My Bibliography

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McDermott JG, Goodlett BL, Navaneethabalakrishnan S, Rutkowski JM, Mitchell BM. Nephron-associated Support Cell Transcriptional Plasticity Expands in Hypertension. bioRxiv. 2026 Jan 17;. doi: 10.64898/2026.01.16.699969. PubMed PMID: 41648558; PubMed Central PMCID: PMC12871107.

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Creed HA, Kannan S, Rutkowski JM. Two-Step Positive Selection Method for the Magnetic Isolation of Lymphatic Endothelial Cells. Methods Mol Biol. 2025;2956:11-22. doi: 10.1007/978-1-0716-4706-6_2. PubMed PMID: 40859071.

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Chatterjee T, Rutkowski J, Soranno DE, Goggins E, Okusa M, Prenna S, Cantaluppi V, Zarjou A. Discovery Pipeline for Acute Kidney Injury: Molecules, Mechanisms, Models, and Targets. Nephron. 2026;150(3):173-183. doi: 10.1159/000549795. Epub 2025 Nov 28. Review. PubMed PMID: 41313738; PubMed Central PMCID: PMC12772422.

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Subramanian B, Johnson S, Narayanan A, Wang W, Seaberg BL, Ball J, Paredes Mares IM, Majumder A, Aceves A, Frazier SE, Rutledge A, Griffin JF 4th, Pal S, Zawieja S, Davis MJ, Rutkowski JM, Nghiem PP, Rimer M, Muthuchamy M. Lymphatic dysfunction is linked to disease pathogenesis in Duchenne muscular dystrophy animal models. Proc Natl Acad Sci U S A. 2025 Sep 23;122(38):e2505656122. doi: 10.1073/pnas.2505656122. Epub 2025 Sep 18. PubMed PMID: 40966282; PubMed Central PMCID: PMC12478126.

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Dalga D, Rinaldi A, Fu X, Chanvillard L, Huber A, Faivre A, Jaques D, Berchtold L, Boccard J, Arnoux G, Lyon A, Rutkowski JM, Gex Q, Paolucci D, Kreuzfeld M, Cagarelli T, Lutz L, Longchamp A, Moll S, Hulo N, Ponte B, Burgess SC, Cippà PE, Verissimo T, de Seigneux S. Phosphoenolpyruvate carboxykinase 1-mediated cataplerosis is required to maintain mitochondrial fitness and to avoid kidney disease progression. Kidney Int. 2025 Nov;108(5):827-847. doi: 10.1016/j.kint.2025.06.018. Epub 2025 Jul 10. PubMed PMID: 40645291.

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Narayanan A, Seaberg BL, Buxton A, Vernino A, Williams VE, Matarazzo A, Kekre J, Subramanian B, Wang W, Rutkowski JM, Hook M, McCreedy DA, Muthuchamy M, Rimer M. Lymphatic dysfunction correlates with inflammation in a mouse model of amyotrophic lateral sclerosis. Dis Model Mech. 2025 Jul 1;18(7). doi: 10.1242/dmm.052148. Epub 2025 Jul 16. PubMed PMID: 40600271; PubMed Central PMCID: PMC12309905.

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Chiu A, Rutkowski JM, Zhang Q, Zhao F. Tissue-Engineered Therapeutics for Lymphatic Regeneration: Solutions for Myocardial Infarction and Secondary Lymphedema. Adv Healthc Mater. 2025 Mar;14(6):e2403551. doi: 10.1002/adhm.202403551. Epub 2025 Jan 13. Review. PubMed PMID: 39806804; PubMed Central PMCID: PMC11936459.

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Kannan S, Phan TT, Creed HA, Reyna AJ, Baranwal G, Rich AL, Weiss DL, Rutkowski JM. Therapeutically Induced Lymphangiogenesis Is Ineffective in Resolving Established Kidney Disease in Mice. Kidney360. 2025 Apr 1;6(4):509-520. doi: 10.34067/KID.0000000671. Epub 2024 Dec 17. PubMed PMID: 39689345; PubMed Central PMCID: PMC12045517.

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McDermott JG, Goodlett BL, Creed HA, Navaneethabalakrishnan S, Rutkowski JM, Mitchell BM. Inflammatory Alterations to Renal Lymphatic Endothelial Cell Gene Expression in Mouse Models of Hypertension. Kidney Blood Press Res. 2024;49(1):588-604. doi: 10.1159/000539721. Epub 2024 Jul 22. PubMed PMID: 38972305; PubMed Central PMCID: PMC11345939.

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Faivre A, Bugarski M, Rinaldi A, Sakhi IB, Verissimo T, Legouis D, Rutkowski JM, Correia S, Kaminska M, Dalga D, Malpetti D, Cippa PE, de Seigneux S, Hall AM. Spatiotemporal Landscape of Kidney Tubular Responses to Glomerular Proteinuria. J Am Soc Nephrol. 2024 Jul 1;35(7):854-869. doi: 10.1681/ASN.0000000000000357. Epub 2024 Apr 23. PubMed PMID: 38652545; PubMed Central PMCID: PMC11230716.

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Rossitto G, Bertoldi G, Rutkowski JM, Mitchell BM, Delles C. Sodium, Interstitium, Lymphatics and Hypertension-A Tale of Hydraulics. Hypertension. 2024 Apr;81(4):727-737. doi: 10.1161/HYPERTENSIONAHA.123.17942. Epub 2024 Feb 22. Review. PubMed PMID: 38385255; PubMed Central PMCID: PMC10954399.

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Kannan S, Rutkowski JM. VEGFR-3 signaling in macrophages: friend or foe in disease?. Front Immunol. 2024;15:1349500. doi: 10.3389/fimmu.2024.1349500. eCollection 2024. Review. PubMed PMID: 38464522; PubMed Central PMCID: PMC10921555.

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Creed HA, Kannan S, Tate BL, Godefroy D, Banerjee P, Mitchell BM, Brakenhielm E, Chakraborty S, Rutkowski JM. Single-Cell RNA Sequencing Identifies Response of Renal Lymphatic Endothelial Cells to Acute Kidney Injury. J Am Soc Nephrol. 2024 May 1;35(5):549-565. doi: 10.1681/ASN.0000000000000325. Epub 2024 Feb 7. PubMed PMID: 38506705; PubMed Central PMCID: PMC11149045.

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Onodera T, Wang MY, Rutkowski JM, Deja S, Chen S, Balzer MS, Kim DS, Sun X, An YA, Field BC, Lee C, Matsuo EI, Mizerska M, Sanjana I, Fujiwara N, Kusminski CM, Gordillo R, Gautron L, Marciano DK, Hu MC, Burgess SC, Susztak K, Moe OW, Scherer PE. Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization. Nat Commun. 2023 Oct 17;14(1):6531. doi: 10.1038/s41467-023-42188-4. PubMed PMID: 37848446; PubMed Central PMCID: PMC10582045.

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Faivre A, Dissard R, Kuo W, Verissimo T, Legouis D, Arnoux G, Heckenmeyer C, Fernandez M, Tihy M, Rajaram RD, Delitsikou V, Le NA, Spingler B, Mueller B, Shulz G, Lindenmeyer M, Cohen C, Rutkowski JM, Moll S, Scholz CC, Kurtcuoglu V, de Seigneux S. Evolution of hypoxia and hypoxia-inducible factor asparaginyl hydroxylase regulation in chronic kidney disease. Nephrol Dial Transplant. 2023 Sep 29;38(10):2276-2288. doi: 10.1093/ndt/gfad075. PubMed PMID: 37096392; PubMed Central PMCID: PMC10539236.

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Creed HA, Kannan S, Tate BL, Banerjee P, Mitchell BM, Chakraborty S, Rutkowski JM. Single-cell RNA sequencing identifies response of renal lymphatic endothelial cells to acute kidney injury. bioRxiv. 2023 Jun 14;. doi: 10.1101/2023.06.09.544380. PubMed PMID: 37333313; PubMed Central PMCID: PMC10274866.

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Baranwal G, Goodlett BL, Arenaz CM, Creed HA, Navaneethabalakrishnan S, Rutkowski JM, Alaniz RC, Mitchell BM. Indole Propionic Acid Increases T Regulatory Cells and Decreases T Helper 17 Cells and Blood Pressure in Mice with Salt-Sensitive Hypertension. Int J Mol Sci. 2023 May 24;24(11). doi: 10.3390/ijms24119192. PubMed PMID: 37298145; PubMed Central PMCID: PMC10252743.

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Verissimo T, Dalga D, Arnoux G, Sakhi I, Faivre A, Auwerx H, Bourgeois S, Paolucci D, Gex Q, Rutkowski JM, Legouis D, Wagner CA, Hall AM, de Seigneux S. PCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells. Am J Physiol Renal Physiol. 2023 Jun 1;324(6):F532-F543. doi: 10.1152/ajprenal.00038.2023. Epub 2023 Apr 27. PubMed PMID: 37102687; PubMed Central PMCID: PMC10202477.

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Chakraborty S, Dixon BJ, Rutkowski JM, Castorena-Gonzalez JA, Breslin JW. Lymphatic Pathophysiology. Microcirculation. 2023 Apr;30(2-3):e12806. doi: 10.1111/micc.12806. PubMed PMID: 37078170; PubMed Central PMCID: PMC11606553.

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Phan TT, Chakraborty A, Tatum MA, Lima-Orellana A, Reyna AJ, Rutkowski JM. Increased adipose tissue lymphatic vessel density inhibits thermogenesis through elevated neurotensin levels. Front Cell Dev Biol. 2023;11:1100788. doi: 10.3389/fcell.2023.1100788. eCollection 2023. PubMed PMID: 36776563; PubMed Central PMCID: PMC9911872.

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An YA, Xiong W, Chen S, Bu D, Rutkowski JM, Berger JP, Kusminski CM, Zhang N, An Z, Scherer PE. Endotrophin neutralization through targeted antibody treatment protects from renal fibrosis in a podocyte ablation model. Mol Metab. 2023 Mar;69:101680. doi: 10.1016/j.molmet.2023.101680. Epub 2023 Jan 22. PubMed PMID: 36696925; PubMed Central PMCID: PMC9918787.

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Goodlett BL, Balasubbramanian D, Navaneethabalakrishnan S, Love SE, Luera EM, Konatham S, Chiasson VL, Wedgeworth S, Rutkowski JM, Mitchell BM. Genetically inducing renal lymphangiogenesis attenuates hypertension in mice. Clin Sci (Lond). 2022 Dec 9;136(23):1759-1772. doi: 10.1042/CS20220547. PubMed PMID: 36345993; PubMed Central PMCID: PMC10586591.

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Goldberg AR, Ferguson M, Pal S, Cohen R, Orlicky DJ, McCullough RL, Rutkowski JM, Burchill MA, Tamburini BAJ. Oxidized low density lipoprotein in the liver causes decreased permeability of liver lymphatic- but not liver sinusoidal-endothelial cells via VEGFR-3 regulation of VE-Cadherin. Front Physiol. 2022;13:1021038. doi: 10.3389/fphys.2022.1021038. eCollection 2022. PubMed PMID: 36338478; PubMed Central PMCID: PMC9626955.

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Chakraborty A, Crescenzi R, Usman TA, Reyna AJ, Garza ME, Al-Ghadban S, Herbst KL, Donahue PMC, Rutkowski JM. Indications of Peripheral Pain, Dermal Hypersensitivity, and Neurogenic Inflammation in Patients with Lipedema. Int J Mol Sci. 2022 Sep 7;23(18). doi: 10.3390/ijms231810313. PubMed PMID: 36142221; PubMed Central PMCID: PMC9499469.

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Duhon BH, Phan TT, Taylor SL, Crescenzi RL, Rutkowski JM. Current Mechanistic Understandings of Lymphedema and Lipedema: Tales of Fluid, Fat, and Fibrosis. Int J Mol Sci. 2022 Jun 14;23(12). doi: 10.3390/ijms23126621. Review. PubMed PMID: 35743063; PubMed Central PMCID: PMC9223758.

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Ghnenis AB, Jones C, Sefiani A, Douthitt AJ, Reyna AJ, Rutkowski JM, Geoffroy CG. Evaluation of the Cardiometabolic Disorders after Spinal Cord Injury in Mice. Biology (Basel). 2022 Mar 24;11(4). doi: 10.3390/biology11040495. PubMed PMID: 35453695; PubMed Central PMCID: PMC9027794.

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Verissimo T, Faivre A, Rinaldi A, Lindenmeyer M, Delitsikou V, Veyrat-Durebex C, Heckenmeyer C, Fernandez M, Berchtold L, Dalga D, Cohen C, Naesens M, Ricksten SE, Martin PY, Pugin J, Merlier F, Haupt K, Rutkowski JM, Moll S, Cippà PE, Legouis D, de Seigneux S. Decreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease. J Am Soc Nephrol. 2022 Apr;33(4):810-827. doi: 10.1681/ASN.2021050680. Epub 2022 Mar 10. PubMed PMID: 35273087; PubMed Central PMCID: PMC8970457.

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Goodlett BL, Kang CS, Yoo E, Navaneethabalakrishnan S, Balasubbramanian D, Love SE, Sims BM, Avilez DL, Tate W, Chavez DR, Baranwal G, Nabity MB, Rutkowski JM, Kim D, Mitchell BM. A Kidney-Targeted Nanoparticle to Augment Renal Lymphatic Density Decreases Blood Pressure in Hypertensive Mice. Pharmaceutics. 2021 Dec 30;14(1). doi: 10.3390/pharmaceutics14010084. PubMed PMID: 35056980; PubMed Central PMCID: PMC8780399.

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Creed HA, Sanfelippo AN, Reyna AJ, Chakraborty A, Rutkowski JM. Impact of High Fat Diet and Bolus Feeding on Chyle Accumulation in a Mouse Model of Generalized Lymphatic Anomaly. Lymphat Res Biol. 2022 Aug;20(4):358-367. doi: 10.1089/lrb.2021.0031. Epub 2021 Nov 8. PubMed PMID: 34748416; PubMed Central PMCID: PMC9422780.

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Baranwal G, Creed HA, Black LM, Auger A, Quach AM, Vegiraju R, Eckenrode HE, Agarwal A, Rutkowski JM. Expanded renal lymphatics improve recovery following kidney injury. Physiol Rep. 2021 Nov;9(22):e15094. doi: 10.14814/phy2.15094. PubMed PMID: 34806312; PubMed Central PMCID: PMC8606868.

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Baranwal G, Pilla R, Goodlett BL, Coleman AK, Arenaz CM, Jayaraman A, Rutkowski JM, Alaniz RC, Mitchell BM. Common Metabolites in Two Different Hypertensive Mouse Models: A Serum and Urine Metabolome Study. Biomolecules. 2021 Sep 21;11(9). doi: 10.3390/biom11091387. PubMed PMID: 34572600; PubMed Central PMCID: PMC8467937.

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Rutkowski JM. Fixing lymphatics improves glucose metabolism. Nat Metab. 2021 Sep;3(9):1139-1141. doi: 10.1038/s42255-021-00442-3. PubMed PMID: 34545252.

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Chakraborty A, Upadhya R, Usman TA, Shetty AK, Rutkowski JM. Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress. Brain Behav Immun. 2021 Nov;98:219-233. doi: 10.1016/j.bbi.2021.08.007. Epub 2021 Aug 11. PubMed PMID: 34389489; PubMed Central PMCID: PMC8511130.

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Baranwal G, Creed HA, Cromer WE, Wang W, Upchurch BD, Smithhart MC, Vadlamani SS, Clark MC, Busbuso NC, Blais SN, Reyna AJ, Dongaonkar RM, Zawieja DC, Rutkowski JM. Dichotomous effects on lymphatic transport with loss of caveolae in mice. Acta Physiol (Oxf). 2021 Aug;232(4):e13656. doi: 10.1111/apha.13656. Epub 2021 Apr 9. PubMed PMID: 33793057; PubMed Central PMCID: PMC8513672.

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Creed HA, Rutkowski JM. Emerging roles for lymphatics in acute kidney injury: Beneficial or maleficent?. Exp Biol Med (Maywood). 2021 Apr;246(7):845-850. doi: 10.1177/1535370220983235. Epub 2021 Jan 19. PubMed PMID: 33467886; PubMed Central PMCID: PMC8719026.

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Faivre A, Katsyuba E, Verissimo T, Lindenmeyer M, Rajaram RD, Naesens M, Heckenmeyer C, Mottis A, Feraille E, Cippà P, Cohen C, Longchamp A, Allagnat F, Rutkowski JM, Legouis D, Auwerx J, de Seigneux S. Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease. Nephrol Dial Transplant. 2021 Jan 1;36(1):60-68. doi: 10.1093/ndt/gfaa124. PubMed PMID: 33099633.

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Navaneethabalakrishnan S, Goodlett BL, Lopez AH, Rutkowski JM, Mitchell BM. Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads. Clin Sci (Lond). 2020 Dec 23;134(24):3237-3257. doi: 10.1042/CS20201023. Review. PubMed PMID: 33346358; PubMed Central PMCID: PMC9208534.

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Balasubbramanian D, Baranwal G, Clark MC, Goodlett BL, Mitchell BM, Rutkowski JM. Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice. J Hypertens. 2020 May;38(5):874-885. doi: 10.1097/HJH.0000000000002349. PubMed PMID: 31913221; PubMed Central PMCID: PMC7754173.

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Chakraborty A, Scogin CK, Rizwan K, Morley TS, Rutkowski JM. Characterizing Lymphangiogenesis and Concurrent Inflammation in Adipose Tissue in Response to VEGF-D. Front Physiol. 2020;11:363. doi: 10.3389/fphys.2020.00363. eCollection 2020. PubMed PMID: 32390866; PubMed Central PMCID: PMC7188984.

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Balasubbramanian D, Gelston CAL, Lopez AH, Iskander G, Tate W, Holderness H, Rutkowski JM, Mitchell BM. Augmenting Renal Lymphatic Density Prevents Angiotensin II-Induced Hypertension in Male and Female Mice. Am J Hypertens. 2020 Jan 1;33(1):61-69. doi: 10.1093/ajh/hpz139. PubMed PMID: 31429865; PubMed Central PMCID: PMC6931897.

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Dizin E, Olivier V, Maire C, Komarynets O, Sassi A, Roth I, Loffing J, de Seigneux S, Maillard M, Rutkowski JM, Edwards A, Feraille E. Time-course of sodium transport along the nephron in nephrotic syndrome: The role of potassium. FASEB J. 2020 Feb;34(2):2408-2424. doi: 10.1096/fj.201901345R. Epub 2019 Dec 29. PubMed PMID: 31908015.

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Delitsikou V, Jarad G, Rajaram RD, Ino F, Rutkowski JM, Chen CD, Santos CXC, Scherer PE, Abraham CR, Shah AM, Feraille E, Miner JH, de Seigneux S. Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress. FASEB J. 2020 Feb;34(2):2087-2104. doi: 10.1096/fj.201900893R. Epub 2019 Dec 23. PubMed PMID: 31907991.

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Baranwal G, Rutkowski JM. Reduced lymphatic function contributes to age-related disease. Aging (Albany NY). 2019 Nov 27;11(22):9969-9970. doi: 10.18632/aging.102503. Epub 2019 Nov 27. PubMed PMID: 31785147; PubMed Central PMCID: PMC6914422.

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Chakraborty A, Barajas S, Lammoglia GM, Reyna AJ, Morley TS, Johnson JA, Scherer PE, Rutkowski JM. Vascular Endothelial Growth Factor-D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity. Am J Pathol. 2019 Apr;189(4):924-939. doi: 10.1016/j.ajpath.2018.12.008. Epub 2019 Mar 13. PubMed PMID: 30878136; PubMed Central PMCID: PMC6458523.

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Crewe C, Joffin N, Rutkowski JM, Kim M, Zhang F, Towler DA, Gordillo R, Scherer PE. An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State. Cell. 2018 Oct 18;175(3):695-708.e13. doi: 10.1016/j.cell.2018.09.005. Epub 2018 Oct 4. PubMed PMID: 30293865; PubMed Central PMCID: PMC6195477.

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Balasubbramanian D, Lopez Gelston CA, Rutkowski JM, Mitchell BM. Immune cell trafficking, lymphatics and hypertension. Br J Pharmacol. 2019 Jun;176(12):1978-1988. doi: 10.1111/bph.14370. Epub 2018 Jun 25. Review. PubMed PMID: 29797446; PubMed Central PMCID: PMC6534781.

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Hominick D, Silva A, Khurana N, Liu Y, Dechow PC, Feng JQ, Pytowski B, Rutkowski JM, Alitalo K, Dellinger MT. VEGF-C promotes the development of lymphatics in bone and bone loss. Elife. 2018 Apr 5;7. doi: 10.7554/eLife.34323. PubMed PMID: 29620526; PubMed Central PMCID: PMC5903859.

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Lopez Gelston CA, Balasubbramanian D, Abouelkheir GR, Lopez AH, Hudson KR, Johnson ER, Muthuchamy M, Mitchell BM, Rutkowski JM. Enhancing Renal Lymphatic Expansion Prevents Hypertension in Mice. Circ Res. 2018 Apr 13;122(8):1094-1101. doi: 10.1161/CIRCRESAHA.118.312765. Epub 2018 Feb 23. PubMed PMID: 29475981.

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Udit S, Burton M, Rutkowski JM, Lee S, Bookout AL, Scherer PE, Elmquist JK, Gautron L. Na(v)1.8 neurons are involved in limiting acute phase responses to dietary fat. Mol Metab. 2017 Oct;6(10):1081-1091. doi: 10.1016/j.molmet.2017.07.012. Epub 2017 Aug 4. Review. PubMed PMID: 29031710; PubMed Central PMCID: PMC5641637.

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Nitschké M, Bell A, Karaman S, Amouzgar M, Rutkowski JM, Scherer PE, Alitalo K, McDonald DM. Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations. Am J Pathol. 2017 Sep;187(9):1984-1997. doi: 10.1016/j.ajpath.2017.05.009. Epub 2017 Jul 3. PubMed PMID: 28683257; PubMed Central PMCID: PMC5808174.