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Jiang N, Xie B, Fan M, Li JJ. Does burning fat make tumor immune hot? Discovery of CD47 overexpression by radiation induced fatty acid oxidation. Genes & Diseases. Forthcoming. doi:
Alexandrou AT, Duan Y, Xu S, Tepper C, Fan M, Tang J, Berg J, Basheer W, Valicenti T, Wilson PF, Coleman MA, Vaughan AT, Fu L, Grdina DJ, Murley J, Wang A, Woloschak G, Li JJ. PERIOD 2 regulates low-dose radioprotection via PER2/pGSK3β/β-catenin/Per2 loop. iScience. 2022 Dec 22;25(12):105546. doi: 10.1016/j.isci.2022.105546. eCollection 2022 Dec 22. PubMed PMID: 36465103; PubMed Central PMCID: PMC9708791.
Jing D, Jiang N, Wang F, Mao C, Han S, Ho PY, Xiao W, Li Y, Li JJ, Zhang L, Lam KS. Nanoradiosensitizer with good tissue penetration and enhances oral cancer radiotherapeutic effect. Biomaterials. 2022 Oct;289:121769. doi: 10.1016/j.biomaterials.2022.121769. Epub 2022 Sep 1. PubMed PMID: 36084485; PubMed Central PMCID: PMC10021813.
Hao D, Lu L, Song H, Duan Y, Chen J, Carney R, Li JJ, Zhou P, Nolta J, Lam KS, Leach JK, Farmer DL, Panitch A, Wang A. Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair. Theranostics. 2022;12(13):6021-6037. doi: 10.7150/thno.70448. eCollection 2022. PubMed PMID: 35966577; PubMed Central PMCID: PMC9373818.
Wang H, Wang Q, Cai G, Duan Z, Nugent Z, Huang J, Zheng J, Borowsky AD, Li JJ, Liu P, Kung HJ, Murphy L, Chen HW, Wang J. Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance. Acta Pharm Sin B. 2022 Apr;12(4):1871-1884. doi: 10.1016/j.apsb.2021.10.015. Epub 2021 Oct 21. PubMed PMID: 35847493; PubMed Central PMCID: PMC9279715.
Jiang N, Xie B, Xiao W, Fan M, Xu S, Duan Y, Hamsafar Y, Evans AC, Huang J, Zhou W, Lin X, Ye N, Wanggou S, Chen W, Jing D, Fragoso RC, Dugger BN, Wilson PF, Coleman MA, Xia S, Li X, Sun LQ, Monjazeb AM, Wang A, Murphy WJ, Kung HJ, Lam KS, Chen HW, Li JJ. Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion. Nat Commun. 2022 Mar 21;13(1):1511. doi: 10.1038/s41467-022-29137-3. PubMed PMID: 35314680; PubMed Central PMCID: PMC8938495.
Candas-Green D, Xie B, Huang J, Fan M, Wang A, Menaa C, Zhang Y, Zhang L, Jing D, Azghadi S, Zhou W, Liu L, Jiang N, Li T, Gao T, Sweeney C, Shen R, Lin TY, Pan CX, Ozpiskin OM, Woloschak G, Grdina DJ, Vaughan AT, Wang JM, Xia S, Monjazeb AM, Murphy WJ, Sun LQ, Chen HW, Lam KS, Weichselbaum RR, Li JJ. Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells. Nat Commun. 2020 Sep 14;11(1):4591. doi: 10.1038/s41467-020-18245-7. PubMed PMID: 32929084; PubMed Central PMCID: PMC7490264.
Li JJ. Mitigating Coronavirus-Induced Acute Respiratory Distress Syndrome by Radiotherapy. iScience. 2020 Jun 26;23(6):101215. doi: 10.1016/j.isci.2020.101215. Epub 2020 May 30. Review. PubMed PMID: 32512383; PubMed Central PMCID: PMC7260547.
Zhang L, Xie B, Qiu Y, Jing D, Zhang J, Duan Y, Li Z, Fan M, He J, Qiu Y, Tan R, Li JJ, Sun LQ. Rab25-Mediated EGFR Recycling Causes Tumor Acquired Radioresistance. iScience. 2020 Apr 24;23(4):100997. doi: 10.1016/j.isci.2020.100997. Epub 2020 Mar 20. PubMed PMID: 32252020; PubMed Central PMCID: PMC7132159.
Huang J, Li JJ. Cell repopulation, rewiring metabolism, and immune regulation in cancer radiotherapy. Radiation Medicine and Protection. 2020 March; 1:24-30. doi:
Zhang L, Jing D, Jiang N, Rojalin T, Baehr CM, Zhang D, Xiao W, Wu Y, Cong Z, Li JJ, Li Y, Wang L, Lam KS. Transformable peptide nanoparticles arrest HER2 signalling and cause cancer cell death in vivo. Nat Nanotechnol. 2020 Feb;15(2):145-153. doi: 10.1038/s41565-019-0626-4. Epub 2020 Jan 27. PubMed PMID: 31988501; PubMed Central PMCID: PMC7147967.
Liu L, Xie B, Fan M, Candas-Green D, Jiang JX, Wei R, Wang Y, Chen HW, Hu Y, Li JJ. Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade. Dev Cell. 2020 Jan 27;52(2):196-209.e9. doi: 10.1016/j.devcel.2019.11.012. Epub 2019 Dec 19. PubMed PMID: 31866205; PubMed Central PMCID: PMC6996588.
Duan Z, Andrews NP, Chen CZ, Fan M, Wang J, Shen J, Li JJ, Chen HW. Targeting bromodomain protein ANCCA/ATAD2 enhances the efficacy of DNA‑damaging chemotherapy agents and radiation. Oncol Rep. 2020 Jan;43(1):318-327. doi: 10.3892/or.2019.7418. Epub 2019 Nov 27. PubMed PMID: 31789405; NIHMSID:NIHMS1627704.
Huang J, Li JJ. Multiple Dynamics in Tumor Microenvironment Under Radiotherapy. Adv Exp Med Biol. 2020;1263:175-202. doi: 10.1007/978-3-030-44518-8_10. Review. PubMed PMID: 32588328.
Han S, Wei R, Zhang X, Jiang N, Fan M, Huang JH, Xie B, Zhang L, Miao W, Butler AC, Coleman MA, Vaughan AT, Wang Y, Chen HW, Liu J, Li JJ. CPT1A/2-Mediated FAO Enhancement-A Metabolic Target in Radioresistant Breast Cancer. Front Oncol. 2019;9:1201. doi: 10.3389/fonc.2019.01201. eCollection 2019. PubMed PMID: 31803610; PubMed Central PMCID: PMC6873486.
Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, Lam KS, To KF, Kung HJ, Fiehn O, Zhao R, Evans RM, Chen HW. RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Nat Commun. 2019 Oct 11;10(1):4621. doi: 10.1038/s41467-019-12529-3. PubMed PMID: 31604910; PubMed Central PMCID: PMC6789042.
Xie B, Zhang L, Hu W, Fan M, Jiang N, Duan Y, Jing D, Xiao W, Fragoso RC, Lam KS, Sun LQ, Li JJ. Dual blockage of STAT3 and ERK1/2 eliminates radioresistant GBM cells. Redox Biol. 2019 Jun;24:101189. doi: 10.1016/j.redox.2019.101189. Epub 2019 Apr 9. PubMed PMID: 30986607; PubMed Central PMCID: PMC6463934.
Ma D, Liu S, Lal B, Wei S, Wang S, Zhan D, Zhang H, Lee RS, Gao P, Lopez-Bertoni H, Ying M, Li JJ, Laterra J, Wilson MA, Xia S. Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. Cancer Res. 2019 May 15;79(10):2697-2708. doi: 10.1158/0008-5472.CAN-18-3125. Epub 2019 Mar 21. PubMed PMID: 30898840; PubMed Central PMCID: PMC8218246.
Xie B, Wang S, Jiang N, Li JJ. Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance. Cancer Lett. 2019 Feb 28;443:56-66. doi: 10.1016/j.canlet.2018.11.019. Epub 2018 Nov 24. Review. PubMed PMID: 30481564; PubMed Central PMCID: PMC6759061.
Miao W, Fan M, Huang M, Li JJ, Wang Y. Targeted Profiling of Heat Shock Proteome in Radioresistant Breast Cancer Cells. Chem Res Toxicol. 2019 Feb 18;32(2):326-332. doi: 10.1021/acs.chemrestox.8b00330. Epub 2019 Jan 11. PubMed PMID: 30596229; PubMed Central PMCID: PMC6469359.
Ozpiskin OM, Zhang L, Li JJ. Immune targets in the tumor microenvironment treated by radiotherapy. Theranostics. 2019;9(5):1215-1231. doi: 10.7150/thno.32648. eCollection 2019. Review. PubMed PMID: 30867826; PubMed Central PMCID: PMC6401500.
Zhang L, Jing D, Wang L, Sun Y, Li JJ, Hill B, Yang F, Li Y, Lam KS. Unique Photochemo-Immuno-Nanoplatform against Orthotopic Xenograft Oral Cancer and Metastatic Syngeneic Breast Cancer. Nano Lett. 2018 Nov 14;18(11):7092-7103. doi: 10.1021/acs.nanolett.8b03096. Epub 2018 Oct 26. PubMed PMID: 30339018; PubMed Central PMCID: PMC6501589.
Navas-Moreno M, Mehrpouyan M, Chernenko T, Candas D, Fan M, Li JJ, Yan M, Chan JW. Nanoparticles for live cell microscopy: A surface-enhanced Raman scattering perspective. Sci Rep. 2017 Jun 30;7(1):4471. doi: 10.1038/s41598-017-04066-0. PubMed PMID: 28667313; PubMed Central PMCID: PMC5493633.
Miller RC, Murley JS, Rademaker AW, Woloschak GE, Li JJ, Weichselbaum RR, Grdina DJ. Very low doses of ionizing radiation and redox associated modifiers affect survivin-associated changes in radiation sensitivity. Free Radic Biol Med. 2016 Oct;99:110-119. doi: 10.1016/j.freeradbiomed.2016.07.009. Epub 2016 Jul 15. PubMed PMID: 27427516; PubMed Central PMCID: PMC6764831.
Wang J, Duan Z, Nugent Z, Zou JX, Borowsky AD, Zhang Y, Tepper CG, Li JJ, Fiehn O, Xu J, Kung HJ, Murphy LC, Chen HW. Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes. Cancer Lett. 2016 Aug 10;378(2):69-79. doi: 10.1016/j.canlet.2016.05.004. Epub 2016 May 6. PubMed PMID: 27164560; PubMed Central PMCID: PMC7505026.
Yan Y, Li Z, Xu X, Chen C, Wei W, Fan M, Chen X, Li JJ, Wang Y, Huang J. All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy. BMC Complement Altern Med. 2016 Mar 31;16:113. doi: 10.1186/s12906-016-1088-y. PubMed PMID: 27036550; PubMed Central PMCID: PMC4815257.
Candas D, Qin L, Fan M, Li JJ. Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1. J Vis Exp. 2016 Feb 25;(108):53417. doi: 10.3791/53417. PubMed PMID: 26967001; PubMed Central PMCID: PMC4828183.
Qin L, Fan M, Candas D, Jiang G, Papadopoulos S, Tian L, Woloschak G, Grdina DJ, Li JJ. CDK1 Enhances Mitochondrial Bioenergetics for Radiation-Induced DNA Repair. Cell Rep. 2015 Dec 15;13(10):2056-63. doi: 10.1016/j.celrep.2015.11.015. Epub 2015 Dec 6. PubMed PMID: 26670043; PubMed Central PMCID: PMC4684969.
Sun W, Wei X, Niu A, Ma X, Li JJ, Gao D. Enhanced anti-colon cancer immune responses with modified eEF2-derived peptides. Cancer Lett. 2015 Dec 1;369(1):112-23. doi: 10.1016/j.canlet.2015.08.002. Epub 2015 Aug 21. PubMed PMID: 26304717.
Nantajit D, Lin D, Li JJ. The network of epithelial-mesenchymal transition: potential new targets for tumor resistance. J Cancer Res Clin Oncol. 2015 Oct;141(10):1697-713. doi: 10.1007/s00432-014-1840-y. Epub 2014 Oct 1. Review. PubMed PMID: 25270087; PubMed Central PMCID: PMC4382462.
Candas D, Li JJ. MKP1 mediates resistance to therapy in HER2-positive breast tumors. Mol Cell Oncol. 2015 Oct-Dec;2(4):e997518. doi: 10.1080/23723556.2014.997518. eCollection 2015 Oct-Dec. PubMed PMID: 27308517; PubMed Central PMCID: PMC4905363.
Liu R, Fan M, Candas D, Qin L, Zhang X, Eldridge A, Zou JX, Zhang T, Juma S, Jin C, Li RF, Perks J, Sun LQ, Vaughan AT, Hai CX, Gius DR, Li JJ. CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance. Mol Cancer Ther. 2015 Sep;14(9):2090-102. doi: 10.1158/1535-7163.MCT-15-0017. Epub 2015 Jul 3. PubMed PMID: 26141949; PubMed Central PMCID: PMC4560959.
Cui Y, Qin L, Wu J, Qu X, Hou C, Sun W, Li S, Vaughan AT, Li JJ, Liu J. SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells. PLoS One. 2015;10(6):e0129834. doi: 10.1371/journal.pone.0129834. eCollection 2015. PubMed PMID: 26121691; PubMed Central PMCID: PMC4487898.
Jin C, Qin L, Shi Y, Candas D, Fan M, Lu CL, Vaughan AT, Shen R, Wu LS, Liu R, Li RF, Murley JS, Woloschak G, Grdina DJ, Li JJ. CDK4-mediated MnSOD activation and mitochondrial homeostasis in radioadaptive protection. Free Radic Biol Med. 2015 Apr;81:77-87. doi: 10.1016/j.freeradbiomed.2014.12.026. Epub 2015 Jan 8. PubMed PMID: 25578653; PubMed Central PMCID: PMC4359946.
Grdina DJ, Murley JS, Miller RC, Woloschak GE, Li JJ. NFκB and Survivin-Mediated Radio-Adaptive Response. Radiat Res. 2015 Apr;183(4):391-7. doi: 10.1667/RR14002.1. Epub 2015 Mar 12. PubMed PMID: 25763931.
Lu CL, Qin L, Liu HC, Candas D, Fan M, Li JJ. Tumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition--a Warburg-reversing effect. PLoS One. 2015;10(3):e0121046. doi: 10.1371/journal.pone.0121046. eCollection 2015. PubMed PMID: 25807077; PubMed Central PMCID: PMC4373728.
Perks JR, Lucero S, Monjazeb AM, Li JJ. Anthropomorphic Phantoms for Confirmation of Linear Accelerator-Based Small Animal Irradiation. Cureus. 2015 Mar;7(3):e254. doi: 10.7759/cureus.254. eCollection 2015 Mar. PubMed PMID: 26180678; PubMed Central PMCID: PMC4494576.
Guo L, Xiao Y, Fan M, Li JJ, Wang Y. Profiling global kinome signatures of the radioresistant MCF-7/C6 breast cancer cells using MRM-based targeted proteomics. J Proteome Res. 2015 Jan 2;14(1):193-201. doi: 10.1021/pr500919w. Epub 2014 Nov 4. PubMed PMID: 25341124; PubMed Central PMCID: PMC4286165.
Candas D, Lu CL, Fan M, Chuang FY, Sweeney C, Borowsky AD, Li JJ. Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells. Cancer Res. 2014 Dec 15;74(24):7498-509. doi: 10.1158/0008-5472.CAN-14-0844. Epub 2014 Nov 6. PubMed PMID: 25377473; PubMed Central PMCID: PMC4267894.
Geng SQ, Alexandrou AT, Li JJ. Breast cancer stem cells: Multiple capacities in tumor metastasis. Cancer Lett. 2014 Jul 10;349(1):1-7. doi: 10.1016/j.canlet.2014.03.036. Epub 2014 Apr 12. Review. PubMed PMID: 24727284; PubMed Central PMCID: PMC4177877.
Wang Y, Li W, Patel SS, Cong J, Zhang N, Sabbatino F, Liu X, Qi Y, Huang P, Lee H, Taghian A, Li JJ, DeLeo AB, Ferrone S, Epperly MW, Ferrone CR, Ly A, Brachtel EF, Wang X. Blocking the formation of radiation-induced breast cancer stem cells. Oncotarget. 2014 Jun 15;5(11):3743-55. doi: 10.18632/oncotarget.1992. PubMed PMID: 25003837; PubMed Central PMCID: PMC4116517.
Wang Z, Fan M, Candas D, Zhang TQ, Qin L, Eldridge A, Wachsmann-Hogiu S, Ahmed KM, Chromy BA, Nantajit D, Duru N, He F, Chen M, Finkel T, Weinstein LS, Li JJ. Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression. Dev Cell. 2014 Apr 28;29(2):217-32. doi: 10.1016/j.devcel.2014.03.012. Epub 2014 Apr 17. PubMed PMID: 24746669; PubMed Central PMCID: PMC4156313.
Gao D, Li C, Xie X, Zhao P, Wei X, Sun W, Liu HC, Alexandrou AT, Jones J, Zhao R, Li JJ. Autologous tumor lysate-pulsed dendritic cell immunotherapy with cytokine-induced killer cells improves survival in gastric and colorectal cancer patients. PLoS One. 2014;9(4):e93886. doi: 10.1371/journal.pone.0093886. eCollection 2014. PubMed PMID: 24699863; PubMed Central PMCID: PMC3974849.
Zou JX, Duan Z, Wang J, Sokolov A, Xu J, Chen CZ, Li JJ, Chen HW. Kinesin family deregulation coordinated by bromodomain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistance. Mol Cancer Res. 2014 Apr;12(4):539-49. doi: 10.1158/1541-7786.MCR-13-0459. Epub 2014 Jan 3. PubMed PMID: 24391143; PubMed Central PMCID: PMC4139106.
Candas D, Li JJ. MnSOD in oxidative stress response-potential regulation via mitochondrial protein influx. Antioxid Redox Signal. 2014 Apr 1;20(10):1599-617. doi: 10.1089/ars.2013.5305. Epub 2013 Jun 8. Review. PubMed PMID: 23581847; PubMed Central PMCID: PMC3942709.
Alexandrou AT, Li JJ. Cell cycle regulators guide mitochondrial activity in radiation-induced adaptive response. Antioxid Redox Signal. 2014 Mar 20;20(9):1463-80. doi: 10.1089/ars.2013.5684. Epub 2014 Feb 14. Review. PubMed PMID: 24180340; PubMed Central PMCID: PMC3936506.
Duru N, Candas D, Jiang G, Li JJ. Breast cancer adaptive resistance: HER2 and cancer stem cell repopulation in a heterogeneous tumor society. J Cancer Res Clin Oncol. 2014 Jan;140(1):1-14. doi: 10.1007/s00432-013-1494-1. Epub 2013 Aug 30. Review. PubMed PMID: 23990015; PubMed Central PMCID: PMC3889683.
Bourguignon LY, Shiina M, Li JJ. Hyaluronan-CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor progression. Adv Cancer Res. 2014;123:255-75. doi: 10.1016/B978-0-12-800092-2.00010-1. Review. PubMed PMID: 25081533; PubMed Central PMCID: PMC6759082.
Diaz AJ, Tamae D, Yen Y, Li J, Wang T. Enhanced radiation response in radioresistant MCF-7 cells by targeting peroxiredoxin II. Breast Cancer (Dove Med Press). 2013;5:87-101. doi: 10.2147/BCTT.S51378. eCollection 2013. PubMed PMID: 24648762; PubMed Central PMCID: PMC3929248.
Ding NH, Li JJ, Sun LQ. Molecular mechanisms and treatment of radiation-induced lung fibrosis. Curr Drug Targets. 2013 Oct;14(11):1347-56. doi: 10.2174/13894501113149990198. Review. PubMed PMID: 23909719; PubMed Central PMCID: PMC4156316.
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