My Bibliography

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Willems E, Mercola M. What your heart doth know. Cell Stem Cell. 2011 Feb 4;8(2):124-6. doi: 10.1016/j.stem.2011.01.003. PubMed PMID: 21295266; PubMed Central PMCID: PMC3057384.

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Cao X, Weil MM, Wu JC. Clinical Trial in a Dish for Space Radiation Countermeasure Discovery. Life Sci Space Res (Amst). 2022 Nov;35:140-149. doi: 10.1016/j.lssr.2022.05.006. Epub 2022 May 27. Review. PubMed PMID: 36336359; PubMed Central PMCID: PMC10947779.

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Liu W, Zeng W, Kong X, Htet M, Yu R, Wheeler M, Day JW, Wu JC. Generation of two induced pluripotent stem cell lines from Duchenne muscular dystrophy patients. Stem Cell Res. 2023 Oct;72:103207. doi: 10.1016/j.scr.2023.103207. Epub 2023 Sep 18. PubMed PMID: 37740996; PubMed Central PMCID: PMC10949967.

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Cao X, Thomas D, Whitcomb LA, Wang M, Chatterjee A, Chicco AJ, Weil MM, Wu JC. Modeling ionizing radiation-induced cardiovascular dysfunction with human iPSC-derived engineered heart tissues. J Mol Cell Cardiol. 2024 Mar;188:105-107. doi: 10.1016/j.yjmcc.2023.11.012. Epub 2024 Feb 29. PubMed PMID: 38431383; PubMed Central PMCID: PMC10961094.

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Wood EH, Kreymerman A, Kowal T, Buickians D, Sun Y, Muscat S, Mercola M, Moshfeghi DM, Goldberg JL. Cellular and subcellular optogenetic approaches towards neuroprotection and vision restoration. Prog Retin Eye Res. 2023 Sep;96:101153. doi: 10.1016/j.preteyeres.2022.101153. Epub 2022 Dec 8. Review. PubMed PMID: 36503723; PubMed Central PMCID: PMC10247900.

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Melesio J, Bonilauri B, Li A, Pang PD, Liao R, Witteles RM, Wu JC, Sallam K. Generation of two induced pluripotent stem cell lines from hereditary amyloidosis patients with polyneuropathy carrying heterozygous transthyretin (TTR) mutation. Stem Cell Res. 2024 Feb;74:103265. doi: 10.1016/j.scr.2023.103265. Epub 2023 Nov 29. PubMed PMID: 38100909; PubMed Central PMCID: PMC10883469.

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Bonilauri B, Shin HS, Htet M, Yan CD, Witteles RM, Sallam K, Wu JC. Generation of two induced pluripotent stem cell lines from patients with cardiac amyloidosis carrying heterozygous transthyretin (TTR) mutation. Stem Cell Res. 2023 Oct;72:103215. doi: 10.1016/j.scr.2023.103215. Epub 2023 Sep 27. PubMed PMID: 37788558; PubMed Central PMCID: PMC10821799.

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Han D, Wu JC. Using Bioengineered Bioluminescence to Track Stem Cell Transplantation In Vivo. Methods Mol Biol. 2020;2126:1-11. doi: 10.1007/978-1-0716-0364-2_1. PubMed PMID: 32112374; PubMed Central PMCID: PMC10902212.

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Khokhar Y, Bhowmik A, Rui Zhao S, Cook Z, Nallamshetty S, Wu JC. Generation of induced pluripotent stem cell lines from South Asian ethnicity. Stem Cell Res. 2024 Feb;74:103272. doi: 10.1016/j.scr.2023.103272. Epub 2023 Dec 7. PubMed PMID: 38100915; PubMed Central PMCID: PMC10902214.

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Liu C, Shen M, Tan WLW, Chen IY, Liu Y, Yu X, Yang H, Zhang A, Liu Y, Zhao MT, Ameen M, Zhang M, Gross ER, Qi LS, Sayed N, Wu JC. Statins improve endothelial function via suppression of epigenetic-driven EndMT. Nat Cardiovasc Res. 2023 May;2(5):467-485. doi: 10.1038/s44161-023-00267-1. Epub 2023 May 8. PubMed PMID: 37693816; PubMed Central PMCID: PMC10489108.

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Guo H, Yu X, Liu Y, Paik DT, Justesen JM, Chandy M, Jahng JWS, Zhang T, Wu W, Rwere F, Zhao SR, Pokhrel S, Shivnaraine RV, Mukherjee S, Simon DJ, Manhas A, Zhang A, Chen CH, Rivas MA, Gross ER, Mochly-Rosen D, Wu JC. SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant. Sci Transl Med. 2023 Jan 25;15(680):eabp9952. doi: 10.1126/scitranslmed.abp9952. Epub 2023 Jan 25. PubMed PMID: 36696485; PubMed Central PMCID: PMC10297796.

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Zushin PH, Zhou Y, Li A, Ashley EA, Wheeler MT, Wu JC. Generation of two human iPSC lines with Exon 3 mutations in BCL2-Associated Athanogene 3 (BAG3) from dilated cardiomyopathy patients. Stem Cell Res. 2023 Mar;67:103019. doi: 10.1016/j.scr.2023.103019. Epub 2023 Jan 5. PubMed PMID: 36642055; PubMed Central PMCID: PMC10042224.

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Serrano R, Feyen DAM, Bruyneel AAN, Hnatiuk AP, Vu MM, Amatya PL, Perea-Gil I, Prado M, Seeger T, Wu JC, Karakikes I, Mercola M. A deep learning platform to assess drug proarrhythmia risk. Cell Stem Cell. 2023 Jan 5;30(1):86-95.e4. doi: 10.1016/j.stem.2022.12.002. Epub 2022 Dec 22. PubMed PMID: 36563695; PubMed Central PMCID: PMC9924077.

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Shen M, Liu C, Zhao SR, Manhas A, Sundaram L, Ameen M, Wu JC. Stepwise Generation of Human Induced Pluripotent Stem Cell-Derived Cardiac Pericytes to Model Coronary Microvascular Dysfunction. Circulation. 2023 Feb 7;147(6):515-518. doi: 10.1161/CIRCULATIONAHA.122.061770. Epub 2023 Feb 6. PubMed PMID: 36745700; PubMed Central PMCID: PMC9909621.

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Chen IY, Olshausen J, Thomas D, Lai C, McLaughlin TL, Wu JC. Generation of three induced pluripotent stem cell lines to model and investigate diseases affecting Hispanics. Stem Cell Res. 2022 Dec;65:102969. doi: 10.1016/j.scr.2022.102969. Epub 2022 Nov 14. PubMed PMID: 36427473; PubMed Central PMCID: PMC10082602.

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Shen M, Liu C, Wu JC. Generation of Embryonic Origin-Specific Vascular Smooth Muscle Cells from Human Induced Pluripotent Stem Cells. Methods Mol Biol. 2022;2429:233-246. doi: 10.1007/978-1-0716-1979-7_15. PubMed PMID: 35507165; PubMed Central PMCID: PMC9667909.

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Caudal A, Ren L, Tu C, Wu JC. Human induced pluripotent stem cells for studying mitochondrial diseases in the heart. FEBS Lett. 2022 Jul;596(14):1735-1745. doi: 10.1002/1873-3468.14444. Epub 2022 Jul 11. Review. PubMed PMID: 35788991; PubMed Central PMCID: PMC9668541.

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Vincent F, Nueda A, Lee J, Schenone M, Prunotto M, Mercola M. Phenotypic drug discovery: recent successes, lessons learned and new directions. Nat Rev Drug Discov. 2022 Dec;21(12):899-914. doi: 10.1038/s41573-022-00472-w. Epub 2022 May 30. Review. PubMed PMID: 35637317; PubMed Central PMCID: PMC9708951.

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Hnatiuk AP, Bruyneel AAN, Tailor D, Pandrala M, Dheeraj A, Li W, Serrano R, Feyen DAM, Vu MM, Amatya P, Gupta S, Nakauchi Y, Morgado I, Wiebking V, Liao R, Porteus MH, Majeti R, Malhotra SV, Mercola M. Reengineering Ponatinib to Minimize Cardiovascular Toxicity. Cancer Res. 2022 Aug 3;82(15):2777-2791. doi: 10.1158/0008-5472.CAN-21-3652. PubMed PMID: 35763671; PubMed Central PMCID: PMC9620869.

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Jung JH, Ikeda G, Tada Y, von Bornstädt D, Santoso MR, Wahlquist C, Rhee S, Jeon YJ, Yu AC, O'brien CG, Red-Horse K, Appel EA, Mercola M, Woo J, Yang PC. miR-106a-363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury. Basic Res Cardiol. 2021 Mar 19;116(1):19. doi: 10.1007/s00395-021-00858-8. PubMed PMID: 33742276; PubMed Central PMCID: PMC8601755.

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Cho S, Lee C, Skylar-Scott MA, Heilshorn SC, Wu JC. Reconstructing the heart using iPSCs: Engineering strategies and applications. J Mol Cell Cardiol. 2021 Aug;157:56-65. doi: 10.1016/j.yjmcc.2021.04.006. Epub 2021 Apr 22. Review. PubMed PMID: 33895197; PubMed Central PMCID: PMC8378256.

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Feyen DAM, Perea-Gil I, Maas RGC, Harakalova M, Gavidia AA, Arthur Ataam J, Wu TH, Vink A, Pei J, Vadgama N, Suurmeijer AJ, Te Rijdt WP, Vu M, Amatya PL, Prado M, Zhang Y, Dunkenberger L, Sluijter JPG, Sallam K, Asselbergs FW, Mercola M, Karakikes I. Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy. Circulation. 2021 Aug 3;144(5):382-392. doi: 10.1161/CIRCULATIONAHA.120.049844. Epub 2021 Apr 30. PubMed PMID: 33928785; PubMed Central PMCID: PMC8667423.

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Jahng JWS, Zhang M, Wu JC. The role of metabolism in directed differentiation versus trans-differentiation of cardiomyocytes. Semin Cell Dev Biol. 2022 Feb;122:56-65. doi: 10.1016/j.semcdb.2021.05.018. Epub 2021 May 29. Review. PubMed PMID: 34074592; PubMed Central PMCID: PMC8725317.

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Sato D, Uchinoumi H, Bers DM. Increasing SERCA function promotes initiation of calcium sparks and breakup of calcium waves. J Physiol. 2021 Jul;599(13):3267-3278. doi: 10.1113/JP281579. Epub 2021 Jun 5. PubMed PMID: 33963531; PubMed Central PMCID: PMC8249358.

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Briganti F, Sun H, Wei W, Wu J, Zhu C, Liss M, Karakikes I, Rego S, Cipriano A, Snyder M, Meder B, Xu Z, Millat G, Gotthardt M, Mercola M, Steinmetz LM. iPSC Modeling of RBM20-Deficient DCM Identifies Upregulation of RBM20 as a Therapeutic Strategy. Cell Rep. 2020 Sep 8;32(10):108117. doi: 10.1016/j.celrep.2020.108117. PubMed PMID: 32905764; PubMed Central PMCID: PMC8168789.

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Hegyi B, Fasoli A, Ko CY, Van BW, Alim CC, Shen EY, Ciccozzi MM, Tapa S, Ripplinger CM, Erickson JR, Bossuyt J, Bers DM. CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia. Circ Res. 2021 Jun 25;129(1):98-113. doi: 10.1161/CIRCRESAHA.120.318402. Epub 2021 Apr 30. PubMed PMID: 33926209; PubMed Central PMCID: PMC8221539.

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Hnatiuk AP, Briganti F, Staudt DW, Mercola M. Human iPSC modeling of heart disease for drug development. Cell Chem Biol. 2021 Mar 18;28(3):271-282. doi: 10.1016/j.chembiol.2021.02.016. Review. PubMed PMID: 33740432; PubMed Central PMCID: PMC8054828.

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Shen M, Quertermous T, Fischbein MP, Wu JC. Generation of Vascular Smooth Muscle Cells From Induced Pluripotent Stem Cells: Methods, Applications, and Considerations. Circ Res. 2021 Mar 5;128(5):670-686. doi: 10.1161/CIRCRESAHA.120.318049. Epub 2021 Mar 4. Review. PubMed PMID: 33818124; PubMed Central PMCID: PMC10817206.

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Cheng J, Tsuda M, Okolotowicz K, Dwyer M, Bushway PJ, Colas AR, Lancman JJ, Schade D, Perea-Gil I, Bruyneel AAN, Lee J, Vadgama N, Quach J, McKeithan WL, Biechele TL, Wu JC, Moon RT, Si Dong PD, Karakikes I, Cashman JR, Mercola M. Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness. Cell Chem Biol. 2021 May 20;28(5):625-635.e5. doi: 10.1016/j.chembiol.2021.01.001. Epub 2021 Jan 26. PubMed PMID: 33503403; PubMed Central PMCID: PMC8140986.

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Paige SL, Galdos FX, Lee S, Chin ET, Ranjbarvaziri S, Feyen DAM, Darsha AK, Xu S, Ryan JA, Beck AL, Qureshi MY, Miao Y, Gu M, Bernstein D, Nelson TJ, Mercola M, Rabinovitch M, Ashley EA, Parikh VN, Wu SM. Patient-Specific Induced Pluripotent Stem Cells Implicate Intrinsic Impaired Contractility in Hypoplastic Left Heart Syndrome. Circulation. 2020 Oct 20;142(16):1605-1608. doi: 10.1161/CIRCULATIONAHA.119.045317. Epub 2020 Oct 19. PubMed PMID: 33074758; PubMed Central PMCID: PMC7583658.

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McKeithan WL, Feyen DAM, Bruyneel AAN, Okolotowicz KJ, Ryan DA, Sampson KJ, Potet F, Savchenko A, Gómez-Galeno J, Vu M, Serrano R, George AL Jr, Kass RS, Cashman JR, Mercola M. Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity. Cell Stem Cell. 2020 Nov 5;27(5):813-821.e6. doi: 10.1016/j.stem.2020.08.003. Epub 2020 Sep 14. PubMed PMID: 32931730; PubMed Central PMCID: PMC7655512.

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Feyen DAM, McKeithan WL, Bruyneel AAN, Spiering S, Hörmann L, Ulmer B, Zhang H, Briganti F, Schweizer M, Hegyi B, Liao Z, Pölönen RP, Ginsburg KS, Lam CK, Serrano R, Wahlquist C, Kreymerman A, Vu M, Amatya PL, Behrens CS, Ranjbarvaziri S, Maas RGC, Greenhaw M, Bernstein D, Wu JC, Bers DM, Eschenhagen T, Metallo CM, Mercola M. Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes. Cell Rep. 2020 Jul 21;32(3):107925. doi: 10.1016/j.celrep.2020.107925. PubMed PMID: 32697997; PubMed Central PMCID: PMC7437654.

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Lu S, Liao Z, Lu X, Katschinski DM, Mercola M, Chen J, Heller Brown J, Molkentin JD, Bossuyt J, Bers DM. Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O-linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes. Circ Res. 2020 May 8;126(10):e80-e96. doi: 10.1161/CIRCRESAHA.119.316288. Epub 2020 Mar 5. PubMed PMID: 32134364; PubMed Central PMCID: PMC7210078.

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Fang MY, Markmiller S, Vu AQ, Javaherian A, Dowdle WE, Jolivet P, Bushway PJ, Castello NA, Baral A, Chan MY, Linsley JW, Linsley D, Mercola M, Finkbeiner S, Lecuyer E, Lewcock JW, Yeo GW. Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. Neuron. 2019 Sep 4;103(5):802-819.e11. doi: 10.1016/j.neuron.2019.05.048. Epub 2019 Jul 1. PubMed PMID: 31272829; PubMed Central PMCID: PMC6728177.

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Williams IM, Wu JC. Generation of Endothelial Cells From Human Pluripotent Stem Cells. Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1317-1329. doi: 10.1161/ATVBAHA.119.312265. Epub 2019 May 9. Review. PubMed PMID: 31242035; PubMed Central PMCID: PMC6597190.

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Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC. A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay. Circulation. 2019 Feb 5;139(6):799-811. doi: 10.1161/CIRCULATIONAHA.118.034624. PubMed PMID: 30586709; PubMed Central PMCID: PMC6443405.

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Gómez-Galeno JE, Hurtado C, Cheng J, Yardimci C, Mercola M, Cashman JR. b-Annulated 1,4-dihydropyridines as Notch inhibitors. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3363-3367. doi: 10.1016/j.bmcl.2018.09.002. Epub 2018 Sep 5. PubMed PMID: 30201292; PubMed Central PMCID: PMC6261437.

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Bruyneel AA, McKeithan WL, Feyen DA, Mercola M. Will iPSC-cardiomyocytes revolutionize the discovery of drugs for heart disease?. Curr Opin Pharmacol. 2018 Oct;42:55-61. doi: 10.1016/j.coph.2018.07.003. Epub 2018 Aug 3. Review. PubMed PMID: 30081259; PubMed Central PMCID: PMC6261432.

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Sharma A, McKeithan WL, Serrano R, Kitani T, Burridge PW, Del Álamo JC, Mercola M, Wu JC. Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity. Nat Protoc. 2018 Dec;13(12):3018-3041. doi: 10.1038/s41596-018-0076-8. PubMed PMID: 30413796; PubMed Central PMCID: PMC6502639.

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Diez-Cuñado M, Wei K, Bushway PJ, Maurya MR, Perera R, Subramaniam S, Ruiz-Lozano P, Mercola M. miRNAs that Induce Human Cardiomyocyte Proliferation Converge on the Hippo Pathway. Cell Rep. 2018 May 15;23(7):2168-2174. doi: 10.1016/j.celrep.2018.04.049. PubMed PMID: 29768213; PubMed Central PMCID: PMC6261450.

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Jeong D, Yoo J, Lee P, Kepreotis SV, Lee A, Wahlquist C, Brown BD, Kho C, Mercola M, Hajjar RJ. miR-25 Tough Decoy Enhances Cardiac Function in Heart Failure. Mol Ther. 2018 Mar 7;26(3):718-729. doi: 10.1016/j.ymthe.2017.11.014. Epub 2017 Nov 26. PubMed PMID: 29273502; PubMed Central PMCID: PMC5910658.

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Sharma A, Burridge PW, McKeithan WL, Serrano R, Shukla P, Sayed N, Churko JM, Kitani T, Wu H, Holmström A, Matsa E, Zhang Y, Kumar A, Fan AC, Del Álamo JC, Wu SM, Moslehi JJ, Mercola M, Wu JC. High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Sci Transl Med. 2017 Feb 15;9(377). doi: 10.1126/scitranslmed.aaf2584. PubMed PMID: 28202772; PubMed Central PMCID: PMC5409837.

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Molokanova E, Mercola M, Savchenko A. Bringing new dimensions to drug discovery screening: impact of cellular stimulation technologies. Drug Discov Today. 2017 Jul;22(7):1045-1055. doi: 10.1016/j.drudis.2017.01.015. Epub 2017 Feb 4. Review. PubMed PMID: 28179145; PubMed Central PMCID: PMC5487284.

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Liu Y, Mercola M, Schwartz RJ. The All-Chemical Approach: A Solution for Converting Fibroblasts Into Myocytes. Circ Res. 2016 Aug 5;119(4):505-7. doi: 10.1161/CIRCRESAHA.116.309146. PubMed PMID: 27492839; PubMed Central PMCID: PMC4987128.

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Del Álamo JC, Lemons D, Serrano R, Savchenko A, Cerignoli F, Bodmer R, Mercola M. High throughput physiological screening of iPSC-derived cardiomyocytes for drug development. Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1717-27. doi: 10.1016/j.bbamcr.2016.03.003. Epub 2016 Mar 4. Review. PubMed PMID: 26952934; PubMed Central PMCID: PMC4885786.

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Okolotowicz KJ, Bushway P, Lanier M, Gilley C, Mercola M, Cashman JR. 1,5-Disubstituted benzimidazoles that direct cardiomyocyte differentiation from mouse embryonic stem cells. Bioorg Med Chem. 2015 Sep 1;23(17):5282-92. doi: 10.1016/j.bmc.2015.07.073. Epub 2015 Aug 4. PubMed PMID: 26278027; PubMed Central PMCID: PMC4766108.

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Spiering S, Davidovics H, Bushway PJ, Mercola M, Willems E. High content screening for modulators of cardiac differentiation in human pluripotent stem cells. Methods Mol Biol. 2015;1263:43-61. doi: 10.1007/978-1-4939-2269-7_4. PubMed PMID: 25618335; PubMed Central PMCID: PMC4766105.

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Wei K, Serpooshan V, Hurtado C, Diez-Cuñado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P. Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature. 2015 Sep 24;525(7570):479-85. doi: 10.1038/nature15372. Epub 2015 Sep 16. PubMed PMID: 26375005; PubMed Central PMCID: PMC4762253.

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Cabral-Teixeira J, Martinez-Fernandez A, Cai W, Terzic A, Mercola M, Willems E. Cholesterol-derived glucocorticoids control early fate specification in embryonic stem cells. Stem Cell Res. 2015 Jul;15(1):88-95. doi: 10.1016/j.scr.2015.04.010. Epub 2015 May 14. PubMed PMID: 26024790; PubMed Central PMCID: PMC4516691.

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Banerjee I, Carrion K, Serrano R, Dyo J, Sasik R, Lund S, Willems E, Aceves S, Meili R, Mercola M, Chen J, Zambon A, Hardiman G, Doherty TA, Lange S, del Álamo JC, Nigam V. Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-β signaling. J Mol Cell Cardiol. 2015 Feb;79:133-44. doi: 10.1016/j.yjmcc.2014.11.003. Epub 2014 Nov 13. PubMed PMID: 25446186; PubMed Central PMCID: PMC4302020.