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Tan K, Wilkinson MF. A single-cell view of spermatogonial stem cells. Current Opinion in Cell Biology. 2020 September; 67:71-78.
Tan K, Wilkinson MF. A single-cell view of spermatogonial stem cells. Curr Opin Cell Biol. 2020 Sep 17;67:71-78. doi: 10.1016/j.ceb.2020.07.005. [Epub ahead of print] Review. PubMed PMID: 32950921; NIHMSID:NIHMS1631932.
Domingo D, Nawaz U, Corbett M, Espinoza JL, Tatton-Brown K, Coman D, Wilkinson MF, Gecz J, Jolly LA. A synonymous UPF3B variant causing a speech disorder implicates NMD as a regulator of neurodevelopmental disorder gene networks. Hum Mol Genet. 2020 Aug 29;29(15):2568-2578. doi: 10.1093/hmg/ddaa151. PubMed PMID: 32667670.
Tan K, Jones SH, Lake BB, Dumdie JN, Shum EY, Zhang L, Chen S, Sohni A, Pandya S, Gallo RL, Zhang K, Cook-Andersen H, Wilkinson MF. The role of the NMD factor UPF3B in olfactory sensory neurons. Elife. 2020 Aug 10;9. doi: 10.7554/eLife.57525. PubMed PMID: 32773035; PubMed Central PMCID: PMC7452722.
Tan K, Song HW, Thompson M, Munyoki S, Sukhwani M, Hsieh TC, Orwig KE, Wilkinson MF. Transcriptome profiling reveals signaling conditions dictating human spermatogonia fate in vitro. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):17832-17841. doi: 10.1073/pnas.2000362117. Epub 2020 Jul 13. PubMed PMID: 32661178; PubMed Central PMCID: PMC7395452.
Tan K, Song HW, Wilkinson MF. Single-cell RNAseq analysis of testicular germ and somatic cell development during the perinatal period. Development. 2020 Feb 3;147(3). doi: 10.1242/dev.183251. PubMed PMID: 31964773; PubMed Central PMCID: PMC7033731.
Ramaiah M, Tan K, Plank TM, Song HW, Dumdie JN, Jones S, Shum EY, Sheridan SD, Peterson KJ, Gromoll J, Haggarty SJ, Cook-Andersen H, Wilkinson MF. Response to: X-linked miR-506 family miRNAs promote FMRP expression in mouse spermatogonia. EMBO Rep. 2020 Jan 7;21(1):e49354. doi: 10.15252/embr.201949354. Epub 2019 Dec 6. PubMed PMID: 31808609; PubMed Central PMCID: PMC6944912.
Fox CW, Zhang L, Sohni A, Doblado M, Wilkinson MF, Chang RJ, Duleba AJ. Inflammatory Stimuli Trigger Increased Androgen Production and Shifts in Gene Expression in Theca-Interstitial Cells. Endocrinology. 2019 Dec 1;160(12):2946-2958. doi: 10.1210/en.2019-00588. PubMed PMID: 31599939; PubMed Central PMCID: PMC6855291.
Wilkinson MF. Genetic paradox explained by nonsense. Nature. 2019 Apr;568(7751):179-180. doi: 10.1038/d41586-019-00823-5. PubMed PMID: 30962551.
Tan K, Wilkinson MF. Human Spermatogonial Stem Cells Scrutinized under the Single-Cell Magnifying Glass. Cell Stem Cell. 2019 Feb 7;24(2):201-203. doi: 10.1016/j.stem.2019.01.010. PubMed PMID: 30735645; PubMed Central PMCID: PMC6415922.
Sohni A, Tan K, Song HW, Burow D, de Rooij DG, Laurent L, Hsieh TC, Rabah R, Hammoud SS, Vicini E, Wilkinson MF. The Neonatal and Adult Human Testis Defined at the Single-Cell Level. Cell Rep. 2019 Feb 5;26(6):1501-1517.e4. doi: 10.1016/j.celrep.2019.01.045. PubMed PMID: 30726734; PubMed Central PMCID: PMC6402825.
Ramaiah M, Tan K, Plank TM, Song HW, Dumdie JN, Jones S, Shum EY, Sheridan SD, Peterson KJ, Gromoll J, Haggarty SJ, Cook-Andersen H, Wilkinson MF. A microRNA cluster in the Fragile-X region expressed during spermatogenesis targets FMR1. EMBO Rep. 2019 Feb;20(2). doi: 10.15252/embr.201846566. Epub 2018 Dec 20. PubMed PMID: 30573526; PubMed Central PMCID: PMC6362356.
Wilkinson MF, Cook-Andersen H. Nonsense shielding: protecting RNA from decay leads to cancer. EMBO J. 2019 Feb 1;38(3). doi: 10.15252/embj.2018101417. Epub 2019 Jan 24. PubMed PMID: 30679197; PubMed Central PMCID: PMC6356055.
Jaffrey SR, Wilkinson MF. Nonsense-mediated RNA decay in the brain: emerging modulator of neural development and disease. Nat Rev Neurosci. 2018 Dec;19(12):715-728. doi: 10.1038/s41583-018-0079-z. Review. PubMed PMID: 30410025; PubMed Central PMCID: PMC6396682.
Huang L, Shum EY, Jones SH, Lou CH, Dumdie J, Kim H, Roberts AJ, Jolly LA, Espinoza JL, Skarbrevik DM, Phan MH, Cook-Andersen H, Swerdlow NR, Gecz J, Wilkinson MF. A Upf3b-mutant mouse model with behavioral and neurogenesis defects. Mol Psychiatry. 2018 Aug;23(8):1773-1786. doi: 10.1038/mp.2017.173. Epub 2017 Sep 26. PubMed PMID: 28948974; PubMed Central PMCID: PMC5869067.
Dumdie JN, Cho K, Ramaiah M, Skarbrevik D, Mora-Castilla S, Stumpo DJ, Lykke-Andersen J, Laurent LC, Blackshear PJ, Wilkinson MF, Cook-Andersen H. Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2. Dev Cell. 2018 Feb 5;44(3):392-402.e7. doi: 10.1016/j.devcel.2018.01.006. Epub 2018 Feb 5. PubMed PMID: 29408237; PubMed Central PMCID: PMC5805474.
M Plank TD, Wilkinson MF. RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent. Bioessays. 2018 Jan;40(1). doi: 10.1002/bies.201700170. Epub 2017 Dec 13. Review. PubMed PMID: 29236296; PubMed Central PMCID: PMC5843485.
Gao Z, Wilkinson M. An RNA decay factor wears a new coat: UPF3B modulates translation termination. F1000Res. 2017;6:2159. doi: 10.12688/f1000research.12704.1. eCollection 2017. Review. PubMed PMID: 29333258; PubMed Central PMCID: PMC5749124.
Goetz AE, Wilkinson M. Stress and the nonsense-mediated RNA decay pathway. Cell Mol Life Sci. 2017 Oct;74(19):3509-3531. doi: 10.1007/s00018-017-2537-6. Epub 2017 May 13. Review. PubMed PMID: 28503708; PubMed Central PMCID: PMC5683946.
Jones SH, Wilkinson M. RNA decay, evolution, and the testis. RNA Biol. 2017 Feb;14(2):146-155. doi: 10.1080/15476286.2016.1265199. Epub 2016 Dec 2. Review. PubMed PMID: 27911186; PubMed Central PMCID: PMC5324745.
Borgmann J, Tüttelmann F, Dworniczak B, Röpke A, Song HW, Kliesch S, Wilkinson MF, Laurentino S, Gromoll J. The human RHOX gene cluster: target genes and functional analysis of gene variants in infertile men. Hum Mol Genet. 2016 Nov 15;25(22):4898-4910. doi: 10.1093/hmg/ddw313. PubMed PMID: 28171660; PubMed Central PMCID: PMC6281360.
Song HW, Bettegowda A, Lake BB, Zhao AH, Skarbrevik D, Babajanian E, Sukhwani M, Shum EY, Phan MH, Plank TM, Richardson ME, Ramaiah M, Sridhar V, de Rooij DG, Orwig KE, Zhang K, Wilkinson MF. The Homeobox Transcription Factor RHOX10 Drives Mouse Spermatogonial Stem Cell Establishment. Cell Rep. 2016 Sep 27;17(1):149-164. doi: 10.1016/j.celrep.2016.08.090. PubMed PMID: 27681428; PubMed Central PMCID: PMC5063083.
Lu J, Plank TD, Su F, Shi X, Liu C, Ji Y, Li S, Huynh A, Shi C, Zhu B, Yang G, Wu Y, Wilkinson MF, Lu Y. The nonsense-mediated RNA decay pathway is disrupted in inflammatory myofibroblastic tumors. J Clin Invest. 2016 Aug 1;126(8):3058-62. doi: 10.1172/JCI86508. Epub 2016 Jun 27. PubMed PMID: 27348585; PubMed Central PMCID: PMC4966300.
Lou CH, Dumdie J, Goetz A, Shum EY, Brafman D, Liao X, Mora-Castilla S, Ramaiah M, Cook-Andersen H, Laurent L, Wilkinson MF. Nonsense-Mediated RNA Decay Influences Human Embryonic Stem Cell Fate. Stem Cell Reports. 2016 Jun 14;6(6):844-857. doi: 10.1016/j.stemcr.2016.05.008. PubMed PMID: 27304915; PubMed Central PMCID: PMC4912386.
Shum EY, Jones SH, Shao A, Dumdie J, Krause MD, Chan WK, Lou CH, Espinoza JL, Song HW, Phan MH, Ramaiah M, Huang L, McCarrey JR, Peterson KJ, De Rooij DG, Cook-Andersen H, Wilkinson MF. The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay. Cell. 2016 Apr 7;165(2):382-95. doi: 10.1016/j.cell.2016.02.046. Epub 2016 Mar 31. PubMed PMID: 27040500; PubMed Central PMCID: PMC4826573.
Shum EY, Espinoza JL, Ramaiah M, Wilkinson MF. Identification of novel post-transcriptional features in olfactory receptor family mRNAs. Nucleic Acids Res. 2015 Oct 30;43(19):9314-26. doi: 10.1093/nar/gkv324. Epub 2015 Apr 23. PubMed PMID: 25908788; PubMed Central PMCID: PMC4627058.
Lou CH, Shum EY, Wilkinson MF. RNA degradation drives stem cell differentiation. EMBO J. 2015 Jun 12;34(12):1606-8. doi: 10.15252/embj.201591631. Epub 2015 Apr 21. PubMed PMID: 25899816; PubMed Central PMCID: PMC4475395.
Cook-Andersen H, Wilkinson MF. Molecular biology: Splicing does the two-step. Nature. 2015 May 21;521(7552):300-1. doi: 10.1038/nature14524. Epub 2015 May 13. PubMed PMID: 25970243; PubMed Central PMCID: PMC4809257.
Karam R, Lou CH, Kroeger H, Huang L, Lin JH, Wilkinson MF. The unfolded protein response is shaped by the NMD pathway. EMBO Rep. 2015 May;16(5):599-609. doi: 10.15252/embr.201439696. Epub 2015 Mar 25. PubMed PMID: 25807986; PubMed Central PMCID: PMC4428047.
Wilkinson MF. Evidence that DNA methylation engenders dynamic gene regulation. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2116. doi: 10.1073/pnas.1502195112. Epub 2015 Apr 6. PubMed PMID: 25848065; PubMed Central PMCID: PMC4418857.
Song HW, Bettegowda A, Oliver D, Yan W, Phan MH, de Rooij DG, Corbett MA, Wilkinson MF. shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects. PLoS One. 2015;10(3):e0118549. doi: 10.1371/journal.pone.0118549. eCollection 2015. PubMed PMID: 25790000; PubMed Central PMCID: PMC4366048.
Rao MK, Matsumoto Y, Richardson ME, Panneerdoss S, Bhardwaj A, Ward JM, Shanker S, Bettegowda A, Wilkinson MF. Hormone-induced and DNA demethylation-induced relief of a tissue-specific and developmentally regulated block in transcriptional elongation. J Biol Chem. 2014 Dec 19;289(51):35087-101. doi: 10.1074/jbc.M114.615435. Epub 2014 Oct 20. PubMed PMID: 25331959; PubMed Central PMCID: PMC4271199.
Shao A, Wilkinson MF. Suppressing nonsense--a surprising function for 5-azacytidine. EMBO Mol Med. 2014 Dec;6(12):1518-20. doi: 10.15252/emmm.201404569. PubMed PMID: 25378479; PubMed Central PMCID: PMC4287971.
Nguyen LS, Wilkinson MF, Gecz J. Nonsense-mediated mRNA decay: inter-individual variability and human disease. Neurosci Biobehav Rev. 2014 Oct;46 Pt 2:175-86. doi: 10.1016/j.neubiorev.2013.10.016. Epub 2013 Nov 14. Review. PubMed PMID: 24239855; PubMed Central PMCID: PMC4021004.
Liu C, Karam R, Zhou Y, Su F, Ji Y, Li G, Xu G, Lu L, Wang C, Song M, Zhu J, Wang Y, Zhao Y, Foo WC, Zuo M, Valasek MA, Javle M, Wilkinson MF, Lu Y. The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma. Nat Med. 2014 Jun;20(6):596-8. doi: 10.1038/nm.3548. Epub 2014 May 25. PubMed PMID: 24859531; PubMed Central PMCID: PMC4048332.
Song HW, Wilkinson MF. Transcriptional control of spermatogonial maintenance and differentiation. Semin Cell Dev Biol. 2014 Jun;30:14-26. doi: 10.1016/j.semcdb.2014.02.005. Epub 2014 Feb 19. Review. PubMed PMID: 24560784; PubMed Central PMCID: PMC4043860.
De Gendt K, Verhoeven G, Amieux PS, Wilkinson MF. Genome-wide identification of AR-regulated genes translated in Sertoli cells in vivo using the RiboTag approach. Mol Endocrinol. 2014 Apr;28(4):575-91. doi: 10.1210/me.2013-1391. Epub 2014 Feb 25. PubMed PMID: 24606126; PubMed Central PMCID: PMC3968405.
Lou CH, Shao A, Shum EY, Espinoza JL, Huang L, Karam R, Wilkinson MF. Posttranscriptional control of the stem cell and neurogenic programs by the nonsense-mediated RNA decay pathway. Cell Rep. 2014 Feb 27;6(4):748-64. doi: 10.1016/j.celrep.2014.01.028. Epub 2014 Feb 13. PubMed PMID: 24529710; PubMed Central PMCID: PMC3962089.
Lasalde C, Rivera AV, León AJ, González-Feliciano JA, Estrella LA, Rodríguez-Cruz EN, Correa ME, Cajigas IJ, Bracho DP, Vega IE, Wilkinson MF, González CI. Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. Nucleic Acids Res. 2014 Feb;42(3):1916-29. doi: 10.1093/nar/gkt1049. Epub 2013 Nov 5. PubMed PMID: 24198248; PubMed Central PMCID: PMC3919615.
Richardson ME, Bleiziffer A, Tüttelmann F, Gromoll J, Wilkinson MF. Epigenetic regulation of the RHOX homeobox gene cluster and its association with human male infertility. Hum Mol Genet. 2014 Jan 1;23(1):12-23. doi: 10.1093/hmg/ddt392. Epub 2013 Aug 13. PubMed PMID: 23943794; PubMed Central PMCID: PMC3857941.
Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson MF, Joung JK. Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. Nat Biotechnol. 2013 Dec;31(12):1137-42. doi: 10.1038/nbt.2726. Epub 2013 Oct 9. PubMed PMID: 24108092; PubMed Central PMCID: PMC3858462.
MacLean JA 2nd, Hu Z, Welborn JP, Song HW, Rao MK, Wayne CM, Wilkinson MF. The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis. J Biol Chem. 2013 Nov 29;288(48):34809-25. doi: 10.1074/jbc.M113.486340. Epub 2013 Oct 11. PubMed PMID: 24121513; PubMed Central PMCID: PMC3843094.
Song HW, Anderson RA, Bayne RA, Gromoll J, Shimasaki S, Chang RJ, Parast MM, Laurent LC, de Rooij DG, Hsieh TC, Wilkinson MF. The RHOX homeobox gene cluster is selectively expressed in human oocytes and male germ cells. Hum Reprod. 2013 Jun;28(6):1635-46. doi: 10.1093/humrep/det043. Epub 2013 Mar 12. PubMed PMID: 23482336; PubMed Central PMCID: PMC3657123.
Karam R, Wengrod J, Gardner LB, Wilkinson MF. Regulation of nonsense-mediated mRNA decay: implications for physiology and disease. Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):624-33. doi: 10.1016/j.bbagrm.2013.03.002. Epub 2013 Mar 13. PubMed PMID: 23500037; PubMed Central PMCID: PMC3660545.
Huang L, Wilkinson MF. Regulation of nonsense-mediated mRNA decay. Wiley Interdiscip Rev RNA. 2012 Nov-Dec;3(6):807-28. doi: 10.1002/wrna.1137. Epub 2012 Oct 1. Review. PubMed PMID: 23027648.
Nguyen LS, Jolly L, Shoubridge C, Chan WK, Huang L, Laumonnier F, Raynaud M, Hackett A, Field M, Rodriguez J, Srivastava AK, Lee Y, Long R, Addington AM, Rapoport JL, Suren S, Hahn CN, Gamble J, Wilkinson MF, Corbett MA, Gecz J. Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability. Mol Psychiatry. 2012 Nov;17(11):1103-15. doi: 10.1038/mp.2011.163. Epub 2011 Dec 20. PubMed PMID: 22182939; PubMed Central PMCID: PMC4281019.
Song HW, Wilkinson MF. In vitro spermatogenesis: A long journey to get tails. Spermatogenesis. 2012 Oct 1;2(4):238-244. doi: 10.4161/spmg.22069. PubMed PMID: 23248764; PubMed Central PMCID: PMC3521745.
MacLean JA 2nd, Hayashi K, Turner TT, Wilkinson MF. The Rhox5 homeobox gene regulates the region-specific expression of its paralogs in the rodent epididymis. Biol Reprod. 2012 Jun;86(6):189. doi: 10.1095/biolreprod.112.099184. Print 2012 Jun. PubMed PMID: 22423045; PubMed Central PMCID: PMC3386150.
Song HW, Dann CT, McCarrey JR, Meistrich ML, Cornwall GA, Wilkinson MF. Dynamic expression pattern and subcellular localization of the Rhox10 homeobox transcription factor during early germ cell development. Reproduction. 2012 May;143(5):611-24. doi: 10.1530/REP-11-0479. Epub 2012 Mar 5. PubMed PMID: 22393026; NIHMSID:NIHMS28171660.
Bhardwaj A, Song HW, Beildeck M, Kerkhofs S, Castoro R, Shanker S, De Gendt K, Suzuki K, Claessens F, Issa JP, Orgebin-Crist MC, Wilkinson MF. DNA demethylation-dependent AR recruitment and GATA factors drive Rhox5 homeobox gene transcription in the epididymis. Mol Endocrinol. 2012 Apr;26(4):538-49. doi: 10.1210/me.2011-1059. Epub 2012 Feb 9. PubMed PMID: 22322598; PubMed Central PMCID: PMC3327359.
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