My Bibliography

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Liu ITT, Savage TJ, Tsacogianis TN, Kesselheim AS, Sarpatwari A. Post-Approval Pediatric Use of Drugs Granted Waivers from Pediatric Testing. Clin Pharmacol Ther. 2026 May 15;. doi: 10.1002/cpt.70328. [Epub ahead of print] PubMed PMID: 42138424; PubMed Central PMCID: PMC13317182.

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Rosen KL, Mandl KD. What FDA Clearance Does, and Does Not, Mean for Artificial Intelligence. Ann Intern Med. 2026 Jun;179(6):895-897. doi: 10.7326/ANNALS-26-00362. Epub 2026 May 5. PubMed PMID: 42081821.

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Geanacopoulos AT, Totman MS, Miller KA, Neuman MI, Peltz A. Managing and Communicating Diagnostic Uncertainty in Pediatric Emergency Care: National Insights and Opportunities for Intervention. Pediatr Emerg Care. 2026 Apr 23;. doi: 10.1097/PEC.0000000000003614. [Epub ahead of print] PubMed PMID: 42021594.

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Bergmann KR, Hall M, Ramgopal S, Badaki-Makun O, Chaudhari PP, Eltorki M, Geanacopoulos AT, Gonzalez F, Keating EM, Phamduy TT, Rees CA, Shapiro DJ, Chinnadurai S, Neuman MI. Tranexamic Acid Use for Posttonsillectomy Hemorrhage Across US Children's Hospitals. Pediatr Emerg Care. 2026 Apr 17;. doi: 10.1097/PEC.0000000000003604. [Epub ahead of print] PubMed PMID: 41992793; NIHMSID:NIHMS2177299.

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Zhou D, Tong H, Wang L, Liu S, Xiong X, Gan Z, Romain G, Hejblum BP, Liu YC, Hong C, Bonzel CL, Cai T, Pan K, Ho YL, Costa L, A Panickan V, Gaziano JM, Mandl KD, Jouhet V, Thiebaut R, Xia Z, Cho K, Liao K, Cai T. Representation learning to advance multi-institutional studies with electronic health record data from US and France. Nat Commun. 2026 Apr 3;17(1). doi: 10.1038/s41467-026-71152-1. PubMed PMID: 41932876; PubMed Central PMCID: PMC13219506.

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Klonoff DC, Healey E, Mandl KD, Kerr D. Artificial intelligence for interpreting diabetes data using clinician-curated benchmarks. Lancet Diabetes Endocrinol. 2026 May;14(5):375. doi: 10.1016/S2213-8587(26)00044-6. Epub 2026 Mar 27. PubMed PMID: 41911937.

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Bode L, Xu R, Garber M, Mandl KD, Mcmurry AJ. Identifying Undiagnosed High-Risk Suicidality Cases by Matching Patients With a Similar Comorbidity Burden: Retrospective Observational Study. JMIR Form Res. 2026 Mar 12;10:e81499. doi: 10.2196/81499. PubMed PMID: 41818636; PubMed Central PMCID: PMC12981544.

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Abernethy A, Afsar N, Anderson B, Barfield W, Bharel M, Brown J, Embí P, Eschenlauer A, Gordon W, Gregurick S, James B, Jena A, Lee P, Maddox T, Mandl K, Parikh R, Petersen-Lukenda L, Sarich T, Shaikh A, Speyer P, Yale K. Toward a National Health Digital and Data Architecture: Laying the Foundation for Digital Transformation: Commission on Investment Imperatives for a Healthy Nation. NAM Perspect. 2026;2026. doi: 10.31478/202603b. eCollection 2026. Review. PubMed PMID: 42169969; PubMed Central PMCID: PMC13189397.

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Haendel MA, Ahern R, Bailey KB, Bakas S, Barth-Jones DC, Bohl A, Bian J, Bourne PE, Boyles RR, Chute CG, Cimino JJ, Grannis S, Hartman TS, Holko M, Hotaling NA, Housman DJ, Hunter LE, Hurwitz E, Phua J, Kahn MG, Kuzmanovic D, Lemieux J, Loomba J, Madlock-Brown CR, Mandl KD, Mazumder R, McMurry JA, McMurry AJ, Modi ZJ, Moffitt RA, Mosa ASM, Messina N, O'Neil ST, Peterson JF, Pfaff ER, Phuong J, Presskreischer R, Sanders L, Sarker A, Thomson A, Unertl KM, Walden A, Weinstein J. Governing real-world health data as a public utility. Science. 2026 Mar 5;391(6789):993-996. doi: 10.1126/science.aeb1178. Epub 2026 Mar 5. PubMed PMID: 41785358.

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Geanacopoulos AT, Drescher C, Kanaan J, Neuman MI, Peltz A, Ong MS, Cifra CL, Walsh KE. Physician-Reported Diagnostic Uncertainty Among Children Discharged From the Pediatric Emergency Department With Acute Respiratory Illness. Pediatr Emerg Care. 2026 Jul 1;42(7):544-550. doi: 10.1097/PEC.0000000000003589. Epub 2026 Mar 2. PubMed PMID: 41766130.

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Greco KF, Yang Z, Li M, Tong H, Morini Sweet S, Geva A, Mandl KD, Raby BA, Cai T. A weakly supervised transformer for rare disease diagnosis and subphenotyping from EHRs with pulmonary case studies. NPJ Digit Med. 2026 Feb 6;9(1). doi: 10.1038/s41746-026-02406-x. PubMed PMID: 41652033; PubMed Central PMCID: PMC12987952.

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Lyu N, Schneeweiss S, Bourgeois FT, Savage TJ. US Food and Drug Administration Approval of Biologic Drugs for Use in Children and Adolescents. JAMA Pediatr. 2026 Feb 1;180(2):214-216. doi: 10.1001/jamapediatrics.2025.5087. PubMed PMID: 41359325; PubMed Central PMCID: PMC12687155.

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Wedel J, Tang Y, Alsairafi B, Do V, Maslyar M, Fleming R, Schwartz MA, Gerdemann U, Albanese A, Mitsialis V, Collen LV, Nishitani M, Bresnahan M, Saccocia G, Bearup R, Okoroafor I, Siegel SJ, Wachter F, Waters K, Weichert-Leahey N, Clarke NJ, Mandl KD, Kean LS, Snapper SB, Briscoe DM, Horwitz BH. Multiomic Immune Profiling of Pediatric Transplant Recipients Identifies Cell States Associated with Vaccine Response. Clin J Am Soc Nephrol. 2026 Apr 1;21(4):650-663. doi: 10.2215/CJN.0000000949. Epub 2025 Dec 24. PubMed PMID: 41442217; PubMed Central PMCID: PMC12831166.

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Sun JW, Horton DB, Savage TJ, Burcu M, Hernandez-Diaz S. Application of the Target Trial Emulation Framework to Studies in the Pediatric Population. J Pediatr. 2026 Apr;291:114941. doi: 10.1016/j.jpeds.2025.114941. Epub 2025 Dec 13. PubMed PMID: 41391542; PubMed Central PMCID: PMC13093582.

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Zachariasse JM, Gutiérrez-Sacristán A, Makwana S, Li X, Bhatnagar S, Hanauer DA, Kainth MK, Morris M, Rubio-Mayo P, Sáez C, Shah MA, Aronow BJ, Badenes R, Cai T, Garcia Barrio N, Issitt RW, Mandl KD, Milani GP, Moshal K, Newburger JW, Omenn GS, Romero-Garcia N, Sperotto F, Spiridou A, Visweswaran S, Xia Z, Bourgeois FT, Avillach P, Consortium for Clinical Characterization of COVID-19 by EHR (4CE). Impact of COVID-19 non-pharmaceutical interventions on bacterial infections in children: an international electronic health record-based study. BMJ Public Health. 2025;3(2):e002671. doi: 10.1136/bmjph-2025-002671. eCollection 2025. PubMed PMID: 41394022; PubMed Central PMCID: PMC12699615.

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Sayeed R, Kreda D, Mandel JC, Larson B, Gordon W, Mandl KD, Kohane I. A standards-based approach to digital health research: implementing the people heart study. J Am Med Inform Assoc. 2025 Dec 1;32(12):1811-1821. doi: 10.1093/jamia/ocaf163. PubMed PMID: 41032388; PubMed Central PMCID: PMC12646378.

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Chandak P, Healey E, Villa-Tamayo MF, Scheideman AF, Shao MM, Fabris C, Mandl KD, Kohane I, Klonoff DC. What do LLMs value? An evaluation framework for revealing subjective trade-offs in assessment of glycemic control. Proc Mach Learn Res. 2025 Dec;297:136-151. PubMed PMID: 42389650; PubMed Central PMCID: PMC13322355.

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Angus DC, Khera R, Lieu T, Liu V, Ahmad FS, Anderson B, Bhavani SV, Bindman A, Brennan T, Celi LA, Chen F, Cohen IG, Denniston A, Desai S, Embí P, Faisal A, Ferryman K, Gerhart J, Gross M, Hernandez-Boussard T, Howell M, Johnson K, Lee K, Liu X, Lomis K, London AJ, Longhurst CA, Mandl KD, McGlynn E, Mello MM, Munoz F, Ohno-Machado L, Ouyang D, Perlis R, Phillips A, Rhew D, Ross JS, Saria S, Schwamm L, Seymour CW, Shah NH, Shah R, Singh K, Solomon M, Spates K, Spector-Bagdady K, Wang T, Gichoya JW, Weinstein J, Wiens J, Bibbins-Domingo K, JAMA Summit on AI. AI, Health, and Health Care Today and Tomorrow: The JAMA Summit Report on Artificial Intelligence. JAMA. 2025 Nov 11;334(18):1650-1664. doi: 10.1001/jama.2025.18490. PubMed PMID: 41082366.

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Austin ED, Mullen MP, Avitabile CM, Krishnan US, Rosenzweig EB, Keller RL, Kinsella JP, Yung D, Steffes L, Bates A, Elia EG, Romer LH, McGrath-Morrow S, Bernier ML, Mandl KD, Raj JU, Sleeper LA, Abman SH, Pediatric Pulmonary Hypertension Network (PPHNet) Investigators. Pulmonary Hemodynamics and Long-Term Outcomes in Children with Pulmonary Hypertension-Associated Bronchopulmonary Dysplasia. J Pediatr. 2026 Feb;289:114869. doi: 10.1016/j.jpeds.2025.114869. Epub 2025 Oct 24. PubMed PMID: 41139016; PubMed Central PMCID: PMC12905831.

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Gorman MP, Lee IH, Kerr LM, Mandl KD, Kong SW. Genetic Landscape of Opsoclonus-Myoclonus-Ataxia Syndrome in Children. Pediatr Neurol. 2025 Dec;173:33-40. doi: 10.1016/j.pediatrneurol.2025.08.019. Epub 2025 Sep 4. PubMed PMID: 41014805; PubMed Central PMCID: PMC12476522.

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McMurry AJ, Phelan D, Dixon BE, Geva A, Gottlieb D, Jones JR, Terry M, Taylor DE, Callaway H, Manoharan S, Miller T, Olson KL, Mandl KD. Large Language Model Symptom Identification From Clinical Text: Multicenter Study. J Med Internet Res. 2025 Jul 31;27:e72984. doi: 10.2196/72984. PubMed PMID: 40743494; PubMed Central PMCID: PMC12313083.

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Bode L, Xu R, Garber M, Mandl KD, McMurry AJ. Identifying undiagnosed high-risk suicidality cases through comorbidity-adjusted risk modeling. medRxiv. 2025 Jul 23;. doi: 10.1101/2025.07.22.25331824. PubMed PMID: 40778136; PubMed Central PMCID: PMC12330468.

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Mandl KD. How AI Could Reshape Health Care-Rise in Direct-to-Consumer Models. JAMA. 2025 May 20;333(19):1667-1669. doi: 10.1001/jama.2025.0946. PubMed PMID: 39992661.

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Straub L, Wang SV, Hernandez-Diaz S, Gray KJ, Vine SM, Russo M, Mittal L, Bateman BT, Zhu Y, Huybrechts KF. Hierarchical clustering analysis to inform classification of congenital malformations for surveillance of medication safety in pregnancy. Am J Epidemiol. 2025 May 7;194(5):1436-1447. doi: 10.1093/aje/kwae272. PubMed PMID: 39123096; PubMed Central PMCID: PMC13070530.

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Xu R, Bode L, Geva A, Mandl KD, McMurry AJ. Accuracy of ICD-10 Codes for Suicidal Ideation and Action in Pediatric Emergency Department Encounters. Pediatr Emerg Care. 2025 May 1;41(5):378-382. doi: 10.1097/PEC.0000000000003328. Epub 2025 Apr 30. PubMed PMID: 39730147; PubMed Central PMCID: PMC12445346.

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Sandora TJ, Savage TJ, Ryan ME, Dahlberg SE, Daugherty K, Kelly CP, Pollock NR, Kociolek LK. Comparative effectiveness of metronidazole and vancomycin for treatment of Clostridioides difficile infection in hospitalized children. Antimicrob Steward Healthc Epidemiol. 2025;5(1):e74. doi: 10.1017/ash.2025.51. eCollection 2025. PubMed PMID: 40109913; PubMed Central PMCID: PMC11920915.

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Xiong X, Sweet SM, Liu M, Hong C, Bonzel CL, Ayakulangara Panickan V, Zhou D, Wang L, Costa L, Ho YL, Geva A, Mandl KD, Cheng SC, Xia Z, Cho K, Gaziano JM, Liao KP, Cai T, Cai T. Knowledge-Driven Online Multimodal Automated Phenotyping System. medRxiv. 2025 Mar 5;. doi: 10.1101/2023.09.29.23296239. PubMed PMID: 37873131; PubMed Central PMCID: PMC10593060.

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Kong SW, Lee IH, Collen LV, Field M, Manrai AK, Snapper SB, Mandl KD. Discordance between a deep learning model and clinical-grade variant pathogenicity classification in a rare disease cohort. NPJ Genom Med. 2025 Feb 28;10(1):17. doi: 10.1038/s41525-025-00480-w. PubMed PMID: 40021654; PubMed Central PMCID: PMC11871343.

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Kennedy JC, Vargas SO, Fishman MP, Alesi N, Baek SH, Khabibillin D, Platt CD, Garcia-de-Alba C, Agrawal PB, Carmichael NE, Henderson LA, Wehrman A, Boland S, Walther T, Farese RV Jr, Casey AMH, Manis JP, Collen LV, Lvova M, Barbieri A, Sullivan B, Raby BA. A progranulin variant causing childhood interstitial lung disease responsive to anti-TNF-α biologic therapy. Med. 2025 Jun 13;6(6):100607. doi: 10.1016/j.medj.2025.100607. Epub 2025 Feb 27. PubMed PMID: 40020677; PubMed Central PMCID: PMC13003687.

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Mandl K. Unseen Commercial Forces Could Undermine Artificial Intelligence Decision Support. NEJM AI. 2025 February; 2(3). doi: 10.1056/AIp2400922.

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Payne PRO, Johnson KB, Maddox TM, Embi PJ, Mandl KD, McGraw D, Saria S, Adams L. Toward an artificial intelligence code of conduct for health and healthcare: implications for the biomedical informatics community. J Am Med Inform Assoc. 2025 Feb 1;32(2):408-412. doi: 10.1093/jamia/ocae306. PubMed PMID: 39658328; PubMed Central PMCID: PMC11756637.

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Menezes MCS, Hoffmann AF, Tan ALM, Nalbandyan M, Omenn GS, Mazzotti DR, Hernández-Arango A, Visweswaran S, Venkatesh S, Mandl KD, Bourgeois FT, Lee JWK, Makmur A, Hanauer DA, Semanik MG, Kerivan LT, Hill T, Forero J, Restrepo C, Vigna M, Ceriana P, Abu-El-Rub N, Avillach P, Bellazzi R, Callaci T, Gutiérrez-Sacristán A, Malovini A, Mathew JP, Morris M, Murthy VL, Buonocore TM, Parimbelli E, Patel LP, Sáez C, Samayamuthu MJ, Thompson JA, Tibollo V, Xia Z, Kohane IS, Consortium for Clinical Characterization of COVID-19 by Electronic Health Records. The potential of Generative Pre-trained Transformer 4 (GPT-4) to analyse medical notes in three different languages: a retrospective model-evaluation study. Lancet Digit Health. 2025 Jan;7(1):e35-e43. doi: 10.1016/S2589-7500(24)00246-2. PubMed PMID: 39722251; PubMed Central PMCID: PMC12182955.

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Blease C, Hagström J, Sanchez CG, Kharko A, McMillan B, Gaab J, Brulin E, Locher C, Hägglund M, Riggare S, Mandl KD. General practitioners' adoption of generative artificial intelligence in clinical practice in the UK: An updated online survey. Digit Health. 2025 Jan-Dec;11:20552076251394287. doi: 10.1177/20552076251394287. eCollection 2025 Jan-Dec. PubMed PMID: 41312147; PubMed Central PMCID: PMC12647557.

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Blease CR, Locher C, Gaab J, Hägglund M, Mandl KD. Generative artificial intelligence in primary care: an online survey of UK general practitioners. BMJ Health Care Inform. 2024 Sep 17;31(1). doi: 10.1136/bmjhci-2024-101102. PubMed PMID: 39288998; PubMed Central PMCID: PMC11429366.

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McMurry AJ, Gottlieb DI, Miller TA, Jones JR, Atreja A, Crago J, Desai PM, Dixon BE, Garber M, Ignatov V, Kirchner LA, Payne PRO, Saldanha AJ, Shankar PRV, Solad YV, Sprouse EA, Terry M, Wilcox AB, Mandl KD. Cumulus: a federated electronic health record-based learning system powered by Fast Healthcare Interoperability Resources and artificial intelligence. J Am Med Inform Assoc. 2024 Aug 1;31(8):1638-1647. doi: 10.1093/jamia/ocae130. PubMed PMID: 38860521; PubMed Central PMCID: PMC11258401.

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Xu R, Bode L, Geva A, Mandl KD, McMurry AJ. Accuracy of ICD-10 codes for suicidal ideation and action in pediatric emergency department encounters. medRxiv. 2024 Jul 24;. doi: 10.1101/2024.07.23.24310777. PubMed PMID: 39211891; PubMed Central PMCID: PMC11361224.

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Kong SW, Lee IH, Collen LV, Manrai AK, Snapper SB, Mandl KD. Discordance between a deep learning model and clinical-grade variant pathogenicity classification in a rare disease cohort. medRxiv. 2024 May 23;. doi: 10.1101/2024.05.22.24307756. PubMed PMID: 38826236; PubMed Central PMCID: PMC11142383.

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Jones JR, Gottlieb D, McMurry AJ, Atreja A, Desai PM, Dixon BE, Payne PRO, Saldanha AJ, Shankar P, Solad Y, Wilcox AB, Ali MS, Kang E, Martin AM, Sprouse E, Taylor DE, Terry M, Ignatov V, Mandl KD. Real world performance of the 21st Century Cures Act population-level application programming interface. J Am Med Inform Assoc. 2024 Apr 19;31(5):1144-1150. doi: 10.1093/jamia/ocae040. PubMed PMID: 38447593; PubMed Central PMCID: PMC11031206.

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McMurry AJ, Zipursky AR, Geva A, Olson KL, Jones JR, Ignatov V, Miller TA, Mandl KD. Moving Biosurveillance Beyond Coded Data Using AI for Symptom Detection From Physician Notes: Retrospective Cohort Study. J Med Internet Res. 2024 Apr 4;26:e53367. doi: 10.2196/53367. PubMed PMID: 38573752; PubMed Central PMCID: PMC11027052.

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Phelan D, Gottlieb D, Mandel JC, Ignatov V, Jones J, Marquard B, Ellis A, Mandl KD. Beyond compliance with the 21st Century Cures Act Rule: a patient controlled electronic health information export application programming interface. J Am Med Inform Assoc. 2024 Apr 3;31(4):901-909. doi: 10.1093/jamia/ocae013. PubMed PMID: 38287642; PubMed Central PMCID: PMC10990503.

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Voorhies K, Mohammed A, Chinthala L, Kong SW, Lee IH, Kho AT, McGeachie M, Mandl KD, Raby B, Hayes M, Davis RL, Wu AC, Lutz SM. GSDMB/ORMDL3 Rare/Common Variants Are Associated with Inhaled Corticosteroid Response among Children with Asthma. Genes (Basel). 2024 Mar 28;15(4). doi: 10.3390/genes15040420. PubMed PMID: 38674355; PubMed Central PMCID: PMC11049905.

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Mandl KD, Gottlieb D, Mandel JC. Integration of AI in healthcare requires an interoperable digital data ecosystem. Nat Med. 2024 Mar;30(3):631-634. doi: 10.1038/s41591-023-02783-w. PubMed PMID: 38291298.

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McMurry AJ, Gottlieb DI, Miller TA, Jones JR, Atreja A, Crago J, Desai PM, Dixon BE, Garber M, Ignatov V, Kirchner LA, Payne PRO, Saldanha AJ, Shankar PRV, Solad YV, Sprouse EA, Terry M, Wilcox AB, Mandl KD. Cumulus: A federated EHR-based learning system powered by FHIR and AI. medRxiv. 2024 Feb 6;. doi: 10.1101/2024.02.02.24301940. PubMed PMID: 38370642; PubMed Central PMCID: PMC10871375.

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Blease C, Torous J, McMillan B, Hägglund M, Mandl KD. Generative Language Models and Open Notes: Exploring the Promise and Limitations. JMIR Med Educ. 2024 Jan 4;10:e51183. doi: 10.2196/51183. PubMed PMID: 38175688; PubMed Central PMCID: PMC10797501.

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Felix C, Johnston JD, Owen K, Shirima E, Hinds SR 2nd, Mandl KD, Milinovich A, Alberts JL. Explainable machine learning for predicting conversion to neurological disease: Results from 52,939 medical records. Digit Health. 2024 Jan-Dec;10:20552076241249286. doi: 10.1177/20552076241249286. eCollection 2024 Jan-Dec. PubMed PMID: 38686337; PubMed Central PMCID: PMC11057348.

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Miller TA, McMurry AJ, Jones J, Gottlieb D, Mandl KD. The SMART Text2FHIR Pipeline. AMIA Annu Symp Proc. 2023;2023:514-520. eCollection 2023. PubMed PMID: 38222416; PubMed Central PMCID: PMC10785871.

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La Cava WG, Lett E, Wan G. Fair admission risk prediction with proportional multicalibration. Proc Mach Learn Res. 2023;209:350-378. PubMed PMID: 37576024; PubMed Central PMCID: PMC10417639.

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Mansour O, Russo RG, Straub L, Bateman BT, Gray KJ, Huybrechts KF, Hernández-Díaz S. Prescription medication use during pregnancy in the United States from 2011 to 2020: trends and safety evidence. Am J Obstet Gynecol. 2024 Aug;231(2):250.e1-250.e16. doi: 10.1016/j.ajog.2023.12.020. Epub 2023 Dec 19. PubMed PMID: 38128861; PubMed Central PMCID: PMC11187710.

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Zipursky AR, Olson KL, Bode L, Geva A, Jones J, Mandl KD, McMurry A. Emergency department visits and boarding for pediatric patients with suicidality before and during the COVID-19 pandemic. PLoS One. 2023;18(11):e0286035. doi: 10.1371/journal.pone.0286035. eCollection 2023. PubMed PMID: 37910582; PubMed Central PMCID: PMC10619773.

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Jones JR, Gottlieb D, McMurry AJ, Atreja A, Desai PM, Dixon BE, Payne PRO, Saldanha AJ, Shankar P, Solad Y, Wilcox AB, Ali MS, Kang E, Martin AM, Sprouse E, Taylor D, Terry M, Ignatov V, SMART Cumulus Network, Mandl KD. Real World Performance of the 21st Century Cures Act Population Level Application Programming Interface. medRxiv. 2023 Oct 6;. doi: 10.1101/2023.10.05.23296560. PubMed PMID: 37873390; PubMed Central PMCID: PMC10593080.