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Faivre A, Dissard R, Kuo W, Verissimo T, Legouis D, Arnoux G, Heckenmeyer C, Fernandez M, Tihy M, Rajaram RD, Delitsikou V, Le NA, Spingler B, Mueller B, Shulz G, Lindenmeyer M, Cohen C, Rutkowski JM, Moll S, Scholz CC, Kurtcuoglu V, de Seigneux S. Evolution of hypoxia and hypoxia-inducible factor asparaginyl hydroxylase regulation in chronic kidney disease. Nephrol Dial Transplant. 2023 Sep 29;38(10):2276-2288. doi: 10.1093/ndt/gfad075. PubMed PMID: 37096392; PubMed Central PMCID: PMC10539236.
Creed HA, Kannan S, Tate BL, Banerjee P, Mitchell BM, Chakraborty S, Rutkowski JM. Single-cell RNA sequencing identifies response of renal lymphatic endothelial cells to acute kidney injury. bioRxiv. 2023 Jun 14;. doi: 10.1101/2023.06.09.544380. PubMed PMID: 37333313; PubMed Central PMCID: PMC10274866.
Verissimo T, Dalga D, Arnoux G, Sakhi I, Faivre A, Auwerx H, Bourgeois S, Paolucci D, Gex Q, Rutkowski JM, Legouis D, Wagner CA, Hall AM, de Seigneux S. PCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells. Am J Physiol Renal Physiol. 2023 Jun 1;324(6):F532-F543. doi: 10.1152/ajprenal.00038.2023. Epub 2023 Apr 27. PubMed PMID: 37102687; PubMed Central PMCID: PMC10202477.
Baranwal G, Goodlett BL, Arenaz CM, Creed HA, Navaneethabalakrishnan S, Rutkowski JM, Alaniz RC, Mitchell BM. Indole Propionic Acid Increases T Regulatory Cells and Decreases T Helper 17 Cells and Blood Pressure in Mice with Salt-Sensitive Hypertension. Int J Mol Sci. 2023 May 24;24(11). doi: 10.3390/ijms24119192. PubMed PMID: 37298145; PubMed Central PMCID: PMC10252743.
Chakraborty S, Dixon BJ, Rutkowski JM, Castorena-Gonzalez JA, Breslin JW. Lymphatic Pathophysiology. Microcirculation. 2023 Apr;30(2-3):e12806. doi: 10.1111/micc.12806. PubMed PMID: 37078170.
An YA, Xiong W, Chen S, Bu D, Rutkowski JM, Berger JP, Kusminski CM, Zhang N, An Z, Scherer PE. Endotrophin neutralization through targeted antibody treatment protects from renal fibrosis in a podocyte ablation model. Mol Metab. 2023 Mar;69:101680. doi: 10.1016/j.molmet.2023.101680. Epub 2023 Jan 22. PubMed PMID: 36696925; PubMed Central PMCID: PMC9918787.
Phan TT, Chakraborty A, Tatum MA, Lima-Orellana A, Reyna AJ, Rutkowski JM. Increased adipose tissue lymphatic vessel density inhibits thermogenesis through elevated neurotensin levels. Front Cell Dev Biol. 2023;11:1100788. doi: 10.3389/fcell.2023.1100788. eCollection 2023. PubMed PMID: 36776563; PubMed Central PMCID: PMC9911872.
Goodlett BL, Balasubbramanian D, Navaneethabalakrishnan S, Love SE, Luera EM, Konatham S, Chiasson VL, Wedgeworth S, Rutkowski JM, Mitchell BM. Genetically inducing renal lymphangiogenesis attenuates hypertension in mice. Clin Sci (Lond). 2022 Dec 9;136(23):1759-1772. doi: 10.1042/CS20220547. PubMed PMID: 36345993; PubMed Central PMCID: PMC10586591.
Goldberg AR, Ferguson M, Pal S, Cohen R, Orlicky DJ, McCullough RL, Rutkowski JM, Burchill MA, Tamburini BAJ. Oxidized low density lipoprotein in the liver causes decreased permeability of liver lymphatic- but not liver sinusoidal-endothelial cells via VEGFR-3 regulation of VE-Cadherin. Front Physiol. 2022;13:1021038. doi: 10.3389/fphys.2022.1021038. eCollection 2022. PubMed PMID: 36338478; PubMed Central PMCID: PMC9626955.
Chakraborty A, Crescenzi R, Usman TA, Reyna AJ, Garza ME, Al-Ghadban S, Herbst KL, Donahue PMC, Rutkowski JM. Indications of Peripheral Pain, Dermal Hypersensitivity, and Neurogenic Inflammation in Patients with Lipedema. Int J Mol Sci. 2022 Sep 7;23(18). doi: 10.3390/ijms231810313. PubMed PMID: 36142221; PubMed Central PMCID: PMC9499469.
Creed HA, Sanfelippo AN, Reyna AJ, Chakraborty A, Rutkowski JM. Impact of High Fat Diet and Bolus Feeding on Chyle Accumulation in a Mouse Model of Generalized Lymphatic Anomaly. Lymphat Res Biol. 2022 Aug;20(4):358-367. doi: 10.1089/lrb.2021.0031. Epub 2021 Nov 8. PubMed PMID: 34748416; PubMed Central PMCID: PMC9422780.
Duhon BH, Phan TT, Taylor SL, Crescenzi RL, Rutkowski JM. Current Mechanistic Understandings of Lymphedema and Lipedema: Tales of Fluid, Fat, and Fibrosis. Int J Mol Sci. 2022 Jun 14;23(12). doi: 10.3390/ijms23126621. Review. PubMed PMID: 35743063; PubMed Central PMCID: PMC9223758.
Verissimo T, Faivre A, Rinaldi A, Lindenmeyer M, Delitsikou V, Veyrat-Durebex C, Heckenmeyer C, Fernandez M, Berchtold L, Dalga D, Cohen C, Naesens M, Ricksten SE, Martin PY, Pugin J, Merlier F, Haupt K, Rutkowski JM, Moll S, Cippà PE, Legouis D, de Seigneux S. Decreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease. J Am Soc Nephrol. 2022 Apr;33(4):810-827. doi: 10.1681/ASN.2021050680. Epub 2022 Mar 10. PubMed PMID: 35273087; PubMed Central PMCID: PMC8970457.
Ghnenis AB, Jones C, Sefiani A, Douthitt AJ, Reyna AJ, Rutkowski JM, Geoffroy CG. Evaluation of the Cardiometabolic Disorders after Spinal Cord Injury in Mice. Biology (Basel). 2022 Mar 24;11(4). doi: 10.3390/biology11040495. PubMed PMID: 35453695; PubMed Central PMCID: PMC9027794.
Goodlett BL, Kang CS, Yoo E, Navaneethabalakrishnan S, Balasubbramanian D, Love SE, Sims BM, Avilez DL, Tate W, Chavez DR, Baranwal G, Nabity MB, Rutkowski JM, Kim D, Mitchell BM. A Kidney-Targeted Nanoparticle to Augment Renal Lymphatic Density Decreases Blood Pressure in Hypertensive Mice. Pharmaceutics. 2021 Dec 30;14(1). doi: 10.3390/pharmaceutics14010084. PubMed PMID: 35056980; PubMed Central PMCID: PMC8780399.
Chakraborty A, Upadhya R, Usman TA, Shetty AK, Rutkowski JM. Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress. Brain Behav Immun. 2021 Nov;98:219-233. doi: 10.1016/j.bbi.2021.08.007. Epub 2021 Aug 11. PubMed PMID: 34389489; PubMed Central PMCID: PMC8511130.
Baranwal G, Creed HA, Black LM, Auger A, Quach AM, Vegiraju R, Eckenrode HE, Agarwal A, Rutkowski JM. Expanded renal lymphatics improve recovery following kidney injury. Physiol Rep. 2021 Nov;9(22):e15094. doi: 10.14814/phy2.15094. PubMed PMID: 34806312; PubMed Central PMCID: PMC8606868.
Baranwal G, Pilla R, Goodlett BL, Coleman AK, Arenaz CM, Jayaraman A, Rutkowski JM, Alaniz RC, Mitchell BM. Common Metabolites in Two Different Hypertensive Mouse Models: A Serum and Urine Metabolome Study. Biomolecules. 2021 Sep 21;11(9). doi: 10.3390/biom11091387. PubMed PMID: 34572600; PubMed Central PMCID: PMC8467937.
Rutkowski JM. Fixing lymphatics improves glucose metabolism. Nat Metab. 2021 Sep;3(9):1139-1141. doi: 10.1038/s42255-021-00442-3. PubMed PMID: 34545252.
Baranwal G, Creed HA, Cromer WE, Wang W, Upchurch BD, Smithhart MC, Vadlamani SS, Clark MC, Busbuso NC, Blais SN, Reyna AJ, Dongaonkar RM, Zawieja DC, Rutkowski JM. Dichotomous effects on lymphatic transport with loss of caveolae in mice. Acta Physiol (Oxf). 2021 Aug;232(4):e13656. doi: 10.1111/apha.13656. Epub 2021 Apr 9. PubMed PMID: 33793057; PubMed Central PMCID: PMC8513672.
Creed HA, Rutkowski JM. Emerging roles for lymphatics in acute kidney injury: Beneficial or maleficent?. Exp Biol Med (Maywood). 2021 Apr;246(7):845-850. doi: 10.1177/1535370220983235. Epub 2021 Jan 19. PubMed PMID: 33467886; PubMed Central PMCID: PMC8719026.
Faivre A, Katsyuba E, Verissimo T, Lindenmeyer M, Rajaram RD, Naesens M, Heckenmeyer C, Mottis A, Feraille E, Cippà P, Cohen C, Longchamp A, Allagnat F, Rutkowski JM, Legouis D, Auwerx J, de Seigneux S. Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease. Nephrol Dial Transplant. 2021 Jan 1;36(1):60-68. doi: 10.1093/ndt/gfaa124. PubMed PMID: 33099633.
Navaneethabalakrishnan S, Goodlett BL, Lopez AH, Rutkowski JM, Mitchell BM. Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads. Clin Sci (Lond). 2020 Dec 23;134(24):3237-3257. doi: 10.1042/CS20201023. Review. PubMed PMID: 33346358; PubMed Central PMCID: PMC9208534.
Balasubbramanian D, Baranwal G, Clark MC, Goodlett BL, Mitchell BM, Rutkowski JM. Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice. J Hypertens. 2020 May;38(5):874-885. doi: 10.1097/HJH.0000000000002349. PubMed PMID: 31913221; PubMed Central PMCID: PMC7754173.
Chakraborty A, Scogin CK, Rizwan K, Morley TS, Rutkowski JM. Characterizing Lymphangiogenesis and Concurrent Inflammation in Adipose Tissue in Response to VEGF-D. Front Physiol. 2020;11:363. doi: 10.3389/fphys.2020.00363. eCollection 2020. PubMed PMID: 32390866; PubMed Central PMCID: PMC7188984.
Dizin E, Olivier V, Maire C, Komarynets O, Sassi A, Roth I, Loffing J, de Seigneux S, Maillard M, Rutkowski JM, Edwards A, Feraille E. Time-course of sodium transport along the nephron in nephrotic syndrome: The role of potassium. FASEB J. 2020 Feb;34(2):2408-2424. doi: 10.1096/fj.201901345R. Epub 2019 Dec 29. PubMed PMID: 31908015.
Delitsikou V, Jarad G, Rajaram RD, Ino F, Rutkowski JM, Chen CD, Santos CXC, Scherer PE, Abraham CR, Shah AM, Feraille E, Miner JH, de Seigneux S. Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress. FASEB J. 2020 Feb;34(2):2087-2104. doi: 10.1096/fj.201900893R. Epub 2019 Dec 23. PubMed PMID: 31907991.
Balasubbramanian D, Gelston CAL, Lopez AH, Iskander G, Tate W, Holderness H, Rutkowski JM, Mitchell BM. Augmenting Renal Lymphatic Density Prevents Angiotensin II-Induced Hypertension in Male and Female Mice. Am J Hypertens. 2020 Jan 1;33(1):61-69. doi: 10.1093/ajh/hpz139. PubMed PMID: 31429865; PubMed Central PMCID: PMC6931897.
Baranwal G, Rutkowski JM. Reduced lymphatic function contributes to age-related disease. Aging (Albany NY). 2019 Nov 27;11(22):9969-9970. doi: 10.18632/aging.102503. Epub 2019 Nov 27. PubMed PMID: 31785147; PubMed Central PMCID: PMC6914422.
Balasubbramanian D, Lopez Gelston CA, Rutkowski JM, Mitchell BM. Immune cell trafficking, lymphatics and hypertension. Br J Pharmacol. 2019 Jun;176(12):1978-1988. doi: 10.1111/bph.14370. Epub 2018 Jun 25. Review. PubMed PMID: 29797446; PubMed Central PMCID: PMC6534781.
Chakraborty A, Barajas S, Lammoglia GM, Reyna AJ, Morley TS, Johnson JA, Scherer PE, Rutkowski JM. Vascular Endothelial Growth Factor-D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity. Am J Pathol. 2019 Apr;189(4):924-939. doi: 10.1016/j.ajpath.2018.12.008. Epub 2019 Mar 13. PubMed PMID: 30878136; PubMed Central PMCID: PMC6458523.
Crewe C, Joffin N, Rutkowski JM, Kim M, Zhang F, Towler DA, Gordillo R, Scherer PE. An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State. Cell. 2018 Oct 18;175(3):695-708.e13. doi: 10.1016/j.cell.2018.09.005. Epub 2018 Oct 4. PubMed PMID: 30293865; PubMed Central PMCID: PMC6195477.
Lopez Gelston CA, Balasubbramanian D, Abouelkheir GR, Lopez AH, Hudson KR, Johnson ER, Muthuchamy M, Mitchell BM, Rutkowski JM. Enhancing Renal Lymphatic Expansion Prevents Hypertension in Mice. Circ Res. 2018 Apr 13;122(8):1094-1101. doi: 10.1161/CIRCRESAHA.118.312765. Epub 2018 Feb 23. PubMed PMID: 29475981.
Hominick D, Silva A, Khurana N, Liu Y, Dechow PC, Feng JQ, Pytowski B, Rutkowski JM, Alitalo K, Dellinger MT. VEGF-C promotes the development of lymphatics in bone and bone loss. Elife. 2018 Apr 5;7. doi: 10.7554/eLife.34323. PubMed PMID: 29620526; PubMed Central PMCID: PMC5903859.
Udit S, Burton M, Rutkowski JM, Lee S, Bookout AL, Scherer PE, Elmquist JK, Gautron L. Na(v)1.8 neurons are involved in limiting acute phase responses to dietary fat. Mol Metab. 2017 Oct;6(10):1081-1091. doi: 10.1016/j.molmet.2017.07.012. Epub 2017 Aug 4. Review. PubMed PMID: 29031710; PubMed Central PMCID: PMC5641637.
Nitschké M, Bell A, Karaman S, Amouzgar M, Rutkowski JM, Scherer PE, Alitalo K, McDonald DM. Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations. Am J Pathol. 2017 Sep;187(9):1984-1997. doi: 10.1016/j.ajpath.2017.05.009. Epub 2017 Jul 3. PubMed PMID: 28683257; PubMed Central PMCID: PMC5808174.
Kneedler SC, Phillips LE, Hudson KR, Beckman KM, Lopez Gelston CA, Rutkowski JM, Parrish AR, Doris PA, Mitchell BM. Renal inflammation and injury are associated with lymphangiogenesis in hypertension. Am J Physiol Renal Physiol. 2017 May 1;312(5):F861-F869. doi: 10.1152/ajprenal.00679.2016. Epub 2017 Feb 22. PubMed PMID: 28228406; PubMed Central PMCID: PMC5451556.
Abouelkheir GR, Upchurch BD, Rutkowski JM. Lymphangiogenesis: fuel, smoke, or extinguisher of inflammation's fire?. Exp Biol Med (Maywood). 2017 Apr;242(8):884-895. doi: 10.1177/1535370217697385. Epub 2017 Mar 7. Review. PubMed PMID: 28346012; PubMed Central PMCID: PMC5407543.
Rutkowski JM, Pastor J, Sun K, Park SK, Bobulescu IA, Chen CT, Moe OW, Scherer PE. Adiponectin alters renal calcium and phosphate excretion through regulation of klotho expression. Kidney Int. 2017 Feb;91(2):324-337. doi: 10.1016/j.kint.2016.09.016. Epub 2016 Nov 30. PubMed PMID: 27914707; PubMed Central PMCID: PMC5237401.
Wernstedt Asterholm I, Kim-Muller JY, Rutkowski JM, Crewe C, Tao C, Scherer PE. Pathological Type-2 Immune Response, Enhanced Tumor Growth, and Glucose Intolerance in Retnlβ (RELMβ) Null Mice: A Model of Intestinal Immune System Dysfunction in Disease Susceptibility. Am J Pathol. 2016 Sep;186(9):2404-16. doi: 10.1016/j.ajpath.2016.04.017. Epub 2016 Jul 7. PubMed PMID: 27397737; PubMed Central PMCID: PMC5012468.
Lammoglia GM, Van Zandt CE, Galvan DX, Orozco JL, Dellinger MT, Rutkowski JM. Hyperplasia, de novo lymphangiogenesis, and lymphatic regression in mice with tissue-specific, inducible overexpression of murine VEGF-D. Am J Physiol Heart Circ Physiol. 2016 Aug 1;311(2):H384-94. doi: 10.1152/ajpheart.00208.2016. Epub 2016 Jun 24. PubMed PMID: 27342876.
Haas ME, Levenson AE, Sun X, Liao WH, Rutkowski JM, de Ferranti SD, Schumacher VA, Scherer PE, Salant DJ, Biddinger SB. The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia. Circulation. 2016 Jul 5;134(1):61-72. doi: 10.1161/CIRCULATIONAHA.115.020912. PubMed PMID: 27358438; PubMed Central PMCID: PMC5345853.
Stern JH, Rutkowski JM, Scherer PE. Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk. Cell Metab. 2016 May 10;23(5):770-84. doi: 10.1016/j.cmet.2016.04.011. Review. PubMed PMID: 27166942; PubMed Central PMCID: PMC4864949.
de Seigneux S, Courbebaisse M, Rutkowski JM, Wilhelm-Bals A, Metzger M, Khodo SN, Hasler U, Chehade H, Dizin E, Daryadel A, Stengel B, Girardin E, Prié D, Wagner CA, Scherer PE, Martin PY, Houillier P, Feraille E. Proteinuria Increases Plasma Phosphate by Altering Its Tubular Handling. J Am Soc Nephrol. 2015 Jul;26(7):1608-18. doi: 10.1681/ASN.2014010104. Epub 2014 Oct 27. PubMed PMID: 25349200; PubMed Central PMCID: PMC4483577.
Rutkowski JM, Stern JH, Scherer PE. The cell biology of fat expansion. J Cell Biol. 2015 Mar 2;208(5):501-12. doi: 10.1083/jcb.201409063. Review. PubMed PMID: 25733711; PubMed Central PMCID: PMC4347644.
Asterholm IW, Rutkowski JM, Fujikawa T, Cho YR, Fukuda M, Tao C, Wang ZV, Gupta RK, Elmquist JK, Scherer PE. Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia. 2014 Jun;57(6):1209-18. doi: 10.1007/s00125-014-3210-3. Epub 2014 Mar 13. PubMed PMID: 24623101; PubMed Central PMCID: PMC4106234.
Rutkowski JM, Halberg N, Wang QA, Holland WL, Xia JY, Scherer PE. Differential transendothelial transport of adiponectin complexes. Cardiovasc Diabetol. 2014 Feb 20;13:47. doi: 10.1186/1475-2840-13-47. PubMed PMID: 24552349; PubMed Central PMCID: PMC3932731.
Rutkowski JM, Scherer PE. Isolation and quantitation of adiponectin higher order complexes. Methods Enzymol. 2014;537:243-59. doi: 10.1016/B978-0-12-411619-1.00013-6. PubMed PMID: 24480350; PubMed Central PMCID: PMC4040967.
Rutkowski JM, Ihm JE, Lee ST, Kilarski WW, Greenwood VI, Pasquier MC, Quazzola A, Trono D, Hubbell JA, Swartz MA. VEGFR-3 neutralization inhibits ovarian lymphangiogenesis, follicle maturation, and murine pregnancy. Am J Pathol. 2013 Nov;183(5):1596-1607. doi: 10.1016/j.ajpath.2013.07.031. Epub 2013 Sep 13. PubMed PMID: 24036251; PubMed Central PMCID: PMC3814520.
Gautron L, Rutkowski JM, Burton MD, Wei W, Wan Y, Elmquist JK. Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen. J Comp Neurol. 2013 Nov;521(16):3741-67. doi: 10.1002/cne.23376. PubMed PMID: 23749724; PubMed Central PMCID: PMC4081472.
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