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Gaskill MM, Soluri IV, Branks AE, Boka AP, Stadler MR, Huang HS, Gibson TJ, Mir M, Blythe SA, Harrison MM. Localization of the pioneer factor GAF to subnuclear foci is driven by DNA binding and required to silence satellite repeat expression. [preprint]. 2022 November. Available from:
Rajan A, Anhezini L, Rives-Quinto N, Neville MC, Larson ED, Goodwin SF, Harrison MM, Lee C. Low-level repressive histone marks fine-tune gene transcription in neural stem cells. [preprint]. 2022 November. Available from:
Larson ED, Komori H, Fitzpatrick ZA, Krabbenhoft SD, Lee CY, Harrison M. Premature translation of the Drosophila zygotic genome activator Zelda is not sufficient to precociously activate gene expression. G3 (Bethesda). 2022 Aug 25;12(9). doi: 10.1093/g3journal/jkac159. PubMed PMID: 35876878; PubMed Central PMCID: PMC9434156.
Bellec M, Dufourt J, Hunt G, Lenden-Hasse H, Trullo A, Zine El Aabidine A, Lamarque M, Gaskill MM, Faure-Gautron H, Mannervik M, Harrison MM, Andrau JC, Favard C, Radulescu O, Lagha M. The control of transcriptional memory by stable mitotic bookmarking. Nat Commun. 2022 Mar 4;13(1):1176. doi: 10.1038/s41467-022-28855-y. PubMed PMID: 35246556; PubMed Central PMCID: PMC8897465.
Gaskill M, Harrison M. Tethering gene regulation to chromatin organization. Science. 2022 Feb 4;375(6580):491-492. doi: 10.1126/science.abn6380. Epub 2022 Feb 3. PubMed PMID: 35113712.
Larson ED, Komori H, Gibson TJ, Ostgaard CM, Hamm DC, Schnell JM, Lee CY, Harrison MM. Cell-type-specific chromatin occupancy by the pioneer factor Zelda drives key developmental transitions in Drosophila. Nat Commun. 2021 Dec 9;12(1):7153. doi: 10.1038/s41467-021-27506-y. PubMed PMID: 34887421; PubMed Central PMCID: PMC8660810.
Larson ED, Marsh AJ, Harrison MM. Pioneering the developmental frontier. Mol Cell. 2021 Apr 15;81(8):1640-1650. doi: 10.1016/j.molcel.2021.02.020. Epub 2021 Mar 8. Review. PubMed PMID: 33689750; PubMed Central PMCID: PMC8052302.
Gaskill MM, Gibson TJ, Larson ED, Harrison MM. GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo. Elife. 2021 Mar 15;10. doi: 10.7554/eLife.66668. PubMed PMID: 33720012; PubMed Central PMCID: PMC8079149.
Larson ED, Komori H, Gibson TJ, Ostgaard CM, Hamm DC, Schnell JM, Lee C, Harrison MM. Cell-type-specific chromatin occupancy by the pioneer factor Zelda drives key developmental transitions in Drosophila. bioRxiv : the preprint server for biology. 2021.
Jain SU, Rashoff AQ, Krabbenhoft SD, Hoelper D, Do TJ, Gibson TJ, Lundgren SM, Bondra ER, Deshmukh S, Harutyunyan AS, Juretic N, Jabado N, Harrison MM, Lewis PW. H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2. Mol Cell. 2020 Nov 19;80(4):726-735.e7. doi: 10.1016/j.molcel.2020.09.028. Epub 2020 Oct 12. PubMed PMID: 33049227; PubMed Central PMCID: PMC7680438.
Nevil M, Gibson TJ, Bartolutti C, Iyengar A, Harrison MM. Establishment of chromatin accessibility by the conserved transcription factor Grainy head is developmentally regulated. Development. 2020 Mar 11;147(5). doi: 10.1242/dev.185009. PubMed PMID: 32098765.
McDaniel SL, Hollatz AJ, Branstad AM, Gaskill MM, Fox CA, Harrison MM. Tissue-Specific DNA Replication Defects in Drosophila melanogaster Caused by a Meier-Gorlin Syndrome Mutation in Orc4. Genetics. 2020 Feb;214(2):355-367. doi: 10.1534/genetics.119.302938. Epub 2019 Dec 9. PubMed PMID: 31818869; PubMed Central PMCID: PMC7017028.
Gaskill MM, Gibson TJ, Larson ED, Harrison MM. GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo. bioRxiv : the preprint server for biology. 2020.
Fernandez Garcia M, Moore CD, Schulz KN, Alberto O, Donague G, Harrison MM, Zhu H, Zaret KS. Structural Features of Transcription Factors Associating with Nucleosome Binding. Mol Cell. 2019 Sep 5;75(5):921-932.e6. doi: 10.1016/j.molcel.2019.06.009. Epub 2019 Jul 11. PubMed PMID: 31303471; PubMed Central PMCID: PMC6731145.
McDaniel SL, Harrison MM. Optogenetic Inactivation of Transcription Factors in the Early Embryo of Drosophila. Bio Protoc. 2019 Jul 5;9(13):e3296. doi: 10.21769/BioProtoc.3296. eCollection 2019 Jul 5. PubMed PMID: 33654809; PubMed Central PMCID: PMC7854102.
Reese RM, Harrison MM, Alarid ET. Grainyhead-like Protein 2: The Emerging Role in Hormone-Dependent Cancers and Epigenetics. Endocrinology. 2019 May 1;160(5):1275-1288. doi: 10.1210/en.2019-00213. Review. PubMed PMID: 30958537.
McDaniel SL, Gibson TJ, Schulz KN, Fernandez Garcia M, Nevil M, Jain SU, Lewis PW, Zaret KS, Harrison MM. Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation. Mol Cell. 2019 Apr 4;74(1):185-195.e4. doi: 10.1016/j.molcel.2019.01.014. Epub 2019 Feb 20. PubMed PMID: 30797686; PubMed Central PMCID: PMC6544384.
Schulz KN, Harrison MM. Mechanisms regulating zygotic genome activation. Nat Rev Genet. 2019 Apr;20(4):221-234. doi: 10.1038/s41576-018-0087-x. Review. PubMed PMID: 30573849; PubMed Central PMCID: PMC6558659.
Mir M, Stadler MR, Ortiz SA, Hannon CE, Harrison MM, Darzacq X, Eisen MB. Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos. Elife. 2018 Dec 27;7. doi: 10.7554/eLife.40497. PubMed PMID: 30589412; PubMed Central PMCID: PMC6307861.
Dufourt J, Trullo A, Hunter J, Fernandez C, Lazaro J, Dejean M, Morales L, Nait-Amer S, Schulz KN, Harrison MM, Favard C, Radulescu O, Lagha M. Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs. Nat Commun. 2018 Dec 5;9(1):5194. doi: 10.1038/s41467-018-07613-z. PubMed PMID: 30518940; PubMed Central PMCID: PMC6281682.
Hamm DC, Harrison MM. Regulatory principles governing the maternal-to-zygotic transition: insights from Drosophila melanogaster. Open Biol. 2018 Dec;8(12):180183. doi: 10.1098/rsob.180183. Review. PubMed PMID: 30977698; PubMed Central PMCID: PMC6303782.
Bier E, Harrison MM, O'Connor-Giles KM, Wildonger J. Advances in Engineering the Fly Genome with the CRISPR-Cas System. Genetics. 2018 Jan;208(1):1-18. doi: 10.1534/genetics.117.1113. Review. PubMed PMID: 29301946; PubMed Central PMCID: PMC5753851.
Hamm DC, Larson ED, Nevil M, Marshall KE, Bondra ER, Harrison MM. A conserved maternal-specific repressive domain in Zelda revealed by Cas9-mediated mutagenesis in Drosophila melanogaster. PLoS Genet. 2017 Dec;13(12):e1007120. doi: 10.1371/journal.pgen.1007120. eCollection 2017 Dec. PubMed PMID: 29261646; PubMed Central PMCID: PMC5752043.
Janssens DH, Hamm DC, Anhezini L, Xiao Q, Siller KH, Siegrist SE, Harrison MM, Lee CY. An Hdac1/Rpd3-Poised Circuit Balances Continual Self-Renewal and Rapid Restriction of Developmental Potential during Asymmetric Stem Cell Division. Dev Cell. 2017 Feb 27;40(4):367-380.e7. doi: 10.1016/j.devcel.2017.01.014. PubMed PMID: 28245922; PubMed Central PMCID: PMC5336133.
Nevil M, Bondra ER, Schulz KN, Kaplan T, Harrison MM. Stable Binding of the Conserved Transcription Factor Grainy Head to its Target Genes Throughout Drosophila melanogaster Development. Genetics. 2017 Feb;205(2):605-620. doi: 10.1534/genetics.116.195685. Epub 2016 Dec 22. PubMed PMID: 28007888; PubMed Central PMCID: PMC5289840.
Schulz KN, Bondra ER, Moshe A, Villalta JE, Lieb JD, Kaplan T, McKay DJ, Harrison MM. Zelda is differentially required for chromatin accessibility, transcription factor binding, and gene expression in the early Drosophila embryo. Genome Res. 2015 Nov;25(11):1715-26. doi: 10.1101/gr.192682.115. Epub 2015 Sep 2. PubMed PMID: 26335634; PubMed Central PMCID: PMC4617967.
Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J. BIOSAFETY. Safeguarding gene drive experiments in the laboratory. Science. 2015 Aug 28;349(6251):927-9. doi: 10.1126/science.aac7932. Epub 2015 Jul 30. PubMed PMID: 26229113; PubMed Central PMCID: PMC4692367.
Harrison MM, Eisen MB. Transcriptional Activation of the Zygotic Genome in Drosophila. Curr Top Dev Biol. 2015;113:85-112. doi: 10.1016/bs.ctdb.2015.07.028. Epub 2015 Aug 19. Review. PubMed PMID: 26358871.
Gratz SJ, Rubinstein CD, Harrison MM, Wildonger J, O'Connor-Giles KM. CRISPR-Cas9 Genome Editing in Drosophila. Curr Protoc Mol Biol. 2015 Jul 1;111:31.2.1-31.2.20. doi: 10.1002/0471142727.mb3102s111. PubMed PMID: 26131852; PubMed Central PMCID: PMC4506758.
Hamm DC, Bondra ER, Harrison MM. Transcriptional activation is a conserved feature of the early embryonic factor Zelda that requires a cluster of four zinc fingers for DNA binding and a low-complexity activation domain. J Biol Chem. 2015 Feb 6;290(6):3508-18. doi: 10.1074/jbc.M114.602292. Epub 2014 Dec 23. PubMed PMID: 25538246; PubMed Central PMCID: PMC4319018.
Gratz SJ, Harrison MM, Wildonger J, O'Connor-Giles KM. Precise Genome Editing of Drosophila with CRISPR RNA-Guided Cas9. Methods Mol Biol. 2015;1311:335-48. doi: 10.1007/978-1-4939-2687-9_22. PubMed PMID: 25981484; PubMed Central PMCID: PMC4467458.
Li XY, Harrison MM, Villalta JE, Kaplan T, Eisen MB. Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition. Elife. 2014 Oct 14;3. doi: 10.7554/eLife.03737. PubMed PMID: 25313869; PubMed Central PMCID: PMC4358338.
Harrison MM, Jenkins BV, O'Connor-Giles KM, Wildonger J. A CRISPR view of development. Genes Dev. 2014 Sep 1;28(17):1859-72. doi: 10.1101/gad.248252.114. Review. PubMed PMID: 25184674; PubMed Central PMCID: PMC4197953.
Gratz SJ, Wildonger J, Harrison MM, O'Connor-Giles KM. CRISPR/Cas9-mediated genome engineering and the promise of designer flies on demand. Fly (Austin). 2013 Oct-Dec;7(4):249-55. doi: 10.4161/fly.26566. Epub 2013 Oct 2. PubMed PMID: 24088745; PubMed Central PMCID: PMC3896497.
Gratz SJ, Cummings AM, Nguyen JN, Hamm DC, Donohue LK, Harrison MM, Wildonger J, O'Connor-Giles KM. Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease. Genetics. 2013 Aug;194(4):1029-35. doi: 10.1534/genetics.113.152710. Epub 2013 May 24. PubMed PMID: 23709638; PubMed Central PMCID: PMC3730909.
Harrison MM, Li XY, Kaplan T, Botchan MR, Eisen MB. Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition. PLoS Genet. 2011 Oct;7(10):e1002266. doi: 10.1371/journal.pgen.1002266. Epub 2011 Oct 20. PubMed PMID: 22028662; PubMed Central PMCID: PMC3197655.
Tabuchi TM, Deplancke B, Osato N, Zhu LJ, Barrasa MI, Harrison MM, Horvitz HR, Walhout AJ, Hagstrom KA. Chromosome-biased binding and gene regulation by the Caenorhabditis elegans DRM complex. PLoS Genet. 2011 May;7(5):e1002074. doi: 10.1371/journal.pgen.1002074. Epub 2011 May 12. PubMed PMID: 21589891; PubMed Central PMCID: PMC3093354.
Cline TW, Dorsett M, Sun S, Harrison MM, Dines J, Sefton L, Megna L. Evolution of the Drosophila feminizing switch gene Sex-lethal. Genetics. 2010 Dec;186(4):1321-36. doi: 10.1534/genetics.110.121202. Epub 2010 Sep 13. PubMed PMID: 20837995; PubMed Central PMCID: PMC2998314.
Harrison MM, Botchan MR, Cline TW. Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes. Dev Biol. 2010 Sep 15;345(2):248-55. doi: 10.1016/j.ydbio.2010.06.026. Epub 2010 Jul 1. PubMed PMID: 20599892; PubMed Central PMCID: PMC2927720.
Harrison MM, Lu X, Horvitz HR. LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes. Genetics. 2007 May;176(1):255-71. doi: 10.1534/genetics.106.069633. Epub 2007 Apr 3. PubMed PMID: 17409073; PubMed Central PMCID: PMC1893064.
Harrison MM, Ceol CJ, Lu X, Horvitz HR. Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16782-7. doi: 10.1073/pnas.0608461103. Epub 2006 Oct 30. PubMed PMID: 17075059; PubMed Central PMCID: PMC1636532.
Ceol CJ, Stegmeier F, Harrison MM, Horvitz HR. Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development. Genetics. 2006 Jun;173(2):709-26. doi: 10.1534/genetics.106.056465. Epub 2006 Apr 19. PubMed PMID: 16624904; PubMed Central PMCID: PMC1526536.
Davison EM, Harrison MM, Walhout AJ, Vidal M, Horvitz HR. lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb protein. Genetics. 2005 Nov;171(3):1017-31. doi: 10.1534/genetics.104.034173. Epub 2005 Jul 14. PubMed PMID: 16020796; PubMed Central PMCID: PMC1456809.
Sim RJ, Harrison MM, Moxon ER, Tang CM. Underestimation of meningococci in tonsillar tissue by nasopharyngeal swabbing. Lancet. 2000 Nov 11;356(9242):1653-4. doi: 10.1016/s0140-6736(00)03162-7. PubMed PMID: 11089827.
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