Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Bajpai P, Koc E, Sonpavde G, Singh R, Singh KK. Mitochondrial localization, import, and mitochondrial function of the androgen receptor. J Biol Chem. 2019 Apr 19;294(16):6621-6634. doi: 10.1074/jbc.RA118.006727. Epub 2019 Feb 21. PubMed PMID: 30792308; PubMed Central PMCID: PMC6484137.
Singh B, Schoeb TR, Bajpai P, Slominski A, Singh KK. Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function. Cell Death Dis. 2018 Jul 20;9(7):735. doi: 10.1038/s41419-018-0765-9. PubMed PMID: 30026579; PubMed Central PMCID: PMC6053453.
Koo DH, Singh B, Jiang J, Friebe B, Gill BS, Chastain PD, Manne U, Tiwari HK, Singh KK. Single molecule mtDNA fiber FISH for analyzing numtogenesis. Anal Biochem. 2018 Jul 1;552:45-49. doi: 10.1016/j.ab.2017.03.015. Epub 2017 Mar 18. PubMed PMID: 28322800; PubMed Central PMCID: PMC5814351.
Carden T, Singh B, Mooga V, Bajpai P, Singh KK. Epigenetic modification of miR-663 controls mitochondria-to-nucleus retrograde signaling and tumor progression. J Biol Chem. 2017 Dec 15;292(50):20694-20706. doi: 10.1074/jbc.M117.797001. Epub 2017 Oct 24. PubMed PMID: 29066618; PubMed Central PMCID: PMC5733605.
Singh B, Modica-Napolitano JS, Singh KK. Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome. Semin Cancer Biol. 2017 Dec;47:1-17. doi: 10.1016/j.semcancer.2017.05.004. Epub 2017 May 11. Review. PubMed PMID: 28502611; PubMed Central PMCID: PMC5681893.
Singh KK, Choudhury AR, Tiwari HK. Numtogenesis as a mechanism for development of cancer. Semin Cancer Biol. 2017 Dec;47:101-109. doi: 10.1016/j.semcancer.2017.05.003. Epub 2017 May 13. Review. PubMed PMID: 28511886; PubMed Central PMCID: PMC5683947.
Choudhury AR, Singh KK. Mitochondrial determinants of cancer health disparities. Semin Cancer Biol. 2017 Dec;47:125-146. doi: 10.1016/j.semcancer.2017.05.001. Epub 2017 May 6. Review. PubMed PMID: 28487205; PubMed Central PMCID: PMC5673596.
Singh KK, Modica-Napolitano JS. Special Issue: Mitochondria in Cancer. Semin Cancer Biol. 2017 Dec;47:iv-vi. doi: 10.1016/j.semcancer.2017.10.013. PubMed PMID: 29157537.
Srinivasainagendra V, Sandel MW, Singh B, Sundaresan A, Mooga VP, Bajpai P, Tiwari HK, Singh KK. Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma. Genome Med. 2017 Mar 29;9(1):31. doi: 10.1186/s13073-017-0420-6. PubMed PMID: 28356157; PubMed Central PMCID: PMC5370490.
Singh B, Kulawiec M, Owens KM, Singh A, Singh KK. Sustained Early Disruption of Mitochondrial Function Contributes to Arsenic-Induced Prostate Tumorigenesis. Biochemistry (Mosc). 2016 Oct;81(10):1089-1100. doi: 10.1134/S0006297916100072. PubMed PMID: 27908234.
Ghosh S, Singh KK, Sengupta S, Scaria V. Mitoepigenetics: The different shades of grey. Mitochondrion. 2015 Nov;25:60-6. doi: 10.1016/j.mito.2015.09.003. Epub 2015 Oct 5. Review. PubMed PMID: 26437363.
Singh B, Owens KM, Bajpai P, Desouki MM, Srinivasasainagendra V, Tiwari HK, Singh KK. Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties. PLoS One. 2015;10(10):e0139846. doi: 10.1371/journal.pone.0139846. eCollection 2015. PubMed PMID: 26468652; PubMed Central PMCID: PMC4607296.
Singh B, Li X, Owens KM, Vanniarajan A, Liang P, Singh KK. Human REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial Genome. PLoS One. 2015;10(10):e0140409. doi: 10.1371/journal.pone.0140409. eCollection 2015. PubMed PMID: 26462070; PubMed Central PMCID: PMC4604079.
Kabekkodu SP, Chakrabarty S, Shukla V, Varghese VK, Singh KK, Thangaraj K, Satyamoorthy K. Mitochondrial biology: From molecules to diseases. Mitochondrion. 2015 Sep;24:93-8. doi: 10.1016/j.mito.2015.07.008. Epub 2015 Jul 22. PubMed PMID: 26210788.
Nunes JB, Peixoto J, Soares P, Maximo V, Carvalho S, Pinho SS, Vieira AF, Paredes J, Rego AC, Ferreira IL, Gomez-Lazaro M, Sobrinho-Simoes M, Singh KK, Lima J. OXPHOS dysfunction regulates integrin-β1 modifications and enhances cell motility and migration. Hum Mol Genet. 2015 Apr 1;24(7):1977-90. doi: 10.1093/hmg/ddu612. Epub 2014 Dec 11. PubMed PMID: 25504047.
Zhang H, Singh KK. Global genetic determinants of mitochondrial DNA copy number. PLoS One. 2014;9(8):e105242. doi: 10.1371/journal.pone.0105242. eCollection 2014. PubMed PMID: 25170845; PubMed Central PMCID: PMC4149433.
Donthamsetty S, Brahmbhatt M, Pannu V, Rida PC, Ramarathinam S, Ogden A, Cheng A, Singh KK, Aneja R. Mitochondrial genome regulates mitotic fidelity by maintaining centrosomal homeostasis. Cell Cycle. 2014;13(13):2056-63. doi: 10.4161/cc.29061. Epub 2014 May 5. PubMed PMID: 24799670; PubMed Central PMCID: PMC4111697.
Koochekpour S, Marlowe T, Singh KK, Attwood K, Chandra D. Reduced mitochondrial DNA content associates with poor prognosis of prostate cancer in African American men. PLoS One. 2013;8(9):e74688. doi: 10.1371/journal.pone.0074688. eCollection 2013. PubMed PMID: 24086362; PubMed Central PMCID: PMC3781126.
Rodell A, Rasmussen LJ, Bergersen LH, Singh KK, Gjedde A. Natural selection of mitochondria during somatic lifetime promotes healthy aging. Front Neuroenergetics. 2013;5:7. doi: 10.3389/fnene.2013.00007. eCollection 2013. PubMed PMID: 23964235; PubMed Central PMCID: PMC3740293.
Bhattacharjee P, Chatterjee D, Singh KK, Giri AK. Systems biology approaches to evaluate arsenic toxicity and carcinogenicity: an overview. Int J Hyg Environ Health. 2013 Aug;216(5):574-86. doi: 10.1016/j.ijheh.2012.12.008. Epub 2013 Jan 20. Review. PubMed PMID: 23340121.
Davidson BA, Vethanayagam RR, Grimm MJ, Mullan BA, Raghavendran K, Blackwell TS, Freeman ML, Ayyasamy V, Singh KK, Sporn MB, Itagaki K, Hauser CJ, Knight PR, Segal BH. NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury. J Immunol. 2013 Feb 15;190(4):1714-24. doi: 10.4049/jimmunol.1202410. Epub 2013 Jan 7. PubMed PMID: 23296708; PubMed Central PMCID: PMC3563868.
Desler C, Hansen TL, Frederiksen JB, Marcker ML, Singh KK, Juel Rasmussen L. Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?. J Aging Res. 2012;2012:192503. doi: 10.1155/2012/192503. Epub 2012 Jun 5. PubMed PMID: 22720157; PubMed Central PMCID: PMC3375017.
Minocherhomji S, Tollefsbol TO, Singh KK. Mitochondrial regulation of epigenetics and its role in human diseases. Epigenetics. 2012 Apr;7(4):326-34. doi: 10.4161/epi.19547. Epub 2012 Apr 1. Review. PubMed PMID: 22419065; PubMed Central PMCID: PMC3368816.
Azrak S, Ayyasamy V, Zirpoli G, Ambrosone C, Bandera EV, Bovbjerg DH, Jandorf L, Ciupak G, Davis W, Pawlish KS, Liang P, Singh K. CAG repeat variants in the POLG1 gene encoding mtDNA polymerase-gamma and risk of breast cancer in African-American women. PLoS One. 2012;7(1):e29548. doi: 10.1371/journal.pone.0029548. Epub 2012 Jan 20. PubMed PMID: 22276120; PubMed Central PMCID: PMC3262786.
Hall BM, Owens KM, Singh KK. Distinct functions of evolutionary conserved MSF1 and late embryogenesis abundant (LEA)-like domains in mitochondria. J Biol Chem. 2011 Nov 11;286(45):39141-52. doi: 10.1074/jbc.M111.259853. Epub 2011 Sep 19. PubMed PMID: 21930701; PubMed Central PMCID: PMC3234739.
Ayyasamy V, Owens KM, Desouki MM, Liang P, Bakin A, Thangaraj K, Buchsbaum DJ, LoBuglio AF, Singh KK. Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin. PLoS One. 2011;6(9):e24792. doi: 10.1371/journal.pone.0024792. Epub 2011 Sep 15. PubMed PMID: 21935467; PubMed Central PMCID: PMC3174207.
Owens KM, Kulawiec M, Desouki MM, Vanniarajan A, Singh KK. Impaired OXPHOS complex III in breast cancer. PLoS One. 2011;6(8):e23846. doi: 10.1371/journal.pone.0023846. Epub 2011 Aug 25. PubMed PMID: 21901141; PubMed Central PMCID: PMC3162009.
Chandra D, Singh KK. Genetic insights into OXPHOS defect and its role in cancer. Biochim Biophys Acta. 2011 Jun;1807(6):620-5. doi: 10.1016/j.bbabio.2010.10.023. Epub 2010 Nov 11. Review. PubMed PMID: 21074512; PubMed Central PMCID: PMC4681500.
Desler C, Marcker ML, Singh KK, Rasmussen LJ. The importance of mitochondrial DNA in aging and cancer. J Aging Res. 2011 Mar 30;2011:407536. doi: 10.4061/2011/407536. PubMed PMID: 21584235; PubMed Central PMCID: PMC3092560.
Gonçalves AP, Máximo V, Lima J, Singh KK, Soares P, Videira A. Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone. Biochim Biophys Acta. 2011 Mar;1813(3):492-9. doi: 10.1016/j.bbamcr.2011.01.006. Epub 2011 Jan 9. PubMed PMID: 21223980; PubMed Central PMCID: PMC3051352.
Erikstein BS, Hagland HR, Nikolaisen J, Kulawiec M, Singh KK, Gjertsen BT, Tronstad KJ. Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment. J Cell Biochem. 2010 Oct 15;111(3):574-84. doi: 10.1002/jcb.22741. PubMed PMID: 20568117; PubMed Central PMCID: PMC2946440.
Graham KA, Kulawiec M, Owens KM, Li X, Desouki MM, Chandra D, Singh KK. NADPH oxidase 4 is an oncoprotein localized to mitochondria. Cancer Biol Ther. 2010 Aug 1;10(3):223-31. doi: 10.4161/cbt.10.3.12207. Epub 2010 Aug 3. PubMed PMID: 20523116; PubMed Central PMCID: PMC3040835.
Saneto RP, Singh KK. Illness-induced exacerbation of Leigh syndrome in a patient with the MTATP6 mutation, m. 9185 T>C. Mitochondrion. 2010 Aug;10(5):567-72. doi: 10.1016/j.mito.2010.05.006. Epub 2010 May 27. PubMed PMID: 20546952; PubMed Central PMCID: PMC2918679.
Yang D, Wang MT, Tang Y, Chen Y, Jiang H, Jones TT, Rao K, Brewer GJ, Singh KK, Nie D. Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L). Cancer Biol Ther. 2010 Jan;9(2):122-33. doi: 10.4161/cbt.9.2.10379. Epub 2010 Jan 21. PubMed PMID: 19923925; PubMed Central PMCID: PMC2909490.
Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM, Vassilopoulos A, Ozden O, Park SH, Singh KK, Abdulkadir SA, Spitz DR, Deng CX, Gius D. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell. 2010 Jan 19;17(1):41-52. doi: 10.1016/j.ccr.2009.11.023. PubMed PMID: 20129246; PubMed Central PMCID: PMC3711519.
McKeller MR, Herrera-Rodriguez S, Ma W, Ortiz-Quintero B, Rangel R, Candé C, Sims-Mourtada JC, Melnikova V, Kashi C, Phan LM, Chen Z, Huang P, Dunner K Jr, Kroemer G, Singh KK, Martinez-Valdez H. Vital function of PRELI and essential requirement of its LEA motif. Cell Death Dis. 2010;1:e21. doi: 10.1038/cddis.2009.19. PubMed PMID: 21364629; PubMed Central PMCID: PMC3032331.
Kulawiec M, Owens KM, Singh KK. mtDNA G10398A variant in African-American women with breast cancer provides resistance to apoptosis and promotes metastasis in mice. J Hum Genet. 2009 Nov;54(11):647-54. doi: 10.1038/jhg.2009.89. Epub 2009 Sep 18. PubMed PMID: 19763141; PubMed Central PMCID: PMC2909846.
Singh KK, Ayyasamy V, Owens KM, Koul MS, Vujcic M. Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis. J Hum Genet. 2009 Sep;54(9):516-24. doi: 10.1038/jhg.2009.71. Epub 2009 Jul 24. PubMed PMID: 19629138; PubMed Central PMCID: PMC2782392.
Kulawiec M, Owens KM, Singh KK. Cancer cell mitochondria confer apoptosis resistance and promote metastasis. Cancer Biol Ther. 2009 Jul;8(14):1378-85. doi: 10.4161/cbt.8.14.8751. Epub 2009 Jul 16. PubMed PMID: 19556849.
Hall BM, Ma CX, Liang P, Singh KK. Fluctuation analysis CalculatOR: a web tool for the determination of mutation rate using Luria-Delbruck fluctuation analysis. Bioinformatics. 2009 Jun 15;25(12):1564-5. doi: 10.1093/bioinformatics/btp253. Epub 2009 Apr 15. PubMed PMID: 19369502; PubMed Central PMCID: PMC2687991.
Singh KK, Kulawiec M. Mitochondrial DNA polymorphism and risk of cancer. Methods Mol Biol. 2009;471:291-303. doi: 10.1007/978-1-59745-416-2_15. PubMed PMID: 19109786; PubMed Central PMCID: PMC2825891.
Kulawiec M, Ayyasamy V, Singh KK. p53 regulates mtDNA copy number and mitocheckpoint pathway. J Carcinog. 2009;8:8. doi: 10.4103/1477-3163.50893. PubMed PMID: 19439913; PubMed Central PMCID: PMC2687143.
Kulawiec M, Safina A, Desouki MM, Still I, Matsui S, Bakin A, Singh KK. Tumorigenic transformation of human breast epithelial cells induced by mitochondrial DNA depletion. Cancer Biol Ther. 2008 Nov;7(11):1732-43. doi: 10.4161/cbt.7.11.6729. Epub 2008 Nov 4. PubMed PMID: 19151587; PubMed Central PMCID: PMC2783327.
Smiraglia DJ, Kulawiec M, Bistulfi GL, Gupta SG, Singh KK. A novel role for mitochondria in regulating epigenetic modification in the nucleus. Cancer Biol Ther. 2008 Aug;7(8):1182-90. doi: 10.4161/cbt.7.8.6215. Epub 2008 Aug 1. PubMed PMID: 18458531; PubMed Central PMCID: PMC2639623.
De Chaudhuri S, Kundu M, Banerjee M, Das JK, Majumdar P, Basu S, Roychoudhury S, Singh KK, Giri AK. Arsenic-induced health effects and genetic damage in keratotic individuals: involvement of p53 arginine variant and chromosomal aberrations in arsenic susceptibility. Mutat Res. 2008 Jul-Aug;659(1-2):118-25. doi: 10.1016/j.mrrev.2007.11.008. Epub 2007 Nov 26. Review. PubMed PMID: 18249029.
Desler C, Munch-Petersen B, Stevnsner T, Matsui S, Kulawiec M, Singh KK, Rasmussen LJ. Mitochondria as determinant of nucleotide pools and chromosomal stability. Mutat Res. 2007 Dec 1;625(1-2):112-24. doi: 10.1016/j.mrfmmm.2007.06.002. Epub 2007 Jun 17. PubMed PMID: 17658559.
Katrangi E, D'Souza G, Boddapati SV, Kulawiec M, Singh KK, Bigger B, Weissig V. Xenogenic transfer of isolated murine mitochondria into human rho0 cells can improve respiratory function. Rejuvenation Res. 2007 Dec;10(4):561-70. doi: 10.1089/rej.2007.0575. PubMed PMID: 18069915.
Vujcic M, Shroff M, Singh KK. Genetic determinants of mitochondrial response to arsenic in yeast Saccharomyces cerevisiae. Cancer Res. 2007 Oct 15;67(20):9740-9. doi: 10.1158/0008-5472.CAN-07-1962. PubMed PMID: 17942904.
Weinberger M, Feng L, Paul A, Smith DL Jr, Hontz RD, Smith JS, Vujcic M, Singh KK, Huberman JA, Burhans WC. DNA replication stress is a determinant of chronological lifespan in budding yeast. PLoS One. 2007 Aug 15;2(8):e748. doi: 10.1371/journal.pone.0000748. PubMed PMID: 17710147; PubMed Central PMCID: PMC1939877.
Verma M, Naviaux RK, Tanaka M, Kumar D, Franceschi C, Singh KK. Meeting report: mitochondrial DNA and cancer epidemiology. Cancer Res. 2007 Jan 15;67(2):437-9. doi: 10.1158/0008-5472.CAN-06-4119. Epub 2007 Jan 9. PubMed PMID: 17213255.
What would you like to do?