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Baranwal G, Creed HA, Cromer WE, Wang W, Upchurch BD, Smithhart MC, Vadlamani SS, Clark MC, Busbuso NC, Blais SN, Reyna AJ, Dongaonkar RM, Zawieja DC, Rutkowski JM. Dichotomous effects on lymphatic transport with loss of caveolae in mice. Acta Physiol (Oxf). 2021 Apr 1;:e13656. doi: 10.1111/apha.13656. [Epub ahead of print] PubMed PMID: 33793057.
Creed HA, Rutkowski JM. Emerging roles for lymphatics in acute kidney injury: Beneficial or maleficent?. Exp Biol Med (Maywood). 2021 Apr;246(7):845-850. doi: 10.1177/1535370220983235. Epub 2021 Jan 19. PubMed PMID: 33467886.
Faivre A, Katsyuba E, Verissimo T, Lindenmeyer M, Rajaram RD, Naesens M, Heckenmeyer C, Mottis A, Feraille E, Cippà P, Cohen C, Longchamp A, Allagnat F, Rutkowski JM, Legouis D, Auwerx J, de Seigneux S. Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease. Nephrol Dial Transplant. 2021 Jan 1;36(1):60-68. doi: 10.1093/ndt/gfaa124. PubMed PMID: 33099633.
Navaneethabalakrishnan S, Goodlett BL, Lopez AH, Rutkowski JM, Mitchell BM. Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads. Clin Sci (Lond). 2020 Dec 23;134(24):3237-3257. doi: 10.1042/CS20201023. Review. PubMed PMID: 33346358.
Balasubbramanian D, Baranwal G, Clark MC, Goodlett BL, Mitchell BM, Rutkowski JM. Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice. J Hypertens. 2020 May;38(5):874-885. doi: 10.1097/HJH.0000000000002349. PubMed PMID: 31913221; PubMed Central PMCID: PMC7754173.
Chakraborty A, Scogin CK, Rizwan K, Morley TS, Rutkowski JM. Characterizing Lymphangiogenesis and Concurrent Inflammation in Adipose Tissue in Response to VEGF-D. Front Physiol. 2020;11:363. doi: 10.3389/fphys.2020.00363. eCollection 2020. PubMed PMID: 32390866; PubMed Central PMCID: PMC7188984.
Dizin E, Olivier V, Maire C, Komarynets O, Sassi A, Roth I, Loffing J, de Seigneux S, Maillard M, Rutkowski JM, Edwards A, Feraille E. Time-course of sodium transport along the nephron in nephrotic syndrome: The role of potassium. FASEB J. 2020 Feb;34(2):2408-2424. doi: 10.1096/fj.201901345R. Epub 2019 Dec 29. PubMed PMID: 31908015.
Delitsikou V, Jarad G, Rajaram RD, Ino F, Rutkowski JM, Chen CD, Santos CXC, Scherer PE, Abraham CR, Shah AM, Feraille E, Miner JH, de Seigneux S. Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress. FASEB J. 2020 Feb;34(2):2087-2104. doi: 10.1096/fj.201900893R. Epub 2019 Dec 23. PubMed PMID: 31907991.
Balasubbramanian D, Gelston CAL, Lopez AH, Iskander G, Tate W, Holderness H, Rutkowski JM, Mitchell BM. Augmenting Renal Lymphatic Density Prevents Angiotensin II-Induced Hypertension in Male and Female Mice. Am J Hypertens. 2020 Jan 1;33(1):61-69. doi: 10.1093/ajh/hpz139. PubMed PMID: 31429865; PubMed Central PMCID: PMC6931897.
Baranwal G, Rutkowski JM. Reduced lymphatic function contributes to age-related disease. Aging (Albany NY). 2019 Nov 27;11(22):9969-9970. doi: 10.18632/aging.102503. Epub 2019 Nov 27. PubMed PMID: 31785147; PubMed Central PMCID: PMC6914422.
Balasubbramanian D, Lopez Gelston CA, Rutkowski JM, Mitchell BM. Immune cell trafficking, lymphatics and hypertension. Br J Pharmacol. 2019 Jun;176(12):1978-1988. doi: 10.1111/bph.14370. Epub 2018 Jun 25. Review. PubMed PMID: 29797446; PubMed Central PMCID: PMC6534781.
Chakraborty A, Barajas S, Lammoglia GM, Reyna AJ, Morley TS, Johnson JA, Scherer PE, Rutkowski JM. Vascular Endothelial Growth Factor-D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity. Am J Pathol. 2019 Apr;189(4):924-939. doi: 10.1016/j.ajpath.2018.12.008. Epub 2019 Mar 13. PubMed PMID: 30878136; PubMed Central PMCID: PMC6458523.
Crewe C, Joffin N, Rutkowski JM, Kim M, Zhang F, Towler DA, Gordillo R, Scherer PE. An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State. Cell. 2018 Oct 18;175(3):695-708.e13. doi: 10.1016/j.cell.2018.09.005. Epub 2018 Oct 4. PubMed PMID: 30293865; PubMed Central PMCID: PMC6195477.
Lopez Gelston CA, Balasubbramanian D, Abouelkheir GR, Lopez AH, Hudson KR, Johnson ER, Muthuchamy M, Mitchell BM, Rutkowski JM. Enhancing Renal Lymphatic Expansion Prevents Hypertension in Mice. Circ Res. 2018 Apr 13;122(8):1094-1101. doi: 10.1161/CIRCRESAHA.118.312765. Epub 2018 Feb 23. PubMed PMID: 29475981.
Hominick D, Silva A, Khurana N, Liu Y, Dechow PC, Feng JQ, Pytowski B, Rutkowski JM, Alitalo K, Dellinger MT. VEGF-C promotes the development of lymphatics in bone and bone loss. Elife. 2018 Apr 5;7. doi: 10.7554/eLife.34323. PubMed PMID: 29620526; PubMed Central PMCID: PMC5903859.
Udit S, Burton M, Rutkowski JM, Lee S, Bookout AL, Scherer PE, Elmquist JK, Gautron L. Nav1.8 neurons are involved in limiting acute phase responses to dietary fat. Mol Metab. 2017 Oct;6(10):1081-1091. doi: 10.1016/j.molmet.2017.07.012. Epub 2017 Aug 4. Review. PubMed PMID: 29031710; PubMed Central PMCID: PMC5641637.
Nitschké M, Bell A, Karaman S, Amouzgar M, Rutkowski JM, Scherer PE, Alitalo K, McDonald DM. Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations. Am J Pathol. 2017 Sep;187(9):1984-1997. doi: 10.1016/j.ajpath.2017.05.009. Epub 2017 Jul 3. PubMed PMID: 28683257; PubMed Central PMCID: PMC5808174.
Kneedler SC, Phillips LE, Hudson KR, Beckman KM, Lopez Gelston CA, Rutkowski JM, Parrish AR, Doris PA, Mitchell BM. Renal inflammation and injury are associated with lymphangiogenesis in hypertension. Am J Physiol Renal Physiol. 2017 May 1;312(5):F861-F869. doi: 10.1152/ajprenal.00679.2016. Epub 2017 Feb 22. PubMed PMID: 28228406; PubMed Central PMCID: PMC5451556.
Abouelkheir GR, Upchurch BD, Rutkowski JM. Lymphangiogenesis: fuel, smoke, or extinguisher of inflammation's fire?. Exp Biol Med (Maywood). 2017 Apr;242(8):884-895. doi: 10.1177/1535370217697385. Epub 2017 Mar 7. Review. PubMed PMID: 28346012; PubMed Central PMCID: PMC5407543.
Rutkowski JM, Pastor J, Sun K, Park SK, Bobulescu IA, Chen CT, Moe OW, Scherer PE. Adiponectin alters renal calcium and phosphate excretion through regulation of klotho expression. Kidney Int. 2017 Feb;91(2):324-337. doi: 10.1016/j.kint.2016.09.016. Epub 2016 Nov 30. PubMed PMID: 27914707; PubMed Central PMCID: PMC5237401.
Wernstedt Asterholm I, Kim-Muller JY, Rutkowski JM, Crewe C, Tao C, Scherer PE. Pathological Type-2 Immune Response, Enhanced Tumor Growth, and Glucose Intolerance in Retnlβ (RELMβ) Null Mice: A Model of Intestinal Immune System Dysfunction in Disease Susceptibility. Am J Pathol. 2016 Sep;186(9):2404-16. doi: 10.1016/j.ajpath.2016.04.017. Epub 2016 Jul 7. PubMed PMID: 27397737; PubMed Central PMCID: PMC5012468.
Lammoglia GM, Van Zandt CE, Galvan DX, Orozco JL, Dellinger MT, Rutkowski JM. Hyperplasia, de novo lymphangiogenesis, and lymphatic regression in mice with tissue-specific, inducible overexpression of murine VEGF-D. Am J Physiol Heart Circ Physiol. 2016 Aug 1;311(2):H384-94. doi: 10.1152/ajpheart.00208.2016. Epub 2016 Jun 24. PubMed PMID: 27342876.
Haas ME, Levenson AE, Sun X, Liao WH, Rutkowski JM, de Ferranti SD, Schumacher VA, Scherer PE, Salant DJ, Biddinger SB. The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia. Circulation. 2016 Jul 5;134(1):61-72. doi: 10.1161/CIRCULATIONAHA.115.020912. PubMed PMID: 27358438; PubMed Central PMCID: PMC5345853.
Stern JH, Rutkowski JM, Scherer PE. Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk. Cell Metab. 2016 May 10;23(5):770-84. doi: 10.1016/j.cmet.2016.04.011. Review. PubMed PMID: 27166942; PubMed Central PMCID: PMC4864949.
de Seigneux S, Courbebaisse M, Rutkowski JM, Wilhelm-Bals A, Metzger M, Khodo SN, Hasler U, Chehade H, Dizin E, Daryadel A, Stengel B, Girardin E, Prié D, Wagner CA, Scherer PE, Martin PY, Houillier P, Feraille E. Proteinuria Increases Plasma Phosphate by Altering Its Tubular Handling. J Am Soc Nephrol. 2015 Jul;26(7):1608-18. doi: 10.1681/ASN.2014010104. Epub 2014 Oct 27. PubMed PMID: 25349200; PubMed Central PMCID: PMC4483577.
Rutkowski JM, Stern JH, Scherer PE. The cell biology of fat expansion. J Cell Biol. 2015 Mar 2;208(5):501-12. doi: 10.1083/jcb.201409063. Review. PubMed PMID: 25733711; PubMed Central PMCID: PMC4347644.
Asterholm IW, Rutkowski JM, Fujikawa T, Cho YR, Fukuda M, Tao C, Wang ZV, Gupta RK, Elmquist JK, Scherer PE. Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia. 2014 Jun;57(6):1209-18. doi: 10.1007/s00125-014-3210-3. Epub 2014 Mar 13. PubMed PMID: 24623101; PubMed Central PMCID: PMC4106234.
Rutkowski JM, Halberg N, Wang QA, Holland WL, Xia JY, Scherer PE. Differential transendothelial transport of adiponectin complexes. Cardiovasc Diabetol. 2014 Feb 20;13:47. doi: 10.1186/1475-2840-13-47. PubMed PMID: 24552349; PubMed Central PMCID: PMC3932731.
Rutkowski JM, Scherer PE. Isolation and quantitation of adiponectin higher order complexes. Methods Enzymol. 2014;537:243-59. doi: 10.1016/B978-0-12-411619-1.00013-6. PubMed PMID: 24480350; PubMed Central PMCID: PMC4040967.
Rutkowski JM, Ihm JE, Lee ST, Kilarski WW, Greenwood VI, Pasquier MC, Quazzola A, Trono D, Hubbell JA, Swartz MA. VEGFR-3 neutralization inhibits ovarian lymphangiogenesis, follicle maturation, and murine pregnancy. Am J Pathol. 2013 Nov;183(5):1596-1607. doi: 10.1016/j.ajpath.2013.07.031. Epub 2013 Sep 13. PubMed PMID: 24036251; PubMed Central PMCID: PMC3814520.
Gautron L, Rutkowski JM, Burton MD, Wei W, Wan Y, Elmquist JK. Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen. J Comp Neurol. 2013 Nov;521(16):3741-67. doi: 10.1002/cne.23376. PubMed PMID: 23749724; PubMed Central PMCID: PMC4081472.
Murano I, Rutkowski JM, Wang QA, Cho YR, Scherer PE, Cinti S. Time course of histomorphological changes in adipose tissue upon acute lipoatrophy. Nutr Metab Cardiovasc Dis. 2013 Aug;23(8):723-31. doi: 10.1016/j.numecd.2012.03.005. Epub 2012 Jun 8. PubMed PMID: 22682975; PubMed Central PMCID: PMC3465635.
Platt AM, Rutkowski JM, Martel C, Kuan EL, Ivanov S, Swartz MA, Randolph GJ. Normal dendritic cell mobilization to lymph nodes under conditions of severe lymphatic hypoplasia. J Immunol. 2013 May 1;190(9):4608-20. doi: 10.4049/jimmunol.1202600. Epub 2013 Mar 25. PubMed PMID: 23530147; PubMed Central PMCID: PMC3634097.
Rutkowski JM, Wang ZV, Park AS, Zhang J, Zhang D, Hu MC, Moe OW, Susztak K, Scherer PE. Adiponectin promotes functional recovery after podocyte ablation. J Am Soc Nephrol. 2013 Feb;24(2):268-82. doi: 10.1681/ASN.2012040414. Epub 2013 Jan 18. PubMed PMID: 23334396; PubMed Central PMCID: PMC3559480.
Thomas SN, Rutkowski JM, Pasquier M, Kuan EL, Alitalo K, Randolph GJ, Swartz MA. Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage. J Immunol. 2012 Sep 1;189(5):2181-90. doi: 10.4049/jimmunol.1103545. Epub 2012 Jul 27. PubMed PMID: 22844119; PubMed Central PMCID: PMC3424306.
Asterholm IW, McDonald J, Blanchard PG, Sinha M, Xiao Q, Mistry J, Rutkowski JM, Deshaies Y, Brekken RA, Scherer PE. Lack of "immunological fitness" during fasting in metabolically challenged animals. J Lipid Res. 2012 Jul;53(7):1254-67. doi: 10.1194/jlr.M021725. Epub 2012 Apr 13. PubMed PMID: 22504909; PubMed Central PMCID: PMC3371237.
Rutkowski JM, Santiag LY, Ben-Jebria A, Ultman JS. Comparison of ozone-specific (OZAC) and oxygen radical (ORAC) antioxidant capacity assays for use with nasal lavage fluid. Toxicol In Vitro. 2011 Oct;25(7):1406-13. doi: 10.1016/j.tiv.2011.04.008. Epub 2011 Apr 12. PubMed PMID: 21513792.
Fischer-Posovszky P, Wang QA, Asterholm IW, Rutkowski JM, Scherer PE. Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2 macrophages. Endocrinology. 2011 Aug;152(8):3074-81. doi: 10.1210/en.2011-1031. Epub 2011 Jun 21. PubMed PMID: 21693678; PubMed Central PMCID: PMC3138241.
Holland WL, Miller RA, Wang ZV, Sun K, Barth BM, Bui HH, Davis KE, Bikman BT, Halberg N, Rutkowski JM, Wade MR, Tenorio VM, Kuo MS, Brozinick JT, Zhang BB, Birnbaum MJ, Summers SA, Scherer PE. Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat Med. 2011 Jan;17(1):55-63. doi: 10.1038/nm.2277. Epub 2010 Dec 26. PubMed PMID: 21186369; PubMed Central PMCID: PMC3134999.
Miteva DO, Rutkowski JM, Dixon JB, Kilarski W, Shields JD, Swartz MA. Transmural flow modulates cell and fluid transport functions of lymphatic endothelium. Circ Res. 2010 Mar 19;106(5):920-31. doi: 10.1161/CIRCRESAHA.109.207274. Epub 2010 Feb 4. PubMed PMID: 20133901; NIHMSID:NIHMS181218.
Rutkowski JM, Markhus CE, Gyenge CC, Alitalo K, Wiig H, Swartz MA. Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema. Am J Pathol. 2010 Mar;176(3):1122-9. doi: 10.2353/ajpath.2010.090733. Epub 2010 Jan 28. PubMed PMID: 20110415; PubMed Central PMCID: PMC2832135.
Rutkowski JM, Davis KE, Scherer PE. Mechanisms of obesity and related pathologies: the macro- and microcirculation of adipose tissue. FEBS J. 2009 Oct;276(20):5738-46. doi: 10.1111/j.1742-4658.2009.07303.x. Epub 2009 Sep 15. Review. PubMed PMID: 19754873; PubMed Central PMCID: PMC2896500.
Lim HY, Rutkowski JM, Helft J, Reddy ST, Swartz MA, Randolph GJ, Angeli V. Hypercholesterolemic mice exhibit lymphatic vessel dysfunction and degeneration. Am J Pathol. 2009 Sep;175(3):1328-37. doi: 10.2353/ajpath.2009.080963. Epub 2009 Aug 13. PubMed PMID: 19679879; PubMed Central PMCID: PMC2731150.
Goldman J, Conley KA, Raehl A, Bondy DM, Pytowski B, Swartz MA, Rutkowski JM, Jaroch DB, Ongstad EL. Regulation of lymphatic capillary regeneration by interstitial flow in skin. Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2176-83. doi: 10.1152/ajpheart.01011.2006. Epub 2006 Dec 22. PubMed PMID: 17189348.
Goldman J, Rutkowski JM, Shields JD, Pasquier MC, Cui Y, Schmökel HG, Willey S, Hicklin DJ, Pytowski B, Swartz MA. Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis. FASEB J. 2007 Apr;21(4):1003-12. doi: 10.1096/fj.06-6656com. Epub 2007 Jan 8. PubMed PMID: 17210781.
Rutkowski JM, Swartz MA. A driving force for change: interstitial flow as a morphoregulator. Trends Cell Biol. 2007 Jan;17(1):44-50. doi: 10.1016/j.tcb.2006.11.007. Epub 2006 Dec 1. Review. PubMed PMID: 17141502.
Rutkowski JM, Moya M, Johannes J, Goldman J, Swartz MA. Secondary lymphedema in the mouse tail: Lymphatic hyperplasia, VEGF-C upregulation, and the protective role of MMP-9. Microvasc Res. 2006 Nov;72(3):161-71. doi: 10.1016/j.mvr.2006.05.009. Epub 2006 Jul 28. PubMed PMID: 16876204; PubMed Central PMCID: PMC2676671.
Rutkowski JM, Boardman KC, Swartz MA. Characterization of lymphangiogenesis in a model of adult skin regeneration. Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1402-10. doi: 10.1152/ajpheart.00038.2006. Epub 2006 Apr 28. PubMed PMID: 16648194; PubMed Central PMCID: PMC2751590.
Rutkowski JM, Santiago LY, Ben-Jebria A, Ultman JS. Development of an assay for ozone-specific antioxidant capacity. Inhal Toxicol. 2003 Nov;15(13):1369-85. doi: 10.1080/08958370390241876. PubMed PMID: 14569498.
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