My Bibliography

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Wang J. Asymmetric division rejuvenates stem cell lineages. Cell Res. 2026 Apr;36(4):239-240. doi: 10.1038/s41422-026-01226-8. PubMed PMID: 41692871; PubMed Central PMCID: PMC13013559.

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Wang D, Shi X, Xie J, Zhao L, Wu B, Dong Q, Huang Y, Suo J, Wang X, He B, Yan S, Xue H, Shi Y, Liu Y, Wang J, Chen Y, Li Y. WDR5 remodels NANOG condensates to drive transcriptional programs and sustain stem cell identity. Nat Commun. 2026 Jan 21;17(1). doi: 10.1038/s41467-026-68623-w. PubMed PMID: 41565645; PubMed Central PMCID: PMC12923824.

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Xu M, Wang J. Paraspeckle component 1 in acute myeloid leukemia: prospects for therapeutic targeting. Expert Opin Ther Targets. 2026 Jan;30(1):13-17. doi: 10.1080/14728222.2025.2608021. Epub 2025 Dec 29. PubMed PMID: 41432453; NIHMSID:NIHMS2159805.

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Du P, Wang J. Editorial overview: 3Rs update: a new era in cellular identity and therapeutic plasticity. Curr Opin Genet Dev. 2025 Oct;94:102386. doi: 10.1016/j.gde.2025.102386. Epub 2025 Aug 5. PubMed PMID: 40768826.

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Wen D, Wang J. Totipotency or plenipotency: rethinking stem cell bipotentiality. Curr Opin Genet Dev. 2025 Jun;92:102342. doi: 10.1016/j.gde.2025.102342. Epub 2025 Mar 19. Review. PubMed PMID: 40107116; PubMed Central PMCID: PMC12279028.

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Vann KR, Sharma R, Hsu CC, Devoucoux M, Tencer AH, Zeng L, Lin K, Zhu L, Li Q, Lachance C, Ospina RR, Tong Q, Cheung KL, Yang S, Biswas S, Xuan H, Gatchalian J, Alamillo L, Wang J, Jang SM, Klein BJ, Lu Y, Ernst P, Strahl BD, Rothbart SB, Walsh MJ, Cleary ML, Côté J, Shi X, Zhou MM, Kutateladze TG. Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation. Nat Commun. 2025 Mar 6;16(1):2235. doi: 10.1038/s41467-025-57556-5. PubMed PMID: 40044670; PubMed Central PMCID: PMC11883000.

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Yuan F, Yang J, Ma F, Hu Z, Malik V, Zang R, Li D, Shi X, Huang X, Zhou H, Wang J. Pluripotency factor Tex10 finetunes Wnt signaling for spermatogenesis and primordial germ cell development. Nat Commun. 2025 Feb 23;16(1):1900. doi: 10.1038/s41467-025-57165-2. PubMed PMID: 39988597; PubMed Central PMCID: PMC11847947.

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Hong J, Sui P, Li Y, Xu KY, Lee JH, Wang J, Chen S, Zhang P, Wingate N, Noor A, Yuan Y, Hromas R, Zhou H, Hamamoto K, Su R, Yin CC, Ye F, Quesada AE, Chen J, Huang S, Zhou D, You MJ, Yang FC, Wang J, Xu M. PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1. Cell Stem Cell. 2025 Mar 6;32(3):463-478.e6. doi: 10.1016/j.stem.2025.01.010. Epub 2025 Feb 14. PubMed PMID: 39954676; PubMed Central PMCID: PMC12097264.

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Shi X, Li Y, Zhou H, Hou X, Yang J, Malik V, Faiola F, Ding J, Bao X, Modic M, Zhang W, Chen L, Mahmood SR, Apostolou E, Yang FC, Xu M, Xie W, Huang X, Chen Y, Wang J. DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells. Nat Commun. 2024 Dec 30;15(1):10803. doi: 10.1038/s41467-024-55054-8. PubMed PMID: 39738032; PubMed Central PMCID: PMC11685540.

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Zou Z, Dou X, Li Y, Zhang Z, Wang J, Gao B, Xiao Y, Wang Y, Zhao L, Sun C, Liu Q, Yu X, Wang H, Hong J, Dai Q, Yang FC, Xu M, He C. RNA m(5)C oxidation by TET2 regulates chromatin state and leukaemogenesis. Nature. 2024 Oct;634(8035):986-994. doi: 10.1038/s41586-024-07969-x. Epub 2024 Oct 2. PubMed PMID: 39358506; PubMed Central PMCID: PMC11499264.

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Ngule C, Shi R, Ren X, Jia H, Oyelami F, Li D, Park Y, Kim J, Hemati H, Zhang Y, Xiong X, Shinkle A, Vanderford NL, Bachert S, Zhou BP, Wang J, Song J, Liu X, Yang JM. NAC1 promotes stemness and regulates myeloid-derived cell status in triple-negative breast cancer. Mol Cancer. 2024 Sep 6;23(1):188. doi: 10.1186/s12943-024-02102-y. PubMed PMID: 39243032; PubMed Central PMCID: PMC11378519.

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Hassan N, Yi H, Malik B, Gaspard-Boulinc L, Samaraweera SE, Casolari DA, Seneviratne J, Balachandran A, Chew T, Duly A, Carter DR, Cheung BB, Norris M, Haber M, Kavallaris M, Marshall GM, Zhang XD, Liu T, Wang J, Liebermann DA, D'Andrea RJ, Wang JY. Loss of the stress sensor GADD45A promotes stem cell activity and ferroptosis resistance in LGR4/HOXA9-dependent AML. Blood. 2024 Jul 4;144(1):84-98. doi: 10.1182/blood.2024024072. PubMed PMID: 38579286; PubMed Central PMCID: PMC11251412.

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Huang X, Balmer S, Lyu C, Xiang Y, Malik V, Wang H, Zhang Y, Cai B, Xie W, Hadjantonakis AK, Zhou H, Wang J. ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1. Dev Cell. 2024 Feb 26;59(4):465-481.e6. doi: 10.1016/j.devcel.2023.12.018. Epub 2024 Jan 17. PubMed PMID: 38237590; PubMed Central PMCID: PMC10923053.

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Shah R, Shah VK, Emin M, Gao S, Sampogna RV, Aggarwal B, Chang A, St-Onge MP, Malik V, Wang J, Wei Y, Jelic S. Mild sleep restriction increases endothelial oxidative stress in female persons. Sci Rep. 2023 Sep 16;13(1):15360. doi: 10.1038/s41598-023-42758-y. PubMed PMID: 37717072; PubMed Central PMCID: PMC10505226.

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Daniel JA, Elizarova S, Shaib AH, Chouaib AA, Magnussen HM, Wang J, Brose N, Rhee J, Tirard M. An intellectual-disability-associated mutation of the transcriptional regulator NACC1 impairs glutamatergic neurotransmission. Front Mol Neurosci. 2023;16:1115880. doi: 10.3389/fnmol.2023.1115880. eCollection 2023. Review. PubMed PMID: 37533751; PubMed Central PMCID: PMC10393139.

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Huang X, Balmer S, Lyu C, Xiang Y, Malik V, Wang H, Zhang Y, Xie W, Hadjantonakis AK, Zhou H, Wang J. ZFP281 coordinates DNMT3 and TET1 for transcriptional and epigenetic control in pluripotent state transitions. bioRxiv. 2023 Mar 25;. doi: 10.1101/2023.03.24.534143. PubMed PMID: 36993548; PubMed Central PMCID: PMC10055359.

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Li D, Yang J, Ma F, Malik V, Zang R, Shi X, Huang X, Zhou H, Wang J. The pluripotency factor Tex10 finetunes Wnt signaling for PGC and male germline development. bioRxiv. 2023 Feb 24;. doi: 10.1101/2023.02.23.529824. PubMed PMID: 36865339; PubMed Central PMCID: PMC9980098.

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Li D, Yang J, Malik V, Huang Y, Huang X, Zhou H, Wang J. An RNAi screen of RNA helicases identifies eIF4A3 as a regulator of embryonic stem cell identity. Nucleic Acids Res. 2022 Nov 28;50(21):12462-12479. doi: 10.1093/nar/gkac1084. PubMed PMID: 36416264; PubMed Central PMCID: PMC9757061.

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Kim M, Singh M, Lee BK, Hibbs M, Richardson K, Ellies L, Wintle L, Stuart LM, Wang JY, Voon DC, Blancafort P, Wang J, Kim J, Leedman PJ, Woo AJ. A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancer. Oncogenesis. 2022 Oct 7;11(1):60. doi: 10.1038/s41389-022-00435-1. PubMed PMID: 36207293; PubMed Central PMCID: PMC9546828.

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Nobre AR, Dalla E, Yang J, Huang X, Wullkopf L, Risson E, Razghandi P, Anton ML, Zheng W, Seoane JA, Curtis C, Kenigsberg E, Wang J, Aguirre-Ghiso JA. ZFP281 drives a mesenchymal-like dormancy program in early disseminated breast cancer cells that prevents metastatic outgrowth in the lung. Nat Cancer. 2022 Oct;3(10):1165-1180. doi: 10.1038/s43018-022-00424-8. Epub 2022 Sep 1. PubMed PMID: 36050483.

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Malik V, Zang R, Fuentes-Iglesias A, Huang X, Li D, Fidalgo M, Zhou H, Wang J. Comparative functional genomics identifies unique molecular features of EPSCs. Life Sci Alliance. 2022 Nov;5(11). doi: 10.26508/lsa.202201608. Print 2022 Nov. PubMed PMID: 35961778; PubMed Central PMCID: PMC9378845.

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Yang JM, Ren Y, Kumar A, Xiong X, Das JK, Peng HY, Wang L, Ren X, Zhang Y, Ji C, Cheng Y, Zhang L, Alaniz RC, de Figueiredo P, Fang D, Zhou H, Liu X, Wang J, Song J. NAC1 modulates autoimmunity by suppressing regulatory T cell-mediated tolerance. Sci Adv. 2022 Jul;8(26):eabo0183. doi: 10.1126/sciadv.abo0183. Epub 2022 Jun 29. PubMed PMID: 35767626; PubMed Central PMCID: PMC9242588.

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Huang X, Bashkenova N, Hong Y, Lyu C, Guallar D, Hu Z, Malik V, Li D, Wang H, Shen X, Zhou H, Wang J. A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency. Cell Rep. 2022 Jun 7;39(10):110928. doi: 10.1016/j.celrep.2022.110928. PubMed PMID: 35675764; PubMed Central PMCID: PMC9214724.

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Malik V, Wang J. Pursuing totipotency: authentic totipotent stem cells in culture. Trends Genet. 2022 Jul;38(7):632-636. doi: 10.1016/j.tig.2022.03.012. Epub 2022 Apr 18. PubMed PMID: 35443932; PubMed Central PMCID: PMC9197991.

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Li D, Yang J, Huang X, Zhou H, Wang J. eIF4A2 targets developmental potency and histone H3.3 transcripts for translational control of stem cell pluripotency. Sci Adv. 2022 Apr;8(13):eabm0478. doi: 10.1126/sciadv.abm0478. Epub 2022 Mar 30. PubMed PMID: 35353581; PubMed Central PMCID: PMC8967233.

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Shao W, Bi X, Pan Y, Gao B, Wu J, Yin Y, Liu Z, Peng M, Zhang W, Jiang X, Ren W, Xu Y, Wu Z, Wang K, Zhan G, Lu JY, Han X, Li T, Wang J, Li G, Deng H, Li B, Shen X. Phase separation of RNA-binding protein promotes polymerase binding and transcription. Nat Chem Biol. 2022 Jan;18(1):70-80. doi: 10.1038/s41589-021-00904-5. Epub 2021 Dec 16. PubMed PMID: 34916619.

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Zang R, Huang X, Li D, Zhou H, Gao S, Wang J. Zfp281 is essential for epiblast maturation through a cell autonomous effect. J Genet Genomics. 2022 Jan;49(1):85-88. doi: 10.1016/j.jgg.2021.08.016. Epub 2021 Sep 17. PubMed PMID: 34543730; PubMed Central PMCID: PMC9085266.

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Huang X, Park KM, Gontarz P, Zhang B, Pan J, McKenzie Z, Fischer LA, Dong C, Dietmann S, Xing X, Shliaha PV, Yang J, Li D, Ding J, Lungjangwa T, Mitalipova M, Khan SA, Imsoonthornruksa S, Jensen N, Wang T, Kadoch C, Jaenisch R, Wang J, Theunissen TW. OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human. Nat Commun. 2021 Aug 26;12(1):5123. doi: 10.1038/s41467-021-25107-3. PubMed PMID: 34446700; PubMed Central PMCID: PMC8390644.

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Sun Z, Yu H, Zhao J, Tan T, Pan H, Zhu Y, Chen L, Zhang C, Zhang L, Lei A, Xu Y, Bi X, Huang X, Gao B, Wang L, Correia C, Chen M, Sun Q, Feng Y, Shen L, Wu H, Wang J, Shen X, Daley GQ, Li H, Zhang J. LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells. Protein Cell. 2022 Jul;13(7):490-512. doi: 10.1007/s13238-021-00864-5. Epub 2021 Jul 31. PubMed PMID: 34331666; PubMed Central PMCID: PMC9226220.

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Wang J, Yu H, Ma Q, Zeng P, Wu D, Hou Y, Liu X, Jia L, Sun J, Chen Y, Guallar D, Fidalgo M, Chen J, Yu Y, Jiang S, Li F, Zhao C, Huang X, Wang J, Li C, Sun Y, Zeng X, Zhang W, Miao Y, Ding J. Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions. Cell Stem Cell. 2021 Oct 7;28(10):1868-1883.e11. doi: 10.1016/j.stem.2021.04.023. Epub 2021 May 25. PubMed PMID: 34038708.

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Huang X, Bashkenova N, Yang J, Li D, Wang J. ZFP281 recruits polycomb repressive complex 2 to restrict extraembryonic endoderm potential in safeguarding embryonic stem cell pluripotency. Protein Cell. 2021 Mar;12(3):213-219. doi: 10.1007/s13238-020-00775-x. PubMed PMID: 32812113; PubMed Central PMCID: PMC7895869.

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Lan J, Rajan N, Bizet M, Penning A, Singh NK, Guallar D, Calonne E, Li Greci A, Bonvin E, Deplus R, Hsu PJ, Nachtergaele S, Ma C, Song R, Fuentes-Iglesias A, Hassabi B, Putmans P, Mies F, Menschaert G, Wong JJL, Wang J, Fidalgo M, Yuan B, Fuks F. Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation. Nat Commun. 2020 Oct 2;11(1):4956. doi: 10.1038/s41467-020-18729-6. PubMed PMID: 33009383; PubMed Central PMCID: PMC7532169.

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Guan Y, Greenberg EF, Hasipek M, Chen S, Liu X, Kerr CM, Gackowski D, Zarakowska E, Radivoyevitch T, Gu X, Willard B, Visconte V, Makishima H, Nazha A, Mukherji M, Sekeres MA, Saunthararajah Y, Oliński R, Xu M, Maciejewski JP, Jha BK. Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia. Commun Biol. 2020 Sep 7;3(1):493. doi: 10.1038/s42003-020-01220-9. PubMed PMID: 32895473; PubMed Central PMCID: PMC7477582.

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Fuentes-Iglesias A, Garcia-Outeiral V, Pardavila JA, Wang J, Fidalgo M, Guallar D. An Optimized Immunoprecipitation Protocol for Assessing Protein-RNA Interactions In Vitro. STAR Protoc. 2020 Sep 18;1(2). doi: 10.1016/j.xpro.2020.100093. Epub 2020 Aug 26. PubMed PMID: 32995755; PubMed Central PMCID: PMC7521669.

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Salik B, Yi H, Hassan N, Santiappillai N, Vick B, Connerty P, Duly A, Trahair T, Woo AJ, Beck D, Liu T, Spiekermann K, Jeremias I, Wang J, Kavallaris M, Haber M, Norris MD, Liebermann DA, D'Andrea RJ, Murriel C, Wang JY. Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia. Cancer Cell. 2020 Aug 10;38(2):263-278.e6. doi: 10.1016/j.ccell.2020.05.014. Epub 2020 Jun 18. PubMed PMID: 32559496.

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Li D, Wang J. Ribosome heterogeneity in stem cells and development. J Cell Biol. 2020 Jun 1;219(6). doi: 10.1083/jcb.202001108. Review. PubMed PMID: 32330234; PubMed Central PMCID: PMC7265316.

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Guallar D, Fuentes-Iglesias A, Souto Y, Ameneiro C, Freire-Agulleiro O, Pardavila JA, Escudero A, Garcia-Outeiral V, Moreira T, Saenz C, Xiong H, Liu D, Xiao S, Hou Y, Wu K, Torrecilla D, Hartner JC, Blanco MG, Lee LJ, López M, Walkley CR, Wang J, Fidalgo M. ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress. Cell Stem Cell. 2020 Aug 6;27(2):300-314.e11. doi: 10.1016/j.stem.2020.04.016. Epub 2020 May 11. PubMed PMID: 32396862; PubMed Central PMCID: PMC7415614.

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Li D, Kishta MS, Wang J. Regulation of pluripotency and reprogramming by RNA binding proteins. Curr Top Dev Biol. 2020;138:113-138. doi: 10.1016/bs.ctdb.2020.01.003. Epub 2020 Feb 25. Review. PubMed PMID: 32220295; PubMed Central PMCID: PMC8015705.

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Yang F, Huang X, Zang R, Chen J, Fidalgo M, Sanchez-Priego C, Yang J, Caichen A, Ma F, Macfarlan T, Wang H, Gao S, Zhou H, Wang J. DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State. Cell Stem Cell. 2020 Feb 6;26(2):234-250.e7. doi: 10.1016/j.stem.2020.01.004. PubMed PMID: 32032525; PubMed Central PMCID: PMC8074926.

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Yang J, Bashkenova N, Zang R, Huang X, Wang J. The roles of TET family proteins in development and stem cells. Development. 2020 Jan 15;147(2). doi: 10.1242/dev.183129. Review. PubMed PMID: 31941705; PubMed Central PMCID: PMC6983710.

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Zhang H, Wu Z, Lu JY, Huang B, Zhou H, Xie W, Wang J, Shen X. DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation. Cell Rep. 2020 Jan 7;30(1):81-97.e7. doi: 10.1016/j.celrep.2019.12.021. PubMed PMID: 31914400.

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Woo AJ, Patry CA, Ghamari A, Pregernig G, Yuan D, Zheng K, Piers T, Hibbs M, Li J, Fidalgo M, Wang JY, Lee JH, Leedman PJ, Wang J, Fraenkel E, Cantor AB. Zfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development. Blood Adv. 2019 Aug 27;3(16):2499-2511. doi: 10.1182/bloodadvances.2018030551. PubMed PMID: 31455666; PubMed Central PMCID: PMC6712527.

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Gonzales-Aloy E, Connerty P, Salik B, Liu B, Woo AJ, Haber M, Norris MD, Wang J, Wang JY. miR-101 suppresses the development of MLL-rearranged acute myeloid leukemia. Haematologica. 2019 Jul;104(7):e296-e299. doi: 10.3324/haematol.2018.209437. Epub 2019 Feb 21. PubMed PMID: 30792205; PubMed Central PMCID: PMC6601101.

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Lynch JR, Salik B, Connerty P, Vick B, Leung H, Pijning A, Jeremias I, Spiekermann K, Trahair T, Liu T, Haber M, Norris MD, Woo AJ, Hogg P, Wang J, Wang JY. JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis. Leukemia. 2019 Jun;33(6):1400-1410. doi: 10.1038/s41375-018-0354-z. Epub 2019 Jan 8. PubMed PMID: 30622285.

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Kim KY, Tanaka Y, Su J, Cakir B, Xiang Y, Patterson B, Ding J, Jung YW, Kim JH, Hysolli E, Lee H, Dajani R, Kim J, Zhong M, Lee JH, Skalnik D, Lim JM, Sullivan GJ, Wang J, Park IH. Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a. Nat Commun. 2018 Jul 3;9(1):2583. doi: 10.1038/s41467-018-04818-0. PubMed PMID: 29968706; PubMed Central PMCID: PMC6030064.

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Han S, Tan C, Ding J, Wang J, Ma'ayan A, Gouon-Evans V. Endothelial cells instruct liver specification of embryonic stem cell-derived endoderm through endothelial VEGFR2 signaling and endoderm epigenetic modifications. Stem Cell Res. 2018 Jul;30:163-170. doi: 10.1016/j.scr.2018.06.004. Epub 2018 Jun 21. PubMed PMID: 29936335.

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Wang J, Wu X, Wei C, Huang X, Ma Q, Huang X, Faiola F, Guallar D, Fidalgo M, Huang T, Peng D, Chen L, Yu H, Li X, Sun J, Liu X, Cai X, Chen X, Wang L, Ren J, Wang J, Ding J. YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells. Stem Cell Reports. 2018 Apr 10;10(4):1324-1339. doi: 10.1016/j.stemcr.2018.02.004. Epub 2018 Mar 1. PubMed PMID: 29503092; PubMed Central PMCID: PMC5998734.

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Guallar D, Bi X, Pardavila JA, Huang X, Saenz C, Shi X, Zhou H, Faiola F, Ding J, Haruehanroengra P, Yang F, Li D, Sanchez-Priego C, Saunders A, Pan F, Valdes VJ, Kelley K, Blanco MG, Chen L, Wang H, Sheng J, Xu M, Fidalgo M, Shen X, Wang J. RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells. Nat Genet. 2018 Mar;50(3):443-451. doi: 10.1038/s41588-018-0060-9. Epub 2018 Feb 26. PubMed PMID: 29483655; PubMed Central PMCID: PMC5862756.

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Zhang Y, Xiang Y, Yin Q, Du Z, Peng X, Wang Q, Fidalgo M, Xia W, Li Y, Zhao ZA, Zhang W, Ma J, Xu F, Wang J, Li L, Xie W. Dynamic epigenomic landscapes during early lineage specification in mouse embryos. Nat Genet. 2018 Jan;50(1):96-105. doi: 10.1038/s41588-017-0003-x. Epub 2017 Dec 4. PubMed PMID: 29203909.

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Huang X, Balmer S, Yang F, Fidalgo M, Li D, Guallar D, Hadjantonakis AK, Wang J. Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling. Elife. 2017 Nov 23;6. doi: 10.7554/eLife.33333. PubMed PMID: 29168693; PubMed Central PMCID: PMC5708896.