Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Chalak LF, Adams-Huet B, Sant'Anna G. A Total Sarnat Score in Mild Hypoxic-ischemic Encephalopathy Can Detect Infants at Higher Risk of Disability. J Pediatr. 2019 Nov;214:217-221.e1. doi: 10.1016/j.jpeds.2019.06.026. Epub 2019 Jul 10. PubMed PMID: 31301853.
Mir IN, Steven Brown L, Rosenfeld CR, Chalak LF. Placental clearance/synthesis of neurobiomarkers GFAP and UCH-L1 in healthy term neonates and those with moderate-severe neonatal encephalopathy. Pediatr Res. 2019 Oct;86(4):500-504. doi: 10.1038/s41390-019-0439-z. Epub 2019 May 27. PubMed PMID: 31132788.
Xu Y, Cao M, Liao X, Xia M, Wang X, Jeon T, Ouyang M, Chalak L, Rollins N, Huang H, He Y. Development and Emergence of Individual Variability in the Functional Connectivity Architecture of the Preterm Human Brain. Cereb Cortex. 2019 Sep 13;29(10):4208-4222. doi: 10.1093/cercor/bhy302. PubMed PMID: 30534949; PubMed Central PMCID: PMC6735255.
Stine CN, Koch J, Brown LS, Chalak L, Kapadia V, Wyckoff MH. Quantitative end-tidal CO2 can predict increase in heart rate during infant cardiopulmonary resuscitation. Heliyon. 2019 Jun;5(6):e01871. doi: 10.1016/j.heliyon.2019.e01871. eCollection 2019 Jun. PubMed PMID: 31245640; PubMed Central PMCID: PMC6581839.
Ouyang M, Jeon T, Sotiras A, Peng Q, Mishra V, Halovanic C, Chen M, Chalak L, Rollins N, Roberts TPL, Davatzikos C, Huang H. Differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4681-4688. doi: 10.1073/pnas.1812156116. Epub 2019 Feb 19. PubMed PMID: 30782802; PubMed Central PMCID: PMC6410816.
El-Dib M, Inder TE, Chalak LF, Massaro AN, Thoresen M, Gunn AJ. Should therapeutic hypothermia be offered to babies with mild neonatal encephalopathy in the first 6 h after birth?. Pediatr Res. 2019 Mar;85(4):442-448. doi: 10.1038/s41390-019-0291-1. Epub 2019 Jan 16. PubMed PMID: 30733613.
Feng L, Li H, Oishi K, Mishra V, Song L, Peng Q, Ouyang M, Wang J, Slinger M, Jeon T, Lee L, Heyne R, Chalak L, Peng Y, Liu S, Huang H. Age-specific gray and white matter DTI atlas for human brain at 33, 36 and 39 postmenstrual weeks. Neuroimage. 2019 Jan 15;185:685-698. doi: 10.1016/j.neuroimage.2018.06.069. Epub 2018 Jun 26. PubMed PMID: 29959046; PubMed Central PMCID: PMC6289605.
Zhao T, Mishra V, Jeon T, Ouyang M, Peng Q, Chalak L, Wisnowski JL, Heyne R, Rollins N, Shu N, Huang H. Structural network maturation of the preterm human brain. Neuroimage. 2019 Jan 15;185:699-710. doi: 10.1016/j.neuroimage.2018.06.047. Epub 2018 Jun 18. PubMed PMID: 29913282; PubMed Central PMCID: PMC6289855.
Chalak LF, Nguyen KA, Prempunpong C, Heyne R, Thayyil S, Shankaran S, Laptook AR, Rollins N, Pappas A, Koclas L, Shah B, Montaldo P, Techasaensiri B, Sánchez PJ, Sant'Anna G. Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18-22 months. Pediatr Res. 2018 Dec;84(6):861-868. doi: 10.1038/s41390-018-0174-x. Epub 2018 Sep 13. PubMed PMID: 30250303; PubMed Central PMCID: PMC6445543.
Ibrahim J, Mir I, Chalak L. Brain imaging in preterm infants <32 weeks gestation: a clinical review and algorithm for the use of cranial ultrasound and qualitative brain MRI. Pediatr Res. 2018 Dec;84(6):799-806. doi: 10.1038/s41390-018-0194-6. Epub 2018 Oct 12. Review. PubMed PMID: 30315272.
Chalak L, Latremouille S, Mir I, Sánchez PJ, Sant'Anna G. A review of the conundrum of mild hypoxic-ischemic encephalopathy: Current challenges and moving forward. Early Hum Dev. 2018 May;120:88-94. doi: 10.1016/j.earlhumdev.2018.02.008. Epub 2018 Mar 3. Review. PubMed PMID: 29506900.
Chalak LF. Best practice guidelines on management of mild neonatal encephalopathy: Is it really mild?. Early Hum Dev. 2018 May;120:74. doi: 10.1016/j.earlhumdev.2018.02.005. Epub 2018 Feb 17. PubMed PMID: 29459085.
Prempunpong C, Chalak LF, Garfinkle J, Shah B, Kalra V, Rollins N, Boyle R, Nguyen KA, Mir I, Pappas A, Montaldo P, Thayyil S, Sánchez PJ, Shankaran S, Laptook AR, Sant'Anna G. Prospective research on infants with mild encephalopathy: the PRIME study. J Perinatol. 2018 Jan;38(1):80-85. doi: 10.1038/jp.2017.164. Epub 2017 Nov 2. PubMed PMID: 29095433.
Laptook AR, Shankaran S, Tyson JE, Munoz B, Bell EF, Goldberg RN, Parikh NA, Ambalavanan N, Pedroza C, Pappas A, Das A, Chaudhary AS, Ehrenkranz RA, Hensman AM, Van Meurs KP, Chalak LF, Khan AM, Hamrick SEG, Sokol GM, Walsh MC, Poindexter BB, Faix RG, Watterberg KL, Frantz ID 3rd, Guillet R, Devaskar U, Truog WE, Chock VY, Wyckoff MH, McGowan EC, Carlton DP, Harmon HM, Brumbaugh JE, Cotten CM, Sánchez PJ, Hibbs AM, Higgins RD. Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial. JAMA. 2017 Oct 24;318(16):1550-1560. doi: 10.1001/jama.2017.14972. PubMed PMID: 29067428; PubMed Central PMCID: PMC5783566.
Tian F, Morriss MC, Chalak L, Venkataraman R, Ahn C, Liu H, Raman L. Impairment of cerebral autoregulation in pediatric extracorporeal membrane oxygenation associated with neuroimaging abnormalities. Neurophotonics. 2017 Oct;4(4):041410. doi: 10.1117/1.NPh.4.4.041410. Epub 2017 Aug 19. PubMed PMID: 28840161; PubMed Central PMCID: PMC5562949.
Shankaran S, Laptook AR, Pappas A, McDonald SA, Das A, Tyson JE, Poindexter BB, Schibler K, Bell EF, Heyne RJ, Pedroza C, Bara R, Van Meurs KP, Huitema CMP, Grisby C, Devaskar U, Ehrenkranz RA, Harmon HM, Chalak LF, DeMauro SB, Garg M, Hartley-McAndrew ME, Khan AM, Walsh MC, Ambalavanan N, Brumbaugh JE, Watterberg KL, Shepherd EG, Hamrick SEG, Barks J, Cotten CM, Kilbride HW, Higgins RD. Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial. JAMA. 2017 Jul 4;318(1):57-67. doi: 10.1001/jama.2017.7218. PubMed PMID: 28672318; PubMed Central PMCID: PMC5793705.
Chalak LF, Tian F, Adams-Huet B, Vasil D, Laptook A, Tarumi T, Zhang R. Novel Wavelet Real Time Analysis of Neurovascular Coupling in Neonatal Encephalopathy. Sci Rep. 2017 Apr 10;7:45958. doi: 10.1038/srep45958. PubMed PMID: 28393884; PubMed Central PMCID: PMC5385531.
Chalak LF, Zhang R. New Wavelet Neurovascular Bundle for Bedside Evaluation of Cerebral Autoregulation and Neurovascular Coupling in Newborns with Hypoxic-Ischemic Encephalopathy. Dev Neurosci. 2017;39(1-4):89-96. doi: 10.1159/000457833. Epub 2017 Mar 30. PubMed PMID: 28355608; PubMed Central PMCID: PMC5519424.
Cao M, He Y, Dai Z, Liao X, Jeon T, Ouyang M, Chalak L, Bi Y, Rollins N, Dong Q, Huang H. Early Development of Functional Network Segregation Revealed by Connectomic Analysis of the Preterm Human Brain. Cereb Cortex. 2017 Mar 1;27(3):1949-1963. doi: 10.1093/cercor/bhw038. PubMed PMID: 26941380; PubMed Central PMCID: PMC6059235.
Ouyang M, Liu P, Jeon T, Chalak L, Heyne R, Rollins NK, Licht DJ, Detre JA, Roberts TPL, Lu H, Huang H. Heterogeneous increases of regional cerebral blood flow during preterm brain development: Preliminary assessment with pseudo-continuous arterial spin labeled perfusion MRI. Neuroimage. 2017 Feb 15;147:233-242. doi: 10.1016/j.neuroimage.2016.12.034. Epub 2016 Dec 14. PubMed PMID: 27988320; PubMed Central PMCID: PMC5303673.
Yu Q, Ouyang A, Chalak L, Jeon T, Chia J, Mishra V, Sivarajan M, Jackson G, Rollins N, Liu S, Huang H. Structural Development of Human Fetal and Preterm Brain Cortical Plate Based on Population-Averaged Templates. Cereb Cortex. 2016 Oct 17;26(11):4381-4391. doi: 10.1093/cercor/bhv201. PubMed PMID: 26405055; PubMed Central PMCID: PMC5066822.
Shankaran S, Natarajan G, Chalak L, Pappas A, McDonald SA, Laptook AR. Hypothermia for neonatal hypoxic-ischemic encephalopathy: NICHD Neonatal Research Network contribution to the field. Semin Perinatol. 2016 Oct;40(6):385-390. doi: 10.1053/j.semperi.2016.05.009. Epub 2016 Jun 23. Review. PubMed PMID: 27345952; PubMed Central PMCID: PMC5065734.
Chalak LF. Inflammatory Biomarkers of Birth Asphyxia. Clin Perinatol. 2016 Sep;43(3):501-10. doi: 10.1016/j.clp.2016.04.008. Review. PubMed PMID: 27524450; PubMed Central PMCID: PMC6170165.
Duryea EL, Nelson DB, Wyckoff MH, Grant EN, Tao W, Sadana N, Chalak LF, McIntire DD, Leveno KJ. The impact of ambient operating room temperature on neonatal and maternal hypothermia and associated morbidities: a randomized controlled trial. Am J Obstet Gynecol. 2016 Apr;214(4):505.e1-505.e7. doi: 10.1016/j.ajog.2016.01.190. Epub 2016 Feb 10. PubMed PMID: 26874298.
Liu P, Chalak LF, Krishnamurthy LC, Mir I, Peng SL, Huang H, Lu H. T1 and T2 values of human neonatal blood at 3 Tesla: Dependence on hematocrit, oxygenation, and temperature. Magn Reson Med. 2016 Apr;75(4):1730-5. doi: 10.1002/mrm.25775. Epub 2015 May 18. PubMed PMID: 25981985; PubMed Central PMCID: PMC4651862.
Chalak LF, Tian F, Tarumi T, Zhang R. Cerebral Hemodynamics in Asphyxiated Newborns Undergoing Hypothermia Therapy: Pilot Findings Using a Multiple-Time-Scale Analysis. Pediatr Neurol. 2016 Feb;55:30-6. doi: 10.1016/j.pediatrneurol.2015.11.010. Epub 2015 Nov 27. PubMed PMID: 26858217; PubMed Central PMCID: PMC4748172.
Tian F, Tarumi T, Liu H, Zhang R, Chalak L. Wavelet coherence analysis of dynamic cerebral autoregulation in neonatal hypoxic-ischemic encephalopathy. Neuroimage Clin. 2016;11:124-132. doi: 10.1016/j.nicl.2016.01.020. eCollection 2016. PubMed PMID: 26937380; PubMed Central PMCID: PMC4753811.
Mir IN, Johnson-Welch SF, Nelson DB, Brown LS, Rosenfeld CR, Chalak LF. Placental pathology is associated with severity of neonatal encephalopathy and adverse developmental outcomes following hypothermia. Am J Obstet Gynecol. 2015 Dec;213(6):849.e1-7. doi: 10.1016/j.ajog.2015.09.072. Epub 2015 Sep 25. PubMed PMID: 26408082; NIHMSID:NIHMS725495.
Ouyang A, Yu Q, Mishra V, Chalak L, Jeon T, Sivarajan M, Jackson G, Rollins N, Liu S, Huang H. Structural development of human brain white matter from mid-fetal to perinatal stage. Proc SPIE Int Soc Opt Eng. 2015 Feb 21;9417. doi: 10.1117/12.2082418. Epub 2015 Apr 3. PubMed PMID: 26937064; PubMed Central PMCID: PMC4771190.
Nelson DB, Chalak LF, McIntire DD, Leveno KJ. Is preeclampsia associated with fetal malformation? A review and report of original research. J Matern Fetal Neonatal Med. 2015;28(18):2135-40. doi: 10.3109/14767058.2014.980808. Epub 2014 Nov 14. PubMed PMID: 25354285; PubMed Central PMCID: PMC4605271.
Shankaran S, Laptook AR, Pappas A, McDonald SA, Das A, Tyson JE, Poindexter BB, Schibler K, Bell EF, Heyne RJ, Pedroza C, Bara R, Van Meurs KP, Grisby C, Huitema CM, Garg M, Ehrenkranz RA, Shepherd EG, Chalak LF, Hamrick SE, Khan AM, Reynolds AM, Laughon MM, Truog WE, Dysart KC, Carlo WA, Walsh MC, Watterberg KL, Higgins RD. Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial. JAMA. 2014 Dec 24-31;312(24):2629-39. doi: 10.1001/jama.2014.16058. PubMed PMID: 25536254; PubMed Central PMCID: PMC4335311.
Liu P, Chalak LF, Lu H. Non-invasive assessment of neonatal brain oxygen metabolism: A review of newly available techniques. Early Hum Dev. 2014 Oct;90(10):695-701. doi: 10.1016/j.earlhumdev.2014.06.009. Epub 2014 Jul 11. Review. PubMed PMID: 25028136; PubMed Central PMCID: PMC4170025.
Chalak LF. Introduction. A "neurovascular unit" approach in newborns with HIE: can we improve outcomes?. Early Hum Dev. 2014 Oct;90(10):685. doi: 10.1016/j.earlhumdev.2014.06.011. Epub 2014 Jul 16. PubMed PMID: 25042668; PubMed Central PMCID: PMC4170016.
Mir IN, Chalak LF. Serum biomarkers to evaluate the integrity of the neurovascular unit. Early Hum Dev. 2014 Oct;90(10):707-11. doi: 10.1016/j.earlhumdev.2014.06.010. Epub 2014 Jul 23. Review. PubMed PMID: 25064445; NIHMSID:NIHMS616795.
Chalak LF, Tarumi T, Zhang R. The "neurovascular unit approach" to evaluate mechanisms of dysfunctional autoregulation in asphyxiated newborns in the era of hypothermia therapy. Early Hum Dev. 2014 Oct;90(10):687-94. doi: 10.1016/j.earlhumdev.2014.06.013. Epub 2014 Jul 23. PubMed PMID: 25062804; PubMed Central PMCID: PMC4170014.
Chalak LF, DuPont TL, Sánchez PJ, Lucke A, Heyne RJ, Morriss MC, Rollins NK. Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III. J Perinatol. 2014 Aug;34(8):629-33. doi: 10.1038/jp.2014.67. Epub 2014 Apr 17. PubMed PMID: 24743133; PubMed Central PMCID: PMC4117736.
Nelson DB, Lucke AM, McIntire DD, Sánchez PJ, Leveno KJ, Chalak LF. Obstetric antecedents to body-cooling treatment of the newborn infant. Am J Obstet Gynecol. 2014 Aug;211(2):155.e1-6. doi: 10.1016/j.ajog.2014.02.013. Epub 2014 Feb 13. PubMed PMID: 24530976; PubMed Central PMCID: PMC4117807.
Rollins N, Booth T, Morriss MC, Sanchez P, Heyne R, Chalak L. Predictive value of neonatal MRI showing no or minor degrees of brain injury after hypothermia. Pediatr Neurol. 2014 May;50(5):447-51. doi: 10.1016/j.pediatrneurol.2014.01.013. Epub 2014 Jan 7. PubMed PMID: 24656462; PubMed Central PMCID: PMC4006931.
Chalak LF, Sánchez PJ, Adams-Huet B, Laptook AR, Heyne RJ, Rosenfeld CR. Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy. J Pediatr. 2014 Mar;164(3):468-74.e1. doi: 10.1016/j.jpeds.2013.10.067. Epub 2013 Dec 12. PubMed PMID: 24332821; PubMed Central PMCID: PMC4006934.
Liu P, Huang H, Rollins N, Chalak LF, Jeon T, Halovanic C, Lu H. Quantitative assessment of global cerebral metabolic rate of oxygen (CMRO2) in neonates using MRI. NMR Biomed. 2014 Mar;27(3):332-40. doi: 10.1002/nbm.3067. Epub 2014 Jan 7. PubMed PMID: 24399806; PubMed Central PMCID: PMC3970939.
Kapadia VS, Chalak LF, Sparks JE, Allen JR, Savani RC, Wyckoff MH. Resuscitation of preterm neonates with limited versus high oxygen strategy. Pediatrics. 2013 Dec;132(6):e1488-96. doi: 10.1542/peds.2013-0978. Epub 2013 Nov 11. PubMed PMID: 24218465; PubMed Central PMCID: PMC3838529.
Kapadia VS, Chalak LF, DuPont TL, Rollins NK, Brion LP, Wyckoff MH. Perinatal asphyxia with hyperoxemia within the first hour of life is associated with moderate to severe hypoxic-ischemic encephalopathy. J Pediatr. 2013 Oct;163(4):949-54. doi: 10.1016/j.jpeds.2013.04.043. Epub 2013 Jun 5. PubMed PMID: 23759422.
DuPont TL, Chalak LF, Morriss MC, Burchfield PJ, Christie L, Sánchez PJ. Short-term outcomes of newborns with perinatal acidemia who are not eligible for systemic hypothermia therapy. J Pediatr. 2013 Jan;162(1):35-41. doi: 10.1016/j.jpeds.2012.06.042. Epub 2012 Aug 4. PubMed PMID: 22871488; PubMed Central PMCID: PMC3712522.
Chalak LF, Rollins N, Morriss MC, Brion LP, Heyne R, Sánchez PJ. Perinatal acidosis and hypoxic-ischemic encephalopathy in preterm infants of 33 to 35 weeks' gestation. J Pediatr. 2012 Mar;160(3):388-94. doi: 10.1016/j.jpeds.2011.09.001. Epub 2011 Oct 26. PubMed PMID: 22033298; PubMed Central PMCID: PMC3740949.
Chalak LF, Rouse DJ. Neuroprotective approaches: before and after delivery. Clin Perinatol. 2011 Sep;38(3):455-70. doi: 10.1016/j.clp.2011.06.012. Review. PubMed PMID: 21890019.
Chalak LF, Sikes NC, Mason MJ, Kaiser JR. Low-voltage aEEG as predictor of intracranial hemorrhage in preterm infants. Pediatr Neurol. 2011 May;44(5):364-9. doi: 10.1016/j.pediatrneurol.2010.11.018. PubMed PMID: 21481745; PubMed Central PMCID: PMC3160756.
Chalak LF, Barber CA, Hynan L, Garcia D, Christie L, Wyckoff MH. End-tidal CO₂ detection of an audible heart rate during neonatal cardiopulmonary resuscitation after asystole in asphyxiated piglets. Pediatr Res. 2011 May;69(5 Pt 1):401-5. doi: 10.1203/PDR.0b013e3182125f7f. PubMed PMID: 21283051; PubMed Central PMCID: PMC3089974.
Chalak L, Kaiser J. Neonatal guideline hypoxic-ischemic encephalopathy (HIE). J Ark Med Soc. 2007 Oct;104(4):87-9. PubMed PMID: 17953198.
Chalak LF, Parham DM. A newborn with Poland anomaly and liver ectopy: an unusual association with important prognostic implications. Pediatr Dev Pathol. 2007 Mar-Apr;10(2):134-7. doi: 10.2350/06-04-00801.1. PubMed PMID: 17378683.
Chalak LF, Kaiser JR, Arrington RW. Resolution of pulmonary interstitial emphysema following selective left main stem intubation in a premature newborn: an old procedure revisited. Paediatr Anaesth. 2007 Feb;17(2):183-6. doi: 10.1111/j.1460-9592.2006.02044.x. PubMed PMID: 17238893.
What would you like to do?