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  1. Synthesis of a Heterotelechelic Helical Poly(methacrylamide) and its Incorporation into a Supramolecular Triblock Copolymer. Polymer chemistry. NIHMSID: NIHMS1048437.
  2. Madsen LS, Andersson EC, Jansson L, krogsgaard M, Andersen CB, Engberg J, Strominger JL, Svejgaard A, Hjorth JP, Holmdahl R, Wucherpfennig KW, Fugger L. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat Genet. 1999 Nov;23(3):343-7. doi: 10.1038/15525. PubMed PMID: 10610182.
  3. Krogsgaard M, Wucherpfennig KW, Cannella B, Hansen BE, Svejgaard A, Pyrdol J, Ditzel H, Raine C, Engberg J, Fugger L. Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex. J Exp Med. 2000 Apr 17;191(8):1395-412. doi: 10.1084/jem.191.8.1395. PubMed PMID: 10770805; PubMed Central PMCID: PMC2193136.
  4. Irvine DJ, Purbhoo MA, Krogsgaard M, Davis MM. Direct observation of ligand recognition by T cells. Nature. 2002 Oct 24;419(6909):845-9. doi: 10.1038/nature01076. PubMed PMID: 12397360.
  5. Davis MM, Krogsgaard M, Huppa JB, Sumen C, Purbhoo MA, Irvine DJ, Wu LC, Ehrlich L. Dynamics of cell surface molecules during T cell recognition. Annu Rev Biochem. 2003;72:717-42. doi: 10.1146/annurev.biochem.72.121801.161625. Review. PubMed PMID: 14527326.
  6. Anikeeva N, Lebedeva T, Krogsgaard M, Tetin SY, Martinez-Hackert E, Kalams SA, Davis MM, Sykulev Y. Distinct molecular mechanisms account for the specificity of two different T-cell receptors. Biochemistry. 2003 Apr 29;42(16):4709-16. doi: 10.1021/bi026864+. PubMed PMID: 12705834.
  7. Krogsgaard M, Prado N, Adams EJ, He XL, Chow DC, Wilson DB, Garcia KC, Davis MM. Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol Cell. 2003 Dec;12(6):1367-78. PubMed PMID: 14690592.
  8. Krogsgaard M, Huppa JB, Purbhoo MA, Davis MM. Linking molecular and cellular events in T-cell activation and synapse formation. Semin Immunol. 2003 Dec;15(6):307-15. doi: 10.1016/j.smim.2003.09.002. Review. PubMed PMID: 15001169.
  9. Ranheim EA, Tarbell KV, Krogsgaard M, Mallet-Designe V, Teyton L, McDevitt HO, Weissman IL. Selection of aberrant class II restricted CD8+ T cells in NOD mice expressing a glutamic acid decarboxylase (GAD)65-specific T cell receptor transgene. Autoimmunity. 2004 Dec;37(8):555-67. doi: 10.1080/08916930400020545. PubMed PMID: 15763918.
  10. Kasson PM, Huppa JB, Krogsgaard M, Davis MM, Brunger AT. Quantitative imaging of lymphocyte membrane protein reorganization and signaling. Biophys J. 2005 Jan;88(1):579-89. doi: 10.1529/biophysj.104.048827. Epub 2004 Oct 22. PubMed PMID: 15501943; PubMed Central PMCID: PMC1305035.
  11. Krogsgaard M, Davis MM. How T cells 'see' antigen. Nat Immunol. 2005 Mar;6(3):239-45. doi: 10.1038/ni1173. Review. PubMed PMID: 15716973.
  12. Krogsgaard M, Li QJ, Sumen C, Huppa JB, Huse M, Davis MM. Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature. 2005 Mar 10;434(7030):238-43. doi: 10.1038/nature03391. Epub 2005 Feb 20. PubMed PMID: 15724150.
  13. Maynard J, Adams EJ, Krogsgaard M, Petersson K, Liu CW, Garcia KC. High-level bacterial secretion of single-chain alphabeta T-cell receptors. J Immunol Methods. 2005 Nov 30;306(1-2):51-67. doi: 10.1016/j.jim.2005.07.022. Epub 2005 Sep 12. PubMed PMID: 16198365.
  14. Qi S, Krogsgaard M, Davis MM, Chakraborty AK. Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4416-21. doi: 10.1073/pnas.0510991103. Epub 2006 Mar 13. PubMed PMID: 16537380; PubMed Central PMCID: PMC1450186.
  15. Davis MM, Krogsgaard M, Huse M, Huppa J, Lillemeier BF, Li QJ. T cells as a self-referential, sensory organ. Annu Rev Immunol. 2007;25:681-95. doi: 10.1146/annurev.immunol.24.021605.090600. Review. PubMed PMID: 17291190.
  16. Krogsgaard M, Juang J, Davis MM. A role for "self" in T-cell activation. Semin Immunol. 2007 Aug;19(4):236-44. doi: 10.1016/j.smim.2007.04.003. Epub 2007 Jun 4. Review. PubMed PMID: 17548210; PubMed Central PMCID: PMC2731063.
  17. Call MJ, Xing X, Cuny GD, Seth NP, Altmann DM, Fugger L, Krogsgaard M, Stein RL, Wucherpfennig KW. In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange. J Immunol. 2009 May 15;182(10):6342-52. doi: 10.4049/jimmunol.0803464. PubMed PMID: 19414787; PubMed Central PMCID: PMC2695398.
  18. Juang J, Ebert PJ, Feng D, Garcia KC, Krogsgaard M, Davis MM. Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection. J Exp Med. 2010 Jun 7;207(6):1223-34. doi: 10.1084/jem.20092170. Epub 2010 May 10. PubMed PMID: 20457759; PubMed Central PMCID: PMC2882826.
  19. Corse E, Gottschalk RA, Krogsgaard M, Allison JP. Attenuated T cell responses to a high-potency ligand in vivo. PLoS Biol. 2010 Sep 14;8(9). doi: 10.1371/journal.pbio.1000481. PubMed PMID: 20856903; PubMed Central PMCID: PMC2939023.
  20. Mouquet H, Scheid JF, Zoller MJ, Krogsgaard M, Ott RG, Shukair S, Artyomov MN, Pietzsch J, Connors M, Pereyra F, Walker BD, Ho DD, Wilson PC, Seaman MS, Eisen HN, Chakraborty AK, Hope TJ, Ravetch JV, Wardemann H, Nussenzweig MC. Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature. 2010 Sep 30;467(7315):591-5. doi: 10.1038/nature09385. PubMed PMID: 20882016; PubMed Central PMCID: PMC3699875.
  21. Zhong S, Malecek K, Perez-Garcia A, Krogsgaard M. Retroviral transduction of T-cell receptors in mouse T-cells. J Vis Exp. 2010 Oct 22;(44). doi: 10.3791/2307. PubMed PMID: 21048669; PubMed Central PMCID: PMC3185635.
  22. Wan Q, Kozhaya L, Imberg K, Mercer F, Zhong S, Krogsgaard M, Unutmaz D. Probing the effector and suppressive functions of human T cell subsets using antigen-specific engineered T cell receptors. PLoS One. 2013;8(2):e56302. doi: 10.1371/journal.pone.0056302. Epub 2013 Feb 20. PubMed PMID: 23437112; PubMed Central PMCID: PMC3577812.
  23. Zhong S, Malecek K, Johnson LA, Yu Z, Vega-Saenz de Miera E, Darvishian F, McGary K, Huang K, Boyer J, Corse E, Shao Y, Rosenberg SA, Restifo NP, Osman I, Krogsgaard M. T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6973-8. doi: 10.1073/pnas.1221609110. Epub 2013 Apr 1. PubMed PMID: 23576742; PubMed Central PMCID: PMC3637771.
  24. Malecek K, Zhong S, McGary K, Yu C, Huang K, Johnson LA, Rosenberg SA, Krogsgaard M. Engineering improved T cell receptors using an alanine-scan guided T cell display selection system. J Immunol Methods. 2013 Jun 28;392(1-2):1-11. doi: 10.1016/j.jim.2013.02.018. Epub 2013 Mar 13. PubMed PMID: 23500145; PubMed Central PMCID: PMC3668434.
  25. Wei F, Zhong S, Ma Z, Kong H, Medvec A, Ahmed R, Freeman GJ, Krogsgaard M, Riley JL. Strength of PD-1 signaling differentially affects T-cell effector functions. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2480-9. doi: 10.1073/pnas.1305394110. Epub 2013 Apr 22. PubMed PMID: 23610399; PubMed Central PMCID: PMC3703988.
  26. Liu B, Zhong S, Malecek K, Johnson LA, Rosenberg SA, Zhu C, Krogsgaard M. 2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system. Eur J Immunol. 2014 Jan;44(1):239-50. doi: 10.1002/eji.201343774. Epub 2013 Oct 20. PubMed PMID: 24114747; PubMed Central PMCID: PMC3941036.
  27. Krogsgaard M. Imprinting of the mature T cell response by self. Trends Immunol. 2014 Apr;35(4):141-3. doi: 10.1016/j.it.2014.03.002. Epub 2014 Mar 16. Review. PubMed PMID: 24646828.
  28. Crites TJ, Padhan K, Muller J, Krogsgaard M, Gudla PR, Lockett SJ, Varma R. TCR Microclusters pre-exist and contain molecules necessary for TCR signal transduction. J Immunol. 2014 Jul 1;193(1):56-67. doi: 10.4049/jimmunol.1400315. Epub 2014 May 23. PubMed PMID: 24860189; PubMed Central PMCID: PMC4096552.
  29. Malecek K, Grigoryan A, Zhong S, Gu WJ, Johnson LA, Rosenberg SA, Cardozo T, Krogsgaard M. Specific increase in potency via structure-based design of a TCR. J Immunol. 2014 Sep 1;193(5):2587-99. doi: 10.4049/jimmunol.1302344. Epub 2014 Jul 28. PubMed PMID: 25070852; PubMed Central PMCID: PMC4205480.
  30. Wang W, Li T, Felsovalyi K, Chen C, Cardozo T, Krogsgaard M. Quantitative analysis of T cell receptor complex interaction sites using genetically encoded photo-cross-linkers. ACS Chem Biol. 2014 Sep 19;9(9):2165-72. doi: 10.1021/cb500351s. Epub 2014 Jul 30. PubMed PMID: 25061810; PubMed Central PMCID: PMC4168801.
  31. Moogk D, da Silva IP, Ma MW, Friedman EB, de Miera EV, Darvishian F, Scanlon P, Perez-Garcia A, Pavlick AC, Bhardwaj N, Christos PJ, Osman I, Krogsgaard M. Melanoma expression of matrix metalloproteinase-23 is associated with blunted tumor immunity and poor responses to immunotherapy. J Transl Med. 2014 Dec 10;12:342. doi: 10.1186/s12967-014-0342-7. PubMed PMID: 25491880; PubMed Central PMCID: PMC4272770.
  32. Natarajan A, Nadarajah V, Felsovalyi K, Wang W, Jeyachandran VR, Wasson RA, Cardozo T, Bracken C, Krogsgaard M. Structural Model of the Extracellular Assembly of the TCR-CD3 Complex. Cell Rep. 2016 Mar 29;14(12):2833-45. doi: 10.1016/j.celrep.2016.02.081. Epub 2016 Mar 17. PubMed PMID: 26997265; PubMed Central PMCID: PMC4902171.
  33. Moogk D, Zhong S, Yu Z, Liadi I, Rittase W, Fang V, Dougherty J, Perez-Garcia A, Osman I, Zhu C, Varadarajan N, Restifo NP, Frey AB, Krogsgaard M. Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets. J Immunol. 2016 Jul 15;197(2):644-54. doi: 10.4049/jimmunol.1600178. Epub 2016 Jun 6. PubMed PMID: 27271569; PubMed Central PMCID: PMC4935560.
  34. Hong J, Ge C, Jothikumar P, Yuan Z, Liu B, Bai K, Li K, Rittase W, Shinzawa M, Zhang Y, Palin A, Love P, Yu X, Salaita K, Evavold BD, Singer A, Zhu C. A TCR mechanotransduction signaling loop induces negative selection in the thymus. Nat Immunol. 2018 Dec;19(12):1379-1390. doi: 10.1038/s41590-018-0259-z. Epub 2018 Nov 12. PubMed PMID: 30420628; PubMed Central PMCID: PMC6452639.
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