My Bibliography

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Sawant H, Sun B, Li Y, Zhu C, Meyer R, Sodhi K, Borthakur A, Bihl JC. Hyperglycemic Adipocyte-Derived Exosomes Cause Oxidative Stress and Lipid Peroxidation in Brain Microvascular Endothelial Cells. Curr Issues Mol Biol. 2026 Sep 1;48(9). doi: 10.3390/cimb48090896. PubMed PMID: 42793252; PubMed Central PMCID: PMC13605305.

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Sawant H, Butcher EL, Bihl JC, Arthur S. Extracellular Vesicles in the Gut-Vascular-Brain Axis: A Missing Mechanistic Link Between IBD and Stroke Risk. Biomolecules. 2026 Apr 14;16(4). doi: 10.3390/biom16040577. Review. PubMed PMID: 42072698; PubMed Central PMCID: PMC13113477.

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Grahe C, Egleton RD, Santanam N, Bihl JC. Nicotine-Mediated Alterations in Exosome Content: Implications for Stroke and Neurological Dysfunction. Biomolecules. 2026 Mar 19;16(3). doi: 10.3390/biom16030463. Review. PubMed PMID: 41897398; PubMed Central PMCID: PMC13023558.

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Sawant H, Bihl JC. Neurovascular Impairment in Type 2 Diabetes Mellitus: The Role of Adipocyte-Derived Exosomes. Biomolecules. 2026 Feb 3;16(2). doi: 10.3390/biom16020233. Review. PubMed PMID: 41750303; PubMed Central PMCID: PMC12937626.

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Pillai SS, Chaudhry MA, De Souza Goncalves B, Saeed I, Chaudhry H, Irtiza M, Williams CJ, Bihl J, Borthakur A, Thompson E, Sodhi K. Biomarker Profiling of Cardiac Causes for Chest Pain in Non-acute Coronary Syndrome Patients in West Virginia. Cureus. 2026 Feb;18(2):e104002. doi: 10.7759/cureus.104002. eCollection 2026 Feb. PubMed PMID: 41743145; PubMed Central PMCID: PMC12931920.

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Li Y, Sun B, Yao Z, Li X, Sawant H, Huang L, Wang XA, Wu P, Meng F, Chen J, Shi H, Bihl J. Microglia-derived iron-overloaded exosomes induce neuronal ferroptosis and aggravate neurological impairment after subarachnoid hemorrhage. J Nanobiotechnology. 2026 Jan 8;24(1):119. doi: 10.1186/s12951-025-03974-y. PubMed PMID: 41508018; PubMed Central PMCID: PMC12870926.

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Polaki V, Sawant H, Pinson B, Zhu C, Chen S, Bihl JC. Role of Exercise in Visceral Adipose Tissue Inflammation and Macrophage Polarization in Hypertensive Mice. Int J Mol Sci. 2025 Dec 25;27(1). doi: 10.3390/ijms27010251. PubMed PMID: 41516126; PubMed Central PMCID: PMC12785679.

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Sun B, Li Y, Lan S, Wang XA, Ling Y, Sawant H, Zhang B, Yang J, Wang J, Wu P, Xu S, Bihl J, Shi H. Retinoic acid-inducible gene-I aggravates neuroinflammation in early brain injury after subarachnoid hemorrhage through mediating brain microvascular endothelial cell pyroptosis. Neurotherapeutics. 2025 Jul;22(4):e00572. doi: 10.1016/j.neurot.2025.e00572. Epub 2025 Apr 2. PubMed PMID: 40175216; PubMed Central PMCID: PMC12418424.

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Sawant H, Bihl J, Borthakur A. A Simplified Method for the Isolation of Extracellular Vesicles from Probiotic Bacteria and Their Characterization. Int J Mol Sci. 2025 Jan 26;26(3). doi: 10.3390/ijms26031058. PubMed PMID: 39940832; PubMed Central PMCID: PMC11817318.

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Wang J, Chen S, Sawant H, Chen Y, Bihl JC. The miR-210 Primed Endothelial Progenitor Cell Exosomes Alleviate Acute Ischemic Brain Injury. Curr Stem Cell Res Ther. 2024;19(8):1164-1174. doi: 10.2174/011574888X266357230923113642. PubMed PMID: 37957914; PubMed Central PMCID: PMC11082070.

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Sawant H, Sun B, Mcgrady E, Bihl JC. Role of miRNAs in neurovascular injury and repair. J Cereb Blood Flow Metab. 2024 Oct;44(10):1693-1708. doi: 10.1177/0271678X241254772. Epub 2024 May 10. Review. PubMed PMID: 38726895; PubMed Central PMCID: PMC11494855.

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Chen S, Sigdel S, Sawant H, Bihl J, Wang J. Exercise-Intervened Endothelial Progenitor Cell Exosomes Protect N2a Cells by Improving Mitochondrial Function. Int J Mol Sci. 2024 Jan 17;25(2). doi: 10.3390/ijms25021148. PubMed PMID: 38256220; PubMed Central PMCID: PMC10816803.

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Sun B, Sawant H, Borthakur A, Bihl JC. Emerging therapeutic role of gut microbial extracellular vesicles in neurological disorders. Front Neurosci. 2023;17:1241418. doi: 10.3389/fnins.2023.1241418. eCollection 2023. Review. PubMed PMID: 37621715; PubMed Central PMCID: PMC10445154.

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Chen S, Polaki V, Bihl JC, Wang J. Compromised endothelial progenitor cell exosomal communication with endothelial cells in hypertension ischemia conditions. Front Stroke. 2022;1:1015463. doi: 10.3389/fstro.2022.1015463. Epub 2022 Oct 13. PubMed PMID: 39450345; PubMed Central PMCID: PMC11500974.

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Sawant H, Bihl T, Nguyen D, Iwuchukwu I, Bihl J. The profile of inflammatory extracellular vesicles in intracerebral hemorrhage patients. Front Stroke. 2022;1. doi: 10.3389/fstro.2022.988081. Epub 2022 Sep 19. PubMed PMID: 40129971; PubMed Central PMCID: PMC11932702.

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Yerrapragada SM, Sawant H, Chen S, Bihl T, Wang J, Bihl JC. The protective effects of miR-210 modified endothelial progenitor cells released exosomes in hypoxia/reoxygenation injured neurons. Exp Neurol. 2022 Dec;358:114211. doi: 10.1016/j.expneurol.2022.114211. Epub 2022 Aug 24. PubMed PMID: 36027941; PubMed Central PMCID: PMC11044201.

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Halurkar MS, Wang J, Chen S, Bihl JC. EPC-EXs improve astrocyte survival and oxidative stress through different uptaking pathways in diabetic hypoxia condition. Stem Cell Res Ther. 2022 Mar 3;13(1):91. doi: 10.1186/s13287-022-02766-7. PubMed PMID: 35241178; PubMed Central PMCID: PMC8896364.

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Wang J, Pothana K, Chen S, Sawant H, Travers JB, Bihl J, Chen Y. Ultraviolet B Irradiation Alters the Level and miR Contents of Exosomes Released by Keratinocytes in Diabetic Condition. Photochem Photobiol. 2022 Sep;98(5):1122-1130. doi: 10.1111/php.13583. Epub 2022 Jan 4. PubMed PMID: 34931322; PubMed Central PMCID: PMC9511213.

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Mattingly J, Li Y, Bihl JC, Wang J. The promise of exosome applications in treating central nervous system diseases. CNS Neurosci Ther. 2021 Dec;27(12):1437-1445. doi: 10.1111/cns.13743. Epub 2021 Oct 12. Review. PubMed PMID: 34636491; PubMed Central PMCID: PMC8611778.

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Liu L, Awoyemi AA, Fahy KE, Thapa P, Borchers C, Wu BY, McGlone CL, Schmeusser B, Sattouf Z, Rohan CA, Williams AR, Cates EE, Knisely C, Kelly LE, Bihl JC, Cool DR, Sahu RP, Wang J, Chen Y, Rapp CM, Kemp MG, Johnson RM, Travers JB. Keratinocyte-derived microvesicle particles mediate ultraviolet B radiation-induced systemic immunosuppression. J Clin Invest. 2021 May 17;131(10). doi: 10.1172/JCI144963. PubMed PMID: 33830943; PubMed Central PMCID: PMC8121517.

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Yerrapragada SM, Bihl JC. Role of Exosomes in Mediating the Cross-Talk Between Adipose Tissue and the Brain. Neuromolecular Med. 2022 Jun;24(2):57-61. doi: 10.1007/s12017-021-08664-0. Epub 2021 May 12. Review. PubMed PMID: 33978939; PubMed Central PMCID: PMC8674931.

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Li Y, Wu P, Bihl JC, Shi H. Underlying Mechanisms and Potential Therapeutic Molecular Targets in Blood-Brain Barrier Disruption after Subarachnoid Hemorrhage. Curr Neuropharmacol. 2020;18(12):1168-1179. doi: 10.2174/1570159X18666200106154203. Review. PubMed PMID: 31903882; PubMed Central PMCID: PMC7770641.

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Wang J, Polaki V, Chen S, Bihl JC. Exercise Improves Endothelial Function Associated with Alleviated Inflammation and Oxidative Stress of Perivascular Adipose Tissue in Type 2 Diabetic Mice. Oxid Med Cell Longev. 2020;2020:8830537. doi: 10.1155/2020/8830537. eCollection 2020. PubMed PMID: 33425218; PubMed Central PMCID: PMC7781720.

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Wang J, Chen S, Yerrapragada SM, Zhang W, Bihl JC. Therapeutic effects of exosomes from angiotensin-converting enzyme 2 - overexpressed endothelial progenitor cells on intracerebral hemorrhagic stroke. Brain Hemorrhages. 2021 Mar;2(1):57-62. doi: 10.1016/j.hest.2020.10.007. Epub 2020 Nov 30. PubMed PMID: 40129927; PubMed Central PMCID: PMC11932701.

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Li Y, Wang J, Chen S, Wu P, Xu S, Wang C, Shi H, Bihl J. miR-137 boosts the neuroprotective effect of endothelial progenitor cell-derived exosomes in oxyhemoglobin-treated SH-SY5Y cells partially via COX2/PGE2 pathway. Stem Cell Res Ther. 2020 Oct 26;11(1):330. doi: 10.1186/s13287-020-01836-y. PubMed PMID: 33100224; PubMed Central PMCID: PMC7586676.

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Wang J, Chen S, Zhang W, Chen Y, Bihl JC. Exosomes from miRNA-126-modified endothelial progenitor cells alleviate brain injury and promote functional recovery after stroke. CNS Neurosci Ther. 2020 Dec;26(12):1255-1265. doi: 10.1111/cns.13455. Epub 2020 Oct 3. PubMed PMID: 33009888; PubMed Central PMCID: PMC7702230.

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Liu L, Ye Q, Liu L, Bihl JC, Chen Y, Liu J, Cheng Q. C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway. J Transl Med. 2020 Aug 3;18(1):298. doi: 10.1186/s12967-020-02468-9. PubMed PMID: 32746845; PubMed Central PMCID: PMC7398185.

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Liu L, Fahy KE, Awoyemi AA, Thapa P, Kelly LE, Chen J, Bihl JC, Cool DR, Chen Y, Rapp CM, Johnson RM, Travers JB. Thermal Burn Injury Generates Bioactive Microvesicles: Evidence for a Novel Transport Mechanism for the Lipid Mediator Platelet-Activating Factor (PAF) That Involves Subcellular Particles and the PAF Receptor. J Immunol. 2020 Jul 1;205(1):193-201. doi: 10.4049/jimmunol.1901393. Epub 2020 May 20. PubMed PMID: 32434939; PubMed Central PMCID: PMC7342023.

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Li Y, Liu Y, Wu P, Tian Y, Liu B, Wang J, Bihl J, Shi H. Inhibition of Ferroptosis Alleviates Early Brain Injury After Subarachnoid Hemorrhage In Vitro and In Vivo via Reduction of Lipid Peroxidation. Cell Mol Neurobiol. 2021 Mar;41(2):263-278. doi: 10.1007/s10571-020-00850-1. Epub 2020 Apr 20. PubMed PMID: 32314126; PubMed Central PMCID: PMC11448630.

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Wang J, Chen S, Bihl J. Exosome-Mediated Transfer of ACE2 (Angiotensin-Converting Enzyme 2) from Endothelial Progenitor Cells Promotes Survival and Function of Endothelial Cell. Oxid Med Cell Longev. 2020;2020:4213541. doi: 10.1155/2020/4213541. eCollection 2020. PubMed PMID: 32051731; PubMed Central PMCID: PMC6995312.

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Li Y, Wu P, Dai J, Zhang T, Bihl J, Wang C, Liu Y, Shi H. Inhibition of mTOR Alleviates Early Brain Injury After Subarachnoid Hemorrhage Via Relieving Excessive Mitochondrial Fission. Cell Mol Neurobiol. 2020 May;40(4):629-642. doi: 10.1007/s10571-019-00760-x. Epub 2019 Nov 15. PubMed PMID: 31728694; PubMed Central PMCID: PMC11448794.

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Ma C, Wang J, Liu H, Chen Y, Ma X, Chen S, Chen Y, Bihl JI, Yang YI. Moderate Exercise Enhances Endothelial Progenitor Cell Exosomes Release and Function. Med Sci Sports Exerc. 2018 Oct;50(10):2024-2032. doi: 10.1249/MSS.0000000000001672. PubMed PMID: 30222687.

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Pan Q, Ma C, Wang Y, Wang J, Zheng J, Du D, Liao X, Chen Y, Chen Y, Bihl J, Chen C, Yang Y, Ma X. Microvesicles-mediated communication between endothelial cells modulates, endothelial survival, and angiogenic function via transferring of miR-125a-5p. J Cell Biochem. 2019 Mar;120(3):3160-3172. doi: 10.1002/jcb.27581. Epub 2018 Sep 11. PubMed PMID: 30272818.

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Ma X, Wang J, Li J, Ma C, Chen S, Lei W, Yang Y, Liu S, Bihl J, Chen C. Loading MiR-210 in Endothelial Progenitor Cells Derived Exosomes Boosts Their Beneficial Effects on Hypoxia/Reoxygeneation-Injured Human Endothelial Cells via Protecting Mitochondrial Function. Cell Physiol Biochem. 2018;46(2):664-675. doi: 10.1159/000488635. Epub 2018 Mar 29. PubMed PMID: 29621777.

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Zhang C, Wang J, Ma X, Wang W, Zhao B, Chen Y, Chen C, Bihl JC. ACE2-EPC-EXs protect ageing ECs against hypoxia/reoxygenation-induced injury through the miR-18a/Nox2/ROS pathway. J Cell Mol Med. 2018 Mar;22(3):1873-1882. doi: 10.1111/jcmm.13471. Epub 2018 Jan 24. PubMed PMID: 29363860; PubMed Central PMCID: PMC5824419.

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Liao FL, Tan L, Liu H, Wang JJ, Ma XT, Zhao B, Chen Y, Bihl J, Yang Y, Chen RL. Hematopoietic stem cell-derived exosomes promote hematopoietic differentiation of mouse embryonic stem cells in vitro via inhibiting the miR126/Notch1 pathway. Acta Pharmacol Sin. 2018 Apr;39(4):552-560. doi: 10.1038/aps.2017.130. Epub 2017 Oct 19. PubMed PMID: 29047461; PubMed Central PMCID: PMC5888680.

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Liu H, Wang J, Chen Y, Chen Y, Ma X, Bihl JC, Yang Y. NPC-EXs Alleviate Endothelial Oxidative Stress and Dysfunction through the miR-210 Downstream Nox2 and VEGFR2 Pathways. Oxid Med Cell Longev. 2017;2017:9397631. doi: 10.1155/2017/9397631. Epub 2017 May 28. PubMed PMID: 28630660; PubMed Central PMCID: PMC5467331.

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Fahy K, Liu L, Rapp CM, Borchers C, Bihl JC, Chen Y, Simman R, Travers JB. UVB-generated Microvesicle Particles: A Novel Pathway by Which a Skin-specific Stimulus Could Exert Systemic Effects. Photochem Photobiol. 2017 Jul;93(4):937-942. doi: 10.1111/php.12703. Epub 2017 Mar 2. Review. PubMed PMID: 28039861; PubMed Central PMCID: PMC5494001.

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Pan Q, He C, Liu H, Liao X, Dai B, Chen Y, Yang Y, Zhao B, Bihl J, Ma X. Microvascular endothelial cells-derived microvesicles imply in ischemic stroke by modulating astrocyte and blood brain barrier function and cerebral blood flow. Mol Brain. 2016 Jun 7;9(1):63. doi: 10.1186/s13041-016-0243-1. PubMed PMID: 27267759; PubMed Central PMCID: PMC4897950.

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Wang J, Zhong Y, Ma X, Xiao X, Cheng C, Chen Y, Iwuchukwu I, Gaines KJ, Zhao B, Liu S, Travers JB, Bihl JC, Chen Y. Analyses of Endothelial Cells and Endothelial Progenitor Cells Released Microvesicles by Using Microbead and Q-dot Based Nanoparticle Tracking Analysis. Sci Rep. 2016 Apr 20;6:24679. doi: 10.1038/srep24679. PubMed PMID: 27094208; PubMed Central PMCID: PMC4837394.

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Wang J, Guo R, Yang Y, Jacobs B, Chen S, Iwuchukwu I, Gaines KJ, Chen Y, Simman R, Lv G, Wu K, Bihl JC. The Novel Methods for Analysis of Exosomes Released from Endothelial Cells and Endothelial Progenitor Cells. Stem Cells Int. 2016;2016:2639728. doi: 10.1155/2016/2639728. Epub 2016 Mar 28. PubMed PMID: 27118976; PubMed Central PMCID: PMC4826946.

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Bihl JC, Rapp CM, Chen Y, Travers JB. UVB Generates Microvesicle Particle Release in Part Due to Platelet-activating Factor Signaling. Photochem Photobiol. 2016 May;92(3):503-6. doi: 10.1111/php.12577. Epub 2016 Mar 14. PubMed PMID: 26876152; PubMed Central PMCID: PMC5426906.

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Wu K, Yang Y, Zhong Y, Ammar HM, Zhang P, Guo R, Liu H, Cheng C, Koroscil TM, Chen Y, Liu S, Bihl JC. The effects of microvesicles on endothelial progenitor cells are compromised in type 2 diabetic patients via downregulation of the miR-126/VEGFR2 pathway. Am J Physiol Endocrinol Metab. 2016 May 15;310(10):E828-37. doi: 10.1152/ajpendo.00056.2016. Epub 2016 Mar 8. PubMed PMID: 26956185; PubMed Central PMCID: PMC4895450.

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Wang J, Chen Y, Yang Y, Xiao X, Chen S, Zhang C, Jacobs B, Zhao B, Bihl J, Chen Y. Endothelial progenitor cells and neural progenitor cells synergistically protect cerebral endothelial cells from Hypoxia/reoxygenation-induced injury via activating the PI3K/Akt pathway. Mol Brain. 2016 Feb 3;9:12. doi: 10.1186/s13041-016-0193-7. PubMed PMID: 26842559; PubMed Central PMCID: PMC4738765.

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Bihl J, Rapp C, Chen Y, Travers J. UVB generates microvesicle particle release in part due to platelet-activating factor signaling. [revised 2016 January]. Photochemistry and Photobiology; 2016.

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Xiao X, Ma X, Liu L, Wang J, Bi K, Liu Y, Fan R, Zhao B, Chen Y, Bihl JC. Cellular Membrane Microparticles: Potential Targets of Combinational Therapy for Vascular Disease. Curr Vasc Pharmacol. 2015;13(4):449-58. doi: 10.2174/1570161112666141014145440. Review. PubMed PMID: 25360845.

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Bihl JC, Zhang C, Zhao Y, Xiao X, Ma X, Chen Y, Chen S, Zhao B, Chen Y. Angiotensin-(1-7) counteracts the effects of Ang II on vascular smooth muscle cells, vascular remodeling and hemorrhagic stroke: Role of the NFкB inflammatory pathway. Vascul Pharmacol. 2015 Oct;73:115-123. doi: 10.1016/j.vph.2015.08.007. Epub 2015 Aug 8. PubMed PMID: 26264508; PubMed Central PMCID: PMC4617528.

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Chen Y, Xiao Y, Lin Z, Xiao X, He C, Bihl JC, Zhao B, Ma X, Chen Y. The Role of Circulating Platelets Microparticles and Platelet Parameters in Acute Ischemic Stroke Patients. J Stroke Cerebrovasc Dis. 2015 Oct;24(10):2313-20. doi: 10.1016/j.jstrokecerebrovasdis.2015.06.018. Epub 2015 Jul 11. PubMed PMID: 26169549; PubMed Central PMCID: PMC4592794.

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Xiao X, Zhang C, Ma X, Miao H, Wang J, Liu L, Chen S, Zeng R, Chen Y, Bihl JC. Angiotensin-(1-7) counteracts angiotensin II-induced dysfunction in cerebral endothelial cells via modulating Nox2/ROS and PI3K/NO pathways. Exp Cell Res. 2015 Aug 1;336(1):58-65. doi: 10.1016/j.yexcr.2015.06.010. Epub 2015 Jun 19. PubMed PMID: 26101159; PubMed Central PMCID: PMC4509813.

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Yi D, Bihl J, Newman MS, Chen Y, Simman R. The preliminary study of effects of tolfenamic Acid on cell proliferation, cell apoptosis, and intracellular collagen deposition in keloid fibroblasts in vitro. Dermatol Res Pract. 2014;2014:736957. doi: 10.1155/2014/736957. Epub 2014 Sep 22. PubMed PMID: 25328513; PubMed Central PMCID: PMC4190122.