My Bibliography

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Bashar SJ, Myhr CB, Titi AH, Zheng Z, Shelef MA. Distinct HLA Associations for Antibody Multireactivity With Citrulline-Containing Type II Collagen Epitopes Versus More Limited Antibody Reactivity With Citrulline-Containing IgG Epitopes in Rheumatoid Arthritis. Arthritis Rheumatol. 2026 Mar;78(3):603-612. doi: 10.1002/art.43424. Epub 2026 Jan 11. PubMed PMID: 41169033; PubMed Central PMCID: PMC12991920.

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Shelef MA, Holers VM. Ever-Expanding Connections Between Peptidylarginine Deiminase 4 and Rheumatoid Arthritis. Arthritis Rheumatol. 2025 Sep;77(9):1136-1139. doi: 10.1002/art.43170. Epub 2025 May 2. PubMed PMID: 40181788.

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Titi AH, Krisko BT, Bashar SJ, Adyniec RR, Parker MH, Murren NF, Myhr CB, Shelef MA. Rheumatoid arthritis-associated rheumatoid factors post-COVID-19. Front Immunol. 2025;16:1553540. doi: 10.3389/fimmu.2025.1553540. eCollection 2025. PubMed PMID: 40018049; PubMed Central PMCID: PMC11864925.

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Bashar SJ, Zheng Z, Mergaert AM, Adyniec RR, Gupta S, Amjadi MF, McCoy SS, Newton MA, Shelef MA. Limited Biomarker Potential for IgG Autoantibodies Reactive to Linear Epitopes in Systemic Lupus Erythematosus or Spondyloarthropathy. Antibodies (Basel). 2024 Oct 12;13(4). doi: 10.3390/antib13040087. PubMed PMID: 39449329; PubMed Central PMCID: PMC11503330.

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Parker M, Zheng Z, Lasarev MR, Larsen MC, Vande Loo A, Alexandridis RA, Newton MA, Shelef MA, McCoy SS. Novel autoantibodies help diagnose anti-SSA antibody negative Sjögren disease and predict abnormal labial salivary gland pathology. Ann Rheum Dis. 2024 Aug 27;83(9):1169-1180. doi: 10.1136/ard-2023-224936. PubMed PMID: 38702176; PubMed Central PMCID: PMC11569393.

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Bashar SJ, Holmes CL, Shelef MA. Macrophage extracellular traps require peptidylarginine deiminase 2 and 4 and are a source of citrullinated antigens bound by rheumatoid arthritis autoantibodies. Front Immunol. 2024;15:1167362. doi: 10.3389/fimmu.2024.1167362. eCollection 2024. PubMed PMID: 38476240; PubMed Central PMCID: PMC10927735.

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Wang B, Li Z, Shi Y, Zhu Z, Fields L, Shelef MA, Li L. Mass Spectrometry-Based Precise Identification of Citrullinated Histones via Limited Digestion and Biotin Derivative Tag Enrichment. Anal Chem. 2024 Feb 13;96(6):2309-2317. doi: 10.1021/acs.analchem.3c02646. Epub 2024 Jan 29. PubMed PMID: 38285917; PubMed Central PMCID: PMC11526168.

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Amjadi MF, Parker MH, Adyniec RR, Zheng Z, Robbins AM, Bashar SJ, Denny MF, McCoy SS, Ong IM, Shelef MA. Novel and unique rheumatoid factors cross-react with viral epitopes in COVID-19. J Autoimmun. 2024 Jan;142:103132. doi: 10.1016/j.jaut.2023.103132. Epub 2023 Nov 11. PubMed PMID: 37956528; PubMed Central PMCID: PMC10957334.

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Liu C, Yalavarthi S, Tambralli A, Zeng L, Rysenga CE, Alizadeh N, Hudgins L, Liang W, NaveenKumar SK, Shi H, Shelef MA, Atkins KB, Pennathur S, Knight JS. Inhibition of neutrophil extracellular trap formation alleviates vascular dysfunction in type 1 diabetic mice. Sci Adv. 2023 Oct 27;9(43):eadj1019. doi: 10.1126/sciadv.adj1019. Epub 2023 Oct 25. PubMed PMID: 37878711; PubMed Central PMCID: PMC10599623.

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Parker M, Zheng Z, Lasarev M, Alexandridis RA, Newton MA, Shelef MA, McCoy SS. Novel autoantibodies help diagnose anti-SSA antibody negative Sjögren's disease and predict abnormal labial salivary gland pathology. medRxiv. 2023 Aug 29;. doi: 10.1101/2023.08.29.23294775. PubMed PMID: 37693588; PubMed Central PMCID: PMC10491389.

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Cîrciumaru A, Afonso MG, Wähämaa H, Krishnamurthy A, Hansson M, Mathsson-Alm L, Keszei M, Stålesen R, Ottosson L, de Vries C, Shelef MA, Malmström V, Klareskog L, Catrina AI, Grönwall C, Hensvold A, Réthi B. Anti-Citrullinated Protein Antibody Reactivity towards Neutrophil-Derived Antigens: Clonal Diversity and Inter-Individual Variation. Biomolecules. 2023 Mar 31;13(4). doi: 10.3390/biom13040630. PubMed PMID: 37189377; PubMed Central PMCID: PMC10135477.

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Amjadi MF, Adyniec RR, Gupta S, Bashar SJ, Mergaert AM, Braun KM, Moreno GK, O'Connor DH, Friedrich TC, Safdar N, McCoy SS, Shelef MA. Anti-membrane Antibodies Persist at Least One Year and Discriminate Between Past Coronavirus Disease 2019 Infection and Vaccination. J Infect Dis. 2022 Nov 28;226(11):1897-1902. doi: 10.1093/infdis/jiac263. PubMed PMID: 35758987; PubMed Central PMCID: PMC9278254.

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Deng H, Lin C, Garcia-Gerique L, Fu S, Cruz Z, Bonner EE, Rosenwasser M, Rajagopal S, Sadhu MN, Gajendran C, Zainuddin M, Gosu R, Sivanandhan D, Shelef MA, Nam B, Vogl DT, Gabrilovich DI, Nefedova Y. A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression. Cancer Res. 2022 Oct 4;82(19):3561-3572. doi: 10.1158/0008-5472.CAN-21-4045. PubMed PMID: 36069973; PubMed Central PMCID: PMC9532374.

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Mergaert AM, Zheng Z, Denny MF, Amjadi MF, Bashar SJ, Newton MA, Malmström V, Grönwall C, McCoy SS, Shelef MA. Rheumatoid Factor and Anti-Modified Protein Antibody Reactivities Converge on IgG Epitopes. Arthritis Rheumatol. 2022 Jun;74(6):984-991. doi: 10.1002/art.42064. Epub 2022 Apr 10. PubMed PMID: 35001558; PubMed Central PMCID: PMC9156533.

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Adi W, Biswas D, Shelef MA, Yesilkoy F. Multiplexed COVID-19 antibody quantification from human sera using label-free nanoplasmonic biosensors. Biomed Opt Express. 2022 Apr 1;13(4):2130-2143. doi: 10.1364/BOE.454919. eCollection 2022 Apr 1. PubMed PMID: 35519285; PubMed Central PMCID: PMC9045896.

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Mergaert AM, Warner TF, Shelef MA. Rheumatoid arthritis: Methods for two murine models. Methods Cell Biol. 2022;168:125-137. doi: 10.1016/bs.mcb.2021.12.012. Epub 2022 Mar 1. PubMed PMID: 35366979.

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Mergaert AM, Denny MF, Kingstad-Bakke B, Bawadekar M, Bashar SJ, Warner TF, Suresh M, Shelef MA. Peptidylarginine Deiminase 2 in Murine Antiviral and Autoimmune Antibody Responses. J Immunol Res. 2022;2022:5258221. doi: 10.1155/2022/5258221. eCollection 2022. PubMed PMID: 35083342; PubMed Central PMCID: PMC8786467.

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Amjadi MF, Adyniec RR, Gupta S, Bashar SJ, Mergaert AM, Braun KM, Moreno GK, O'Connor DH, Friedrich TC, Safdar N, McCoy SS, Shelef MA. Anti-membrane and anti-spike antibodies are long-lasting and together discriminate between past COVID-19 infection and vaccination. medRxiv. 2021 Nov 8;. doi: 10.1101/2021.11.02.21265750. PubMed PMID: 34790984; PubMed Central PMCID: PMC8597887.

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Massarenti L, Enevold C, Damgaard D, Ødum N, Garred P, Frisch M, Shelef MA, Jacobsen S, Nielsen CH. PADI4 Polymorphisms Confer Risk of Anti-CCP-Positive Rheumatoid Arthritis in Synergy With HLA-DRB1*04 and Smoking. Front Immunol. 2021;12:707690. doi: 10.3389/fimmu.2021.707690. eCollection 2021. PubMed PMID: 34733271; PubMed Central PMCID: PMC8558474.

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Zheng Z, Mergaert AM, Ong IM, Shelef MA, Newton MA. MixTwice: large-scale hypothesis testing for peptide arrays by variance mixing. Bioinformatics. 2021 Sep 9;37(17):2637-2643. doi: 10.1093/bioinformatics/btab162. PubMed PMID: 33693483; PubMed Central PMCID: PMC8428605.

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Amjadi MF, O'Connell SE, Armbrust T, Mergaert AM, Narpala SR, Halfmann PJ, Bashar SJ, Glover CR, Heffron AS, Taylor A, Flach B, O'Connor DH, Kawaoka Y, McDermott AB, Sethi AK, Shelef MA. Specific COVID-19 Symptoms Correlate with High Antibody Levels against SARS-CoV-2. Immunohorizons. 2021 Jun 17;5(6):466-476. doi: 10.4049/immunohorizons.2100022. PubMed PMID: 34398806; PubMed Central PMCID: PMC8452279.

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Heffron AS, McIlwain SJ, Amjadi MF, Baker DA, Khullar S, Armbrust T, Halfmann PJ, Kawaoka Y, Sethi AK, Palmenberg AC, Shelef MA, O'Connor DH, Ong IM. The landscape of antibody binding in SARS-CoV-2 infection. PLoS Biol. 2021 Jun;19(6):e3001265. doi: 10.1371/journal.pbio.3001265. eCollection 2021 Jun. PubMed PMID: 34143766; PubMed Central PMCID: PMC8245122.

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Heffron AS, McIlwain SJ, Amjadi MF, Baker DA, Khullar S, Sethi AK, Palmenberg AC, Shelef MA, O'Connor DH, Ong IM. The landscape of antibody binding in SARS-CoV-2 infection. bioRxiv. 2021 Jan 8;. doi: 10.1101/2020.10.10.334292. PubMed PMID: 33052349; PubMed Central PMCID: PMC7553183.

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Amjadi MF, O'Connell SE, Armbrust T, Mergaert AM, Narpala SR, Halfmann PJ, Bashar SJ, Glover CR, Heffron AS, Taylor A, Flach B, O'Connor DH, Kawaoka Y, McDermott AB, Sethi AK, Shelef MA. Fever, Diarrhea, and Severe Disease Correlate with High Persistent Antibody Levels against SARS-CoV-2. medRxiv. 2021 Jan 6;. doi: 10.1101/2021.01.05.21249240. PubMed PMID: 33442707; PubMed Central PMCID: PMC7805469.

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Edwards NJ, Hwang C, Marini S, Pagani CA, Spreadborough PJ, Rowe CJ, Yu P, Mei A, Visser N, Li S, Hespe GE, Huber AK, Strong AL, Shelef MA, Knight JS, Davis TA, Levi B. The role of neutrophil extracellular traps and TLR signaling in skeletal muscle ischemia reperfusion injury. FASEB J. 2020 Dec;34(12):15753-15770. doi: 10.1096/fj.202000994RR. Epub 2020 Oct 22. PubMed PMID: 33089917; PubMed Central PMCID: PMC8054227.

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Golenberg N, Squirrell JM, Bennin DA, Rindy J, Pistono PE, Eliceiri KW, Shelef MA, Kang J, Huttenlocher A. Citrullination regulates wound responses and tissue regeneration in zebrafish. J Cell Biol. 2020 Apr 6;219(4). doi: 10.1083/jcb.201908164. PubMed PMID: 32328635; PubMed Central PMCID: PMC7147109.

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Zheng Z, Mergaert AM, Fahmy LM, Bawadekar M, Holmes CL, Ong IM, Bridges AJ, Newton MA, Shelef MA. Disordered Antigens and Epitope Overlap Between Anti-Citrullinated Protein Antibodies and Rheumatoid Factor in Rheumatoid Arthritis. Arthritis Rheumatol. 2020 Feb;72(2):262-272. doi: 10.1002/art.41074. Epub 2019 Dec 10. PubMed PMID: 31397047; PubMed Central PMCID: PMC6994383.

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Sun B, Chang HH, Salinger A, Tomita B, Bawadekar M, Holmes CL, Shelef MA, Weerapana E, Thompson PR, Ho IC. Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination. JCI Insight. 2019 Nov 14;4(22). doi: 10.1172/jci.insight.129687. PubMed PMID: 31723060; PubMed Central PMCID: PMC6948856.

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Shelef MA. New Relationships for Old Autoantibodies in Rheumatoid Arthritis. Arthritis Rheumatol. 2019 Sep;71(9):1396-1399. doi: 10.1002/art.40879. Epub 2019 Aug 1. PubMed PMID: 30861623; PubMed Central PMCID: PMC6716984.

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Mergaert AM, Bawadekar M, Nguyen TQ, Massarenti L, Holmes CL, Rebernick R, Schrodi SJ, Shelef MA. Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans. Int J Mol Sci. 2019 Jun 25;20(12). doi: 10.3390/ijms20123093. PubMed PMID: 31242568; PubMed Central PMCID: PMC6627847.

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Holmes CL, Peyton CG, Bier AM, Donlon TZ, Osman F, Bartels CM, Shelef MA. Reduced IgG titers against pertussis in rheumatoid arthritis: Evidence for a citrulline-biased immune response and medication effects. PLoS One. 2019;14(5):e0217221. doi: 10.1371/journal.pone.0217221. eCollection 2019. PubMed PMID: 31136605; PubMed Central PMCID: PMC6538243.

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Holmes CL, Shim D, Kernien J, Johnson CJ, Nett JE, Shelef MA. Insight into Neutrophil Extracellular Traps through Systematic Evaluation of Citrullination and Peptidylarginine Deiminases. J Immunol Res. 2019;2019:2160192. doi: 10.1155/2019/2160192. eCollection 2019. PubMed PMID: 30993117; PubMed Central PMCID: PMC6434303.

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Damgaard D, Bawadekar M, Senolt L, Stensballe A, Shelef MA, Nielsen CH. Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3. PLoS One. 2018;13(8):e0203214. doi: 10.1371/journal.pone.0203214. eCollection 2018. PubMed PMID: 30161253; PubMed Central PMCID: PMC6117052.

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Rebernick R, Fahmy L, Glover C, Bawadekar M, Shim D, Holmes CL, Rademacher N, Potluri H, Bartels CM, Shelef MA. DNA Area and NETosis Analysis (DANA): a High-Throughput Method to Quantify Neutrophil Extracellular Traps in Fluorescent Microscope Images. Biol Proced Online. 2018;20:7. doi: 10.1186/s12575-018-0072-y. eCollection 2018. PubMed PMID: 29618953; PubMed Central PMCID: PMC5878938.

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Sun B, Dwivedi N, Bechtel TJ, Paulsen JL, Muth A, Bawadekar M, Li G, Thompson PR, Shelef MA, Schiffer CA, Weerapana E, Ho IC. Citrullination of NF-κB p65 promotes its nuclear localization and TLR-induced expression of IL-1β and TNFα. Sci Immunol. 2017 Jun 9;2(12). doi: 10.1126/sciimmunol.aal3062. PubMed PMID: 28783661; PubMed Central PMCID: PMC5718838.

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Bawadekar M, Shim D, Johnson CJ, Warner TF, Rebernick R, Damgaard D, Nielsen CH, Pruijn GJM, Nett JE, Shelef MA. Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation. J Autoimmun. 2017 Jun;80:39-47. doi: 10.1016/j.jaut.2017.01.006. Epub 2017 Feb 7. PubMed PMID: 28188029; PubMed Central PMCID: PMC5422119.

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Bawadekar M, Gendron-Fitzpatrick A, Rebernick R, Shim D, Warner TF, Nicholas AP, Lundblad LK, Thompson PR, Shelef MA. Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation. Arthritis Res Ther. 2016 Jul 22;18(1):173. doi: 10.1186/s13075-016-1068-0. PubMed PMID: 27450561; PubMed Central PMCID: PMC4957385.

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Moussavi-Harami SF, Mladinich KM, Sackmann EK, Shelef MA, Starnes TW, Guckenberger DJ, Huttenlocher A, Beebe DJ. Microfluidic device for simultaneous analysis of neutrophil extracellular traps and production of reactive oxygen species. Integr Biol (Camb). 2016 Feb;8(2):243-52. doi: 10.1039/c5ib00225g. Epub 2016 Jan 25. PubMed PMID: 26805445; PubMed Central PMCID: PMC4776335.

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Shelef MA, Bennin DA, Yasmin N, Warner TF, Ludwig T, Beggs HE, Huttenlocher A. Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis. Arthritis Res Ther. 2014 Oct 4;16(5):464. doi: 10.1186/s13075-014-0464-6. PubMed PMID: 25280866; PubMed Central PMCID: PMC4203874.

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Shelef MA, Sokolove J, Robinson WH, Huttenlocher A. Reply: To PMID 24497204. Arthritis Rheumatol. 2014 Sep;66(9):2644-5. doi: 10.1002/art.38722. PubMed PMID: 24891318.

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Shelef MA, Sokolove J, Lahey LJ, Wagner CA, Sackmann EK, Warner TF, Wang Y, Beebe DJ, Robinson WH, Huttenlocher A. Peptidylarginine deiminase 4 contributes to tumor necrosis factor α-induced inflammatory arthritis. Arthritis Rheumatol. 2014 Jun;66(6):1482-91. doi: 10.1002/art.38393. PubMed PMID: 24497204; PubMed Central PMCID: PMC4148484.

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Shelef MA, Tauzin S, Huttenlocher A. Neutrophil migration: moving from zebrafish models to human autoimmunity. Immunol Rev. 2013 Nov;256(1):269-81. doi: 10.1111/imr.12124. Review. PubMed PMID: 24117827; PubMed Central PMCID: PMC4117680.

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Shelef MA, Bennin DA, Mosher DF, Huttenlocher A. Citrullination of fibronectin modulates synovial fibroblast behavior. Arthritis Res Ther. 2012 Nov 5;14(6):R240. doi: 10.1186/ar4083. PubMed PMID: 23127210; PubMed Central PMCID: PMC3674601.

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Sackmann EK, Berthier E, Young EW, Shelef MA, Wernimont SA, Huttenlocher A, Beebe DJ. Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays. Blood. 2012 Oct 4;120(14):e45-53. doi: 10.1182/blood-2012-03-416453. Epub 2012 Aug 22. PubMed PMID: 22915642; PubMed Central PMCID: PMC3466974.

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Omori SA, Cato MH, Anzelon-Mills A, Puri KD, Shapiro-Shelef M, Calame K, Rickert RC. Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling. Immunity. 2006 Oct;25(4):545-57. doi: 10.1016/j.immuni.2006.08.015. Epub 2006 Sep 28. PubMed PMID: 17000121.

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Martins GA, Cimmino L, Shapiro-Shelef M, Szabolcs M, Herron A, Magnusdottir E, Calame K. Transcriptional repressor Blimp-1 regulates T cell homeostasis and function. Nat Immunol. 2006 May;7(5):457-65. doi: 10.1038/ni1320. Epub 2006 Mar 26. PubMed PMID: 16565721.

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Shapiro-Shelef M, Lin KI, Savitsky D, Liao J, Calame K. Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow. J Exp Med. 2005 Dec 5;202(11):1471-6. doi: 10.1084/jem.20051611. Epub 2005 Nov 28. PubMed PMID: 16314438; PubMed Central PMCID: PMC2213334.

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Shapiro-Shelef M, Calame K. Regulation of plasma-cell development. Nat Rev Immunol. 2005 Mar;5(3):230-42. doi: 10.1038/nri1572. Review. PubMed PMID: 15738953.

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Vincent SD, Dunn NR, Sciammas R, Shapiro-Shalef M, Davis MM, Calame K, Bikoff EK, Robertson EJ. The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse. Development. 2005 Mar;132(6):1315-25. doi: 10.1242/dev.01711. PubMed PMID: 15750184.

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Johnson K, Shapiro-Shelef M, Tunyaplin C, Calame K. Regulatory events in early and late B-cell differentiation. Mol Immunol. 2005 May;42(7):749-61. doi: 10.1016/j.molimm.2004.06.039. Epub 2005 Jan 20. Review. PubMed PMID: 15829263.