Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Shi L, Kang S, Choi CY, Noonan BL, Carrica LK, Liang NC, Gulley JM. Effects of combined exposure to ethanol and delta-9-tetrahydrocannabinol during adolescence on synaptic plasticity in the prefrontal cortex of Long Evans rats. Neuropharmacology. 2024 Jan 1;242:109765. doi: 10.1016/j.neuropharm.2023.109765. Epub 2023 Oct 19. PubMed PMID: 37863313; PubMed Central PMCID: PMC10872915.
Sangiamo DT, Weingarten MJ, Nelson NG, Choi CY, Das A, Liang NC. Experience with dronabinol consumption facilitated a stimulant effect of alcohol and affected alcohol-related changes in frontal cortical endocannabinoid levels in male rats. Behav Brain Res. 2023 Aug 24;452:114587. doi: 10.1016/j.bbr.2023.114587. Epub 2023 Jul 17. PubMed PMID: 37467963; PubMed Central PMCID: PMC10528712.
Carrica LK, Choi CY, Walter FA, Noonan BL, Shi L, Johnson CT, Bradshaw HB, Liang NC, Gulley JM. Effects of combined use of alcohol and delta-9-tetrahydrocannibinol on working memory in Long Evans rats. Behav Brain Res. 2023 Jul 9;449:114475. doi: 10.1016/j.bbr.2023.114475. Epub 2023 May 3. PubMed PMID: 37146720; PubMed Central PMCID: PMC10247469.
Westbrook SR, Carrica LK, Banks A, Gulley JM. AMPed-up adolescents: The role of age in the abuse of amphetamines and its consequences on cognition and prefrontal cortex development. Pharmacol Biochem Behav. 2020 Nov;198:173016. doi: 10.1016/j.pbb.2020.173016. Epub 2020 Aug 20. Review. PubMed PMID: 32828971; PubMed Central PMCID: PMC7554214.
Westbrook SR, Dwyer MR, Cortes LR, Gulley JM. Extended access self-administration of methamphetamine is associated with age- and sex-dependent differences in drug taking behavior and recognition memory in rats. Behav Brain Res. 2020 Jul 15;390:112659. doi: 10.1016/j.bbr.2020.112659. Epub 2020 May 8. PubMed PMID: 32437887; PubMed Central PMCID: PMC7307427.
Hammerslag LR, Belagodu AP, Aladesuyi Arogundade OA, Karountzos AG, Guo Q, Galvez R, Roberts BW, Gulley JM. Adolescent impulsivity as a sex-dependent and subtype-dependent predictor of impulsivity, alcohol drinking and dopamine D(2) receptor expression in adult rats. Addict Biol. 2019 Mar;24(2):193-205. doi: 10.1111/adb.12586. Epub 2017 Dec 5. PubMed PMID: 29210144; PubMed Central PMCID: PMC5988863.
Nelson NG, Law WX, Weingarten MJ, Carnevale LN, Das A, Liang NC. Combined ∆(9)-tetrahydrocannabinol and moderate alcohol administration: effects on ingestive behaviors in adolescent male rats. Psychopharmacology (Berl). 2019 Feb;236(2):671-684. doi: 10.1007/s00213-018-5093-3. Epub 2018 Nov 10. PubMed PMID: 30415276; PubMed Central PMCID: PMC6401297.
Kang S, Cox CL, Gulley JM. High frequency stimulation-induced plasticity in the prelimbic cortex of rats emerges during adolescent development and is associated with an increase in dopamine receptor function. Neuropharmacology. 2018 Oct;141:158-166. doi: 10.1016/j.neuropharm.2018.08.037. Epub 2018 Aug 28. PubMed PMID: 30165079; PubMed Central PMCID: PMC6207435.
Hankosky ER, Westbrook SR, Haake RM, Willing J, Raetzman LT, Juraska JM, Gulley JM. Age- and sex-dependent effects of methamphetamine on cognitive flexibility and 5-HT(2C) receptor localization in the orbitofrontal cortex of Sprague-Dawley rats. Behav Brain Res. 2018 Sep 3;349:16-24. doi: 10.1016/j.bbr.2018.04.047. Epub 2018 Apr 30. PubMed PMID: 29715538; PubMed Central PMCID: PMC5993617.
Sherrill LK, Gulley JM. Effects of amphetamine exposure during adolescence on behavior and prelimbic cortex neuron activity in adulthood. Brain Res. 2018 Sep 1;1694:111-120. doi: 10.1016/j.brainres.2018.05.028. Epub 2018 May 21. PubMed PMID: 29792867; PubMed Central PMCID: PMC6026035.
Westbrook SR, Kang M, Sherrill LK, O'Hearn D, Krishnamani T, Gulley JM. Sex differences in adolescent ethanol drinking to behavioral intoxication. J Exp Anal Behav. 2018 Jul;110(1):54-62. doi: 10.1002/jeab.440. Epub 2018 May 21. PubMed PMID: 29781150; PubMed Central PMCID: PMC6064645.
Westbrook SR, Hankosky ER, Dwyer MR, Gulley JM. Age and sex differences in behavioral flexibility, sensitivity to reward value, and risky decision-making. Behav Neurosci. 2018 Apr;132(2):75-87. doi: 10.1037/bne0000235. Epub 2018 Feb 26. PubMed PMID: 29481101; PubMed Central PMCID: PMC5908747.
Hankosky ER, Westbrook SR, Haake RM, Marinelli M, Gulley JM. Reduced sensitivity to reinforcement in adolescent compared to adult Sprague-Dawley rats of both sexes. Psychopharmacology (Berl). 2018 Mar;235(3):861-871. doi: 10.1007/s00213-017-4804-5. Epub 2017 Dec 2. PubMed PMID: 29197983; PubMed Central PMCID: PMC5963930.
Walker DM, Bell MR, Flores C, Gulley JM, Willing J, Paul MJ. Adolescence and Reward: Making Sense of Neural and Behavioral Changes Amid the Chaos. J Neurosci. 2017 Nov 8;37(45):10855-10866. doi: 10.1523/JNEUROSCI.1834-17.2017. Review. PubMed PMID: 29118215; PubMed Central PMCID: PMC5678018.
Hankosky ER, Sherrill LK, Ruvola LA, Haake RM, Kim T, Hammerslag LR, Kougias DG, Juraska JM, Gulley JM. Effects of β-hydroxy-β-methyl butyrate on working memory and cognitive flexibility in an animal model of aging. Nutr Neurosci. 2017 Sep;20(7):379-387. doi: 10.1080/1028415X.2016.1145376. Epub 2016 Feb 19. PubMed PMID: 26896292.
Kougias DG, Hankosky ER, Gulley JM, Juraska JM. Beta-hydroxy-beta-methylbutyrate (HMB) ameliorates age-related deficits in water maze performance, especially in male rats. Physiol Behav. 2017 Mar 1;170:93-99. doi: 10.1016/j.physbeh.2016.12.025. Epub 2016 Dec 27. PubMed PMID: 28038406.
Kang S, Wu MM, Galvez R, Gulley JM. Timing of amphetamine exposure in relation to puberty onset determines its effects on anhedonia, exploratory behavior, and dopamine D(1) receptor expression in young adulthood. Neuroscience. 2016 Dec 17;339:72-84. doi: 10.1016/j.neuroscience.2016.09.044. Epub 2016 Oct 1. PubMed PMID: 27702645; PubMed Central PMCID: PMC5118128.
Paul K, Kang S, Cox CL, Gulley JM. Repeated exposure to amphetamine during adolescence alters inhibitory tone in the medial prefrontal cortex following drug re-exposure in adulthood. Behav Brain Res. 2016 Aug 1;309:9-13. doi: 10.1016/j.bbr.2016.04.018. Epub 2016 Apr 13. PubMed PMID: 27085589; PubMed Central PMCID: PMC5149400.
Kang S, Paul K, Hankosky ER, Cox CL, Gulley JM. D1 receptor-mediated inhibition of medial prefrontal cortex neurons is disrupted in adult rats exposed to amphetamine in adolescence. Neuroscience. 2016 Jun 2;324:40-9. doi: 10.1016/j.neuroscience.2016.02.064. Epub 2016 Mar 2. PubMed PMID: 26946269; PubMed Central PMCID: PMC4864726.
Kougias DG, Nolan SO, Koss WA, Kim T, Hankosky ER, Gulley JM, Juraska JM. Beta-hydroxy-beta-methylbutyrate ameliorates aging effects in the dendritic tree of pyramidal neurons in the medial prefrontal cortex of both male and female rats. Neurobiol Aging. 2016 Apr;40:78-85. doi: 10.1016/j.neurobiolaging.2016.01.004. Epub 2016 Jan 18. PubMed PMID: 26973106.
Hammerslag LR, Gulley JM. Sex differences in behavior and neural development and their role in adolescent vulnerability to substance use. Behav Brain Res. 2016 Feb 1;298(Pt A):15-26. doi: 10.1016/j.bbr.2015.04.008. Epub 2015 Apr 13. Review. PubMed PMID: 25882721; PubMed Central PMCID: PMC4603997.
Hammerslag LR, Gulley JM. Age and sex differences in reward behavior in adolescent and adult rats. Dev Psychobiol. 2014 May;56(4):611-21. doi: 10.1002/dev.21127. Epub 2013 Jun 10. PubMed PMID: 23754712; PubMed Central PMCID: PMC4782597.
Hammerslag LR, Waldman AJ, Gulley JM. Effects of amphetamine exposure in adolescence or young adulthood on inhibitory control in adult male and female rats. Behav Brain Res. 2014 Apr 15;263:22-33. doi: 10.1016/j.bbr.2014.01.015. Epub 2014 Jan 22. PubMed PMID: 24462963; PubMed Central PMCID: PMC3954703.
Hankosky ER, Gulley JM. Performance on an impulse control task is altered in adult rats exposed to amphetamine during adolescence. Dev Psychobiol. 2013 Nov;55(7):733-44. doi: 10.1002/dev.21067. Epub 2012 Jul 6. PubMed PMID: 22778047; PubMed Central PMCID: PMC3491181.
Gulley JM, Juraska JM. The effects of abused drugs on adolescent development of corticolimbic circuitry and behavior. Neuroscience. 2013 Sep 26;249:3-20. doi: 10.1016/j.neuroscience.2013.05.026. Epub 2013 May 24. Review. PubMed PMID: 23711583; PubMed Central PMCID: PMC3755361.
Hankosky ER, Kofsky NM, Gulley JM. Age of exposure-dependent effects of amphetamine on behavioral flexibility. Behav Brain Res. 2013 Sep 1;252:117-25. doi: 10.1016/j.bbr.2013.06.002. Epub 2013 Jun 10. PubMed PMID: 23756139; PubMed Central PMCID: PMC3742571.
Sherrill LK, Stanis JJ, Gulley JM. Age-dependent effects of repeated amphetamine exposure on working memory in rats. Behav Brain Res. 2013 Apr 1;242:84-94. doi: 10.1016/j.bbr.2012.12.044. Epub 2013 Jan 3. PubMed PMID: 23291159; PubMed Central PMCID: PMC3566264.
Romanova EV, Lee JE, Kelleher NL, Sweedler JV, Gulley JM. Comparative peptidomics analysis of neural adaptations in rats repeatedly exposed to amphetamine. J Neurochem. 2012 Oct;123(2):276-87. doi: 10.1111/j.1471-4159.2012.07912.x. Epub 2012 Sep 3. PubMed PMID: 22860605; PubMed Central PMCID: PMC3463764.
Koss WA, Sadowski RN, Sherrill LK, Gulley JM, Juraska JM. Effects of ethanol during adolescence on the number of neurons and glia in the medial prefrontal cortex and basolateral amygdala of adult male and female rats. Brain Res. 2012 Jul 23;1466:24-32. doi: 10.1016/j.brainres.2012.05.023. Epub 2012 May 22. PubMed PMID: 22627163; PubMed Central PMCID: PMC3389213.
Sherrill LK, Berthold C, Koss WA, Juraska JM, Gulley JM. Sex differences in the effects of ethanol pre-exposure during adolescence on ethanol-induced conditioned taste aversion in adult rats. Behav Brain Res. 2011 Nov 20;225(1):104-9. doi: 10.1016/j.bbr.2011.07.003. Epub 2011 Jul 8. PubMed PMID: 21767576; PubMed Central PMCID: PMC3170442.
Sherrill LK, Koss WA, Foreman ES, Gulley JM. The effects of pre-pubertal gonadectomy and binge-like ethanol exposure during adolescence on ethanol drinking in adult male and female rats. Behav Brain Res. 2011 Jan 20;216(2):569-75. doi: 10.1016/j.bbr.2010.08.048. Epub 2010 Sep 15. PubMed PMID: 20816899; PubMed Central PMCID: PMC2981628.
Hall DA, Gulley JM. Disruptive effect of amphetamines on Pavlovian to instrumental transfer. Behav Brain Res. 2011 Jan 1;216(1):440-5. doi: 10.1016/j.bbr.2010.08.040. Epub 2010 Sep 9. PubMed PMID: 20817041; PubMed Central PMCID: PMC2975878.
Romanova EV, Lee JE, Kelleher NL, Sweedler JV, Gulley JM. Mass spectrometry screening reveals peptides modulated differentially in the medial prefrontal cortex of rats with disparate initial sensitivity to cocaine. AAPS J. 2010 Sep;12(3):443-54. doi: 10.1208/s12248-010-9204-2. Epub 2010 May 19. PubMed PMID: 20490734; PubMed Central PMCID: PMC2895454.
Gulley JM, Stanis JJ. Adaptations in medial prefrontal cortex function associated with amphetamine-induced behavioral sensitization. Neuroscience. 2010 Mar 17;166(2):615-24. doi: 10.1016/j.neuroscience.2009.12.044. Epub 2009 Dec 24. PubMed PMID: 20035836; PubMed Central PMCID: PMC2824062.
Hall DA, Powers JP, Gulley JM. Blockade of D1 dopamine receptors in the medial prefrontal cortex attenuates amphetamine- and methamphetamine-induced locomotor activity in the rat. Brain Res. 2009 Dec 1;1300:51-7. doi: 10.1016/j.brainres.2009.08.084. Epub 2009 Sep 3. PubMed PMID: 19733155.
Rubinow MJ, Hagerbaumer DA, Juraska JM. The food-conditioned place preference task in adolescent, adult and aged rats of both sexes. Behav Brain Res. 2009 Mar 2;198(1):263-6. doi: 10.1016/j.bbr.2008.11.024. Epub 2008 Nov 24. PubMed PMID: 19084035; PubMed Central PMCID: PMC2800074.
Rubinow MJ, Juraska JM. Neuron and glia numbers in the basolateral nucleus of the amygdala from preweaning through old age in male and female rats: a stereological study. J Comp Neurol. 2009 Feb 20;512(6):717-25. doi: 10.1002/cne.21924. PubMed PMID: 19065620; PubMed Central PMCID: PMC2647367.
Klein DA, Gulley JM. Reduced sensitivity to the locomotor-stimulant effects of cocaine is associated with increased sensitivity to its discriminative stimulus properties. Behav Pharmacol. 2009 Feb;20(1):67-77. doi: 10.1097/FBP.0b013e3283242fdd. PubMed PMID: 19125118.
Stanis JJ, Burns RM, Sherrill LK, Gulley JM. Disparate cocaine-induced locomotion as a predictor of choice behavior in rats trained in a delay-discounting task. Drug Alcohol Depend. 2008 Nov 1;98(1-2):54-62. doi: 10.1016/j.drugalcdep.2008.04.009. Epub 2008 Jun 9. PubMed PMID: 18539407; PubMed Central PMCID: PMC2574610.
Stanis JJ, Marquez Avila H, White MD, Gulley JM. Dissociation between long-lasting behavioral sensitization to amphetamine and impulsive choice in rats performing a delay-discounting task. Psychopharmacology (Berl). 2008 Sep;199(4):539-48. doi: 10.1007/s00213-008-1182-z. Epub 2008 May 13. PubMed PMID: 18473112; PubMed Central PMCID: PMC2574859.
Hall DA, Stanis JJ, Marquez Avila H, Gulley JM. A comparison of amphetamine- and methamphetamine-induced locomotor activity in rats: evidence for qualitative differences in behavior. Psychopharmacology (Berl). 2008 Jan;195(4):469-78. doi: 10.1007/s00213-007-0923-8. Epub 2007 Sep 17. PubMed PMID: 17874316; PubMed Central PMCID: PMC2423722.
Gulley JM, Everett CV, Zahniser NR. Inbred Lewis and Fischer 344 rat strains differ not only in novelty- and amphetamine-induced behaviors, but also in dopamine transporter activity in vivo. Brain Res. 2007 Jun 2;1151:32-45. doi: 10.1016/j.brainres.2007.03.009. Epub 2007 Mar 12. PubMed PMID: 17395161; PubMed Central PMCID: PMC1936412.
Gulley JM. Individual differences in novelty- and cocaine-induced locomotor activity as predictors of food-reinforced operant behavior in two outbred rat strains. Pharmacol Biochem Behav. 2007 Apr;86(4):749-57. doi: 10.1016/j.pbb.2007.03.002. Epub 2007 Mar 12. PubMed PMID: 17408729.
Gulley JM, Larson GA, Zahniser NR. Using High-Speed Chronoamperometry with Local Dopamine Application to Assess Dopamine Transporter Function. 2007;. Review. PubMed PMID: 21204388.
Allen RM, Everett CV, Nelson AM, Gulley JM, Zahniser NR. Low and high locomotor responsiveness to cocaine predicts intravenous cocaine conditioned place preference in male Sprague-Dawley rats. Pharmacol Biochem Behav. 2007 Jan;86(1):37-44. doi: 10.1016/j.pbb.2006.12.005. Epub 2006 Dec 20. PubMed PMID: 17250883; PubMed Central PMCID: PMC2712248.
Briegleb SK, Gulley JM, Hoover BR, Zahniser NR. Individual differences in cocaine- and amphetamine-induced activation of male Sprague-Dawley rats: contribution of the dopamine transporter. Neuropsychopharmacology. 2004 Dec;29(12):2168-79. doi: 10.1038/sj.npp.1300536. PubMed PMID: 15292903.
Hanania T, Gulley JM, Salaz DO, Larson GA, Zahniser NR. Role of the dopamine transporter in the differential cocaine-induced locomotor activation of inbred long-sleep and short-sleep mice. Neuropsychopharmacology. 2004 Oct;29(10):1814-22. doi: 10.1038/sj.npp.1300501. PubMed PMID: 15199369.
Gulley JM, Reed JL, Kuwajima M, Rebec GV. Amphetamine-induced behavioral activation is associated with variable changes in basal ganglia output neurons recorded from awake, behaving rats. Brain Res. 2004 Jun 25;1012(1-2):108-18. doi: 10.1016/j.brainres.2004.03.044. PubMed PMID: 15158167.
Gulley JM, Hoover BR, Larson GA, Zahniser NR. Individual differences in cocaine-induced locomotor activity in rats: behavioral characteristics, cocaine pharmacokinetics, and the dopamine transporter. Neuropsychopharmacology. 2003 Dec;28(12):2089-101. doi: 10.1038/sj.npp.1300279. PubMed PMID: 12902997.
Gulley JM, Zahniser NR. Rapid regulation of dopamine transporter function by substrates, blockers and presynaptic receptor ligands. Eur J Pharmacol. 2003 Oct 31;479(1-3):139-52. doi: 10.1016/j.ejphar.2003.08.064. Review. PubMed PMID: 14612145.
What would you like to do?