Res Commun. 1997 Nov 26;240(3):772-7. doi: 10.1006/bbrc.1997.7583. PubMed PMID: 9398643.

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Yamaguchi N, Igami K, Kasai M. Kinetics of depolarization-induced calcium release from skeletal muscle triads in vitro. J Biochem. 1997 Mar;121(3):432-9. doi: 10.1093/oxfordjournals.jbchem.a021607. PubMed PMID: 9133611.

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Kagari T, Yamaguchi N, Kasai M. Biochemical characterization of calsequestrin-binding 30-kDa protein in sarcoplasmic reticulum of skeletal muscle. Biochem Biophys Res Commun. 1996 Oct 23;227(3):700-6. doi: 10.1006/bbrc.1996.1572. PubMed PMID: 8885997.

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Yamaguchi N, Kawasaki T, Kasai M. DIDS binding 30-kDa protein regulates the calcium release channel in the sarcoplasmic reticulum. Biochem Biophys Res Commun. 1995 May 25;210(3):648-53. doi: 10.1006/bbrc.1995.1709. PubMed PMID: 7763237.

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Kasai M, Yamaguchi N, Kawasaki T. Effect of KCl concentration on gating properties of calcium release channels in sarcoplasmic reticulum vesicles. J Biochem. 1995 Feb;117(2):251-6. doi: 10.1093/jb/117.2.251. PubMed PMID: 7541789.