My Bibliography

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MALDI Tandem Mass Spectrometry for Colony-Based Dereplication of Natural Products. Journal of natural products. . NIHMSID: NIHMS2210797.doi: 10.1021/acs.jnatprod.6c00765.

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Spatial metabolomics reveals the role of penicillic acid in cheese-rind microbiome disruption by a spoilage fungus. mSystems. . NIHMSID: NIHMS2149505.

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Ralifo P, Sanchez L, Gassner N, Tenney K, Lokey R, Holman T, Valeriote F, Crews P. Pyrroloacridine Alkaloids from Plakortis quasiamphiaster :  Structures and Bioactivity. Journal of Natural Products. 2007 January; 70(1):95-99. doi: 10.1021/np060585w.

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Sanchez LM, Lopez D, Vesely BA, Della Togna G, Gerwick WH, Kyle DE, Linington RG. Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds. J Med Chem. 2010 May 27;53(10):4187-97. doi: 10.1021/jm100265s. PubMed PMID: 20441198; PubMed Central PMCID: PMC4418807.

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Sanchez LM, Curtis ME, Bracamonte BE, Kurita KL, Navarro G, Sparkman OD, Linington RG. Versatile method for the detection of covalently bound substrates on solid supports by DART mass spectrometry. Org Lett. 2011 Aug 5;13(15):3770-3. doi: 10.1021/ol201404v. Epub 2011 Jun 24. PubMed PMID: 21699263; PubMed Central PMCID: PMC3146587.

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Sanchez LM, Wong WR, Riener RM, Schulze CJ, Linington RG. Examining the fish microbiome: vertebrate-derived bacteria as an environmental niche for the discovery of unique marine natural products. PLoS One. 2012;7(5):e35398. doi: 10.1371/journal.pone.0035398. Epub 2012 May 4. PubMed PMID: 22574119; PubMed Central PMCID: PMC3344833.

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Sanchez L, Dorrestein P. Virulence caught green-handed. Nature Chemistry. 2013-2-; 5(3):155-157. doi: 10.1038/nchem.1583.

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Sanchez LM, Knudsen GM, Helbig C, De Muylder G, Mascuch SM, Mackey ZB, Gerwick L, Clayton C, McKerrow JH, Linington RG. Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. J Nat Prod. 2013 Apr 26;76(4):630-41. doi: 10.1021/np300834q. Epub 2013 Feb 27. PubMed PMID: 23445522; PubMed Central PMCID: PMC3971013.

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Sanchez L, Knudsen G, Helbig C, De Muylder G, Mascuch S, Mackey Z, Gerwick L, Clayton C, McKerrow J, Linington R. Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei. Journal of Natural Products. 2013 February; 76(4):630-641. doi: 10.1021/np300834q.

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Hsu CC, ElNaggar MS, Peng Y, Fang J, Sanchez LM, Mascuch SJ, Møller KA, Alazzeh EK, Pikula J, Quinn RA, Zeng Y, Wolfe BE, Dutton RJ, Gerwick L, Zhang L, Liu X, Månsson M, Dorrestein PC. Real-time metabolomics on living microorganisms using ambient electrospray ionization flow-probe. Anal Chem. 2013 Aug 6;85(15):7014-8. doi: 10.1021/ac401613x. Epub 2013 Jul 11. PubMed PMID: 23819546; PubMed Central PMCID: PMC3890442.

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Yang JY, Sanchez LM, Rath CM, Liu X, Boudreau PD, Bruns N, Glukhov E, Wodtke A, de Felicio R, Fenner A, Wong WR, Linington RG, Zhang L, Debonsi HM, Gerwick WH, Dorrestein PC. Molecular networking as a dereplication strategy. J Nat Prod. 2013 Sep 27;76(9):1686-99. doi: 10.1021/np400413s. Epub 2013 Sep 11. PubMed PMID: 24025162; PubMed Central PMCID: PMC3936340.

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Bouslimani A, Sanchez LM, Garg N, Dorrestein PC. Mass spectrometry of natural products: current, emerging and future technologies. Nat Prod Rep. 2014 Jun;31(6):718-29. doi: 10.1039/c4np00044g. Epub 2014 May 7. Review. PubMed PMID: 24801551; PubMed Central PMCID: PMC4161218.

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Moree WJ, McConnell OJ, Nguyen DD, Sanchez LM, Yang YL, Zhao X, Liu WT, Boudreau PD, Srinivasan J, Atencio L, Ballesteros J, Gavilán RG, Torres-Mendoza D, Guzmán HM, Gerwick WH, Gutiérrez M, Dorrestein PC. Microbiota of healthy corals are active against fungi in a light-dependent manner. ACS Chem Biol. 2014 Oct 17;9(10):2300-8. doi: 10.1021/cb500432j. Epub 2014 Aug 6. PubMed PMID: 25058318; PubMed Central PMCID: PMC4201335.

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Spraker JE, Sanchez LM, Lowe TM, Dorrestein PC, Keller NP. Ralstonia solanacearum lipopeptide induces chlamydospore development in fungi and facilitates bacterial entry into fungal tissues. ISME J. 2016 Sep;10(9):2317-30. doi: 10.1038/ismej.2016.32. Epub 2016 Mar 4. PubMed PMID: 26943626; PubMed Central PMCID: PMC4989320.

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Sanchez LM, Cheng AT, Warner CJ, Townsley L, Peach KC, Navarro G, Shikuma NJ, Bray WM, Riener RM, Yildiz FH, Linington RG. Biofilm Formation and Detachment in Gram-Negative Pathogens Is Modulated by Select Bile Acids. PLoS One. 2016;11(3):e0149603. doi: 10.1371/journal.pone.0149603. eCollection 2016. PubMed PMID: 26992172; PubMed Central PMCID: PMC4798295.

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Maansson M, Vynne NG, Klitgaard A, Nybo JL, Melchiorsen J, Nguyen DD, Sanchez LM, Ziemert N, Dorrestein PC, Andersen MR, Gram L. An Integrated Metabolomic and Genomic Mining Workflow To Uncover the Biosynthetic Potential of Bacteria. mSystems. 2016 May-Jun;1(3). doi: 10.1128/mSystems.00028-15. eCollection 2016 May-Jun. PubMed PMID: 27822535; PubMed Central PMCID: PMC5069768.

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Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol. 2016 Aug 9;34(8):828-837. doi: 10.1038/nbt.3597. PubMed PMID: 27504778; PubMed Central PMCID: PMC5321674.

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Spraker J, Sanchez L, Lowe T, Dorrestein P, Keller N. Ralstonia solanacearum lipopeptide induces chlamydospore development in fungi and facilitates bacterial entry into fungal tissues. The ISME Journal. 2016 September; 10(9):2317-2330. doi: 10.1038/ismej.2016.32.

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Nguyen DD, Melnik AV, Koyama N, Lu X, Schorn M, Fang J, Aguinaldo K, Lincecum TL Jr, Ghequire MG, Carrion VJ, Cheng TL, Duggan BM, Malone JG, Mauchline TH, Sanchez LM, Kilpatrick AM, Raaijmakers JM, De Mot R, Moore BS, Medema MH, Dorrestein PC. Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. Nat Microbiol. 2016 Oct 31;2:16197. doi: 10.1038/nmicrobiol.2016.197. PubMed PMID: 27798598; PubMed Central PMCID: PMC5538791.

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Garg N, Zeng Y, Edlund A, Melnik AV, Sanchez LM, Mohimani H, Gurevich A, Miao V, Schiffler S, Lim YW, Luzzatto-Knaan T, Cai S, Rohwer F, Pevzner PA, Cichewicz RH, Alexandrov T, Dorrestein PC. Spatial Molecular Architecture of the Microbial Community of a Peltigera Lichen. mSystems. 2016 Nov-Dec;1(6). doi: 10.1128/mSystems.00139-16. eCollection 2016 Nov-Dec. PubMed PMID: 28028548; PubMed Central PMCID: PMC5183598.

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Garg N, Zeng Y, Edlund A, Melnik A, Sanchez L, Mohimani H, Gurevich A, Miao V, Schiffler S, Lim Y, Luzzatto-Knaan T, Cai S, Rohwer F, Pevzner P, Cichewicz R, Alexandrov T, Dorrestein P. Spatial Molecular Architecture of the Microbial Community of a Peltigera Lichen. mSystems. 2016 December; 1(6):-. doi: 10.1128/mSystems.00139-16.

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Cleary JL, Condren AR, Zink KE, Sanchez LM. Calling all hosts: Bacterial communication in situ. Chem. 2017 Mar 9;2(3):334-358. doi: 10.1016/j.chempr.2017.02.001. PubMed PMID: 28948238; PubMed Central PMCID: PMC5609483.

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Ochoa JL, Sanchez LM, Koo BM, Doherty JS, Rajendram M, Huang KC, Gross CA, Linington RG. Marine Mammal Microbiota Yields Novel Antibiotic with Potent Activity Against Clostridium difficile. ACS Infect Dis. 2018 Jan 12;4(1):59-67. doi: 10.1021/acsinfecdis.7b00105. Epub 2017 Oct 18. PubMed PMID: 29043783; PubMed Central PMCID: PMC6530793.

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Clark CM, Costa MS, Sanchez LM, Murphy BT. Coupling MALDI-TOF mass spectrometry protein and specialized metabolite analyses to rapidly discriminate bacterial function. Proc Natl Acad Sci U S A. 2018 May 8;115(19):4981-4986. doi: 10.1073/pnas.1801247115. Epub 2018 Apr 23. PubMed PMID: 29686101; PubMed Central PMCID: PMC5949002.

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David BP, Dubrovskyi O, Speltz TE, Wolff JJ, Frasor J, Sanchez LM, Moore TW. Using Tumor Explants for Imaging Mass Spectrometry Visualization of Unlabeled Peptides and Small Molecules. ACS Med Chem Lett. 2018 Jul 12;9(7):768-772. doi: 10.1021/acsmedchemlett.8b00091. eCollection 2018 Jul 12. PubMed PMID: 30034616; PubMed Central PMCID: PMC6047048.

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Spraker JE, Wiemann P, Baccile JA, Venkatesh N, Schumacher J, Schroeder FC, Sanchez LM, Keller NP. Conserved Responses in a War of Small Molecules between a Plant-Pathogenic Bacterium and Fungi. mBio. 2018 May 22;9(3). doi: 10.1128/mBio.00820-18. PubMed PMID: 29789359; PubMed Central PMCID: PMC5964348.

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Cleary JL, Kolachina S, Wolfe BE, Sanchez LM. Coproporphyrin III Produced by the Bacterium Glutamicibacter arilaitensis Binds Zinc and Is Upregulated by Fungi in Cheese Rinds. mSystems. 2018 Jul-Aug;3(4). doi: 10.1128/mSystems.00036-18. eCollection 2018 Jul-Aug. PubMed PMID: 30175236; PubMed Central PMCID: PMC6104308.

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Zink KE, Dean M, Burdette JE, Sanchez LM. Imaging Mass Spectrometry Reveals Crosstalk between the Fallopian Tube and the Ovary that Drives Primary Metastasis of Ovarian Cancer. ACS Cent Sci. 2018 Oct 24;4(10):1360-1370. doi: 10.1021/acscentsci.8b00405. Epub 2018 Oct 9. PubMed PMID: 30410974; PubMed Central PMCID: PMC6202655.

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Petukhova VZ, Young AN, Wang J, Wang M, Ladanyi A, Kothari R, Burdette JE, Sanchez LM. Whole Cell MALDI Fingerprinting Is a Robust Tool for Differential Profiling of Two-Component Mammalian Cell Mixtures. J Am Soc Mass Spectrom. 2019 Feb;30(2):344-354. doi: 10.1007/s13361-018-2088-6. Epub 2018 Oct 23. PubMed PMID: 30353292; PubMed Central PMCID: PMC6347503.

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Sporer, Abigail J, Beierschmitt, Christopher, Bendebury, Anastasia, Zink, Katherine E, Price-Whelan, Alexa, Buzzeo, Marisa C, Sanchez, Laura M, Dietrich, Lars E P. Pseudomonas aeruginosa PumA acts on an endogenous phenazine to promote self-resistance. Microbiology. 2018 May; 164(5):790--800.

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Galey, Melissa M, Sanchez, Laura M. Spatial Analyses of Specialized Metabolites: The Key to Studying Function in Hosts. mSystems. 2018 March; 3(2).

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Zink KE, Dean M, Burdette JE, Sanchez LM. Capturing Small Molecule Communication Between Tissues and Cells Using Imaging Mass Spectrometry. J Vis Exp. 2019 Apr 3;(146). doi: 10.3791/59490. PubMed PMID: 31009015; PubMed Central PMCID: PMC6638549.

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Cleary JL, Luu GT, Pierce EC, Dutton RJ, Sanchez LM. BLANKA: an Algorithm for Blank Subtraction in Mass Spectrometry of Complex Biological Samples. J Am Soc Mass Spectrom. 2019 Aug;30(8):1426-1434. doi: 10.1007/s13361-019-02185-8. Epub 2019 Apr 16. PubMed PMID: 30993641; PubMed Central PMCID: PMC6675636.

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Clark CM, Costa MS, Conley E, Li E, Sanchez LM, Murphy BT. Using the Open-Source MALDI TOF-MS IDBac Pipeline for Analysis of Microbial Protein and Specialized Metabolite Data. J Vis Exp. 2019 May 15;(147). doi: 10.3791/59219. PubMed PMID: 31157770; PubMed Central PMCID: PMC7204650.

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Grim CM, Luu GT, Sanchez LM. Staring into the void: demystifying microbial metabolomics. FEMS Microbiol Lett. 2019 Jun 1;366(11). doi: 10.1093/femsle/fnz135. PubMed PMID: 31210257; PubMed Central PMCID: PMC6597752.

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Costa MS, Clark CM, Ómarsdóttir S, Sanchez LM, Murphy BT. Minimizing Taxonomic and Natural Product Redundancy in Microbial Libraries Using MALDI-TOF MS and the Bioinformatics Pipeline IDBac. J Nat Prod. 2019 Aug 23;82(8):2167-2173. doi: 10.1021/acs.jnatprod.9b00168. Epub 2019 Jul 23. PubMed PMID: 31335140; PubMed Central PMCID: PMC7197193.

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Zink KE, Tarnowski DA, Mandel MJ, Sanchez LM. Optimization of a minimal sample preparation protocol for imaging mass spectrometry of unsectioned juvenile invertebrates. J Mass Spectrom. 2020 Apr;55(4):e4458. doi: 10.1002/jms.4458. Epub 2019 Nov 6. PubMed PMID: 31693273; PubMed Central PMCID: PMC7145758.

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van Santen JA, Jacob G, Singh AL, Aniebok V, Balunas MJ, Bunsko D, Neto FC, Castaño-Espriu L, Chang C, Clark TN, Cleary Little JL, Delgadillo DA, Dorrestein PC, Duncan KR, Egan JM, Galey MM, Haeckl FPJ, Hua A, Hughes AH, Iskakova D, Khadilkar A, Lee JH, Lee S, LeGrow N, Liu DY, Macho JM, McCaughey CS, Medema MH, Neupane RP, O'Donnell TJ, Paula JS, Sanchez LM, Shaikh AF, Soldatou S, Terlouw BR, Tran TA, Valentine M, van der Hooft JJJ, Vo DA, Wang M, Wilson D, Zink KE, Linington RG. The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery. ACS Cent Sci. 2019 Nov 27;5(11):1824-1833. doi: 10.1021/acscentsci.9b00806. Epub 2019 Nov 14. PubMed PMID: 31807684; PubMed Central PMCID: PMC6891855.

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Li F, Hopwood JP, Galey MM, Sanchez LM, Ciszek JW. Chemically transformed monolayers on acene thin films for improved metal/organic interfaces. Chem Commun (Camb). 2019 Nov 19;55(93):13975-13978. doi: 10.1039/c9cc07234a. PubMed PMID: 31687695.

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Galey MM, Young AN, Petukhova VZ, Wang M, Wang J, Salvi A, Russo A, Burdette JE, Sanchez LM. Detection of Ovarian Cancer Using Samples Sourced from the Vaginal Microenvironment. J Proteome Res. 2020 Jan 3;19(1):503-510. doi: 10.1021/acs.jproteome.9b00694. Epub 2019 Dec 2. PubMed PMID: 31738564; PubMed Central PMCID: PMC7020100.

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Condren A, Kahl L, Boelter G, Kritikos G, Banzhaf M, Dietrich L, Sanchez L. Biofilm Inhibitor Taurolithocholic Acid Alters Colony Morphology, Specialized Metabolism, and Virulence of Pseudomonas aeruginosa. ACS Infectious Diseases. 2019 December; 6(4):603-612. doi: 10.1021/acsinfecdis.9b00424.

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Condren AR, Kahl LJ, Boelter G, Kritikos G, Banzhaf M, Dietrich LEP, Sanchez LM. Biofilm Inhibitor Taurolithocholic Acid Alters Colony Morphology, Specialized Metabolism, and Virulence of Pseudomonas aeruginosa. ACS Infect Dis. 2020 Apr 10;6(4):603-612. doi: 10.1021/acsinfecdis.9b00424. Epub 2020 Jan 3. PubMed PMID: 31851822; PubMed Central PMCID: PMC7150652.

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Clark CM, Murphy BT, Sanchez LM. A Call to Action: the Need for Standardization in Developing Open-Source Mass Spectrometry-Based Methods for Microbial Subspecies Discrimination. mSystems. 2020 Feb 18;5(1). doi: 10.1128/mSystems.00813-19. PubMed PMID: 32071161; PubMed Central PMCID: PMC7029221.

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Spraker JE, Luu GT, Sanchez LM. Imaging mass spectrometry for natural products discovery: a review of ionization methods. Nat Prod Rep. 2020 Feb 26;37(2):150-162. doi: 10.1039/c9np00038k. PubMed PMID: 31364647; PubMed Central PMCID: PMC6992513.

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Condren AR, Costa MS, Sanchez NR, Konkapaka S, Gallik KL, Saxena A, Murphy BT, Sanchez LM. Addition of insoluble fiber to isolation media allows for increased metabolite diversity of lab-cultivable microbes derived from zebrafish gut samples. Gut Microbes. 2020 Jul 3;11(4):1064-1076. doi: 10.1080/19490976.2020.1740073. Epub 2020 Mar 22. PubMed PMID: 32202200; PubMed Central PMCID: PMC7524352.

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Luu GT, Condren AR, Kahl LJ, Dietrich LEP, Sanchez LM. Evaluation of Data Analysis Platforms and Compatibility with MALDI-TOF Imaging Mass Spectrometry Data Sets. J Am Soc Mass Spectrom. 2020 Jun 3;31(6):1313-1320. doi: 10.1021/jasms.0c00039. Epub 2020 May 7. PubMed PMID: 32329613; PubMed Central PMCID: PMC7275808.

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Pierce EC, Morin M, Little JC, Liu RB, Tannous J, Keller NP, Pogliano K, Wolfe BE, Sanchez LM, Dutton RJ. Bacterial-fungal interactions revealed by genome-wide analysis of bacterial mutant fitness. Nat Microbiol. 2021 Jan;6(1):87-102. doi: 10.1038/s41564-020-00800-z. Epub 2020 Nov 2. PubMed PMID: 33139882; PubMed Central PMCID: PMC8515420.

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Shao L, Elujoba-Bridenstine A, Zink KE, Sanchez LM, Cox BJ, Pollok KE, Sinn AL, Bailey BJ, Sims EC, Cooper SH, Broxmeyer HE, Pajcini KV, Tamplin OJ. The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells. Blood. 2021 Feb 11;137(6):775-787. doi: 10.1182/blood.2019004415. PubMed PMID: 32881992; PubMed Central PMCID: PMC7885825.

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Zink KE, Ludvik DA, Lazzara PR, Moore TW, Mandel MJ, Sanchez LM. A Small Molecule Coordinates Symbiotic Behaviors in a Host Organ. mBio. 2021 Mar 9;12(2). doi: 10.1128/mBio.03637-20. PubMed PMID: 33688014; PubMed Central PMCID: PMC8092321.

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Schorn MA, Verhoeven S, Ridder L, Huber F, Acharya DD, Aksenov AA, Aleti G, Moghaddam JA, Aron AT, Aziz S, Bauermeister A, Bauman KD, Baunach M, Beemelmanns C, Beman JM, Berlanga-Clavero MV, Blacutt AA, Bode HB, Boullie A, Brejnrod A, Bugni TS, Calteau A, Cao L, Carrión VJ, Castelo-Branco R, Chanana S, Chase AB, Chevrette MG, Costa-Lotufo LV, Crawford JM, Currie CR, Cuypers B, Dang T, de Rond T, Demko AM, Dittmann E, Du C, Drozd C, Dujardin JC, Dutton RJ, Edlund A, Fewer DP, Garg N, Gauglitz JM, Gentry EC, Gerwick L, Glukhov E, Gross H, Gugger M, Guillén Matus DG, Helfrich EJN, Hempel BF, Hur JS, Iorio M, Jensen PR, Kang KB, Kaysser L, Kelleher NL, Kim CS, Kim KH, Koester I, König GM, Leao T, Lee SR, Lee YY, Li X, Little JC, Maloney KN, Männle D, Martin H C, McAvoy AC, Metcalf WW, Mohimani H, Molina-Santiago C, Moore BS, Mullowney MW, Muskat M, Nothias LF, O'Neill EC, Parkinson EI, Petras D, Piel J, Pierce EC, Pires K, Reher R, Romero D, Roper MC, Rust M, Saad H, Saenz C, Sanchez LM, Sørensen SJ, Sosio M, Süssmuth RD, Sweeney D, Tahlan K, Thomson RJ, Tobias NJ, Trindade-Silva AE, van Wezel GP, Wang M, Weldon KC, Zhang F, Ziemert N, Duncan KR, Crüsemann M, Rogers S, Dorrestein PC, Medema MH, van der Hooft JJJ. A community resource for paired genomic and metabolomic data mining. Nat Chem Biol. 2021 Apr;17(4):363-368. doi: 10.1038/s41589-020-00724-z. PubMed PMID: 33589842; PubMed Central PMCID: PMC7987574.