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  1. Brand MD, Goncalves RL, Orr AL, Vargas L, Gerencser AA, Borch Jensen M, Wang YT, Melov S, Turk CN, Matzen JT, Dardov VJ, Petrassi HM, Meeusen SL, Perevoshchikova IV, Jasper H, Brookes PS, Ainscow EK. Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury. Cell Metab. 2016 Oct 11;24(4):582-592. doi: 10.1016/j.cmet.2016.08.012. Epub 2016 Sep 22. PubMed PMID: 27667666; PubMed Central PMCID: PMC5061631.
  2. Goncalves RL, Bunik VI, Brand MD. Production of superoxide/hydrogen peroxide by the mitochondrial 2-oxoadipate dehydrogenase complex. Free Radic Biol Med. 2016 Feb;91:247-55. doi: 10.1016/j.freeradbiomed.2015.12.020. Epub 2015 Dec 18. PubMed PMID: 26708453.
  3. Deng H, Gerencser AA, Jasper H. Signal integration by Ca(2+) regulates intestinal stem-cell activity. Nature. 2015 Dec 10;528(7581):212-7. doi: 10.1038/nature16170. Epub 2015 Dec 2. PubMed PMID: 26633624; PubMed Central PMCID: PMC4669953.
  4. Orr AL, Vargas L, Turk CN, Baaten JE, Matzen JT, Dardov VJ, Attle SJ, Li J, Quackenbush DC, Goncalves RL, Perevoshchikova IV, Petrassi HM, Meeusen SL, Ainscow EK, Brand MD. Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol. 2015 Nov;11(11):834-6. doi: 10.1038/nchembio.1910. Epub 2015 Sep 14. PubMed PMID: 26368590; PubMed Central PMCID: PMC4618194.
  5. Nicholls DG, Brand MD, Gerencser AA. Mitochondrial bioenergetics and neuronal survival modelled in primary neuronal culture and isolated nerve terminals. J Bioenerg Biomembr. 2015 Apr;47(1-2):63-74. doi: 10.1007/s10863-014-9573-9. Epub 2014 Aug 30. Review. PubMed PMID: 25172197.
  6. Anderson CM, Kazantzis M, Wang J, Venkatraman S, Goncalves RL, Quinlan CL, Ng R, Jastroch M, Benjamin DI, Nie B, Herber C, Van AA, Park MJ, Yun D, Chan K, Yu A, Vuong P, Febbraio M, Nomura DK, Napoli JL, Brand MD, Stahl A. Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptake. Cell Rep. 2015 Feb 3;10(4):505-15. doi: 10.1016/j.celrep.2014.12.048. Epub 2015 Jan 22. PubMed PMID: 25620701; PubMed Central PMCID: PMC4318762.
  7. Mookerjee SA, Goncalves RLS, Gerencser AA, Nicholls DG, Brand MD. The contributions of respiration and glycolysis to extracellular acid production. Biochim Biophys Acta. 2015 Feb;1847(2):171-181. doi: 10.1016/j.bbabio.2014.10.005. Epub 2014 Oct 27. PubMed PMID: 25449966.
  8. Goncalves RL, Quinlan CL, Perevoshchikova IV, Hey-Mogensen M, Brand MD. Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise. J Biol Chem. 2015 Jan 2;290(1):209-27. doi: 10.1074/jbc.M114.619072. Epub 2014 Nov 11. PubMed PMID: 25389297; PubMed Central PMCID: PMC4281723.
  9. Goncalves RL, Rothschild DE, Quinlan CL, Scott GK, Benz CC, Brand MD. Sources of superoxide/H2O2 during mitochondrial proline oxidation. Redox Biol. 2014;2:901-9. doi: 10.1016/j.redox.2014.07.003. eCollection 2014. PubMed PMID: 25184115; PubMed Central PMCID: PMC4143814.
  10. Hey-Mogensen M, Goncalves RL, Orr AL, Brand MD. Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria. Free Radic Biol Med. 2014 Jul;72:149-55. doi: 10.1016/j.freeradbiomed.2014.04.007. Epub 2014 Apr 16. PubMed PMID: 24746616.
  11. Brand MD. The role of mitochondria in longevity and healthspan. Longev Healthspan. 2014;3:7. doi: 10.1186/2046-2395-3-7. eCollection 2014. PubMed PMID: 24855560; PubMed Central PMCID: PMC4030464.
  12. Quinlan CL, Goncalves RL, Hey-Mogensen M, Yadava N, Bunik VI, Brand MD. The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I. J Biol Chem. 2014 Mar 21;289(12):8312-25. doi: 10.1074/jbc.M113.545301. Epub 2014 Feb 10. PubMed PMID: 24515115; PubMed Central PMCID: PMC3961658.
  13. Orr AL, Ashok D, Sarantos MR, Ng R, Shi T, Gerencser AA, Hughes RE, Brand MD. Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase. PLoS One. 2014;9(2):e89938. doi: 10.1371/journal.pone.0089938. eCollection 2014. PubMed PMID: 24587137; PubMed Central PMCID: PMC3933693.
  14. Orr AL, Ashok D, Sarantos MR, Shi T, Hughes RE, Brand MD. Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening. Free Radic Biol Med. 2013 Dec;65:1047-1059. doi: 10.1016/j.freeradbiomed.2013.08.170. Epub 2013 Aug 27. PubMed PMID: 23994103; PubMed Central PMCID: PMC4321955.
  15. Perevoshchikova IV, Quinlan CL, Orr AL, Gerencser AA, Brand MD. Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria. Free Radic Biol Med. 2013 Aug;61:298-309. doi: 10.1016/j.freeradbiomed.2013.04.006. Epub 2013 Apr 11. PubMed PMID: 23583329; PubMed Central PMCID: PMC3871980.
  16. Brand MD, Orr AL, Perevoshchikova IV, Quinlan CL. The role of mitochondrial function and cellular bioenergetics in ageing and disease. Br J Dermatol. 2013 Jul;169 Suppl 2:1-8. doi: 10.1111/bjd.12208. Review. PubMed PMID: 23786614; PubMed Central PMCID: PMC4321783.
  17. McQuaker SJ, Quinlan CL, Caldwell ST, Brand MD, Hartley RC. A prototypical small-molecule modulator uncouples mitochondria in response to endogenous hydrogen peroxide production. Chembiochem. 2013 May 27;14(8):993-1000. doi: 10.1002/cbic.201300115. Epub 2013 May 2. PubMed PMID: 23640856; PubMed Central PMCID: PMC3743171.
  18. Quinlan CL, Perevoshchikova IV, Hey-Mogensen M, Orr AL, Brand MD. Sites of reactive oxygen species generation by mitochondria oxidizing different substrates. Redox Biol. 2013;1:304-12. doi: 10.1016/j.redox.2013.04.005. eCollection 2013. PubMed PMID: 24024165; PubMed Central PMCID: PMC3757699.
  19. Patil YN, Marden B, Brand MD, Hand SC. Metabolic downregulation and inhibition of carbohydrate catabolism during diapause in embryos of Artemia franciscana. Physiol Biochem Zool. 2013 Jan-Feb;86(1):106-18. doi: 10.1086/667808. Epub 2012 Oct 30. PubMed PMID: 23303325.
  20. Quinlan CL, Perevoschikova IV, Goncalves RL, Hey-Mogensen M, Brand MD. The determination and analysis of site-specific rates of mitochondrial reactive oxygen species production. Methods Enzymol. 2013;526:189-217. doi: 10.1016/B978-0-12-405883-5.00012-0. PubMed PMID: 23791102; PubMed Central PMCID: PMC4034747.
  21. Barlow J, Hirschberg V, Brand MD, Affourtit C. Measuring mitochondrial uncoupling protein-2 level and activity in insulinoma cells. Methods Enzymol. 2013;528:257-67. doi: 10.1016/B978-0-12-405881-1.00015-X. PubMed PMID: 23849870.
  22. Orr AL, Quinlan CL, Perevoshchikova IV, Brand MD. A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase. J Biol Chem. 2012 Dec 14;287(51):42921-35. doi: 10.1074/jbc.M112.397828. Epub 2012 Nov 2. PubMed PMID: 23124204; PubMed Central PMCID: PMC3522288.
  23. Choi SW, Gerencser AA, Ng R, Flynn JM, Melov S, Danielson SR, Gibson BW, Nicholls DG, Bredesen DE, Brand MD. No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease. J Neurosci. 2012 Nov 21;32(47):16775-84. doi: 10.1523/JNEUROSCI.2414-12.2012. PubMed PMID: 23175831; PubMed Central PMCID: PMC3736741.
  24. Quinlan CL, Treberg JR, Perevoshchikova IV, Orr AL, Brand MD. Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters. Free Radic Biol Med. 2012 Nov 1;53(9):1807-17. doi: 10.1016/j.freeradbiomed.2012.08.015. Epub 2012 Aug 17. PubMed PMID: 22940066; PubMed Central PMCID: PMC3472107.
  25. Divakaruni AS, Humphrey DM, Brand MD. Fatty acids change the conformation of uncoupling protein 1 (UCP1). J Biol Chem. 2012 Oct 26;287(44):36845-53. doi: 10.1074/jbc.M112.381780. Epub 2012 Sep 5. PubMed PMID: 22952235; PubMed Central PMCID: PMC3481287.
  26. Smith S, Witkowski A, Moghul A, Yoshinaga Y, Nefedov M, de Jong P, Feng D, Fong L, Tu Y, Hu Y, Young SG, Pham T, Cheung C, Katzman SM, Brand MD, Quinlan CL, Fens M, Kuypers F, Misquitta S, Griffey SM, Tran S, Gharib A, Knudsen J, Hannibal-Bach HK, Wang G, Larkin S, Thweatt J, Pasta S. Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. PLoS One. 2012;7(10):e47196. doi: 10.1371/journal.pone.0047196. Epub 2012 Oct 15. PubMed PMID: 23077570; PubMed Central PMCID: PMC3471957.
  27. Quinlan CL, Orr AL, Perevoshchikova IV, Treberg JR, Ackrell BA, Brand MD. Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions. J Biol Chem. 2012 Aug 3;287(32):27255-64. doi: 10.1074/jbc.M112.374629. Epub 2012 Jun 11. PubMed PMID: 22689576; PubMed Central PMCID: PMC3411067.
  28. Gerencser AA, Chinopoulos C, Birket MJ, Jastroch M, Vitelli C, Nicholls DG, Brand MD. Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondria. J Physiol. 2012 Jun 15;590(12):2845-71. doi: 10.1113/jphysiol.2012.228387. Epub 2012 Apr 10. PubMed PMID: 22495585; PubMed Central PMCID: PMC3448152.
  29. Goehring I, Gerencser AA, Schmidt S, Brand MD, Mulder H, Nicholls DG. Plasma membrane potential oscillations in insulin secreting Ins-1 832/13 cells do not require glycolysis and are not initiated by fluctuations in mitochondrial bioenergetics. J Biol Chem. 2012 May 4;287(19):15706-17. doi: 10.1074/jbc.M111.314567. Epub 2012 Mar 14. PubMed PMID: 22418435; PubMed Central PMCID: PMC3346073.
  30. Affourtit C, Quinlan CL, Brand MD. Measurement of proton leak and electron leak in isolated mitochondria. Methods Mol Biol. 2012;810:165-82. doi: 10.1007/978-1-61779-382-0_11. PubMed PMID: 22057567.
  31. Mookerjee SA, Brand MD. Characteristics of the turnover of uncoupling protein 3 by the ubiquitin proteasome system in isolated mitochondria. Biochim Biophys Acta. 2011 Nov;1807(11):1474-81. doi: 10.1016/j.bbabio.2011.07.011. Epub 2011 Jul 28. PubMed PMID: 21820402; PubMed Central PMCID: PMC3578713.
  32. Quinlan CL, Gerencser AA, Treberg JR, Brand MD. The mechanism of superoxide production by the antimycin-inhibited mitochondrial Q-cycle. J Biol Chem. 2011 Sep 9;286(36):31361-72. doi: 10.1074/jbc.M111.267898. Epub 2011 Jun 27. PubMed PMID: 21708945; PubMed Central PMCID: PMC3173136.
  33. Treberg JR, Quinlan CL, Brand MD. Evidence for two sites of superoxide production by mitochondrial NADH-ubiquinone oxidoreductase (complex I). J Biol Chem. 2011 Aug 5;286(31):27103-10. doi: 10.1074/jbc.M111.252502. Epub 2011 Jun 8. PubMed PMID: 21659507; PubMed Central PMCID: PMC3149303.
  34. Rogers GW, Brand MD, Petrosyan S, Ashok D, Elorza AA, Ferrick DA, Murphy AN. High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria. PLoS One. 2011;6(7):e21746. doi: 10.1371/journal.pone.0021746. Epub 2011 Jul 25. PubMed PMID: 21799747; PubMed Central PMCID: PMC3143121.
  35. Divakaruni AS, Brand MD. The regulation and physiology of mitochondrial proton leak. Physiology (Bethesda). 2011 Jun;26(3):192-205. doi: 10.1152/physiol.00046.2010. Review. PubMed PMID: 21670165.
  36. Treberg JR, Brand MD. A model of the proton translocation mechanism of complex I. J Biol Chem. 2011 May 20;286(20):17579-84. doi: 10.1074/jbc.M111.227751. Epub 2011 Mar 30. PubMed PMID: 21454533; PubMed Central PMCID: PMC3093832.
  37. Brand MD, Nicholls DG. Assessing mitochondrial dysfunction in cells. Biochem J. 2011 Apr 15;435(2):297-312. doi: 10.1042/BJ20110162. Review. PubMed PMID: 21726199; PubMed Central PMCID: PMC3076726.
  38. Choi SW, Gerencser AA, Lee DW, Rajagopalan S, Nicholls DG, Andersen JK, Brand MD. Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes. J Neurosci. 2011 Mar 23;31(12):4524-34. doi: 10.1523/JNEUROSCI.5817-10.2011. PubMed PMID: 21430153; PubMed Central PMCID: PMC3083118.
  39. Affourtit C, Jastroch M, Brand MD. Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species. Free Radic Biol Med. 2011 Mar 1;50(5):609-16. doi: 10.1016/j.freeradbiomed.2010.12.020. Epub 2010 Dec 21. PubMed PMID: 21172424; PubMed Central PMCID: PMC3036803.
  40. Birket MJ, Orr AL, Gerencser AA, Madden DT, Vitelli C, Swistowski A, Brand MD, Zeng X. A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells. J Cell Sci. 2011 Feb 1;124(Pt 3):348-58. doi: 10.1242/jcs.072272. PubMed PMID: 21242311; PubMed Central PMCID: PMC3021997.
  41. Quinlan C, Treberg J, Brand M, Bartzokis G, Brown-Borg HM, Brunet A, Colman RJ, Cuervo AM, Depre C, Faraci FM, Finch CE, Florido R, E. Mechanisms of mitochondrial free radical production and their relationship to the aging process . In: In "Handbook of the Biology of Aging" (Book). 7th ed. Masoro EJ, Austad SN, editors. London, UK: Academic Press; 2011. Chapter 3; p.47-61.
  42. Rodriguez KA, Wywial E, Perez VI, Lambert AJ, Edrey YH, Lewis KN, Grimes K, Lindsey ML, Brand MD, Buffenstein R. Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent. Curr Pharm Des. 2011;17(22):2290-307. Review. PubMed PMID: 21736541; PubMed Central PMCID: PMC3980719.
  43. Brand MD, Parker N, Affourtit C, Mookerjee SA, Azzu V. Mitochondrial uncoupling protein 2 in pancreatic β-cells. Diabetes Obes Metab. 2010 Oct;12 Suppl 2:134-40. doi: 10.1111/j.1463-1326.2010.01264.x. Review. PubMed PMID: 21029310.
  44. Seebacher F, Brand MD, Else PL, Guderley H, Hulbert AJ, Moyes CD. Plasticity of oxidative metabolism in variable climates: molecular mechanisms. Physiol Biochem Zool. 2010 Sep-Oct;83(5):721-32. doi: 10.1086/649964. Review. PubMed PMID: 20586603.
  45. Toime LJ, Brand MD. Uncoupling protein-3 lowers reactive oxygen species production in isolated mitochondria. Free Radic Biol Med. 2010 Aug 15;49(4):606-11. doi: 10.1016/j.freeradbiomed.2010.05.010. Epub 2010 May 21. PubMed PMID: 20493945; PubMed Central PMCID: PMC2903626.
  46. Brand MD. The sites and topology of mitochondrial superoxide production. Exp Gerontol. 2010 Aug;45(7-8):466-72. doi: 10.1016/j.exger.2010.01.003. Epub 2010 Jan 11. Review. PubMed PMID: 20064600; PubMed Central PMCID: PMC2879443.
  47. Jacobson J, Lambert AJ, Portero-Otín M, Pamplona R, Magwere T, Miwa S, Driege Y, Brand MD, Partridge L. Biomarkers of aging in Drosophila. Aging Cell. 2010 Aug;9(4):466-477. doi: 10.1111/j.1474-9726.2010.00573.x. Epub 2010 Mar 29. PubMed PMID: 20367621; PubMed Central PMCID: PMC4467031.
  48. Mookerjee SA, Divakaruni AS, Jastroch M, Brand MD. Mitochondrial uncoupling and lifespan. Mech Ageing Dev. 2010 Jul-Aug;131(7-8):463-72. doi: 10.1016/j.mad.2010.03.010. Epub 2010 Apr 2. Review. PubMed PMID: 20363244; PubMed Central PMCID: PMC2924931.
  49. Treberg JR, Quinlan CL, Brand MD. Hydrogen peroxide efflux from muscle mitochondria underestimates matrix superoxide production--a correction using glutathione depletion. FEBS J. 2010 Jul;277(13):2766-78. doi: 10.1111/j.1742-4658.2010.07693.x. Epub 2010 May 18. PubMed PMID: 20491900; PubMed Central PMCID: PMC2891561.
  50. Azzu V, Jastroch M, Divakaruni AS, Brand MD. The regulation and turnover of mitochondrial uncoupling proteins. Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):785-91. doi: 10.1016/j.bbabio.2010.02.035. Epub 2010 Mar 6. Review. PubMed PMID: 20211596; PubMed Central PMCID: PMC2891119.