My Bibliography

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Jansen M, Potschka H, Brandt C, Löscher W, Dannhardt G. Hydantoin-substituted 4,6-dichloroindole-2-carboxylic acids as ligands with high affinity for the glycine binding site of the NMDA receptor. J Med Chem. 2003 Jan 2;46(1):64-73. doi: 10.1021/jm020955n. PubMed PMID: 12502360.

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Jansen M, Dannhardt G. Antagonists and agonists at the glycine site of the NMDA receptor for therapeutic interventions. Eur J Med Chem. 2003 Jul-Aug;38(7-8):661-70. doi: 10.1016/s0223-5234(03)00113-2. Review. PubMed PMID: 12932897.

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Jansen M, Dannhardt G. Variations of acidic functions at position 2 and substituents at positions 4, 5 and 6 of the indole moiety and their effect on NMDA-glycine site affinity. Eur J Med Chem. 2003 Oct;38(10):855-65. doi: 10.1016/j.ejmech.2003.07.001. PubMed PMID: 14575932.

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Reeves DC, Jansen M, Bali M, Lemster T, Akabas MH. A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors. J Neurosci. 2005 Oct 12;25(41):9358-66. doi: 10.1523/JNEUROSCI.1045-05.2005. PubMed PMID: 16221844; PubMed Central PMCID: PMC6725699.

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Jansen M, Akabas MH. State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments. J Neurosci. 2006 Apr 26;26(17):4492-9. doi: 10.1523/JNEUROSCI.0224-06.2006. PubMed PMID: 16641228; PubMed Central PMCID: PMC6674078.

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Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E, Sandoval C, Zhao R, Akabas MH, Goldman ID. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell. 2006 Dec 1;127(5):917-28. doi: 10.1016/j.cell.2006.09.041. PubMed PMID: 17129779.

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Qiu A, Min SH, Jansen M, Malhotra U, Tsai E, Cabelof DC, Matherly LH, Zhao R, Akabas MH, Goldman ID. Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. Am J Physiol Cell Physiol. 2007 Nov;293(5):C1669-78. doi: 10.1152/ajpcell.00202.2007. Epub 2007 Sep 26. PubMed PMID: 17898134.

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Jansen M, Bali M, Akabas MH. Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop. J Gen Physiol. 2008 Feb;131(2):137-46. doi: 10.1085/jgp.200709896. PubMed PMID: 18227272; PubMed Central PMCID: PMC2213565.

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Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH, Goldman ID. The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol Pharmacol. 2008 Sep;74(3):854-62. doi: 10.1124/mol.108.045443. Epub 2008 Jun 4. PubMed PMID: 18524888; PubMed Central PMCID: PMC2716086.

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Jansen M, Rabe H, Strehle A, Dieler S, Debus F, Dannhardt G, Akabas MH, Lüddens H. Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site. J Med Chem. 2008 Aug 14;51(15):4430-48. doi: 10.1021/jm701562x. Epub 2008 Jul 24. PubMed PMID: 18651727; PubMed Central PMCID: PMC2566937.

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Wiltfong RE, Jansen M. Probing protein packing surrounding the residues in and flanking the nicotinic acetylcholine receptor M2M3 loop. J Neurosci. 2009 Feb 11;29(6):1626-35. doi: 10.1523/JNEUROSCI.4121-08.2009. PubMed PMID: 19211870; PubMed Central PMCID: PMC2654246.

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Bali M, Jansen M, Akabas MH. GABA-induced intersubunit conformational movement in the GABAA receptor alpha 1M1-beta 2M3 transmembrane subunit interface: experimental basis for homology modeling of an intravenous anesthetic binding site. J Neurosci. 2009 Mar 11;29(10):3083-92. doi: 10.1523/JNEUROSCI.6090-08.2009. PubMed PMID: 19279245; PubMed Central PMCID: PMC2677711.

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Goyal R, Salahudeen AA, Jansen M. Engineering a prokaryotic Cys-loop receptor with a third functional domain. J Biol Chem. 2011 Oct 7;286(40):34635-42. doi: 10.1074/jbc.M111.269647. Epub 2011 Aug 15. PubMed PMID: 21844195; PubMed Central PMCID: PMC3186389.

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Pandhare A, Hamouda AK, Staggs B, Aggarwal S, Duddempudi PK, Lever JR, Lapinsky DJ, Jansen M, Cohen JB, Blanton MP. Bupropion binds to two sites in the Torpedo nicotinic acetylcholine receptor transmembrane domain: a photoaffinity labeling study with the bupropion analogue [(125)I]-SADU-3-72. Biochemistry. 2012 Mar 27;51(12):2425-35. doi: 10.1021/bi300101r. Epub 2012 Mar 15. PubMed PMID: 22394379; PubMed Central PMCID: PMC3315157.

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Duddempudi PK, Goyal R, Date SS, Jansen M. Delineating the extracellular water-accessible surface of the proton-coupled folate transporter. PLoS One. 2013;8(10):e78301. doi: 10.1371/journal.pone.0078301. eCollection 2013. PubMed PMID: 24205192; PubMed Central PMCID: PMC3799626.

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Labriola JM, Pandhare A, Jansen M, Blanton MP, Corringer PJ, Baenziger JE. Structural sensitivity of a prokaryotic pentameric ligand-gated ion channel to its membrane environment. J Biol Chem. 2013 Apr 19;288(16):11294-303. doi: 10.1074/jbc.M113.458133. Epub 2013 Mar 5. PubMed PMID: 23463505; PubMed Central PMCID: PMC3630840.

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Mnatsakanyan N, Jansen M. Experimental determination of the vertical alignment between the second and third transmembrane segments of muscle nicotinic acetylcholine receptors. J Neurochem. 2013 Jun;125(6):843-54. doi: 10.1111/jnc.12260. Epub 2013 Apr 30. PubMed PMID: 23565737; PubMed Central PMCID: PMC3676432.

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Duddempudi PK, Nakashe P, Blanton MP, Jansen M. The monomeric state of the proton-coupled folate transporter represents the functional unit in the plasma membrane. FEBS J. 2013 Jun;280(12):2900-15. doi: 10.1111/febs.12293. Epub 2013 May 28. PubMed PMID: 23601781.

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Mnatsakanyan N, Nishtala SN, Pandhare A, Fiori MC, Goyal R, Pauwels JE, Navetta AF, Ahrorov A, Jansen M. Functional Chimeras of GLIC Obtained by Adding the Intracellular Domain of Anion- and Cation-Conducting Cys-Loop Receptors. Biochemistry. 2015 Apr 28;54(16):2670-2682. doi: 10.1021/acs.biochem.5b00203. Epub 2015 Apr 17. PubMed PMID: 25861708; PubMed Central PMCID: PMC4414916.

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Date SS, Chen CY, Chen Y, Jansen M. Experimentally optimized threading structures of the proton-coupled folate transporter. FEBS Open Bio. 2016 Mar;6(3):216-30. doi: 10.1002/2211-5463.12041. eCollection 2016 Mar. PubMed PMID: 27047750; PubMed Central PMCID: PMC4794783.

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Nishtala SN, Mnatsakanyan N, Pandhare A, Leung C, Jansen M. Direct interaction of the resistance to inhibitors of cholinesterase type 3 protein with the serotonin receptor type 3A intracellular domain. J Neurochem. 2016 May;137(4):528-38. doi: 10.1111/jnc.13578. Epub 2016 Mar 11. PubMed PMID: 26875553; PubMed Central PMCID: PMC4860158.

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Pandhare A, Grozdanov PN, Jansen M. Pentameric quaternary structure of the intracellular domain of serotonin type 3A receptors. Sci Rep. 2016 Apr 5;6:23921. doi: 10.1038/srep23921. PubMed PMID: 27045630; PubMed Central PMCID: PMC4820698.

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Pandhare A, Pappu AS, Wilms H, Blanton MP, Jansen M. The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors. Neuropharmacology. 2017 Feb;113(Pt A):89-99. doi: 10.1016/j.neuropharm.2016.09.021. Epub 2016 Sep 24. PubMed PMID: 27671323; PubMed Central PMCID: PMC5148637.

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Date SS, Fiori MC, Altenberg GA, Jansen M. Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1). PLoS One. 2017;12(5):e0177572. doi: 10.1371/journal.pone.0177572. eCollection 2017. PubMed PMID: 28493963; PubMed Central PMCID: PMC5426777.

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Pandhare A, Stuebler AG, Pirayesh E, Jansen M. A modified clear-native polyacrylamide gel electrophoresis technique to investigate the oligomeric state of MBP-5-HT(3A)-intracellular domain chimeras. Protein Expr Purif. 2019 Jan;153:45-52. doi: 10.1016/j.pep.2018.08.010. Epub 2018 Aug 18. PubMed PMID: 30130580; PubMed Central PMCID: PMC6261512.

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Jansen M. An in-depth structural view of a GABA(A) brain receptor. Nature. 2019 Jan;565(7740):436-438. doi: 10.1038/d41586-018-07843-7. PubMed PMID: 30666053.

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Pandhare A, Pirayesh E, Stuebler AG, Jansen M. Triple arginines as molecular determinants for pentameric assembly of the intracellular domain of 5-HT(3A) receptors. J Gen Physiol. 2019 Sep 2;151(9):1135-1145. doi: 10.1085/jgp.201912421. Epub 2019 Aug 13. PubMed PMID: 31409663; PubMed Central PMCID: PMC6719409.

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Pirayesh E, Stuebler AG, Pandhare A, Jansen M. Delineating the Site of Interaction of the 5-HT(3A) Receptor with the Chaperone Protein RIC-3. Biophys J. 2020 Feb 25;118(4):934-943. doi: 10.1016/j.bpj.2019.11.3380. Epub 2019 Nov 28. PubMed PMID: 31870537; PubMed Central PMCID: PMC7036741.

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Stuebler AG, Jansen M. Bupropion Inhibits Serotonin Type 3AB Heteromeric Channels at Clinically Relevant Concentrations. Mol Pharmacol. 2020 Mar;97(3):171-179. doi: 10.1124/mol.119.118349. Epub 2019 Dec 23. PubMed PMID: 31871303; PubMed Central PMCID: PMC6978693.

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Stuebler AG, Jansen M. Mobility of Lower MA-Helices for Ion Conduction through Lateral Portals in 5-HT(3A) Receptors. Biophys J. 2020 Dec 15;119(12):2593-2603. doi: 10.1016/j.bpj.2020.10.029. Epub 2020 Nov 4. PubMed PMID: 33157122; PubMed Central PMCID: PMC7822733.

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Do HQ, Bassil CM, Andersen EI, Jansen M. Impact of nanodisc lipid composition on cell-free expression of proton-coupled folate transporter. PLoS One. 2021;16(11):e0253184. doi: 10.1371/journal.pone.0253184. eCollection 2021. PubMed PMID: 34793461; PubMed Central PMCID: PMC8601550.

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Do HQ, Jansen M. Cell-Free Expression of Proton-Coupled Folate Transporter in the Presence of Nanodiscs. Methods Mol Biol. 2022;2507:425-444. doi: 10.1007/978-1-0716-2368-8_23. PubMed PMID: 35773596.

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Do HQ, Jansen M. Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors. J Gen Physiol. 2023 Jun 5;155(6). doi: 10.1085/jgp.202213305. Epub 2023 Apr 7. PubMed PMID: 37026993; PubMed Central PMCID: PMC10083716.

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Do HQ, Pirayesh E, Ferreira G, Pandhare A, Gallardo ZR, Jansen M. A bupropion modulatory site in the Gloeobacter violaceus ligand-gated ion channel. Biophys J. 2024 Jul 16;123(14):2185-2198. doi: 10.1016/j.bpj.2024.04.027. Epub 2024 Apr 27. PubMed PMID: 38678367; PubMed Central PMCID: PMC11309978.