My Bibliography

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Purdy SC, Matlin K, Alderman C, Baldwin A, Shrivastava N, Sarioglu G, Dutta S, Webb KJ, Wolin A, Boulton DP, Gustafson A, Kapali J, Landua JD, Lewis MT, Caino MC, Costello JC, Old W, Wang X, Zhao R, Ford HL, Mukherjee N. eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by small molecules. Cell Rep. 2025 Dec 23;44(12):116643. doi: 10.1016/j.celrep.2025.116643. Epub 2025 Dec 8. PubMed PMID: 41364558; PubMed Central PMCID: PMC12822916.

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Sessions DT, Boulton DP, Spoelstra NS, Caino MC, Yu M, Goodspeed A, Richer JK. Androgen Receptors Promote Oxidative Phosphorylation and Resistance to Palmitate Lipotoxicity in ER-Mutant Breast Cancer. Endocrinology. 2025 Dec 5;167(1). doi: 10.1210/endocr/bqaf168. PubMed PMID: 41216931; PubMed Central PMCID: PMC12679916.

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Affandi T, Ohm AM, Speidel JT, Caino MC, Boulton DP, Reyland ME. PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response. Mol Cancer Res. 2025 Sep 4;23(9):779-791. doi: 10.1158/1541-7786.MCR-24-0805. PubMed PMID: 40358612; PubMed Central PMCID: PMC12354018.

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Purdy SC, Matlin K, Alderman C, Baldwin A, Shrivastava N, Dutta S, Webb KJ, Wolin A, Boulton DP, Kapali J, Landua JD, Lewis MT, Caino MC, Costello JC, Old W, Wang X, Zhao R, Ford HL, Mukherjee N. eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by novel small molecules. bioRxiv. 2025 May 29;. doi: 10.1101/2025.05.29.656739. PubMed PMID: 40501575; PubMed Central PMCID: PMC12154685.

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Boulton DP, Hughes CJ, Vaira V, Del Gobbo A, Palleschi A, Locatelli M, Danis E, Raza M, Neumann AJ, Purdy SC, Lerma R, Meshki J, Ford HL, Prekeris R, Morrissey C, Caino MC. MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity. Cell Rep. 2025 Jan 28;44(1):115120. doi: 10.1016/j.celrep.2024.115120. Epub 2024 Dec 24. PubMed PMID: 39723893; PubMed Central PMCID: PMC11837739.

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Boulton DP, Caino MC. Emerging roles for Mitochondrial Rho GTPases in tumor biology. J Biol Chem. 2024 Sep;300(9):107670. doi: 10.1016/j.jbc.2024.107670. Epub 2024 Aug 14. Review. PubMed PMID: 39128718; PubMed Central PMCID: PMC11402688.

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Ohm AM, Affandi T, Reisz JA, Caino MC, D'Alessandro A, Reyland ME. Metabolic reprogramming contributes to radioprotection by protein kinase Cδ. J Biol Chem. 2023 Oct;299(10):105186. doi: 10.1016/j.jbc.2023.105186. Epub 2023 Aug 21. PubMed PMID: 37611829; PubMed Central PMCID: PMC10519828.

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Yeon M, Bertolini I, Agarwal E, Ghosh JC, Tang HY, Speicher DW, Keeney F, Sossey-Alaoui K, Pluskota E, Bialkowska K, Plow EF, Languino LR, Skordalakes E, Caino MC, Altieri DC. Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression. J Biol Chem. 2023 Jun;299(6):104774. doi: 10.1016/j.jbc.2023.104774. Epub 2023 May 2. PubMed PMID: 37142218; PubMed Central PMCID: PMC10236456.

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O'Neill KI, Kuo LW, Williams MM, Lind H, Crump LS, Hammond NG, Spoelstra NS, Caino MC, Richer JK. NPC1 Confers Metabolic Flexibility in Triple Negative Breast Cancer. Cancers (Basel). 2022 Jul 21;14(14). doi: 10.3390/cancers14143543. PubMed PMID: 35884604; PubMed Central PMCID: PMC9319388.

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Furnish M, Boulton DP, Genther V, Grofova D, Ellinwood ML, Romero L, Lucia MS, Cramer SD, Caino MC. MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling. Mol Cancer Res. 2022 Apr 1;20(4):607-621. doi: 10.1158/1541-7786.MCR-21-0374. PubMed PMID: 34992146; PubMed Central PMCID: PMC8983529.

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Boulton DP, Caino MC. Mitochondrial Fission and Fusion in Tumor Progression to Metastasis. Front Cell Dev Biol. 2022;10:849962. doi: 10.3389/fcell.2022.849962. eCollection 2022. Review. PubMed PMID: 35356277; PubMed Central PMCID: PMC8959575.

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Ghosh JC, Perego M, Agarwal E, Bertolini I, Wang Y, Goldman AR, Tang HY, Kossenkov AV, Landis CJ, Languino LR, Plow EF, Morotti A, Ottobrini L, Locatelli M, Speicher DW, Caino MC, Cassel J, Salvino JM, Robert ME, Vaira V, Altieri DC. Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability. Proc Natl Acad Sci U S A. 2022 Feb 22;119(8). doi: 10.1073/pnas.2115624119. PubMed PMID: 35177476; PubMed Central PMCID: PMC8872753.

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Towers CG, Wodetzki DK, Thorburn J, Smith KR, Caino MC, Thorburn A. Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy. Dev Cell. 2021 Jul 26;56(14):2029-2042.e5. doi: 10.1016/j.devcel.2021.06.003. Epub 2021 Jun 24. PubMed PMID: 34171288; PubMed Central PMCID: PMC8319140.

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Li J, Agarwal E, Bertolini I, Seo JH, Caino MC, Ghosh JC, Kossenkov AV, Liu Q, Tang HY, Goldman AR, Languino LR, Speicher DW, Altieri DC. The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells. Sci Signal. 2020 Jul 28;13(642). doi: 10.1126/scisignal.aaz8240. PubMed PMID: 32723812; PubMed Central PMCID: PMC7484983.

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Alicea GM, Rebecca VW, Goldman AR, Fane ME, Douglass SM, Behera R, Webster MR, Kugel CH 3rd, Ecker BL, Caino MC, Kossenkov AV, Tang HY, Frederick DT, Flaherty KT, Xu X, Liu Q, Gabrilovich DI, Herlyn M, Blair IA, Schug ZT, Speicher DW, Weeraratna AT. Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2. Cancer Discov. 2020 Sep;10(9):1282-1295. doi: 10.1158/2159-8290.CD-20-0329. Epub 2020 Jun 4. PubMed PMID: 32499221; PubMed Central PMCID: PMC7483379.

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Lee YG, Nam Y, Shin KJ, Yoon S, Park WS, Joung JY, Seo JK, Jang J, Lee S, Nam D, Caino MC, Suh PG, Chan Chae Y. Androgen-induced expression of DRP1 regulates mitochondrial metabolic reprogramming in prostate cancer. Cancer Lett. 2020 Feb 28;471:72-87. doi: 10.1016/j.canlet.2019.12.017. Epub 2019 Dec 12. PubMed PMID: 31838085.

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Wheeler LJ, Watson ZL, Qamar L, Yamamoto TM, Sawyer BT, Sullivan KD, Khanal S, Joshi M, Ferchaud-Roucher V, Smith H, Vanderlinden LA, Brubaker SW, Caino CM, Kim H, Espinosa JM, Richer JK, Bitler BG. Multi-Omic Approaches Identify Metabolic and Autophagy Regulators Important in Ovarian Cancer Dissemination. iScience. 2019 Sep 27;19:474-491. doi: 10.1016/j.isci.2019.07.049. Epub 2019 Aug 6. PubMed PMID: 31437751; PubMed Central PMCID: PMC6710300.

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Furnish M, Caino MC. Altered mitochondrial trafficking as a novel mechanism of cancer metastasis. Cancer Rep (Hoboken). 2020 Feb;3(1):e1157. doi: 10.1002/cnr2.1157. Epub 2019 Feb 14. Review. PubMed PMID: 32671955; PubMed Central PMCID: PMC7370516.

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Seo JH, Agarwal E, Bryant KG, Caino MC, Kim ET, Kossenkov AV, Tang HY, Languino LR, Gabrilovich DI, Cohen AR, Speicher DW, Altieri DC. Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements. Cancer Res. 2018 Aug 1;78(15):4215-4228. doi: 10.1158/0008-5472.CAN-18-0595. Epub 2018 Jun 13. PubMed PMID: 29898993; PubMed Central PMCID: PMC6072605.

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Williams M, Caino MC. Mitochondrial Dynamics in Type 2 Diabetes and Cancer. Front Endocrinol (Lausanne). 2018;9:211. doi: 10.3389/fendo.2018.00211. eCollection 2018. Review. PubMed PMID: 29755415; PubMed Central PMCID: PMC5934432.

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Caino MC, Seo JH, Wang Y, Rivadeneira DB, Gabrilovich DI, Kim ET, Weeraratna AT, Languino LR, Altieri DC. Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. J Clin Invest. 2017 Oct 2;127(10):3755-3769. doi: 10.1172/JCI93172. Epub 2017 Sep 11. PubMed PMID: 28891816; PubMed Central PMCID: PMC5617650.

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Behera R, Kaur A, Webster MR, Kim S, Ndoye A, Kugel CH 3rd, Alicea GM, Wang J, Ghosh K, Cheng P, Lisanti S, Marchbank K, Dang V, Levesque M, Dummer R, Xu X, Herlyn M, Aplin AE, Roesch A, Caino C, Altieri DC, Weeraratna AT. Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho. Clin Cancer Res. 2017 Jun 15;23(12):3181-3190. doi: 10.1158/1078-0432.CCR-17-0201. Epub 2017 Feb 23. PubMed PMID: 28232477; PubMed Central PMCID: PMC5474161.

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Caino MC, Seo JH, Aguinaldo A, Wait E, Bryant KG, Kossenkov AV, Hayden JE, Vaira V, Morotti A, Ferrero S, Bosari S, Gabrilovich DI, Languino LR, Cohen AR, Altieri DC. A neuronal network of mitochondrial dynamics regulates metastasis. Nat Commun. 2016 Dec 19;7:13730. doi: 10.1038/ncomms13730. PubMed PMID: 27991488; PubMed Central PMCID: PMC5187409.

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Chae YC, Vaira V, Caino MC, Tang HY, Seo JH, Kossenkov AV, Ottobrini L, Martelli C, Lucignani G, Bertolini I, Locatelli M, Bryant KG, Ghosh JC, Lisanti S, Ku B, Bosari S, Languino LR, Speicher DW, Altieri DC. Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming. Cancer Cell. 2016 Aug 8;30(2):257-272. doi: 10.1016/j.ccell.2016.07.004. PubMed PMID: 27505672; PubMed Central PMCID: PMC5131882.

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Seo JH, Rivadeneira DB, Caino MC, Chae YC, Speicher DW, Tang HY, Vaira V, Bosari S, Palleschi A, Rampini P, Kossenkov AV, Languino LR, Altieri DC. The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis. PLoS Biol. 2016 Jul;14(7):e1002507. doi: 10.1371/journal.pbio.1002507. eCollection 2016 Jul. PubMed PMID: 27389535; PubMed Central PMCID: PMC4936714.

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Caino MC, Altieri DC. Cancer cells exploit adaptive mitochondrial dynamics to increase tumor cell invasion. Cell Cycle. 2015;14(20):3242-7. doi: 10.1080/15384101.2015.1084448. Review. PubMed PMID: 26317663; PubMed Central PMCID: PMC4825634.

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Caino MC, Altieri DC. Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy. Clin Cancer Res. 2016 Feb 1;22(3):540-5. doi: 10.1158/1078-0432.CCR-15-0460. Epub 2015 Dec 9. Review. PubMed PMID: 26660517; PubMed Central PMCID: PMC4738153.

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Caino MC, Altieri DC. Disabling mitochondrial reprogramming in cancer. Pharmacol Res. 2015 Dec;102:42-5. doi: 10.1016/j.phrs.2015.08.022. Epub 2015 Sep 10. PubMed PMID: 26365877; PubMed Central PMCID: PMC4684442.

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Rivadeneira DB, Caino MC, Seo JH, Angelin A, Wallace DC, Languino LR, Altieri DC. Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion. Sci Signal. 2015 Aug 11;8(389):ra80. doi: 10.1126/scisignal.aab1624. PubMed PMID: 26268608; PubMed Central PMCID: PMC4539531.

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Caino MC, Ghosh JC, Chae YC, Vaira V, Rivadeneira DB, Faversani A, Rampini P, Kossenkov AV, Aird KM, Zhang R, Webster MR, Weeraratna AT, Bosari S, Languino LR, Altieri DC. PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8638-43. doi: 10.1073/pnas.1500722112. Epub 2015 Jun 29. PubMed PMID: 26124089; PubMed Central PMCID: PMC4507184.

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Ghosh JC, Siegelin MD, Vaira V, Faversani A, Tavecchio M, Chae YC, Lisanti S, Rampini P, Giroda M, Caino MC, Seo JH, Kossenkov AV, Michalek RD, Schultz DC, Bosari S, Languino LR, Altieri DC. Adaptive mitochondrial reprogramming and resistance to PI3K therapy. J Natl Cancer Inst. 2015 Mar;107(3). doi: 10.1093/jnci/dju502. Print 2015 Mar. PubMed PMID: 25650317; PubMed Central PMCID: PMC4565533.

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Garg R, Caino MC, Kazanietz MG. Regulation of Transcriptional Networks by PKC Isozymes: Identification of c-Rel as a Key Transcription Factor for PKC-Regulated Genes. PLoS One. 2013;8(6):e67319. doi: 10.1371/journal.pone.0067319. Print 2013. PubMed PMID: 23826267; PubMed Central PMCID: PMC3694964.

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Caino MC, Chae YC, Vaira V, Ferrero S, Nosotti M, Martin NM, Weeraratna A, O'Connell M, Jernigan D, Fatatis A, Languino LR, Bosari S, Altieri DC. Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells. J Clin Invest. 2013 Jul;123(7):2907-20. doi: 10.1172/JCI67841. Epub 2013 Jun 10. PubMed PMID: 23921130; PubMed Central PMCID: PMC3998961.

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Chae YC, Caino MC, Lisanti S, Ghosh JC, Dohi T, Danial NN, Villanueva J, Ferrero S, Vaira V, Santambrogio L, Bosari S, Languino LR, Herlyn M, Altieri DC. Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s. Cancer Cell. 2012 Sep 11;22(3):331-44. doi: 10.1016/j.ccr.2012.07.015. PubMed PMID: 22975376; PubMed Central PMCID: PMC3615709.

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Caino MC, Lopez-Haber C, Kissil JL, Kazanietz MG. Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon. PLoS One. 2012;7(2):e31714. doi: 10.1371/journal.pone.0031714. Epub 2012 Feb 27. PubMed PMID: 22384062; PubMed Central PMCID: PMC3288050.

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Caino MC, Lopez-Haber C, Kim J, Mochly-Rosen D, Kazanietz MG. Proteins kinase Cɛ is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes. Oncogene. 2012 May 17;31(20):2593-600. doi: 10.1038/onc.2011.428. Epub 2011 Sep 26. PubMed PMID: 21996750; PubMed Central PMCID: PMC3432976.

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Caino MC, von Burstin VA, Lopez-Haber C, Kazanietz MG. Differential regulation of gene expression by protein kinase C isozymes as determined by genome-wide expression analysis. J Biol Chem. 2011 Apr 1;286(13):11254-64. doi: 10.1074/jbc.M110.194332. Epub 2011 Jan 20. PubMed PMID: 21252239; PubMed Central PMCID: PMC3064181.

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Filone CM, Hanna SL, Caino MC, Bambina S, Doms RW, Cherry S. Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon. PLoS One. 2010 Nov 24;5(11):e15483. doi: 10.1371/journal.pone.0015483. PubMed PMID: 21124804; PubMed Central PMCID: PMC2991366.

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Meshki J, Caino MC, von Burstin VA, Griner E, Kazanietz MG. Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway. J Biol Chem. 2010 Aug 20;285(34):26033-40. doi: 10.1074/jbc.M110.128371. Epub 2010 Jun 21. PubMed PMID: 20566643; PubMed Central PMCID: PMC2924002.

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Griner EM, Caino MC, Sosa MS, Colón-González F, Chalmers MJ, Mischak H, Kazanietz MG. A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation. J Biol Chem. 2010 May 28;285(22):16931-41. doi: 10.1074/jbc.M109.099036. Epub 2010 Mar 24. PubMed PMID: 20335173; PubMed Central PMCID: PMC2878072.

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Caino MC, Meshki J, Kazanietz MG. Hallmarks for senescence in carcinogenesis: novel signaling players. Apoptosis. 2009 Apr;14(4):392-408. doi: 10.1007/s10495-009-0316-z. Review. PubMed PMID: 19169823.

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Xiao L, Caino MC, von Burstin VA, Oliva JL, Kazanietz MG. Phorbol ester-induced apoptosis and senescence in cancer cell models. Methods Enzymol. 2008;446:123-39. doi: 10.1016/S0076-6879(08)01607-8. PubMed PMID: 18603119.

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Oliva JL, Caino MC, Senderowicz AM, Kazanietz MG. S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells. J Biol Chem. 2008 Feb 29;283(9):5466-76. doi: 10.1074/jbc.M707576200. Epub 2007 Dec 26. PubMed PMID: 18162471.

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Caino MC, Oliva JL, Jiang H, Penning TM, Kazanietz MG. Benzo[a]pyrene-7,8-dihydrodiol promotes checkpoint activation and G2/M arrest in human bronchoalveolar carcinoma H358 cells. Mol Pharmacol. 2007 Mar;71(3):744-50. doi: 10.1124/mol.106.032078. Epub 2006 Nov 17. PubMed PMID: 17114299.