My Bibliography

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Zarling LC, Stevenson PA, Soma LA, Martino CH, Percival MM, Halpern AB, Ghiuzeli CM, Becker PS, Oehler VG, Cooper JP, Orozco JJ, Hendrie PC, Walter RB, Estey EH, Cassaday RD. Hyper-CVAD versus dose-adjusted EPOCH as initial treatment for adults with acute lymphoblastic leukemia. Eur J Haematol. 2023 Dec;111(6):863-871. doi: 10.1111/ejh.14089. Epub 2023 Sep 5. PubMed PMID: 37670560.

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Halpern AB, Rodríguez-Arbolí E, Othus M, Garcia KA, Percival MM, Cassaday RD, Oehler VG, Becker PS, Appelbaum JS, Abkowitz JL, Orozco JJ, Keel SB, Hendrie PC, Scott BL, Ghiuzeli MC, Estey EH, Walter RB. Phase 1/2 study of sorafenib added to cladribine, high-dose cytarabine, G-CSF, and mitoxantrone in untreated AML. Blood Adv. 2023 Sep 12;7(17):4950-4961. doi: 10.1182/bloodadvances.2023010392. PubMed PMID: 37339483; PubMed Central PMCID: PMC10463192.

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Laszlo GS, Sandmaier BM, Kehret AR, Orozco JJ, Hamlin DK, Dexter SL, Lim SYT, Cole FM, Huo J, Wilbur DS, Walter RB. [(211)At]astatine-based anti-CD22 radioimmunotherapy for B-cell malignancies. Leuk Lymphoma. 2023 Jul-Aug;64(7):1335-1339. doi: 10.1080/10428194.2023.2210710. Epub 2023 May 11. PubMed PMID: 37170642; PubMed Central PMCID: PMC10529842.

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Cassaday RD, Zarling LC, Garcia KA, Sala-Torra O, Stevenson PA, Martino CH, Liu YJ, Fang M, Percival MM, Halpern AB, Becker PS, Oehler VG, Shustov AR, Cooper JP, Orozco JJ, Hendrie PC, Walter RB, Radich JP, Soma LA, Estey EH. Phase II study of dose-adjusted EPOCH as initial therapy for adults with high-risk acute lymphoblastic leukemia. Leuk Lymphoma. 2023 May;64(5):927-937. doi: 10.1080/10428194.2023.2189803. Epub 2023 Mar 20. PubMed PMID: 36938892; PubMed Central PMCID: PMC10357946.

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Labadie KP, Lehnert AL, Kenoyer AL, Hamlin DK, Ludwig AD, Utria AF, Daniel SK, Mihailovic TN, Prossnitz A, Orozco JJ, Li Y, Wilbur DS, Miyaoka RS, Park JO. Glypican-3 targeted positron emission tomography detects sub-centimeter tumors in a xenograft model of hepatocellular carcinoma. EJNMMI Res. 2023 Apr 27;13(1):35. doi: 10.1186/s13550-023-00980-9. PubMed PMID: 37103671; PubMed Central PMCID: PMC10140215.

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Ford ES, Simmons W, Karmarkar EN, Yoke LH, Braimah AB, Orozco JJ, Ghiuzeli CM, Barnhill S, Sack CL, Benditt JO, Roychoudhury P, Greninger AL, Shapiro AE, Hammond JL, Rusnak JM, Dolsten M, Boeckh M, Liu C, Cheng GS, Corey L. Successful Treatment of Prolonged, Severe Coronavirus Disease 2019 Lower Respiratory Tract Disease in a B cell Acute Lymphoblastic Leukemia Patient With an Extended Course of Remdesivir and Nirmatrelvir/Ritonavir. Clin Infect Dis. 2023 Mar 4;76(5):926-929. doi: 10.1093/cid/ciac868. PubMed PMID: 36326680; PubMed Central PMCID: PMC10226728.

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Labadie KP, Hamlin DK, Kenoyer A, Daniel SK, Utria AF, Ludwig AD, Kenerson HL, Li L, Sham JG, Chen DL, Orozco JJ, Yeung RS, Orvig C, Li Y, Wilbur DS, Park JO. Glypican-3-Targeted (227)Th α-Therapy Reduces Tumor Burden in an Orthotopic Xenograft Murine Model of Hepatocellular Carcinoma. J Nucl Med. 2022 Jul;63(7):1033-1038. doi: 10.2967/jnumed.121.262562. Epub 2021 Nov 12. PubMed PMID: 34772791; PubMed Central PMCID: PMC9258570.

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Laszlo GS, Orozco JJ, Kehret AR, Lunn MC, Huo J, Hamlin DK, Scott Wilbur D, Dexter SL, Comstock ML, O'Steen S, Sandmaier BM, Green DJ, Walter RB. Development of [(211)At]astatine-based anti-CD123 radioimmunotherapy for acute leukemias and other CD123+ malignancies. Leukemia. 2022 Jun;36(6):1485-1491. doi: 10.1038/s41375-022-01580-7. Epub 2022 Apr 26. PubMed PMID: 35474099; PubMed Central PMCID: PMC9177726.

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Garcia KA, Cherian S, Stevenson PA, Martino CH, Shustov AR, Becker PS, Percival MM, Oehler VG, Halpern AB, Walter RB, Orozco JJ, Keel SB, Estey EH, Cassaday RD. Cerebrospinal fluid flow cytometry and risk of central nervous system relapse after hyperCVAD in adults with acute lymphoblastic leukemia. Cancer. 2022 Apr 1;128(7):1411-1417. doi: 10.1002/cncr.34073. Epub 2021 Dec 21. PubMed PMID: 34931301.

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Chow VA, Cassaday RD, Gooley TA, Smith SD, Sandmaier BM, Green DJ, Orozco JJ, Tuazon SA, Matesan M, Fisher DR, Maloney DG, Press OW, Gopal AK. Megadose 90Y-ibritumomab tiuxetan prior to allogeneic transplantation is effective for aggressive large B-cell lymphoma. Blood Adv. 2022 Jan 11;6(1):37-45. doi: 10.1182/bloodadvances.2021005056. PubMed PMID: 34649272; PubMed Central PMCID: PMC8753215.

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Labadie KP, Ludwig AD, Lehnert AL, Hamlin DK, Kenoyer AL, Sullivan KM, Daniel SK, Mihailovic TN, Sham JG, Orozco JJ, Yeung RS, Chen DL, Wilbur DS, Miyaoka RS, Park JO. Glypican-3 targeted delivery of (89)Zr and (90)Y as a theranostic radionuclide platform for hepatocellular carcinoma. Sci Rep. 2021 Feb 12;11(1):3731. doi: 10.1038/s41598-021-82172-w. PubMed PMID: 33580090; PubMed Central PMCID: PMC7881163.

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Tuazon SA, Sandmaier BM, Gooley TA, Fisher DR, Holmberg LA, Becker PS, Lundberg SJ, Orozco JJ, Gopal AK, Till BG, Coffey DG, Nartea ME, Matesan MC, Pagel JM, Rajendran JG, Press OW, Bensinger WI, Green DJ. (90)Y-labeled anti-CD45 antibody allogeneic hematopoietic cell transplantation for high-risk multiple myeloma. Bone Marrow Transplant. 2021 Jan;56(1):202-209. doi: 10.1038/s41409-020-01000-3. Epub 2020 Jul 24. PubMed PMID: 32710011; PubMed Central PMCID: PMC8328580.

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Orozco JJ, Kenoyer AL, Lin Y, O'Steen S, Guel R, Nartea ME, Hernandez AH, Hylarides MD, Fisher DR, Balkin ER, Hamlin DK, Wilbur DS, Orcutt KD, Wittrup KD, Green DJ, Gopal AK, Till BG, Sandmaier B, Press OW, Pagel JM. Therapy of Myeloid Leukemia using Novel Bispecific Fusion Proteins Targeting CD45 and (90)Y-DOTA. Mol Cancer Ther. 2020 Dec;19(12):2575-2584. doi: 10.1158/1535-7163.MCT-20-0306. Epub 2020 Oct 20. PubMed PMID: 33082277; PubMed Central PMCID: PMC7718432.

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Matesan M, Fisher DR, Wong R, Gopal AK, Green DJ, Sandmaier BM, Bensinger W, Pagel JM, Orozco J, Press OW, Cassaday RD, Hutchinson E, Wanner M, Pal S, Thostenson C, Rajendran JG. Biokinetics of Radiolabeled Monoclonal Antibody BC8: Differences in Biodistribution and Dosimetry Among Hematologic Malignancies. J Nucl Med. 2020 Sep;61(9):1300-1306. doi: 10.2967/jnumed.119.234443. Epub 2020 Mar 13. PubMed PMID: 32169919; PubMed Central PMCID: PMC7456175.

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Vo P, Gooley TA, Rajendran JG, Fisher DR, Orozco JJ, Green DJ, Gopal AK, Haaf R, Nartea M, Storb R, Appelbaum FR, Press OW, Pagel JM, Sandmaier BM. Yttrium-90-labeled anti-CD45 antibody followed by a reduced-intensity hematopoietic cell transplantation for patients with relapsed/refractory leukemia or myelodysplasia. Haematologica. 2020 Jun;105(6):1731-1737. doi: 10.3324/haematol.2019.229492. Epub 2019 Oct 3. PubMed PMID: 31582553; PubMed Central PMCID: PMC7271581.

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O'Steen S, Comstock ML, Orozco JJ, Hamlin DK, Wilbur DS, Jones JC, Kenoyer A, Nartea ME, Lin Y, Miller BW, Gooley TA, Tuazon SA, Till BG, Gopal AK, Sandmaier BM, Press OW, Green DJ. The α-emitter astatine-211 targeted to CD38 can eradicate multiple myeloma in a disseminated disease model. Blood. 2019 Oct 10;134(15):1247-1256. doi: 10.1182/blood.2019001250. PubMed PMID: 31395601; PubMed Central PMCID: PMC6788008.

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Halpern AB, Othus M, Huebner EM, Scott BL, Hendrie PC, Percival MM, Becker PS, Smith HA, Oehler VG, Orozco JJ, Cassaday RD, Gardner KM, Chen TL, Buckley SA, Orlowski KF, Anwar A, Estey EH, Walter RB. Phase I/II trial of cladribine, high-dose cytarabine, mitoxantrone, and G-CSF with dose-escalated mitoxantrone for relapsed/refractory acute myeloid leukemia and other high-grade myeloid neoplasms. Haematologica. 2019 Apr;104(4):e143-e146. doi: 10.3324/haematol.2018.204792. Epub 2018 Nov 8. PubMed PMID: 30409798; PubMed Central PMCID: PMC6442971.

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Li Y, Hamlin DK, Chyan MK, Wong R, Dorman EF, Emery RC, Woodle DR, Manger RL, Nartea M, Kenoyer AL, Orozco JJ, Green DJ, Press OW, Storb R, Sandmaier BM, Wilbur DS. cGMP production of astatine-211-labeled anti-CD45 antibodies for use in allogeneic hematopoietic cell transplantation for treatment of advanced hematopoietic malignancies. PLoS One. 2018;13(10):e0205135. doi: 10.1371/journal.pone.0205135. eCollection 2018. PubMed PMID: 30335787; PubMed Central PMCID: PMC6193629.

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Green DJ, O'Steen S, Lin Y, Comstock ML, Kenoyer AL, Hamlin DK, Wilbur DS, Fisher DR, Nartea M, Hylarides MD, Gopal AK, Gooley TA, Orozco JJ, Till BG, Orcutt KD, Wittrup KD, Press OW. CD38-bispecific antibody pretargeted radioimmunotherapy for multiple myeloma and other B-cell malignancies. Blood. 2018 Feb 8;131(6):611-620. doi: 10.1182/blood-2017-09-807610. Epub 2017 Nov 20. PubMed PMID: 29158362; PubMed Central PMCID: PMC5805491.

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Orozco JJ, Gooley TA, Rajendran JG, Fisher DR, Deeg J, Storb RF, Mayad R, Shadman M, Cassaday RD, Green DJ, Gopal AK, Till BG, Graf S, Haaf R, Lundberg SJ, O'Donnell P, Press OW, Appelbaum FR, Pagel JM, Sandmaier BM. Anti-CD45 Radioimmunotherapy Followed By Haploidentical Allogeneic Hematopoietic Cell Transplantation for Advanced Acute Leukemia or High-Risk MDS. American Society of Hematology; 2017 December; Atlanta, GA. Blood 2017, 130:2048.: American Society of Hematology; c2017.

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Orozco JJ, Kenoyer A, Lin Y, Fisher DR, Hamlin DK, Wilbur DS, Hernandez A, Guel R, Nartea ME, O'Steen S, Hylarides MD, Till BG, Green DJ, Gopal AK, Orcutt KD, Wittrup KD, Sandmaier BM, Pagel JM, Press OW. Novel Bispecific Antibody Targeting CD45 and 90Y-DOTA Is Effective Therapy for Acute Myeloid Leukemia in Preclinical Murine Models. American Society of Hematology; 2017 December; Atlanta, GA. Blood 2017, 130:1355: American Society of Hematology; c2017.

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O'Steen S, Green DJ, Gopal AK, Orozco JJ, Kenoyer AL, Lin Y, Wilbur DS, Hamlin DK, Fisher DR, Hylarides MD, Gooley TA, Waltman A, Till BG, Press OW. Venetoclax Synergizes with Radiotherapy for Treatment of B-cell Lymphomas. Cancer Res. 2017 Jul 15;77(14):3885-3893. doi: 10.1158/0008-5472.CAN-17-0082. Epub 2017 May 31. PubMed PMID: 28566329; PubMed Central PMCID: PMC5560265.

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Green DJ, Frayo SL, Lin Y, Hamlin DK, Fisher DR, Frost SH, Kenoyer AL, Hylarides MD, Gopal AK, Gooley TA, Orozco JJ, Till BG, O'Steen S, Orcutt KD, Wilbur DS, Wittrup KD, Press OW. Comparative Analysis of Bispecific Antibody and Streptavidin-Targeted Radioimmunotherapy for B-cell Cancers. Cancer Res. 2016 Nov 15;76(22):6669-6679. doi: 10.1158/0008-5472.CAN-16-0571. Epub 2016 Sep 2. PubMed PMID: 27590740; PubMed Central PMCID: PMC5290195.

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Cowan AJ, Stevenson PA, Cassaday RD, Graf SA, Fromm JR, Wu D, Holmberg LA, Till BG, Chauncey TR, Smith SD, Philip M, Orozco JJ, Shustov AR, Green DJ, Libby EN 3rd, Bensinger WI, Shadman M, Maloney DG, Press OW, Gopal AK. Pretransplantation Minimal Residual Disease Predicts Survival in Patients with Mantle Cell Lymphoma Undergoing Autologous Stem Cell Transplantation in Complete Remission. Biol Blood Marrow Transplant. 2016 Feb;22(2):380-385. doi: 10.1016/j.bbmt.2015.08.035. Epub 2015 Sep 5. PubMed PMID: 26348890; PubMed Central PMCID: PMC4716882.

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Orozco JJ, Kenoyer A, Balkin ER, Gooley TA, Hamlin DK, Wilbur DS, Hylarides MD, Frost SH, Mawad R, O'Donnell P, Sandmaier BM, Fuchs EJ, Luznik L, Green DJ, Gopal AK, Press OW, Pagel JM. Anti-CD45 radioimmunotherapy without TBI before transplantation facilitates persistent haploidentical donor engraftment. Blood. 2016 Jan 21;127(3):352-9. doi: 10.1182/blood-2014-12-617019. Epub 2015 Nov 17. PubMed PMID: 26576864; PubMed Central PMCID: PMC4722286.

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Cassaday RD, Stevenson PA, Gooley TA, Chauncey TR, Pagel JM, Rajendran J, Till BG, Philip M, Orozco JJ, Bensinger WI, Holmberg LA, Shustov AR, Green DJ, Smith SD, Libby EN, Maloney DG, Press OW, Gopal AK. High-dose CD20-targeted radioimmunotherapy-based autologous transplantation improves outcomes for persistent mantle cell lymphoma. Br J Haematol. 2015 Dec;171(5):788-97. doi: 10.1111/bjh.13773. Epub 2015 Oct 12. PubMed PMID: 26455717; PubMed Central PMCID: PMC4715476.

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Graf SA, Stevenson PA, Holmberg LA, Till BG, Press OW, Chauncey TR, Smith SD, Philip M, Orozco JJ, Shustov AR, Green DJ, Libby EN 3rd, Bensinger WI, Pagel JM, Maloney DG, Zhou Y, Cassaday RD, Gopal AK. Maintenance rituximab after autologous stem cell transplantation in patients with mantle cell lymphoma. Ann Oncol. 2015 Nov;26(11):2323-8. doi: 10.1093/annonc/mdv364. Epub 2015 Sep 7. PubMed PMID: 26347113; PubMed Central PMCID: PMC4621031.

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Miller BW, Frost SH, Frayo SL, Kenoyer AL, Santos E, Jones JC, Green DJ, Hamlin DK, Wilbur DS, Fisher DR, Orozco JJ, Press OW, Pagel JM, Sandmaier BM. Quantitative single-particle digital autoradiography with α-particle emitters for targeted radionuclide therapy using the iQID camera. Med Phys. 2015 Jul;42(7):4094-105. doi: 10.1118/1.4921997. PubMed PMID: 26133610; PubMed Central PMCID: PMC4464071.

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Green DJ, Shadman M, Jones JC, Frayo SL, Kenoyer AL, Hylarides MD, Hamlin DK, Wilbur DS, Balkan ER, Lin Y, Miller BW, Frost SH, Gopal AK, Orozco JJ, Gooley TA, Laird KL, Till BG, Bäck T, Sandmaier BM, Pagel JM, Press OW. Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model. Blood. 2015 Mar 26;125(13):2111-9. doi: 10.1182/blood-2014-11-612770. Epub 2015 Jan 27. PubMed PMID: 25628467; PubMed Central PMCID: PMC4375108.

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Frost SH, Frayo SL, Miller BW, Orozco JJ, Booth GC, Hylarides MD, Lin Y, Green DJ, Gopal AK, Pagel JM, Bäck TA, Fisher DR, Press OW. Comparative efficacy of 177Lu and 90Y for anti-CD20 pretargeted radioimmunotherapy in murine lymphoma xenograft models. PLoS One. 2015;10(3):e0120561. doi: 10.1371/journal.pone.0120561. eCollection 2015. PubMed PMID: 25785845; PubMed Central PMCID: PMC4364776.

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Orozco JJ, Balkin ER, Gooley TA, Kenoyer A, Hamlin DK, Wilbur DS, Fisher DR, Hylarides MD, Shadman M, Green DJ, Gopal AK, Press OW, Pagel JM. Anti-CD45 radioimmunotherapy with 90Y but not 177Lu is effective treatment in a syngeneic murine leukemia model. PLoS One. 2014;9(12):e113601. doi: 10.1371/journal.pone.0113601. eCollection 2014. PubMed PMID: 25460570; PubMed Central PMCID: PMC4252056.

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Balkin ER, Kenoyer A, Orozco JJ, Hernandez A, Shadman M, Fisher DR, Green DJ, Hylarides MD, Press OW, Wilbur DS, Pagel JM. In vivo localization of ⁹⁰Y and ¹⁷⁷Lu radioimmunoconjugates using Cerenkov luminescence imaging in a disseminated murine leukemia model. Cancer Res. 2014 Oct 15;74(20):5846-54. doi: 10.1158/0008-5472.CAN-14-0764. Epub 2014 Sep 26. PubMed PMID: 25261237; PubMed Central PMCID: PMC4199906.

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Green DJ, Orgun NN, Jones JC, Hylarides MD, Pagel JM, Hamlin DK, Wilbur DS, Lin Y, Fisher DR, Kenoyer AL, Frayo SL, Gopal AK, Orozco JJ, Gooley TA, Wood BL, Bensinger WI, Press OW. A preclinical model of CD38-pretargeted radioimmunotherapy for plasma cell malignancies. Cancer Res. 2014 Feb 15;74(4):1179-89. doi: 10.1158/0008-5472.CAN-13-1589. Epub 2013 Dec 26. PubMed PMID: 24371230; PubMed Central PMCID: PMC3970848.

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Orozco JJ, Bäck T, Kenoyer A, Balkin ER, Hamlin DK, Wilbur DS, Fisher DR, Frayo SL, Hylarides MD, Green DJ, Gopal AK, Press OW, Pagel JM. Anti-CD45 radioimmunotherapy using (211)At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model. Blood. 2013 May 2;121(18):3759-67. doi: 10.1182/blood-2012-11-467035. Epub 2013 Mar 7. PubMed PMID: 23471305; PubMed Central PMCID: PMC3643772.

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Orozco JJ, Appelbaum FR. Unfavorable, complex, and monosomal karyotypes: the most challenging forms of acute myeloid leukemia. Oncology (Williston Park). 2012 Aug;26(8):706-12. PubMed PMID: 22957403.

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Orozco JJ, Zeller J, Pagel JM. Radiolabeled antibodies directed at CD45 for conditioning prior to allogeneic transplantation in acute myeloid leukemia and myelodysplastic syndrome. Ther Adv Hematol. 2012 Feb;3(1):5-16. doi: 10.1177/2040620711422265. PubMed PMID: 23556108; PubMed Central PMCID: PMC3573428.

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Pagel JM, Kenoyer AL, Bäck T, Hamlin DK, Wilbur DS, Fisher DR, Park SI, Frayo S, Axtman A, Orgun N, Orozco J, Shenoi J, Lin Y, Gopal AK, Green DJ, Appelbaum FR, Press OW. Anti-CD45 pretargeted radioimmunotherapy using bismuth-213: high rates of complete remission and long-term survival in a mouse myeloid leukemia xenograft model. Blood. 2011 Jul 21;118(3):703-11. doi: 10.1182/blood-2011-04-347039. Epub 2011 May 25. PubMed PMID: 21613259; PubMed Central PMCID: PMC3142907.

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Orozco JJ, Carter JJ, Koutsky LA, Galloway DA. Humoral immune response recognizes a complex set of epitopes on human papillomavirus type 6 l1 capsomers. J Virol. 2005 Aug;79(15):9503-14. doi: 10.1128/JVI.79.15.9503-9514.2005. PubMed PMID: 16014913; PubMed Central PMCID: PMC1181614.

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Vo PT, Gooley T, Rajendran JG, Fisher DR, Orozco JJ, Green DJ, Gopal AK, Haaf R, Nartea ME, Storb RF, Appelbaum FR, Press OW, Pagel J, Sandmaier BM. Safety and Efficacy of Yttrium-90-Labeled Anti-CD45 Antibody (90Y-DOTA-BC8) Followed By a Standard Reduced-Intensity Hematopoietic Stem Cell Transplant (HCT) Regimen for Patients with Refractory/Relapsed Leukemia or High-Risk Myelodysplastic Syndrome (MDS). American Society of Hematology Annual Meeting; 2018 December; San Diego, CA.

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O'Steen S, Comstock MC, Orozco JJ, Hamlin DK, Wilbur DS, Jones J, Kenoyer A, Nartea ME, Lin Y, Miller BW, Tuazon SA, Till BG, Gopal AK, Sandmaier BS, Press OW, Green DJ. The Alpha Emitter Astatine-211 Targeted to CD38 Can Eradicate Multiple Myeloma in Minimal Residual Disease Models. American Society of Hematology Annual Meeting; 2018 December; San Diego, CA.

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Atallah EL, Orozco JJ, Craig M, Levy M, Finn LE, Khan SS, Perl AE, Park JH, Roboz GJ, Tse W, Begna KH, Mawad R, Rizzieri DA, Berger MS, Jurcic JG. A Phase 2 Study of Actinium-225 (225Ac)-Lintuzumab in Older Patients with Untreated Acute Myeloid Leukemia (AML) - Interim Analysis of 1.5 µci/Kg/Dose. American Society of Hematology Annual Meeting; 2018 December; San Diego, CA.