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Johnson CN, Pattanayek R, Potet F, Rebbeck RT, Blackwell DJ, Nikolaienko R, Sequeira V, Le Meur R, Radwański PB, Davis JP, Zima AV, Cornea RL, Damo SM, Györke S, George AL Jr, Knollmann BC. The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function. Cell Calcium. 2019 Sep;82:102063. doi: 10.1016/j.ceca.2019.102063. Epub 2019 Jul 30. PubMed PMID: 31401388; PubMed Central PMCID: PMC6708471.
Hurtado C, Safarova A, Smith M, Chung R, Bruyneel AAN, Gomez-Galeno J, Oswald F, Larson CJ, Cashman JR, Ruiz-Lozano P, Janiak P, Suzuki T, Mercola M. Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci Rep. 2019 Jul 25;9(1):10811. doi: 10.1038/s41598-019-46948-5. PubMed PMID: 31346210; PubMed Central PMCID: PMC6658660.
Wu H, Yang H, Rhee JW, Zhang JZ, Lam CK, Sallam K, Chang ACY, Ma N, Lee J, Zhang H, Blau HM, Bers DM, Wu JC. Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients. Eur Heart J. 2019 Jun 20;. doi: 10.1093/eurheartj/ehz326. [Epub ahead of print] PubMed PMID: 31219556.
Walweel K, Gomez-Hurtado N, Rebbeck RT, Oo YW, Beard NA, Molenaar P, Dos Remedios C, van Helden DF, Cornea RL, Knollmann BC, Laver DR. Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814. J Mol Cell Cardiol. 2019 May;130:96-106. doi: 10.1016/j.yjmcc.2019.03.018. Epub 2019 Mar 27. PubMed PMID: 30928430; PubMed Central PMCID: PMC6791359.
Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC. A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay. Circulation. 2019 Feb 5;139(6):799-811. doi: 10.1161/CIRCULATIONAHA.118.034624. PubMed PMID: 30586709; PubMed Central PMCID: PMC6443405.
Xie Y, Yang Y, Galice S, Bers DM, Sato D. Size Matters: Ryanodine Receptor Cluster Size Heterogeneity Potentiates Calcium Waves. Biophys J. 2019 Feb 5;116(3):530-539. doi: 10.1016/j.bpj.2018.12.017. Epub 2019 Jan 3. PubMed PMID: 30686487; PubMed Central PMCID: PMC6369574.
Sharma A, McKeithan WL, Serrano R, Kitani T, Burridge PW, Del Álamo JC, Mercola M, Wu JC. Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity. Nat Protoc. 2018 Dec;13(12):3018-3041. doi: 10.1038/s41596-018-0076-8. PubMed PMID: 30413796; PubMed Central PMCID: PMC6502639.
Oda T, Yamamoto T, Kato T, Uchinoumi H, Fukui G, Hamada Y, Nanno T, Ishiguchi H, Nakamura Y, Okamoto Y, Kono M, Okuda S, Kobayashi S, Bers DM, Yano M. Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin. J Mol Cell Cardiol. 2018 Dec;125:87-97. doi: 10.1016/j.yjmcc.2018.10.011. Epub 2018 Oct 22. PubMed PMID: 30359562; PubMed Central PMCID: PMC6402808.
Gómez-Galeno JE, Hurtado C, Cheng J, Yardimci C, Mercola M, Cashman JR. b-Annulated 1,4-dihydropyridines as Notch inhibitors. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3363-3367. doi: 10.1016/j.bmcl.2018.09.002. Epub 2018 Sep 5. PubMed PMID: 30201292; PubMed Central PMCID: PMC6261437.
Schaaf TM, Li A, Grant BD, Peterson K, Yuen S, Bawaskar P, Kleinboehl E, Li J, Thomas DD, Gillispie GD. Red-Shifted FRET Biosensors for High-Throughput Fluorescence Lifetime Screening. Biosensors (Basel). 2018 Oct 24;8(4). doi: 10.3390/bios8040099. PubMed PMID: 30352972; PubMed Central PMCID: PMC6315989.
Bruyneel AA, McKeithan WL, Feyen DA, Mercola M. Will iPSC-cardiomyocytes revolutionize the discovery of drugs for heart disease?. Curr Opin Pharmacol. 2018 Oct;42:55-61. doi: 10.1016/j.coph.2018.07.003. Epub 2018 Aug 3. Review. PubMed PMID: 30081259; PubMed Central PMCID: PMC6261432.
Bruyneel AAN, McKeithan WL, Feyen DAM, Mercola M. Using iPSC Models to Probe Regulation of Cardiac Ion Channel Function. Curr Cardiol Rep. 2018 May 25;20(7):57. doi: 10.1007/s11886-018-1000-0. Review. PubMed PMID: 29802473.
Diez-Cuñado M, Wei K, Bushway PJ, Maurya MR, Perera R, Subramaniam S, Ruiz-Lozano P, Mercola M. miRNAs that Induce Human Cardiomyocyte Proliferation Converge on the Hippo Pathway. Cell Rep. 2018 May 15;23(7):2168-2174. doi: 10.1016/j.celrep.2018.04.049. PubMed PMID: 29768213; PubMed Central PMCID: PMC6261450.
Jeong D, Yoo J, Lee P, Kepreotis SV, Lee A, Wahlquist C, Brown BD, Kho C, Mercola M, Hajjar RJ. miR-25 Tough Decoy Enhances Cardiac Function in Heart Failure. Mol Ther. 2018 Mar 7;26(3):718-729. doi: 10.1016/j.ymthe.2017.11.014. Epub 2017 Nov 26. PubMed PMID: 29273502; PubMed Central PMCID: PMC5910658.
McKeithan WL, Savchenko A, Yu MS, Cerignoli F, Bruyneel AAN, Price JH, Colas AR, Miller EW, Cashman JR, Mercola M. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol. 2017;8:766. doi: 10.3389/fphys.2017.00766. eCollection 2017. PubMed PMID: 29075196; PubMed Central PMCID: PMC5641590.
Cunningham TJ, Yu MS, McKeithan WL, Spiering S, Carrette F, Huang CT, Bushway PJ, Tierney M, Albini S, Giacca M, Mano M, Puri PL, Sacco A, Ruiz-Lozano P, Riou JF, Umbhauer M, Duester G, Mercola M, Colas AR. Id genes are essential for early heart formation. Genes Dev. 2017 Jul 1;31(13):1325-1338. doi: 10.1101/gad.300400.117. Epub 2017 Aug 9. PubMed PMID: 28794185; PubMed Central PMCID: PMC5580654.
Molokanova E, Mercola M, Savchenko A. Bringing new dimensions to drug discovery screening: impact of cellular stimulation technologies. Drug Discov Today. 2017 Jul;22(7):1045-1055. doi: 10.1016/j.drudis.2017.01.015. Epub 2017 Feb 4. Review. PubMed PMID: 28179145; PubMed Central PMCID: PMC5487284.
Ma Y, Li Q, Li A, Wei Y, Long P, Jiang X, Sun F, Weiskirchen R, Wu B, Liang C, Grötzinger J, Wei Y, Yu W, Mercola M, Huang Y, Wang J, Yu Y, Schwartz RJ. The CSRP2BP histone acetyltransferase drives smooth muscle gene expression. Nucleic Acids Res. 2017 Apr 7;45(6):3046-3058. doi: 10.1093/nar/gkw1227. PubMed PMID: 27940555; PubMed Central PMCID: PMC5389687.
Crespo R, Wei K, Rodenak-Kladniew B, Mercola M, Ruiz-Lozano P, Hurtado C. Effect of geraniol on rat cardiomyocytes and its potential use as a cardioprotective natural compound. Life Sci. 2017 Mar 1;172:8-12. doi: 10.1016/j.lfs.2017.01.008. Epub 2017 Jan 25. PubMed PMID: 28131760.
Sharma A, Burridge PW, McKeithan WL, Serrano R, Shukla P, Sayed N, Churko JM, Kitani T, Wu H, Holmström A, Matsa E, Zhang Y, Kumar A, Fan AC, Del Álamo JC, Wu SM, Moslehi JJ, Mercola M, Wu JC. High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Sci Transl Med. 2017 Feb 15;9(377). doi: 10.1126/scitranslmed.aaf2584. PubMed PMID: 28202772; PubMed Central PMCID: PMC5409837.
Shen X, Soibam B, Benham A, Xu X, Chopra M, Peng X, Yu W, Bao W, Liang R, Azares A, Liu P, Gunaratne PH, Mercola M, Cooney AJ, Schwartz RJ, Liu Y. miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9551-6. doi: 10.1073/pnas.1608256113. Epub 2016 Aug 10. PubMed PMID: 27512039; PubMed Central PMCID: PMC5003281.
Liu Y, Mercola M, Schwartz RJ. The All-Chemical Approach: A Solution for Converting Fibroblasts Into Myocytes. Circ Res. 2016 Aug 5;119(4):505-7. doi: 10.1161/CIRCRESAHA.116.309146. PubMed PMID: 27492839; PubMed Central PMCID: PMC4987128.
Del Álamo JC, Lemons D, Serrano R, Savchenko A, Cerignoli F, Bodmer R, Mercola M. High throughput physiological screening of iPSC-derived cardiomyocytes for drug development. Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1717-27. doi: 10.1016/j.bbamcr.2016.03.003. Epub 2016 Mar 4. Review. PubMed PMID: 26952934; PubMed Central PMCID: PMC4885786.
Díaz-Trelles R, Scimia MC, Bushway P, Tran D, Monosov A, Monosov E, Peterson K, Rentschler S, Cabrales P, Ruiz-Lozano P, Mercola M. Notch-independent RBPJ controls angiogenesis in the adult heart. Nat Commun. 2016 Jun 30;7:12088. doi: 10.1038/ncomms12088. PubMed PMID: 27357444; PubMed Central PMCID: PMC4931341.
Zaretski AV, Root SE, Savchenko A, Molokanova E, Printz AD, Jibril L, Arya G, Mercola M, Lipomi DJ. Metallic Nanoislands on Graphene as Highly Sensitive Transducers of Mechanical, Biological, and Optical Signals. Nano Lett. 2016 Feb 10;16(2):1375-80. doi: 10.1021/acs.nanolett.5b04821. Epub 2016 Jan 14. PubMed PMID: 26765039; PubMed Central PMCID: PMC4751512.
Wei K, Serpooshan V, Hurtado C, Diez-Cuñado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P. Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature. 2015 Sep 24;525(7570):479-85. doi: 10.1038/nature15372. Epub 2015 Sep 16. PubMed PMID: 26375005; PubMed Central PMCID: PMC4762253.
Cunningham TJ, Brade T, Sandell LL, Lewandoski M, Trainor PA, Colas A, Mercola M, Duester G. Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis. PLoS One. 2015;10(9):e0137894. doi: 10.1371/journal.pone.0137894. eCollection 2015. PubMed PMID: 26368825; PubMed Central PMCID: PMC4569375.
Okolotowicz KJ, Bushway P, Lanier M, Gilley C, Mercola M, Cashman JR. 1,5-Disubstituted benzimidazoles that direct cardiomyocyte differentiation from mouse embryonic stem cells. Bioorg Med Chem. 2015 Sep 1;23(17):5282-92. doi: 10.1016/j.bmc.2015.07.073. Epub 2015 Aug 4. PubMed PMID: 26278027; PubMed Central PMCID: PMC4766108.
Wei K, Díaz-Trelles R, Liu Q, Diez-Cuñado M, Scimia MC, Cai W, Sawada J, Komatsu M, Boyle JJ, Zhou B, Ruiz-Lozano P, Mercola M. Developmental origin of age-related coronary artery disease. Cardiovasc Res. 2015 Jul 15;107(2):287-94. doi: 10.1093/cvr/cvv167. Epub 2015 Jun 8. PubMed PMID: 26054850; PubMed Central PMCID: PMC4565989.
Cabral-Teixeira J, Martinez-Fernandez A, Cai W, Terzic A, Mercola M, Willems E. Cholesterol-derived glucocorticoids control early fate specification in embryonic stem cells. Stem Cell Res. 2015 Jul;15(1):88-95. doi: 10.1016/j.scr.2015.04.010. Epub 2015 May 14. PubMed PMID: 26024790; PubMed Central PMCID: PMC4516691.
Banerjee I, Carrion K, Serrano R, Dyo J, Sasik R, Lund S, Willems E, Aceves S, Meili R, Mercola M, Chen J, Zambon A, Hardiman G, Doherty TA, Lange S, del Álamo JC, Nigam V. Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-β signaling. J Mol Cell Cardiol. 2015 Feb;79:133-44. doi: 10.1016/j.yjmcc.2014.11.003. Epub 2014 Nov 13. PubMed PMID: 25446186; PubMed Central PMCID: PMC4302020.
Spiering S, Davidovics H, Bushway PJ, Mercola M, Willems E. High content screening for modulators of cardiac differentiation in human pluripotent stem cells. Methods Mol Biol. 2015;1263:43-61. doi: 10.1007/978-1-4939-2269-7_4. PubMed PMID: 25618335; PubMed Central PMCID: PMC4766105.
Gupta S, Kim SM, Wang Y, Dinasarapu AR, Subramaniam S. Statistical insights into major human muscular diseases. Hum Mol Genet. 2014 Jul 15;23(14):3772-8. doi: 10.1093/hmg/ddu090. Epub 2014 Feb 25. PubMed PMID: 24569163; PubMed Central PMCID: PMC4415066.
Reineke EL, Benham A, Soibam B, Stashi E, Taegtmeyer H, Entman ML, Schwartz RJ, O'Malley BW. Steroid receptor coactivator-2 is a dual regulator of cardiac transcription factor function. J Biol Chem. 2014 Jun 20;289(25):17721-31. doi: 10.1074/jbc.M113.539908. Epub 2014 May 8. PubMed PMID: 24811170; PubMed Central PMCID: PMC4067206.
Wahlquist C, Jeong D, Rojas-Muñoz A, Kho C, Lee A, Mitsuyama S, van Mil A, Park WJ, Sluijter JP, Doevendans PA, Hajjar RJ, Mercola M. Inhibition of miR-25 improves cardiac contractility in the failing heart. Nature. 2014 Apr 24;508(7497):531-5. doi: 10.1038/nature13073. Epub 2014 Mar 12. PubMed PMID: 24670661; PubMed Central PMCID: PMC4131725.
Saccone V, Consalvi S, Giordani L, Mozzetta C, Barozzi I, Sandoná M, Ryan T, Rojas-Muñoz A, Madaro L, Fasanaro P, Borsellino G, De Bardi M, Frigè G, Termanini A, Sun X, Rossant J, Bruneau BG, Mercola M, Minucci S, Puri PL. HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles. Genes Dev. 2014 Apr 15;28(8):841-57. doi: 10.1101/gad.234468.113. Epub 2014 Mar 28. PubMed PMID: 24682306; PubMed Central PMCID: PMC4003277.
Willems E, Mercola M. Reprogramming the cardiac field. Circ Res. 2014 Jan 31;114(3):409-11. doi: 10.1161/CIRCRESAHA.113.302946. PubMed PMID: 24481840; PubMed Central PMCID: PMC4046860.
Bhargava V, Head SR, Ordoukhanian P, Mercola M, Subramaniam S. Technical variations in low-input RNA-seq methodologies. Sci Rep. 2014 Jan 14;4:3678. doi: 10.1038/srep03678. PubMed PMID: 24419370; PubMed Central PMCID: PMC3890974.
Cai W, Albini S, Wei K, Willems E, Guzzo RM, Tsuda M, Giordani L, Spiering S, Kurian L, Yeo GW, Puri PL, Mercola M. Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment. Genes Dev. 2013 Nov 1;27(21):2332-44. doi: 10.1101/gad.225144.113. PubMed PMID: 24186978; PubMed Central PMCID: PMC3828519.
Willems E, Mercola M. Jumonji and cardiac fate. Circ Res. 2013 Sep 13;113(7):837-9. doi: 10.1161/CIRCRESAHA.113.302202. PubMed PMID: 24030015; PubMed Central PMCID: PMC3974910.
Lemons D, Maurya MR, Subramaniam S, Mercola M. Developing microRNA screening as a functional genomics tool for disease research. Front Physiol. 2013;4:223. doi: 10.3389/fphys.2013.00223. eCollection 2013. PubMed PMID: 23986717; PubMed Central PMCID: PMC3753477.
Mercola M, Colas A, Willems E. Induced pluripotent stem cells in cardiovascular drug discovery. Circ Res. 2013 Feb 1;112(3):534-48. doi: 10.1161/CIRCRESAHA.111.250266. Review. PubMed PMID: 23371902; PubMed Central PMCID: PMC3706265.
Bhargava V, Ko P, Willems E, Mercola M, Subramaniam S. Quantitative transcriptomics using designed primer-based amplification. Sci Rep. 2013;3:1740. doi: 10.1038/srep01740. PubMed PMID: 23624976; PubMed Central PMCID: PMC3638165.
Mercola M. Cardiovascular biology: A boost for heart regeneration. Nature. 2012 Dec 20;492(7429):360-2. doi: 10.1038/nature11763. Epub 2012 Dec 5. PubMed PMID: 23222522.
Puri PL, Mercola M. BAF60 A, B, and Cs of muscle determination and renewal. Genes Dev. 2012 Dec 15;26(24):2673-83. doi: 10.1101/gad.207415.112. Epub 2012 Dec 7. Review. PubMed PMID: 23222103; PubMed Central PMCID: PMC3533072.
Colas AR, McKeithan WL, Cunningham TJ, Bushway PJ, Garmire LX, Duester G, Subramaniam S, Mercola M. Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis. Genes Dev. 2012 Dec 1;26(23):2567-79. doi: 10.1101/gad.200758.112. Epub 2012 Nov 14. PubMed PMID: 23152446; PubMed Central PMCID: PMC3521625.
Schade D, Lanier M, Willems E, Okolotowicz K, Bushway P, Wahlquist C, Gilley C, Mercola M, Cashman JR. Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling. J Med Chem. 2012 Nov 26;55(22):9946-57. doi: 10.1021/jm301144g. Epub 2012 Nov 6. PubMed PMID: 23130626; PubMed Central PMCID: PMC3518459.
Forte E, Miraldi F, Chimenti I, Angelini F, Zeuner A, Giacomello A, Mercola M, Messina E. TGFβ-dependent epithelial-to-mesenchymal transition is required to generate cardiospheres from human adult heart biopsies. Stem Cells Dev. 2012 Nov 20;21(17):3081-90. doi: 10.1089/scd.2012.0277. Epub 2012 Aug 7. PubMed PMID: 22765842; PubMed Central PMCID: PMC4146498.
McKeithan WL, Colas AR, Bushway PJ, Ray S, Mercola M. Serum-free generation of multipotent mesoderm (Kdr+) progenitor cells in mouse embryonic stem cells for functional genomics screening. Curr Protoc Stem Cell Biol. 2012 Nov;Chapter 1:Unit 1F.13. doi: 10.1002/9780470151808.sc01f13s23. PubMed PMID: 23154934; PubMed Central PMCID: PMC3562707.
Cerignoli F, Charlot D, Whittaker R, Ingermanson R, Gehalot P, Savchenko A, Gallacher DJ, Towart R, Price JH, McDonough PM, Mercola M. High throughput measurement of Ca²⁺ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry. J Pharmacol Toxicol Methods. 2012 Nov-Dec;66(3):246-56. doi: 10.1016/j.vascn.2012.08.167. Epub 2012 Aug 25. PubMed PMID: 22926323; PubMed Central PMCID: PMC3667588.
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