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Infant airway epithelium is susceptible to persistent effects of tobacco smoke exposure. Differential regulation of innate responses to virus and bacteria. Annals of the American Thoracic Society. . NIHMSID: NIHMS1799545.
Obasaju MF, Wiley LM, Miller L, Samuels SJ, Chang RJ, Overstreet JW. Reproductive effects of chlorpromazine exposure to female mice: cell proliferation disadvantage revealed by the Chimera Embryo Assay. Reprod Toxicol. 1987;1(1):17-23. doi: 10.1016/0890-6238(87)90067-0. PubMed PMID: 2980360.
Obasaju MF, Wiley LM, Oudiz DJ, Miller L, Samuels SJ, Chang RJ, Overstreet JW. An assay using embryo aggregation chimeras for the detection of nonlethal changes in X-irradiated mouse preimplantation embryos. Radiat Res. 1988 Feb;113(2):289-99. PubMed PMID: 3124205.
Miller LA, Cheng LZ, Wu R. Inhibition of epidermal growth factor-like growth factor secretion in tracheobronchial epithelial cells by vitamin A. Cancer Res. 1993 Jun 1;53(11):2527-33. PubMed PMID: 8495415.
Miller LA, Zhao YH, Wu R. Inhibition of TGF-alpha gene expression by vitamin A in airway epithelium. J Clin Invest. 1996 Mar 15;97(6):1429-35. doi: 10.1172/JCI118564. PubMed PMID: 8617875; PubMed Central PMCID: PMC507202.
Miller LA, Butcher EC. Human airway epithelial monolayers promote selective transmigration of memory T cells: a transepithelial model of lymphocyte migration into the airways. Am J Respir Cell Mol Biol. 1998 Dec;19(6):892-900. doi: 10.1165/ajrcmb.19.6.3245mrev. PubMed PMID: 9843923.
Hyde DM, Miller LA, McDonald RJ, Stovall MY, Wong V, Pinkerton KE, Wegner CD, Rothlein R, Plopper CG. Neutrophils enhance clearance of necrotic epithelial cells in ozone-induced lung injury in rhesus monkeys. Am J Physiol. 1999 Dec;277(6):L1190-8. doi: 10.1152/ajplung.1999.277.6.L1190. PubMed PMID: 10600890.
Miller LA, Li C, Hyde DM. Expression of the HML-1 Epitope on Human Monocytes is Independent of αE Integrin mRNA. Inflammation. 2000 Jun;24(3):195-205. doi: 10.1023/a:1007007428255. PubMed PMID: 23255840; PubMed Central PMCID: PMC3523340.
Miller LA, Usachenko J, McDonald RJ, Hyde DM. Trafficking of neutrophils across airway epithelium is dependent upon both thioredoxin- and pertussis toxin-sensitive signaling mechanisms. J Leukoc Biol. 2000 Aug;68(2):201-8. PubMed PMID: 10947064.
Schelegle ES, Gershwin LJ, Miller LA, Fanucchi MV, Van Winkle LS, Gerriets JP, Walby WF, Omlor AM, Buckpitt AR, Tarkington BK, Wong VJ, Joad JP, Pinkerton KB, Wu R, Evans MJ, Hyde DM, Plopper CG. Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae). Am J Pathol. 2001 Jan;158(1):333-41. doi: 10.1016/S0002-9440(10)63973-9. PubMed PMID: 11141508; PubMed Central PMCID: PMC1850255.
Miller LA, Barnett NL, Sheppard D, Hyde DM. Expression of the beta6 integrin subunit is associated with sites of neutrophil influx in lung epithelium. J Histochem Cytochem. 2001 Jan;49(1):41-8. doi: 10.1177/002215540104900105. PubMed PMID: 11118477.
Plopper CG, Buckpitt A, Evans M, Van Winkle L, Fanucchi M, Smiley-Jewell S, Lakritz J, West J, Lawson G, Paige R, Miller L, Hyde D. Factors modulating the epithelial response to toxicants in tracheobronchial airways. Toxicology. 2001 Mar 7;160(1-3):173-80. doi: 10.1016/s0300-483x(00)00453-4. PubMed PMID: 11246137.
Miller LA, Hyde DM, Gershwin LJ, Schelegle ES, Fanucchi MV, Evans MJ, Gerriets JE, Putney LF, Stovall MY, Tyler NK, Usachenko JL, Plopper CG. The effect of house dust mite aeroallergen and air pollutant exposures during infancy. Chest. 2003 Mar;123(3 Suppl):434S. doi: 10.1378/chest.123.3_suppl.434s. Review. PubMed PMID: 12629026.
Schelegle ES, Miller LA, Gershwin LJ, Fanucchi MV, Van Winkle LS, Gerriets JE, Walby WF, Mitchell V, Tarkington BK, Wong VJ, Baker GL, Pantle LM, Joad JP, Pinkerton KE, Wu R, Evans MJ, Hyde DM, Plopper CG. Repeated episodes of ozone inhalation amplifies the effects of allergen sensitization and inhalation on airway immune and structural development in Rhesus monkeys. Toxicol Appl Pharmacol. 2003 Aug 15;191(1):74-85. doi: 10.1016/s0041-008x(03)00218-7. PubMed PMID: 12915105.
Evans MJ, Fanucchi MV, Baker GL, Van Winkle LS, Pantle LM, Nishio SJ, Schelegle ES, Gershwin LJ, Miller LA, Hyde DM, Sannes PL, Plopper CG. Atypical development of the tracheal basement membrane zone of infant rhesus monkeys exposed to ozone and allergen. Am J Physiol Lung Cell Mol Physiol. 2003 Oct;285(4):L931-9. doi: 10.1152/ajplung.00175.2003. Epub 2003 Jun 27. PubMed PMID: 12832283.
Miller LA, Plopper CG, Hyde DM, Gerriets JE, Pieczarka EM, Tyler NK, Evans MJ, Gershwin LJ, Schelegle ES, Van Winkle LS. Immune and airway effects of house dust mite aeroallergen exposures during postnatal development of the infant rhesus monkey. Clin Exp Allergy. 2003 Dec;33(12):1686-94. doi: 10.1111/j.1365-2222.2003.01812.x. PubMed PMID: 14656356.
Oslund KL, Miller LA, Usachenko JL, Tyler NK, Wu R, Hyde DM. Oxidant-injured airway epithelial cells upregulate thioredoxin but do not produce interleukin-8. Am J Respir Cell Mol Biol. 2004 May;30(5):597-604. doi: 10.1165/rcmb.2002-0273OC. PubMed PMID: 15096327.
Evans MJ, Fanucchi MV, Baker GL, Van Winkle LS, Pantle LM, Nishio SJ, Schelegle ES, Gershwin LJ, Miller LA, Hyde DM, Plopper CG. The remodelled tracheal basement membrane zone of infant rhesus monkeys after 6 months of recovery. Clin Exp Allergy. 2004 Jul;34(7):1131-6. doi: 10.1111/j.1365-2222.2004.02004.x. PubMed PMID: 15248862.
Boland B, Lin CY, Morin D, Miller L, Plopper C, Buckpitt A. Site-specific metabolism of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques. J Pharmacol Exp Ther. 2004 Aug;310(2):546-54. doi: 10.1124/jpet.103.063669. Epub 2004 Apr 13. PubMed PMID: 15082753.
Tran MU, Weir AJ, Fanucchi MV, Rodriguez AE, Pantle LM, Smiley-Jewell SM, Van Winkle LS, Evans MJ, Miller LA, Schelegle ES, Gershwin LJ, Hyde DM, Plopper CG. Smooth muscle hypertrophy in distal airways of sensitized infant rhesus monkeys exposed to house dust mite allergen. Clin Exp Allergy. 2004 Oct;34(10):1627-33. doi: 10.1111/j.1365-2222.2004.02057.x. PubMed PMID: 15479280.
Van Winkle LS, Fanucchi MV, Miller LA, Baker GL, Gershwin LJ, Schelegle ES, Hyde DM, Evans MJ, Plopper CG. Epithelial cell distribution and abundance in rhesus monkey airways during postnatal lung growth and development. J Appl Physiol (1985). 2004 Dec;97(6):2355-63; discussion 2354. doi: 10.1152/japplphysiol.00470.2004. Epub 2004 Aug 6. PubMed PMID: 15298983.
Fanucchi MV, Schelegle ES, Baker GL, Evans MJ, McDonald RJ, Gershwin LJ, Raz E, Hyde DM, Plopper CG, Miller LA. Immunostimulatory oligonucleotides attenuate airways remodeling in allergic monkeys. Am J Respir Crit Care Med. 2004 Dec 1;170(11):1153-7. doi: 10.1164/rccm.200404-533OC. Epub 2004 Aug 11. PubMed PMID: 15306532; PubMed Central PMCID: PMC3927836.
Miller LA, Hurst SD, Coffman RL, Tyler NK, Stovall MY, Chou DL, Putney LF, Gershwin LJ, Schelegle ES, Plopper CG, Hyde DM. Airway generation-specific differences in the spatial distribution of immune cells and cytokines in allergen-challenged rhesus monkeys. Clin Exp Allergy. 2005 Jul;35(7):894-906. doi: 10.1111/j.1365-2222.2005.02271.x. PubMed PMID: 16008676; PubMed Central PMCID: PMC3918236.
Chou DL, Daugherty BL, McKenna EK, Hsu WM, Tyler NK, Plopper CG, Hyde DM, Schelegle ES, Gershwin LJ, Miller LA. Chronic aeroallergen during infancy enhances eotaxin-3 expression in airway epithelium and nerves. Am J Respir Cell Mol Biol. 2005 Jul;33(1):1-8. doi: 10.1165/rcmb.2004-0236RC. Epub 2005 Apr 15. PubMed PMID: 15834047; PubMed Central PMCID: PMC2715301.
Lin CY, Boland BC, Lee YJ, Salemi MR, Morin D, Miller LA, Plopper CG, Buckpitt AR. Identification of proteins adducted by reactive metabolites of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques. Proteomics. 2006 Feb;6(3):972-82. doi: 10.1002/pmic.200500170. PubMed PMID: 16453347.
Avdalovic MV, Putney LF, Schelegle ES, Miller L, Usachenko JL, Tyler NK, Plopper CG, Gershwin LJ, Hyde DM. Vascular remodeling is airway generation-specific in a primate model of chronic asthma. Am J Respir Crit Care Med. 2006 Nov 15;174(10):1069-76. doi: 10.1164/rccm.200506-848OC. Epub 2006 Aug 24. PubMed PMID: 16931639; PubMed Central PMCID: PMC2648107.
Plopper CG, Smiley-Jewell SM, Miller LA, Fanucchi MV, Evans MJ, Buckpitt AR, Avdalovic M, Gershwin LJ, Joad JP, Kajekar R, Larson S, Pinkerton KE, Van Winkle LS, Schelegle ES, Pieczarka EM, Wu R, Hyde DM. Asthma/allergic airways disease: does postnatal exposure to environmental toxicants promote airway pathobiology?. Toxicol Pathol. 2007 Jan;35(1):97-110. doi: 10.1080/01926230601132030. PubMed PMID: 17325978.
Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl L, Austin CD, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F. In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J Clin Invest. 2007 Dec;117(12):3868-78. doi: 10.1172/JCI33559. PubMed PMID: 18060034; PubMed Central PMCID: PMC2096422.
Miller LA, Gerriets JE, Tyler NK, Abel K, Schelegle ES, Plopper CG, Hyde DM. Ozone and allergen exposure during postnatal development alters the frequency and airway distribution of CD25+ cells in infant rhesus monkeys. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):39-48. doi: 10.1016/j.taap.2008.12.031. Epub 2009 Feb 7. PubMed PMID: 19371618; PubMed Central PMCID: PMC2670960.
Evans MJ, Fanucchi MV, Miller LA, Carlson MA, Nishio SJ, Hyde DM. Reduction of collagen VII anchoring fibrils in the airway basement membrane zone of infant rhesus monkeys exposed to house dust mite. Am J Physiol Lung Cell Mol Physiol. 2010 Apr;298(4):L543-7. doi: 10.1152/ajplung.00337.2009. Epub 2010 Feb 5. PubMed PMID: 20139177; PubMed Central PMCID: PMC2853345.
Maniar-Hew K, Postlethwait EM, Fanucchi MV, Ballinger CA, Evans MJ, Harkema JR, Carey SA, McDonald RJ, Bartolucci AA, Miller LA. Postnatal episodic ozone results in persistent attenuation of pulmonary and peripheral blood responses to LPS challenge. Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L462-71. doi: 10.1152/ajplung.00254.2010. Epub 2010 Dec 3. PubMed PMID: 21131396; PubMed Central PMCID: PMC3064293.
Capitanio JP, Miller LA, Schelegle ES, Mendoza SP, Mason WA, Hyde DM. Behavioral inhibition is associated with airway hyperresponsiveness but not atopy in a monkey model of asthma. Psychosom Med. 2011 May;73(4):288-94. doi: 10.1097/PSY.0b013e3182155c83. Epub 2011 May 2. PubMed PMID: 21536834; PubMed Central PMCID: PMC3090450.
Abbas AR, Jackman JK, Bullens SL, Davis SM, Choy DF, Fedorowicz G, Tan M, Truong BT, Gloria Meng Y, Diehl L, Miller LA, Schelegle ES, Hyde DM, Clark HF, Modrusan Z, Arron JR, Wu LC. Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model. Am J Pathol. 2011 Oct;179(4):1667-80. doi: 10.1016/j.ajpath.2011.06.009. Epub 2011 Aug 3. PubMed PMID: 21819959; PubMed Central PMCID: PMC3181391.
Sun YH, Reid B, Fontaine JH, Miller LA, Hyde DM, Mogilner A, Zhao M. Airway epithelial wounds in rhesus monkey generate ionic currents that guide cell migration to promote healing. J Appl Physiol (1985). 2011 Oct;111(4):1031-41. doi: 10.1152/japplphysiol.00915.2010. Epub 2011 Jun 30. PubMed PMID: 21719726; PubMed Central PMCID: PMC3774198.
Chou DL, Gerriets JE, Schelegle ES, Hyde DM, Miller LA. Increased CCL24/eotaxin-2 with postnatal ozone exposure in allergen-sensitized infant monkeys is not associated with recruitment of eosinophils to airway mucosa. Toxicol Appl Pharmacol. 2011 Dec 15;257(3):309-18. doi: 10.1016/j.taap.2011.09.001. Epub 2011 Sep 12. PubMed PMID: 21945493; PubMed Central PMCID: PMC3226879.
Moore BD, Hyde D, Miller L, Wong E, Frelinger J, Schelegle ES. Allergen and ozone exacerbate serotonin-induced increases in airway smooth muscle contraction in a model of childhood asthma. Respiration. 2012;83(6):529-42. doi: 10.1159/000336835. Epub 2012 Apr 13. PubMed PMID: 22507883; PubMed Central PMCID: PMC7068792.
Plopper CG, Joad JP, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Lasley WL, Buckpitt AR, Pinkerton KE, Tarkington BK, Davis S, Nishio SJ, Gershwin LJ, Wu R, Hyde DM. Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma. Clin Exp Allergy. 2012 Jul;42(7):1104-18. doi: 10.1111/j.1365-2222.2012.04005.x. PubMed PMID: 22702509; PubMed Central PMCID: PMC3913647.
Avdalovic MV, Tyler NK, Putney L, Nishio SJ, Quesenberry S, Singh PJ, Miller LA, Schelegle ES, Plopper CG, Vu T, Hyde DM. Ozone exposure during the early postnatal period alters the timing and pattern of alveolar growth and development in nonhuman primates. Anat Rec (Hoboken). 2012 Oct;295(10):1707-16. doi: 10.1002/ar.22545. Epub 2012 Aug 13. PubMed PMID: 22887719; PubMed Central PMCID: PMC5462601.
Murphy SR, Schelegle ES, Edwards PC, Miller LA, Hyde DM, Van Winkle LS. Postnatal exposure history and airways: oxidant stress responses in airway explants. Am J Respir Cell Mol Biol. 2012 Dec;47(6):815-23. doi: 10.1165/rcmb.2012-0110OC. Epub 2012 Sep 6. PubMed PMID: 22962062; PubMed Central PMCID: PMC3547096.
Murphy SR, Schelegle ES, Miller LA, Hyde DM, Van Winkle LS. Ozone exposure alters serotonin and serotonin receptor expression in the developing lung. Toxicol Sci. 2013 Jul;134(1):168-79. doi: 10.1093/toxsci/kft090. Epub 2013 Apr 9. PubMed PMID: 23570994; PubMed Central PMCID: PMC3693130.
Evans MJ, Miller LA, Hyde DM. The Basement Membrane Zone in Asthma: The Supracellular Anchoring Network. Curr Respir Med Rev. 2013 Aug;9(4):268-273. doi: 10.2174/1573398x09666131121231852. PubMed PMID: 35505688; PubMed Central PMCID: PMC9060264.
Kallapur SG, Presicce P, Senthamaraikannan P, Alvarez M, Tarantal AF, Miller LM, Jobe AH, Chougnet CA. Intra-amniotic IL-1β induces fetal inflammation in rhesus monkeys and alters the regulatory T cell/IL-17 balance. J Immunol. 2013 Aug 1;191(3):1102-9. doi: 10.4049/jimmunol.1300270. Epub 2013 Jun 21. PubMed PMID: 23794628; PubMed Central PMCID: PMC3720768.
Chun K, Miller LA, Schelegle ES, Hyde DM, Capitanio JP. Behavioral inhibition in rhesus monkeys (Macaca mulatta) is related to the airways response, but not immune measures, commonly associated with asthma. PLoS One. 2013;8(8):e71575. doi: 10.1371/journal.pone.0071575. eCollection 2013. PubMed PMID: 23951195; PubMed Central PMCID: PMC3739724.
Maniar-Hew K, Clay CC, Postlethwait EM, Evans MJ, Fontaine JH, Miller LA. Innate immune response to LPS in airway epithelium is dependent on chronological age and antecedent exposures. Am J Respir Cell Mol Biol. 2013 Nov;49(5):710-20. doi: 10.1165/rcmb.2012-0321OC. PubMed PMID: 23600597; PubMed Central PMCID: PMC3931090.
Clay CC, Miller LA. Infant airway epithelium is susceptible to persistent effects of tobacco smoke exposure. Differential regulation of innate responses to virus and bacteria. Annals of the American Thoracic Society. 2014; Suppl 1:S75-S76.
Clay CC, Maniar-Hew K, Gerriets JE, Wang TT, Postlethwait EM, Evans MJ, Fontaine JH, Miller LA. Early life ozone exposure results in dysregulated innate immune function and altered microRNA expression in airway epithelium. PLoS One. 2014;9(3):e90401. doi: 10.1371/journal.pone.0090401. eCollection 2014. PubMed PMID: 24594710; PubMed Central PMCID: PMC3942419.
Moore BD, Hyde DM, Miller LA, Wong EM, Schelegle ES. Persistence of serotonergic enhancement of airway response in a model of childhood asthma. Am J Respir Cell Mol Biol. 2014 Jul;51(1):77-85. doi: 10.1165/rcmb.2013-0387OC. PubMed PMID: 24484440; PubMed Central PMCID: PMC4091858.
Clay CC, Reader JR, Gerriets JE, Wang TT, Harrod KS, Miller LA. Enhanced viral replication and modulated innate immune responses in infant airway epithelium following H1N1 infection. J Virol. 2014 Jul;88(13):7412-25. doi: 10.1128/JVI.00188-14. Epub 2014 Apr 16. PubMed PMID: 24741104; PubMed Central PMCID: PMC4054429.
Phillips KA, Bales KL, Capitanio JP, Conley A, Czoty PW, 't Hart BA, Hopkins WD, Hu SL, Miller LA, Nader MA, Nathanielsz PW, Rogers J, Shively CA, Voytko ML. Why primate models matter. Am J Primatol. 2014 Sep;76(9):801-27. doi: 10.1002/ajp.22281. Epub 2014 Apr 10. Review. PubMed PMID: 24723482; PubMed Central PMCID: PMC4145602.
Murphy SR, Oslund KL, Hyde DM, Miller LA, Van Winkle LS, Schelegle ES. Ozone-induced airway epithelial cell death, the neurokinin-1 receptor pathway, and the postnatal developing lung. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15;307(6):L471-81. doi: 10.1152/ajplung.00324.2013. Epub 2014 Jul 25. PubMed PMID: 25063800; PubMed Central PMCID: PMC4166783.
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