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Weinstein JJ, Chohan MO, Slifstein M, Kegeles LS, Moore H, Abi-Dargham A. Pathway-Specific Dopamine Abnormalities in Schizophrenia. Biol Psychiatry. 2017 Jan 1;81(1):31-42. doi: 10.1016/j.biopsych.2016.03.2104. Epub 2016 Mar 31. Review. PubMed PMID: 27206569; PubMed Central PMCID: PMC5177794.
van de Giessen E, Weinstein JJ, Cassidy CM, Haney M, Dong Z, Ghazzaoui R, Ojeil N, Kegeles LS, Xu X, Vadhan NP, Volkow ND, Slifstein M, Abi-Dargham A. Deficits in striatal dopamine release in cannabis dependence. Mol Psychiatry. 2017 Jan;22(1):68-75. doi: 10.1038/mp.2016.21. Epub 2016 Mar 22. PubMed PMID: 27001613; PubMed Central PMCID: PMC5033654.
Van Snellenberg JX, Girgis RR, Horga G, van de Giessen E, Slifstein M, Ojeil N, Weinstein JJ, Moore H, Lieberman JA, Shohamy D, Smith EE, Abi-Dargham A. Mechanisms of Working Memory Impairment in Schizophrenia. Biol Psychiatry. 2016 Oct 15;80(8):617-26. doi: 10.1016/j.biopsych.2016.02.017. Epub 2016 Feb 23. PubMed PMID: 27056754; PubMed Central PMCID: PMC4995154.
Girgis RR, Slifstein M, D'Souza D, Lee Y, Periclou A, Ghahramani P, Laszlovszky I, Durgam S, Adham N, Nabulsi N, Huang Y, Carson RE, Kiss B, Kapás M, Abi-Dargham A, Rakhit A. Preferential binding to dopamine D3 over D2 receptors by cariprazine in patients with schizophrenia using PET with the D3/D2 receptor ligand [(11)C]-(+)-PHNO. Psychopharmacology (Berl). 2016 Oct;233(19-20):3503-12. doi: 10.1007/s00213-016-4382-y. Epub 2016 Aug 15. PubMed PMID: 27525990; PubMed Central PMCID: PMC5035321.
Horga G, Cassidy CM, Xu X, Moore H, Slifstein M, Van Snellenberg JX, Abi-Dargham A. Dopamine-Related Disruption of Functional Topography of Striatal Connections in Unmedicated Patients With Schizophrenia. JAMA Psychiatry. 2016 Aug 1;73(8):862-70. doi: 10.1001/jamapsychiatry.2016.0178. PubMed PMID: 27145361; PubMed Central PMCID: PMC5310843.
Girgis RR, Van Snellenberg JX, Glass A, Kegeles LS, Thompson JL, Wall M, Cho RY, Carter CS, Slifstein M, Abi-Dargham A, Lieberman JA. A proof-of-concept, randomized controlled trial of DAR-0100A, a dopamine-1 receptor agonist, for cognitive enhancement in schizophrenia. J Psychopharmacol. 2016 May;30(5):428-35. doi: 10.1177/0269881116636120. Epub 2016 Mar 10. PubMed PMID: 26966119.
Cassidy CM, Van Snellenberg JX, Benavides C, Slifstein M, Wang Z, Moore H, Abi-Dargham A, Horga G. Dynamic Connectivity between Brain Networks Supports Working Memory: Relationships to Dopamine Release and Schizophrenia. J Neurosci. 2016 Apr 13;36(15):4377-88. doi: 10.1523/JNEUROSCI.3296-15.2016. PubMed PMID: 27076432; PubMed Central PMCID: PMC4829655.
Gunn RN, Slifstein M, Searle GE, Price JC. Quantitative imaging of protein targets in the human brain with PET. Phys Med Biol. 2015 Nov 21;60(22):R363-411. doi: 10.1088/0031-9155/60/22/R363. Epub 2015 Oct 29. PubMed PMID: 26513176; NIHMSID:NIHMS735413.
Girgis RR, Xu X, Gil RB, Hackett E, Ojeil N, Lieberman JA, Slifstein M, Abi-Dargham A. Antipsychotic binding to the dopamine-3 receptor in humans: A PET study with [(11)C]-(+)-PHNO. Schizophr Res. 2015 Oct;168(1-2):373-6. doi: 10.1016/j.schres.2015.06.027. Epub 2015 Jul 17. PubMed PMID: 26190300; PubMed Central PMCID: PMC4591174.
Broft A, Slifstein M, Osborne J, Kothari P, Morim S, Shingleton R, Kenney L, Vallabhajosula S, Attia E, Martinez D, Timothy Walsh B. Striatal dopamine type 2 receptor availability in anorexia nervosa. Psychiatry Res. 2015 Sep 30;233(3):380-7. doi: 10.1016/j.pscychresns.2015.06.013. Epub 2015 Jul 26. PubMed PMID: 26272038; PubMed Central PMCID: PMC5055757.
Hwang DR, Hu E, Allen JR, Davis C, Treanor J, Miller S, Chen H, Shi B, Narayanan TK, Barret O, Alagille D, Yu Z, Slifstein M. Radiosynthesis and initial characterization of a PDE10A specific PET tracer [18F]AMG 580 in non-human primates. Nucl Med Biol. 2015 Aug;42(8):654-63. doi: 10.1016/j.nucmedbio.2015.04.004. Epub 2015 Apr 16. PubMed PMID: 25935386.
Simpson HB, Kegeles LS, Hunter L, Mao X, Van Meter P, Xu X, Kimeldorf MB, Pearlstein SL, Slifstein M, Shungu DC. Assessment of glutamate in striatal subregions in obsessive-compulsive disorder with proton magnetic resonance spectroscopy. Psychiatry Res. 2015 Apr 30;232(1):65-70. doi: 10.1016/j.pscychresns.2015.01.009. Epub 2015 Feb 3. PubMed PMID: 25715904; PubMed Central PMCID: PMC4404189.
Slifstein M, van de Giessen E, Van Snellenberg J, Thompson JL, Narendran R, Gil R, Hackett E, Girgis R, Ojeil N, Moore H, D'Souza D, Malison RT, Huang Y, Lim K, Nabulsi N, Carson RE, Lieberman JA, Abi-Dargham A. Deficits in prefrontal cortical and extrastriatal dopamine release in schizophrenia: a positron emission tomographic functional magnetic resonance imaging study. JAMA Psychiatry. 2015 Apr;72(4):316-24. doi: 10.1001/jamapsychiatry.2014.2414. PubMed PMID: 25651194; PubMed Central PMCID: PMC4768742.
Van Snellenberg JX, Slifstein M, Read C, Weber J, Thompson JL, Wager TD, Shohamy D, Abi-Dargham A, Smith EE. Dynamic shifts in brain network activation during supracapacity working memory task performance. Hum Brain Mapp. 2015 Apr;36(4):1245-64. doi: 10.1002/hbm.22699. Epub 2014 Nov 24. PubMed PMID: 25422039; PubMed Central PMCID: PMC4722876.
Ridler K, Cunningham V, Huiban M, Martarello L, Pampols-Maso S, Passchier J, Gunn RN, Searle G, Abi-Dargham A, Slifstein M, Watson J, Laruelle M, Rabiner EA. An evaluation of the brain distribution of [(11)C]GSK1034702, a muscarinic-1 (M 1) positive allosteric modulator in the living human brain using positron emission tomography. EJNMMI Res. 2014 Dec;4(1):66. doi: 10.1186/s13550-014-0066-y. Epub 2014 Dec 5. PubMed PMID: 26116126; PubMed Central PMCID: PMC4452589.
van de Giessen E, Rosell DR, Thompson JL, Xu X, Girgis RR, Ehrlich Y, Slifstein M, Abi-Dargham A, Siever LJ. Serotonin transporter availability in impulsive aggressive personality disordered patients: a PET study with [11C]DASB. J Psychiatr Res. 2014 Nov;58:147-54. doi: 10.1016/j.jpsychires.2014.07.025. Epub 2014 Aug 6. PubMed PMID: 25145808.
Luo SX, Martinez D, Carpenter KM, Slifstein M, Nunes EV. Multimodal predictive modeling of individual treatment outcome in cocaine dependence with combined neuroimaging and behavioral predictors. Drug Alcohol Depend. 2014 Oct 1;143:29-35. doi: 10.1016/j.drugalcdep.2014.04.030. Epub 2014 Jul 10. PubMed PMID: 25108585; PubMed Central PMCID: PMC4358761.
Thompson JL, Rosell DR, Slifstein M, Girgis RR, Xu X, Ehrlich Y, Kegeles LS, Hazlett EA, Abi-Dargham A, Siever LJ. Prefrontal dopamine D1 receptors and working memory in schizotypal personality disorder: a PET study with [¹¹C]NNC112. Psychopharmacology (Berl). 2014 Oct;231(21):4231-40. doi: 10.1007/s00213-014-3566-6. Epub 2014 Apr 30. PubMed PMID: 24781514; PubMed Central PMCID: PMC4194223.
Hwang DR, Hu E, Rumfelt S, Easwaramoorthy B, Castrillon J, Davis C, Allen JR, Chen H, Treanor J, Abi-Dargham A, Slifstein M. Initial characterization of a PDE10A selective positron emission tomography tracer [11C]AMG 7980 in non-human primates. Nucl Med Biol. 2014 Apr;41(4):343-9. doi: 10.1016/j.nucmedbio.2014.01.007. Epub 2014 Jan 17. PubMed PMID: 24607437.
Martinez D, Slifstein M, Nabulsi N, Grassetti A, Urban NB, Perez A, Liu F, Lin SF, Ropchan J, Mao X, Kegeles LS, Shungu DC, Carson RE, Huang Y. Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopy. Biol Psychiatry. 2014 Jan 15;75(2):165-71. doi: 10.1016/j.biopsych.2013.06.026. Epub 2013 Sep 12. PubMed PMID: 24035345; PubMed Central PMCID: PMC4106018.
Ravan S, Martinez D, Slifstein M, Abi-Dargham A. Molecular imaging in alcohol dependence. Handb Clin Neurol. 2014;125:293-311. doi: 10.1016/B978-0-444-62619-6.00018-5. Review. PubMed PMID: 25307582.
Poels EM, Kegeles LS, Kantrowitz JT, Slifstein M, Javitt DC, Lieberman JA, Abi-Dargham A, Girgis RR. Imaging glutamate in schizophrenia: review of findings and implications for drug discovery. Mol Psychiatry. 2014 Jan;19(1):20-9. doi: 10.1038/mp.2013.136. Epub 2013 Oct 29. Review. PubMed PMID: 24166406.
Thompson JL, Urban N, Slifstein M, Xu X, Kegeles LS, Girgis RR, Beckerman Y, Harkavy-Friedman JM, Gil R, Abi-Dargham A. Striatal dopamine release in schizophrenia comorbid with substance dependence. Mol Psychiatry. 2013 Aug;18(8):909-15. doi: 10.1038/mp.2012.109. Epub 2012 Aug 7. PubMed PMID: 22869037; PubMed Central PMCID: PMC4128915.
Comley RA, Salinas CA, Slifstein M, Petrone M, Marzano C, Bennacef I, Shotbolt P, Van der Aart J, Neve M, Iavarone L, Gomeni R, Laruelle M, Gray FA, Gunn RN, Rabiner EA. Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography. J Pharmacol Exp Ther. 2013 Aug;346(2):311-7. doi: 10.1124/jpet.112.202895. Epub 2013 May 17. PubMed PMID: 23685546.
Poels EM, Girgis RR, Thompson JL, Slifstein M, Abi-Dargham A. In vivo binding of the dopamine-1 receptor PET tracers [¹¹C]NNC112 and [¹¹C]SCH23390: a comparison study in individuals with schizophrenia. Psychopharmacology (Berl). 2013 Jul;228(1):167-74. doi: 10.1007/s00213-013-3026-8. Epub 2013 Mar 5. PubMed PMID: 23460265.
Simpson HB, Shungu DC, Bender J Jr, Mao X, Xu X, Slifstein M, Kegeles LS. Investigation of cortical glutamate-glutamine and γ-aminobutyric acid in obsessive-compulsive disorder by proton magnetic resonance spectroscopy. Neuropsychopharmacology. 2012 Nov;37(12):2684-92. doi: 10.1038/npp.2012.132. Epub 2012 Aug 1. PubMed PMID: 22850733; PubMed Central PMCID: PMC3473334.
Howes OD, Kambeitz J, Kim E, Stahl D, Slifstein M, Abi-Dargham A, Kapur S. The nature of dopamine dysfunction in schizophrenia and what this means for treatment. Arch Gen Psychiatry. 2012 Aug;69(8):776-86. doi: 10.1001/archgenpsychiatry.2012.169. PubMed PMID: 22474070; PubMed Central PMCID: PMC3730746.
Broft A, Shingleton R, Kaufman J, Liu F, Kumar D, Slifstein M, Abi-Dargham A, Schebendach J, Van Heertum R, Attia E, Martinez D, Walsh BT. Striatal dopamine in bulimia nervosa: a PET imaging study. Int J Eat Disord. 2012 Jul;45(5):648-56. doi: 10.1002/eat.20984. Epub 2012 Feb 13. PubMed PMID: 22331810; PubMed Central PMCID: PMC3640453.
Abi-Dargham A, Xu X, Thompson JL, Gil R, Kegeles LS, Urban N, Narendran R, Hwang DR, Laruelle M, Slifstein M. Increased prefrontal cortical D₁ receptors in drug naive patients with schizophrenia: a PET study with [¹¹C]NNC112. J Psychopharmacol. 2012 Jun;26(6):794-805. doi: 10.1177/0269881111409265. Epub 2011 Jul 18. PubMed PMID: 21768159.
Gallezot JD, Beaver JD, Gunn RN, Nabulsi N, Weinzimmer D, Singhal T, Slifstein M, Fowles K, Ding YS, Huang Y, Laruelle M, Carson RE, Rabiner EA. Affinity and selectivity of [¹¹C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo. Synapse. 2012 Jun;66(6):489-500. doi: 10.1002/syn.21535. Epub 2012 Feb 24. PubMed PMID: 22213512.
Kegeles LS, Mao X, Stanford AD, Girgis R, Ojeil N, Xu X, Gil R, Slifstein M, Abi-Dargham A, Lisanby SH, Shungu DC. Elevated prefrontal cortex γ-aminobutyric acid and glutamate-glutamine levels in schizophrenia measured in vivo with proton magnetic resonance spectroscopy. Arch Gen Psychiatry. 2012 May;69(5):449-59. doi: 10.1001/archgenpsychiatry.2011.1519. Epub 2012 Jan 2. PubMed PMID: 22213769; NIHMSID:NIHMS352541.
Urban NB, Slifstein M, Meda S, Xu X, Ayoub R, Medina O, Pearlson GD, Krystal JH, Abi-Dargham A. Imaging human reward processing with positron emission tomography and functional magnetic resonance imaging. Psychopharmacology (Berl). 2012 May;221(1):67-77. doi: 10.1007/s00213-011-2543-6. Epub 2011 Nov 4. PubMed PMID: 22052081.
Urban NB, Girgis RR, Talbot PS, Kegeles LS, Xu X, Frankle WG, Hart CL, Slifstein M, Abi-Dargham A, Laruelle M. Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907. Neuropsychopharmacology. 2012 May;37(6):1465-73. doi: 10.1038/npp.2011.332. Epub 2012 Feb 22. PubMed PMID: 22353758; PubMed Central PMCID: PMC3327851.
Urban NB, Slifstein M, Thompson JL, Xu X, Girgis RR, Raheja S, Haney M, Abi-Dargham A. Dopamine release in chronic cannabis users: a [11c]raclopride positron emission tomography study. Biol Psychiatry. 2012 Apr 15;71(8):677-83. doi: 10.1016/j.biopsych.2011.12.018. Epub 2012 Jan 29. PubMed PMID: 22290115; PubMed Central PMCID: PMC3314125.
Parker CA, Gunn RN, Rabiner EA, Slifstein M, Comley R, Salinas C, Johnson CN, Jakobsen S, Houle S, Laruelle M, Cunningham VJ, Martarello L. Radiosynthesis and characterization of 11C-GSK215083 as a PET radioligand for the 5-HT6 receptor. J Nucl Med. 2012 Feb;53(2):295-303. doi: 10.2967/jnumed.111.093419. Epub 2012 Jan 5. PubMed PMID: 22223878.
Martinez D, Saccone PA, Liu F, Slifstein M, Orlowska D, Grassetti A, Cook S, Broft A, Van Heertum R, Comer SD. Deficits in dopamine D(2) receptors and presynaptic dopamine in heroin dependence: commonalities and differences with other types of addiction. Biol Psychiatry. 2012 Feb 1;71(3):192-8. doi: 10.1016/j.biopsych.2011.08.024. Epub 2011 Oct 19. PubMed PMID: 22015315; PubMed Central PMCID: PMC3253988.
Talbot PS, Slifstein M, Hwang DR, Huang Y, Scher E, Abi-Dargham A, Laruelle M. Extended characterisation of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in humans: quantitative analysis, test-retest reproducibility, and vulnerability to endogenous 5-HT tone. Neuroimage. 2012 Jan 2;59(1):271-85. doi: 10.1016/j.neuroimage.2011.07.001. Epub 2011 Jul 18. PubMed PMID: 21782029; PubMed Central PMCID: PMC3195881.
Girgis RR, Slifstein M, Xu X, Frankle WG, Anagnostou E, Wasserman S, Pepa L, Kolevzon A, Abi-Dargham A, Laruelle M, Hollander E. The 5-HT(2A) receptor and serotonin transporter in Asperger's disorder: A PET study with [¹¹C]MDL 100907 and [¹¹C]DASB. Psychiatry Res. 2011 Dec 30;194(3):230-234. doi: 10.1016/j.pscychresns.2011.04.007. Epub 2011 Nov 12. PubMed PMID: 22079057; PubMed Central PMCID: PMC3225493.
Gunn RN, Murthy V, Catafau AM, Searle G, Bullich S, Slifstein M, Ouellet D, Zamuner S, Herance R, Salinas C, Pardo-Lozano R, Rabiner EA, Farre M, Laruelle M. Translational characterization of [11C]GSK931145, a PET ligand for the glycine transporter type 1. Synapse. 2011 Dec;65(12):1319-32. doi: 10.1002/syn.20966. Epub 2011 Aug 12. PubMed PMID: 21688322.
Simpson HB, Slifstein M, Bender J Jr, Xu X, Hackett E, Maher MJ, Abi-Dargham A. Serotonin 2A receptors in obsessive-compulsive disorder: a positron emission tomography study with [11C]MDL 100907. Biol Psychiatry. 2011 Nov 1;70(9):897-904. doi: 10.1016/j.biopsych.2011.06.023. PubMed PMID: 21855857; PubMed Central PMCID: PMC3951757.
Ridler K, Plisson C, Rabiner EA, Gunn RN, Easwaramoorthy B, Abi-Dargham A, Laruelle M, Slifstein M. Characterization of in vivo pharmacological properties and sensitivity to endogenous serotonin of [11C] P943: a positron emission tomography study in Papio anubis. Synapse. 2011 Nov;65(11):1119-27. doi: 10.1002/syn.20946. Epub 2011 May 19. PubMed PMID: 21538549.
Bullich S, Slifstein M, Passchier J, Murthy NV, Kegeles LS, Kim JH, Xu X, Gunn RN, Herance R, Gispert JD, Gutiérrez A, Farré M, Laruelle M, Catafau AM. Biodistribution and radiation dosimetry of the glycine transporter-1 ligand 11C-GSK931145 determined from primate and human whole-body PET. Mol Imaging Biol. 2011 Aug;13(4):776-84. doi: 10.1007/s11307-010-0398-6. PubMed PMID: 20730499.
Martinez D, Carpenter KM, Liu F, Slifstein M, Broft A, Friedman AC, Kumar D, Van Heertum R, Kleber HD, Nunes E. Imaging dopamine transmission in cocaine dependence: link between neurochemistry and response to treatment. Am J Psychiatry. 2011 Jun;168(6):634-41. doi: 10.1176/appi.ajp.2010.10050748. Epub 2011 Mar 15. PubMed PMID: 21406463; PubMed Central PMCID: PMC3235735.
Frankle WG, Lombardo I, Kegeles LS, Slifstein M, Martin JH, Huang Y, Hwang DR, Reich E, Cangiano C, Gil R, Abi-Dargham A, Laruelle M. Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone. J Psychopharmacol. 2011 Jun;25(6):734-43. doi: 10.1177/0269881110388329. Epub 2010 Nov 25. PubMed PMID: 21109614.
Miyake N, Skinbjerg M, Easwaramoorthy B, Kumar D, Girgis RR, Xu X, Slifstein M, Abi-Dargham A. Imaging changes in glutamate transmission in vivo with the metabotropic glutamate receptor 5 tracer [11C] ABP688 and N-acetylcysteine challenge. Biol Psychiatry. 2011 May 1;69(9):822-4. doi: 10.1016/j.biopsych.2010.12.023. Epub 2011 Feb 2. PubMed PMID: 21288506.
Girgis RR, Xu X, Miyake N, Easwaramoorthy B, Gunn RN, Rabiner EA, Abi-Dargham A, Slifstein M. In vivo binding of antipsychotics to D3 and D2 receptors: a PET study in baboons with [11C]-(+)-PHNO. Neuropsychopharmacology. 2011 Mar;36(4):887-95. doi: 10.1038/npp.2010.228. Epub 2010 Dec 22. PubMed PMID: 21178982; PubMed Central PMCID: PMC3055723.
Slifstein M, Suckow RF, Javitch JA, Cooper T, Lieberman J, Abi-Dargham A. Characterization of in vivo pharmacokinetic properties of the dopamine D1 receptor agonist DAR-0100A in nonhuman primates using PET with [11C] NNC112 and [11C] raclopride. J Cereb Blood Flow Metab. 2011 Jan;31(1):293-304. doi: 10.1038/jcbfm.2010.91. Epub 2010 Jun 23. PubMed PMID: 20571519; PubMed Central PMCID: PMC3049493.
Urban NB, Kegeles LS, Slifstein M, Xu X, Martinez D, Sakr E, Castillo F, Moadel T, O'Malley SS, Krystal JH, Abi-Dargham A. Sex differences in striatal dopamine release in young adults after oral alcohol challenge: a positron emission tomography imaging study with [¹¹C]raclopride. Biol Psychiatry. 2010 Oct 15;68(8):689-96. doi: 10.1016/j.biopsych.2010.06.005. Epub 2010 Aug 3. PubMed PMID: 20678752; PubMed Central PMCID: PMC2949533.
Kegeles LS, Slifstein M, Xu X, Urban N, Thompson JL, Moadel T, Harkavy-Friedman JM, Gil R, Laruelle M, Abi-Dargham A. Striatal and extrastriatal dopamine D2/D3 receptors in schizophrenia evaluated with [18F]fallypride positron emission tomography. Biol Psychiatry. 2010 Oct 1;68(7):634-41. doi: 10.1016/j.biopsych.2010.05.027. Epub 2010 Jul 31. PubMed PMID: 20673873; PubMed Central PMCID: PMC2952433.
Searle G, Beaver JD, Comley RA, Bani M, Tziortzi A, Slifstein M, Mugnaini M, Griffante C, Wilson AA, Merlo-Pich E, Houle S, Gunn R, Rabiner EA, Laruelle M. Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist. Biol Psychiatry. 2010 Aug 15;68(4):392-9. doi: 10.1016/j.biopsych.2010.04.038. PubMed PMID: 20599188.
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