My Bibliography

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Luan G, Drlica K. Fluoroquinolone-Gyrase-DNA Cleaved Complexes. Methods Mol Biol. 2018;1703:269-281. doi: 10.1007/978-1-4939-7459-7_19. PubMed PMID: 29177748.

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Luan G, Hong Y, Drlica K, Zhao X. Suppression of Reactive Oxygen Species Accumulation Accounts for Paradoxical Bacterial Survival at High Quinolone Concentration. Antimicrob Agents Chemother. 2018 Mar;62(3). doi: 10.1128/AAC.01622-17. Print 2018 Mar. PubMed PMID: 29229642; PubMed Central PMCID: PMC5826153.

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Naqvi SAR, Drlica K. Fluoroquinolones as imaging agents for bacterial infection. Dalton Trans. 2017 Oct 31;46(42):14452-14460. doi: 10.1039/c7dt01189j. Review. PubMed PMID: 28920628; PubMed Central PMCID: PMC5739321.

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Kumar K, Chen J, Drlica K, Shopsin B. Tuning of the Lethal Response to Multiple Stressors with a Single-Site Mutation during Clinical Infection by Staphylococcus aureus. mBio. 2017 Oct 24;8(5). doi: 10.1128/mBio.01476-17. PubMed PMID: 29066545; PubMed Central PMCID: PMC5654930.

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Hong Y, Li L, Luan G, Drlica K, Zhao X. Contribution of reactive oxygen species to thymineless death in Escherichia coli. Nat Microbiol. 2017 Dec;2(12):1667-1675. doi: 10.1038/s41564-017-0037-y. Epub 2017 Oct 2. PubMed PMID: 28970486; PubMed Central PMCID: PMC5705385.

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Mi H, Wang D, Xue Y, Zhang Z, Niu J, Hong Y, Drlica K, Zhao X. Dimethyl Sulfoxide Protects Escherichia coli from Rapid Antimicrobial-Mediated Killing. Antimicrob Agents Chemother. 2016 Aug;60(8):5054-8. doi: 10.1128/AAC.03003-15. Print 2016 Aug. PubMed PMID: 27246776; PubMed Central PMCID: PMC4958201.

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Liu Y, Zhou J, Qu Y, Yang X, Shi G, Wang X, Hong Y, Drlica K, Zhao X. Resveratrol Antagonizes Antimicrobial Lethality and Stimulates Recovery of Bacterial Mutants. PLoS One. 2016;11(4):e0153023. doi: 10.1371/journal.pone.0153023. eCollection 2016. PubMed PMID: 27045517; PubMed Central PMCID: PMC4821490.

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Malik M, Mustaev A, Schwanz HA, Luan G, Shah N, Oppegard LM, de Souza EC, Hiasa H, Zhao X, Kerns RJ, Drlica K. Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones. Nucleic Acids Res. 2016 Apr 20;44(7):3304-16. doi: 10.1093/nar/gkw161. Epub 2016 Mar 16. PubMed PMID: 26984528; PubMed Central PMCID: PMC4838383.

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Long Q, Du Q, Fu T, Drlica K, Zhao X, Xie J. Involvement of Holliday junction resolvase in fluoroquinolone-mediated killing of Mycobacterium smegmatis. Antimicrob Agents Chemother. 2015 Mar;59(3):1782-5. doi: 10.1128/AAC.04434-14. Epub 2014 Dec 22. PubMed PMID: 25534729; PubMed Central PMCID: PMC4325773.

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Li L, Hong Y, Luan G, Mosel M, Malik M, Drlica K, Zhao X. Ribosomal elongation factor 4 promotes cell death associated with lethal stress. mBio. 2014 Dec 9;5(6):e01708. doi: 10.1128/mBio.01708-14. PubMed PMID: 25491353; PubMed Central PMCID: PMC4324249.

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Zhao X, Hong Y, Drlica K. Moving forward with reactive oxygen species involvement in antimicrobial lethality. J Antimicrob Chemother. 2015 Mar;70(3):639-42. doi: 10.1093/jac/dku463. Epub 2014 Nov 23. Review. PubMed PMID: 25422287; PubMed Central PMCID: PMC4319487.

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Drlica K, Mustaev A, Towle TR, Luan G, Kerns RJ, Berger JM. Bypassing fluoroquinolone resistance with quinazolinediones: studies of drug-gyrase-DNA complexes having implications for drug design. ACS Chem Biol. 2014 Dec 19;9(12):2895-904. doi: 10.1021/cb500629k. Epub 2014 Nov 4. PubMed PMID: 25310082; PubMed Central PMCID: PMC4273985.

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Hesje CK, Drlica K, Blondeau JM. Mutant prevention concentration of tigecycline for clinical isolates of Streptococcus pneumoniae and Staphylococcus aureus. J Antimicrob Chemother. 2015 Feb;70(2):494-7. doi: 10.1093/jac/dku389. Epub 2014 Oct 16. PubMed PMID: 25324419; PubMed Central PMCID: PMC4291236.

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Malik M, Li L, Zhao X, Kerns RJ, Berger JM, Drlica K. Lethal synergy involving bicyclomycin: an approach for reviving old antibiotics. J Antimicrob Chemother. 2014 Dec;69(12):3227-35. doi: 10.1093/jac/dku285. Epub 2014 Jul 31. PubMed PMID: 25085655; PubMed Central PMCID: PMC4228776.

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Zhao X, Drlica K. Reactive oxygen species and the bacterial response to lethal stress. Curr Opin Microbiol. 2014 Oct;21:1-6. doi: 10.1016/j.mib.2014.06.008. Epub 2014 Jul 30. Review. PubMed PMID: 25078317; PubMed Central PMCID: PMC4254325.

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Mustaev A, Malik M, Zhao X, Kurepina N, Luan G, Oppegard LM, Hiasa H, Marks KR, Kerns RJ, Berger JM, Drlica K. Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding. J Biol Chem. 2014 May 2;289(18):12300-12. doi: 10.1074/jbc.M113.529164. Epub 2014 Feb 4. PubMed PMID: 24497635; PubMed Central PMCID: PMC4007428.

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Mosel M, Li L, Drlica K, Zhao X. Superoxide-mediated protection of Escherichia coli from antimicrobials. Antimicrob Agents Chemother. 2013 Nov;57(11):5755-9. doi: 10.1128/AAC.00754-13. Epub 2013 Aug 26. PubMed PMID: 23979754; PubMed Central PMCID: PMC3811261.

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Dorsey-Oresto A, Lu T, Mosel M, Wang X, Salz T, Drlica K, Zhao X. YihE kinase is a central regulator of programmed cell death in bacteria. Cell Rep. 2013 Feb 21;3(2):528-37. doi: 10.1016/j.celrep.2013.01.026. Epub 2013 Feb 14. PubMed PMID: 23416055; PubMed Central PMCID: PMC3594398.

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Metzler K, Drlica K, Blondeau JM. Minimal inhibitory and mutant prevention concentrations of azithromycin, clarithromycin and erythromycin for clinical isolates of Streptococcus pneumoniae. J Antimicrob Chemother. 2013 Mar;68(3):631-5. doi: 10.1093/jac/dks461. Epub 2012 Nov 20. PubMed PMID: 23169894; PubMed Central PMCID: PMC3566671.

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Liu Y, Liu X, Qu Y, Wang X, Li L, Zhao X. Inhibitors of reactive oxygen species accumulation delay and/or reduce the lethality of several antistaphylococcal agents. Antimicrob Agents Chemother. 2012 Nov;56(11):6048-50. doi: 10.1128/AAC.00754-12. Epub 2012 Sep 4. PubMed PMID: 22948880; PubMed Central PMCID: PMC3486621.

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Malik M, Chavda K, Zhao X, Shah N, Hussain S, Kurepina N, Kreiswirth BN, Kerns RJ, Drlica K. Induction of mycobacterial resistance to quinolone class antimicrobials. Antimicrob Agents Chemother. 2012 Jul;56(7):3879-87. doi: 10.1128/AAC.00474-12. Epub 2012 May 7. PubMed PMID: 22564842; PubMed Central PMCID: PMC3393424.

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Wu X, Wang X, Drlica K, Zhao X. A toxin-antitoxin module in Bacillus subtilis can both mitigate and amplify effects of lethal stress. PLoS One. 2011;6(8):e23909. doi: 10.1371/journal.pone.0023909. Epub 2011 Aug 29. PubMed PMID: 21897862; PubMed Central PMCID: PMC3163665.

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Marks KR, Malik M, Mustaev A, Hiasa H, Drlica K, Kerns RJ. Synthesis and evaluation of 1-cyclopropyl-2-thioalkyl-8-methoxy fluoroquinolones. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4585-8. doi: 10.1016/j.bmcl.2011.05.112. Epub 2011 Jun 6. PubMed PMID: 21705218; PubMed Central PMCID: PMC3138821.

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Malik M, Marks KR, Mustaev A, Zhao X, Chavda K, Kerns RJ, Drlica K. Fluoroquinolone and quinazolinedione activities against wild-type and gyrase mutant strains of Mycobacterium smegmatis. Antimicrob Agents Chemother. 2011 May;55(5):2335-43. doi: 10.1128/AAC.00033-11. Epub 2011 Mar 7. PubMed PMID: 21383100; PubMed Central PMCID: PMC3088267.

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Liang B, Bai N, Cai Y, Wang R, Drlica K, Zhao X. Mutant prevention concentration-based pharmacokinetic/pharmacodynamic indices as dosing targets for suppressing the enrichment of levofloxacin-resistant subpopulations of Staphylococcus aureus. Antimicrob Agents Chemother. 2011 May;55(5):2409-12. doi: 10.1128/AAC.00975-10. Epub 2011 Feb 22. PubMed PMID: 21343454; PubMed Central PMCID: PMC3088181.

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Malik M, Marks KR, Schwanz HA, German N, Drlica K, Kerns RJ. Effect of N-1/c-8 ring fusion and C-7 ring structure on fluoroquinolone lethality. Antimicrob Agents Chemother. 2010 Dec;54(12):5214-21. doi: 10.1128/AAC.01054-10. Epub 2010 Sep 20. PubMed PMID: 20855738; PubMed Central PMCID: PMC2981251.

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Oppegard LM, Streck KR, Rosen JD, Schwanz HA, Drlica K, Kerns RJ, Hiasa H. Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones. Antimicrob Agents Chemother. 2010 Jul;54(7):3011-4. doi: 10.1128/AAC.00190-10. Epub 2010 Apr 19. PubMed PMID: 20404126; PubMed Central PMCID: PMC2897325.

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Han X, Dorsey-Oresto A, Malik M, Wang JY, Drlica K, Zhao X, Lu T. Escherichia coli genes that reduce the lethal effects of stress. BMC Microbiol. 2010 Feb 4;10:35. doi: 10.1186/1471-2180-10-35. PubMed PMID: 20128927; PubMed Central PMCID: PMC2824699.

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Wang X, Zhao X, Malik M, Drlica K. Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death. J Antimicrob Chemother. 2010 Mar;65(3):520-4. doi: 10.1093/jac/dkp486. Epub 2010 Jan 12. PubMed PMID: 20067982; PubMed Central PMCID: PMC2818107.

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Drlica K, Hiasa H, Kerns R, Malik M, Mustaev A, Zhao X. Quinolones: action and resistance updated. Curr Top Med Chem. 2009;9(11):981-98. doi: 10.2174/156802609789630947. Review. PubMed PMID: 19747119; PubMed Central PMCID: PMC3182077.

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Malik M, Hoatam G, Chavda K, Kerns RJ, Drlica K. Novel approach for comparing the abilities of quinolones to restrict the emergence of resistant mutants during quinolone exposure. Antimicrob Agents Chemother. 2010 Jan;54(1):149-56. doi: 10.1128/AAC.01035-09. Epub 2009 Oct 5. PubMed PMID: 19805561; PubMed Central PMCID: PMC2798492.

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Burger RM, Drlica K. Superoxide protects Escherichia coli from bleomycin mediated lethality. J Inorg Biochem. 2009 Sep;103(9):1273-7. doi: 10.1016/j.jinorgbio.2009.07.009. Epub 2009 Jul 17. PubMed PMID: 19679357; PubMed Central PMCID: PMC2768765.

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Malik M, Capecci J, Drlica K. Lon protease is essential for paradoxical survival of Escherichia coli exposed to high concentrations of quinolone. Antimicrob Agents Chemother. 2009 Jul;53(7):3103-5. doi: 10.1128/AAC.00019-09. Epub 2009 May 4. PubMed PMID: 19414573; PubMed Central PMCID: PMC2704693.

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Rosen JD, German N, Kerns RJ. Efficient Synthesis of the 2-amino-6-chloro-4-cyclopropyl-7-fluoro-5-methoxy-pyrido[1,2-c]pyrimidine-1,3-dione core ring system. Tetrahedron Lett. 2009 Feb 18;50(7):785-789. doi: 10.1016/j.tetlet.2008.11.121. PubMed PMID: 20160840; PubMed Central PMCID: PMC2631556.

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Wang X, Zhao X. Contribution of oxidative damage to antimicrobial lethality. Antimicrob Agents Chemother. 2009 Apr;53(4):1395-402. doi: 10.1128/AAC.01087-08. Epub 2009 Feb 17. PubMed PMID: 19223646; PubMed Central PMCID: PMC2663088.

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Hussain S, Malik M, Shi L, Gennaro ML, Drlica K. In vitro model of mycobacterial growth arrest using nitric oxide with limited air. Antimicrob Agents Chemother. 2009 Jan;53(1):157-61. doi: 10.1128/AAC.00442-08. Epub 2008 Oct 27. PubMed PMID: 18955516; PubMed Central PMCID: PMC2612189.

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Baaklini I, Usongo V, Nolent F, Sanscartier P, Hraiky C, Drlica K, Drolet M. Hypernegative supercoiling inhibits growth by causing RNA degradation. J Bacteriol. 2008 Nov;190(22):7346-56. doi: 10.1128/JB.00680-08. Epub 2008 Sep 12. PubMed PMID: 18790862; PubMed Central PMCID: PMC2576660.

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German N, Malik M, Rosen JD, Drlica K, Kerns RJ. Use of gyrase resistance mutants to guide selection of 8-methoxy-quinazoline-2,4-diones. Antimicrob Agents Chemother. 2008 Nov;52(11):3915-21. doi: 10.1128/AAC.00330-08. Epub 2008 Sep 2. PubMed PMID: 18765690; PubMed Central PMCID: PMC2573108.

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Usongo V, Nolent F, Sanscartier P, Tanguay C, Broccoli S, Baaklini I, Drlica K, Drolet M. Depletion of RNase HI activity in Escherichia coli lacking DNA topoisomerase I leads to defects in DNA supercoiling and segregation. Mol Microbiol. 2008 Aug;69(4):968-81. doi: 10.1111/j.1365-2958.2008.06334.x. Epub 2008 Jun 28. PubMed PMID: 18554330; PubMed Central PMCID: PMC2875999.

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Zhao X, Drlica K. A unified anti-mutant dosing strategy. J Antimicrob Chemother. 2008 Sep;62(3):434-6. doi: 10.1093/jac/dkn229. Epub 2008 Jun 10. Review. PubMed PMID: 18544596; PubMed Central PMCID: PMC2734085.

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Drlica K, Zhao X, Kreiswirth B. Minimising moxifloxacin resistance with tuberculosis. Lancet Infect Dis. 2008 May;8(5):273-5. doi: 10.1016/S1473-3099(08)70077-X. PubMed PMID: 18471768.

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Quinn B, Hussain S, Malik M, Drlica K, Zhao X. Daptomycin inoculum effects and mutant prevention concentration with Staphylococcus aureus. J Antimicrob Chemother. 2007 Dec;60(6):1380-3. doi: 10.1093/jac/dkm375. Epub 2007 Sep 28. PubMed PMID: 17905797.

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Drlica K, Malik M, Kerns RJ, Zhao X. Quinolone-mediated bacterial death. Antimicrob Agents Chemother. 2008 Feb;52(2):385-92. doi: 10.1128/AAC.01617-06. Epub 2007 Aug 27. Review. PubMed PMID: 17724149; PubMed Central PMCID: PMC2224783.

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Ye F, Brauer T, Niehus E, Drlica K, Josenhans C, Suerbaum S. Flagellar and global gene regulation in Helicobacter pylori modulated by changes in DNA supercoiling. Int J Med Microbiol. 2007 Apr;297(2):65-81. doi: 10.1016/j.ijmm.2006.11.006. Epub 2007 Feb 1. PubMed PMID: 17276136.

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Drlica K, Zhao X. Mutant selection window hypothesis updated. Clin Infect Dis. 2007 Mar 1;44(5):681-8. doi: 10.1086/511642. Epub 2007 Jan 24. Review. PubMed PMID: 17278059.

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Cui J, Liu Y, Wang R, Tong W, Drlica K, Zhao X. The mutant selection window in rabbits infected with Staphylococcus aureus. J Infect Dis. 2006 Dec 1;194(11):1601-8. doi: 10.1086/508752. Epub 2006 Oct 20. PubMed PMID: 17083047.

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Malik M, Hussain S, Drlica K. Effect of anaerobic growth on quinolone lethality with Escherichia coli. Antimicrob Agents Chemother. 2007 Jan;51(1):28-34. doi: 10.1128/AAC.00739-06. Epub 2006 Oct 16. PubMed PMID: 17043118; PubMed Central PMCID: PMC1797672.

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Zhao X, Quinn B, Kerns R, Drlica K. Bactericidal activity and target preference of a piperazinyl-cross-linked ciprofloxacin dimer with Staphylococcus aureus and Escherichia coli. J Antimicrob Chemother. 2006 Dec;58(6):1283-6. doi: 10.1093/jac/dkl388. Epub 2006 Sep 26. PubMed PMID: 17003060.

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Malik M, Drlica K. Moxifloxacin lethality against Mycobacterium tuberculosis in the presence and absence of chloramphenicol. Antimicrob Agents Chemother. 2006 Aug;50(8):2842-4. doi: 10.1128/AAC.00250-06. PubMed PMID: 16870782; PubMed Central PMCID: PMC1538652.

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Malik M, Zhao X, Drlica K. Lethal fragmentation of bacterial chromosomes mediated by DNA gyrase and quinolones. Mol Microbiol. 2006 Aug;61(3):810-25. doi: 10.1111/j.1365-2958.2006.05275.x. Epub 2006 Jun 27. PubMed PMID: 16803589.