Targeting PELP1 oncogenic signaling in TNBC with the small molecule inhibitor SMIP34.
Breast Cancer Res Treat.
2023 Jul;200(1):151-162. doi: 10.1007/s10549-023-06958-4. Epub 2023 May 18. PubMed PMID:
37199805; PubMed Central PMCID:
PMC10224866.
The RNA Demethylase ALKBH5 Maintains Endoplasmic Reticulum Homeostasis by Regulating UPR, Autophagy, and Mitochondrial Function.
Cells.
2023 Apr 29;12(9). doi: 10.3390/cells12091283. PubMed PMID:
37174684; PubMed Central PMCID:
PMC10177234.
A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer.
Cancer Res.
2022 Oct 17;82(20):3830-3844. doi: 10.1158/0008-5472.CAN-22-0698. PubMed PMID:
35950923; PubMed Central PMCID:
PMC9588738.
The antidepressant imipramine inhibits breast cancer growth by targeting estrogen receptor signaling and DNA repair events.
Cancer Lett.
2022 Aug 1;540:215717. doi: 10.1016/j.canlet.2022.215717. Epub 2022 May 12. PubMed PMID:
35568265; PubMed Central PMCID:
PMC10313451.
Targeting aberrant replication and DNA repair events for treating breast cancers.
Commun Biol.
2022 May 24;5(1):493. doi: 10.1038/s42003-022-03413-w. PubMed PMID:
35610507; PubMed Central PMCID:
PMC9130234.
M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression.
Cancer Res.
2022 May 16;82(10):1872-1889. doi: 10.1158/0008-5472.CAN-21-2106. PubMed PMID:
35303054; PubMed Central PMCID:
PMC9336196.
LIFR inhibition enhances the therapeutic efficacy of HDAC inhibitors in triple negative breast cancer.
Commun Biol.
2021 Oct 29;4(1):1235. doi: 10.1038/s42003-021-02741-7. PubMed PMID:
34716410; PubMed Central PMCID:
PMC8556368.
Role of estrogen receptor coregulators in endocrine resistant breast cancer.
Explor Target Antitumor Ther.
2021;2(4):385-400. doi: 10.37349/etat.2021.00052. Epub 2021 Aug 30. PubMed PMID:
34528025; PubMed Central PMCID:
PMC8439438.
Predicting and characterizing a cancer dependency map of tumors with deep learning.
Sci Adv.
2021 Aug;7(34). doi: 10.1126/sciadv.abh1275. Print 2021 Aug. PubMed PMID:
34417181; PubMed Central PMCID:
PMC8378822.
LIF/LIFR oncogenic signaling is a novel therapeutic target in endometrial cancer.
Cell Death Discov.
2021 Aug 16;7(1):216. doi: 10.1038/s41420-021-00603-z. PubMed PMID:
34400617; PubMed Central PMCID:
PMC8367961.
Regulation of telomere homeostasis and genomic stability in cancer by N (6)-adenosine methylation (m(6)A).
Sci Adv.
2021 Jul;7(31). doi: 10.1126/sciadv.abg7073. Print 2021 Jul. PubMed PMID:
34321211; PubMed Central PMCID:
PMC8318370.
Histone deacetylase inhibitors enhance estrogen receptor beta expression and augment agonist-mediated tumor suppression in glioblastoma.
Neurooncol Adv.
2021 Jan-Dec;3(1):vdab099. doi: 10.1093/noajnl/vdab099. eCollection 2021 Jan-Dec. PubMed PMID:
34485908; PubMed Central PMCID:
PMC8412056.
Interaction of transcription factor AP-2 gamma with proto-oncogene PELP1 promotes tumorigenesis by enhancing RET signaling.
Mol Oncol.
2021 Apr;15(4):1146-1161. doi: 10.1002/1878-0261.12871. Epub 2021 Feb 9. PubMed PMID:
33269540; PubMed Central PMCID:
PMC8024722.
PELP1 signaling contributes to medulloblastoma progression by regulating the NF-κB pathway.
Mol Carcinog.
2020 Mar;59(3):281-292. doi: 10.1002/mc.23152. Epub 2019 Dec 24. PubMed PMID:
31872914; PubMed Central PMCID:
PMC7021561.
MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma.
Nat Commun.
2018 Oct 31;9(1):4541. doi: 10.1038/s41467-018-06808-8. PubMed PMID:
30382096; PubMed Central PMCID:
PMC6208371.
Cross-talk among writers, readers, and erasers of m(6)A regulates cancer growth and progression.
Sci Adv.
2018 Oct;4(10):eaar8263. doi: 10.1126/sciadv.aar8263. eCollection 2018 Oct. PubMed PMID:
30306128; PubMed Central PMCID:
PMC6170038.
Topological Characterization of Human and Mouse m(5)C Epitranscriptome Revealed by Bisulfite Sequencing.
Int J Genomics.
2018;2018:1351964. doi: 10.1155/2018/1351964. eCollection 2018. PubMed PMID:
30009162; PubMed Central PMCID:
PMC6020461.
MeTDiff: A Novel Differential RNA Methylation Analysis for MeRIP-Seq Data.
IEEE/ACM Trans Comput Biol Bioinform.
2018 Mar-Apr;15(2):526-534. doi: 10.1109/TCBB.2015.2403355. PubMed PMID:
29610101.
Novel post-transcriptional and post-translational regulation of pro-apoptotic protein BOK and anti-apoptotic protein Mcl-1 determine the fate of breast cancer cells to survive or die.
Oncotarget.
2017 Oct 17;8(49):85984-85996. doi: 10.18632/oncotarget.20841. eCollection 2017 Oct 17. PubMed PMID:
29156771; PubMed Central PMCID:
PMC5689661.
Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells.
Nat Commun.
2017 Sep 19;8(1):598. doi: 10.1038/s41467-017-00590-9. PubMed PMID:
28928467; PubMed Central PMCID:
PMC5605700.
A hierarchical model for clustering m(6)A methylation peaks in MeRIP-seq data.
BMC Genomics.
2016 Aug 22;17 Suppl 7(Suppl 7):520. doi: 10.1186/s12864-016-2913-x. PubMed PMID:
27556597; PubMed Central PMCID:
PMC5001242.
Inhibition of FoxM1-Mediated DNA Repair by Imipramine Blue Suppresses Breast Cancer Growth and Metastasis.
Clin Cancer Res.
2016 Jul 15;22(14):3524-36. doi: 10.1158/1078-0432.CCR-15-2535. Epub 2016 Feb 29. PubMed PMID:
26927663; PubMed Central PMCID:
PMC4947433.
Rhox8 Ablation in the Sertoli Cells Using a Tissue-Specific RNAi Approach Results in Impaired Male Fertility in Mice.
Biol Reprod.
2015 Jul;93(1):8. doi: 10.1095/biolreprod.114.124834. Epub 2015 May 13. PubMed PMID:
25972016; PubMed Central PMCID:
PMC4706311.
HEPeak: an HMM-based exome peak-finding package for RNA epigenome sequencing data.
BMC Genomics.
2015;16 Suppl 4(Suppl 4):S2. doi: 10.1186/1471-2164-16-S4-S2. Epub 2015 Apr 21. PubMed PMID:
25917296; PubMed Central PMCID:
PMC4416174.
MeT-DB: a database of transcriptome methylation in mammalian cells.
Nucleic Acids Res.
2015 Jan;43(Database issue):D197-203. doi: 10.1093/nar/gku1024. Epub 2014 Nov 6. PubMed PMID:
25378335; PubMed Central PMCID:
PMC4383883.
Hormone-induced and DNA demethylation-induced relief of a tissue-specific and developmentally regulated block in transcriptional elongation.
J Biol Chem.
2014 Dec 19;289(51):35087-101. doi: 10.1074/jbc.M114.615435. Epub 2014 Oct 20. PubMed PMID:
25331959; PubMed Central PMCID:
PMC4271199.
A protocol for RNA methylation differential analysis with MeRIP-Seq data and exomePeak R/Bioconductor package.
Methods.
2014 Oct 1;69(3):274-81. doi: 10.1016/j.ymeth.2014.06.008. Epub 2014 Jun 27. PubMed PMID:
24979058; PubMed Central PMCID:
PMC4194139.
Androgen receptor and microRNA-21 axis downregulates transforming growth factor beta receptor II (TGFBR2) expression in prostate cancer.
Oncogene.
2014 Jul 31;33(31):4097-106. doi: 10.1038/onc.2013.374. Epub 2013 Sep 16. PubMed PMID:
24037531; PubMed Central PMCID:
PMC3962713.
Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer.
Oncogene.
2014 Jul 10;33(28):3707-16. doi: 10.1038/onc.2013.332. Epub 2013 Aug 26. PubMed PMID:
23975430; PubMed Central PMCID:
PMC3935988.
WTAP is a novel oncogenic protein in acute myeloid leukemia.
Leukemia.
2014 May;28(5):1171-4. doi: 10.1038/leu.2014.16. Epub 2014 Jan 13. PubMed PMID:
24413322; PubMed Central PMCID:
PMC4369791.
The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis.
J Biol Chem.
2013 Nov 29;288(48):34809-25. doi: 10.1074/jbc.M113.486340. Epub 2013 Oct 11. PubMed PMID:
24121513; PubMed Central PMCID:
PMC3843094.
Exome-based analysis for RNA epigenome sequencing data.
Bioinformatics.
2013 Jun 15;29(12):1565-7. doi: 10.1093/bioinformatics/btt171. Epub 2013 Apr 14. PubMed PMID:
23589649; PubMed Central PMCID:
PMC3673212.
Differential analysis of RNA Methylation sequencing data.
Differential analysis of RNA Methylation sequencing data. 2013. doi: 0.1109/GlobalSIP.2013.6736806.
Unveiling the dynamics in RNA epigenetic regulations.
Bioinformatics and Biomedicine. 2013; :139-144 144. doi: 10.1109/BIBM.2013.6732477.
Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT/mTOR/Rac1 signaling and actin reorganization.
PLoS One.
2012;7(12):e52397. doi: 10.1371/journal.pone.0052397. Epub 2012 Dec 21. PubMed PMID:
23285024; PubMed Central PMCID:
PMC3528651.
The transcription factor Wilms tumor 1 confers resistance in myeloid leukemia cells against the proapoptotic therapeutic agent TRAIL (tumor necrosis factor α-related apoptosis-inducing ligand) by regulating the antiapoptotic protein Bcl-xL.
J Biol Chem.
2012 Sep 21;287(39):32875-80. doi: 10.1074/jbc.C112.366559. Epub 2012 Aug 16. PubMed PMID:
22898820; PubMed Central PMCID:
PMC3463302.
Androgen-responsive microRNAs in mouse Sertoli cells.
PLoS One.
2012;7(7):e41146. doi: 10.1371/journal.pone.0041146. Epub 2012 Jul 20. PubMed PMID:
22911753; PubMed Central PMCID:
PMC3401116.
Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation.
Proc Natl Acad Sci U S A.
2012 Apr 10;109(15):5750-5. doi: 10.1073/pnas.1117837109. Epub 2012 Mar 23. PubMed PMID:
22447776; PubMed Central PMCID:
PMC3326518.
Role of β-catenin in post-meiotic male germ cell differentiation.
PLoS One.
2011;6(11):e28039. doi: 10.1371/journal.pone.0028039. Epub 2011 Nov 18. PubMed PMID:
22125654; PubMed Central PMCID:
PMC3220672.
Isolation of Sertoli, Leydig, and spermatogenic cells from the mouse testis.
Biotechniques.
2011 Nov;51(5):341-2, 344. doi: 10.2144/000113764. PubMed PMID:
22054547; PubMed Central PMCID:
PMC3774005.
Heat shock protein 90 regulates the expression of Wilms tumor 1 protein in myeloid leukemias.
Blood.
2010 Nov 25;116(22):4591-9. doi: 10.1182/blood-2009-10-247239. Epub 2010 Jul 22. PubMed PMID:
20651072; PubMed Central PMCID:
PMC2996117.
MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers.
Oncogene.
2010 Sep 2;29(35):4971-9. doi: 10.1038/onc.2010.233. Epub 2010 Jul 5. PubMed PMID:
20603620.
GATA factors and androgen receptor collaborate to transcriptionally activate the Rhox5 homeobox gene in Sertoli cells.
Mol Cell Biol.
2008 Apr;28(7):2138-53. doi: 10.1128/MCB.01170-07. Epub 2008 Jan 22. PubMed PMID:
18212046; PubMed Central PMCID:
PMC2268436.
Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis.
Genes Dev.
2006 Jan 15;20(2):147-52. doi: 10.1101/gad1367806. PubMed PMID:
16418481; PubMed Central PMCID:
PMC1356106.
Tissue-specific and cell type-specific RNA interference in vivo.
Nat Protoc.
2006;1(3):1494-501. doi: 10.1038/nprot.2006.260. PubMed PMID:
17406440.
RNAi As A Tool to Silence Genes of Interest in Specific Tissues or Cell types.
Drug Discovery. 2006; :35-36.
Regulation of the Rhox5 homeobox gene in primary granulosa cells: preovulatory expression and dependence on SP1/SP3 and GABP.
Biol Reprod.
2005 Dec;73(6):1126-34. doi: 10.1095/biolreprod.105.042747. Epub 2005 Aug 10. PubMed PMID:
16093360.
Rhox: a new homeobox gene cluster.
Cell.
2005 Feb 11;120(3):369-82. doi: 10.1016/j.cell.2004.12.022. PubMed PMID:
15707895.
Pem homeobox gene promoter sequences that direct transcription in a Sertoli cell-specific, stage-specific, and androgen-dependent manner in the testis in vivo.
Mol Endocrinol.
2003 Feb;17(2):223-33. doi: 10.1210/me.2002-0232. PubMed PMID:
12554750.
Pem homeobox gene regulatory sequences that direct androgen-dependent developmentally regulated gene expression in different subregions of the epididymis.
J Biol Chem.
2002 Dec 13;277(50):48771-8. doi: 10.1074/jbc.M209417200. Epub 2002 Sep 25. PubMed PMID:
12351657.
What would you like to do?