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Wang J, Polaki V, Chen S, Bihl JC. Exercise Improves Endothelial Function Associated with Alleviated Inflammation and Oxidative Stress of Perivascular Adipose Tissue in Type 2 Diabetic Mice. Oxid Med Cell Longev. 2020;2020:8830537. doi: 10.1155/2020/8830537. eCollection 2020. PubMed PMID: 33425218; PubMed Central PMCID: PMC7781720.
Wang J, Chen S, Zhang W, Chen Y, Bihl JC. Exosomes from miRNA-126-modified endothelial progenitor cells alleviate brain injury and promote functional recovery after stroke. CNS Neurosci Ther. 2020 Dec;26(12):1255-1265. doi: 10.1111/cns.13455. Epub 2020 Oct 3. PubMed PMID: 33009888; PubMed Central PMCID: PMC7702230.
Li Y, Wang J, Chen S, Wu P, Xu S, Wang C, Shi H, Bihl J. miR-137 boosts the neuroprotective effect of endothelial progenitor cell-derived exosomes in oxyhemoglobin-treated SH-SY5Y cells partially via COX2/PGE2 pathway. Stem Cell Res Ther. 2020 Oct 26;11(1):330. doi: 10.1186/s13287-020-01836-y. PubMed PMID: 33100224; PubMed Central PMCID: PMC7586676.
Zhang H, Pan Q, Xie Z, Chen Y, Wang J, Bihl J, Zhong W, Chen Y, Zhao B, Ma X. Implication of MicroRNA503 in Brain Endothelial Cell Function and Ischemic Stroke. Transl Stroke Res. 2020 Oct;11(5):1148-1164. doi: 10.1007/s12975-020-00794-0. Epub 2020 Apr 14. PubMed PMID: 32285355.
Liu L, Ye Q, Liu L, Bihl JC, Chen Y, Liu J, Cheng Q. C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway. J Transl Med. 2020 Aug 3;18(1):298. doi: 10.1186/s12967-020-02468-9. PubMed PMID: 32746845; PubMed Central PMCID: PMC7398185.
Liu L, Fahy KE, Awoyemi AA, Thapa P, Kelly LE, Chen J, Bihl JC, Cool DR, Chen Y, Rapp CM, Johnson RM, Travers JB. Thermal Burn Injury Generates Bioactive Microvesicles: Evidence for a Novel Transport Mechanism for the Lipid Mediator Platelet-Activating Factor (PAF) That Involves Subcellular Particles and the PAF Receptor. J Immunol. 2020 Jul 1;205(1):193-201. doi: 10.4049/jimmunol.1901393. Epub 2020 May 20. PubMed PMID: 32434939; PubMed Central PMCID: PMC7342023.
Pan Q, Kuang X, Cai S, Wang X, Du D, Wang J, Wang Y, Chen Y, Bihl J, Chen Y, Zhao B, Ma X. miR-132-3p priming enhances the effects of mesenchymal stromal cell-derived exosomes on ameliorating brain ischemic injury. Stem Cell Res Ther. 2020 Jun 29;11(1):260. doi: 10.1186/s13287-020-01761-0. PubMed PMID: 32600449; PubMed Central PMCID: PMC7322840.
Li Y, Wu P, Dai J, Zhang T, Bihl J, Wang C, Liu Y, Shi H. Inhibition of mTOR Alleviates Early Brain Injury After Subarachnoid Hemorrhage Via Relieving Excessive Mitochondrial Fission. Cell Mol Neurobiol. 2020 May;40(4):629-642. doi: 10.1007/s10571-019-00760-x. Epub 2019 Nov 15. PubMed PMID: 31728694.
Li Y, Liu Y, Wu P, Tian Y, Liu B, Wang J, Bihl J, Shi H. Inhibition of Ferroptosis Alleviates Early Brain Injury After Subarachnoid Hemorrhage In Vitro and In Vivo via Reduction of Lipid Peroxidation. Cell Mol Neurobiol. 2020 Apr 20;. doi: 10.1007/s10571-020-00850-1. [Epub ahead of print] PubMed PMID: 32314126.
Wang J, Chen S, Bihl J. Exosome-Mediated Transfer of ACE2 (Angiotensin-Converting Enzyme 2) from Endothelial Progenitor Cells Promotes Survival and Function of Endothelial Cell. Oxid Med Cell Longev. 2020;2020:4213541. doi: 10.1155/2020/4213541. eCollection 2020. PubMed PMID: 32051731; PubMed Central PMCID: PMC6995312.
Li Y, Wu P, Bihl JC, Shi H. Underlying Mechanisms and Potential Therapeutic Molecular Targets in Blood-Brain Barrier Disruption after Subarachnoid Hemorrhage. Curr Neuropharmacol. 2020;18(12):1168-1179. doi: 10.2174/1570159X18666200106154203. PubMed PMID: 31903882; PubMed Central PMCID: PMC7770641.
Pan Q, Ma C, Wang Y, Wang J, Zheng J, Du D, Liao X, Chen Y, Chen Y, Bihl J, Chen C, Yang Y, Ma X. Microvesicles-mediated communication between endothelial cells modulates, endothelial survival, and angiogenic function via transferring of miR-125a-5p. J Cell Biochem. 2019 Mar;120(3):3160-3172. doi: 10.1002/jcb.27581. Epub 2018 Sep 11. PubMed PMID: 30272818.
Ma C, Wang J, Liu H, Chen Y, Ma X, Chen S, Chen Y, Bihl JI, Yang YI. Moderate Exercise Enhances Endothelial Progenitor Cell Exosomes Release and Function. Med Sci Sports Exerc. 2018 Oct;50(10):2024-2032. doi: 10.1249/MSS.0000000000001672. PubMed PMID: 30222687.
Liao FL, Tan L, Liu H, Wang JJ, Ma XT, Zhao B, Chen Y, Bihl J, Yang Y, Chen RL. Hematopoietic stem cell-derived exosomes promote hematopoietic differentiation of mouse embryonic stem cells in vitro via inhibiting the miR126/Notch1 pathway. Acta Pharmacol Sin. 2018 Apr;39(4):552-560. doi: 10.1038/aps.2017.130. Epub 2017 Oct 19. PubMed PMID: 29047461; PubMed Central PMCID: PMC5888680.
Ma X, Wang J, Li J, Ma C, Chen S, Lei W, Yang Y, Liu S, Bihl J, Chen C. Loading MiR-210 in Endothelial Progenitor Cells Derived Exosomes Boosts Their Beneficial Effects on Hypoxia/Reoxygeneation-Injured Human Endothelial Cells via Protecting Mitochondrial Function. Cell Physiol Biochem. 2018;46(2):664-675. doi: 10.1159/000488635. Epub 2018 Mar 29. PubMed PMID: 29621777.
Zhang C, Wang J, Ma X, Wang W, Zhao B, Chen Y, Chen C, Bihl JC. ACE2-EPC-EXs protect ageing ECs against hypoxia/reoxygenation-induced injury through the miR-18a/Nox2/ROS pathway. J Cell Mol Med. 2018 Mar;22(3):1873-1882. doi: 10.1111/jcmm.13471. Epub 2018 Jan 24. PubMed PMID: 29363860; PubMed Central PMCID: PMC5824419.
Fahy K, Liu L, Rapp CM, Borchers C, Bihl JC, Chen Y, Simman R, Travers JB. UVB-generated Microvesicle Particles: A Novel Pathway by Which a Skin-specific Stimulus Could Exert Systemic Effects. Photochem Photobiol. 2017 Jul;93(4):937-942. doi: 10.1111/php.12703. Epub 2017 Mar 2. Review. PubMed PMID: 28039861; PubMed Central PMCID: PMC5494001.
Sun X, Ma X, Wang J, Zhao Y, Wang Y, Bihl JC, Chen Y, Jiang C. Glioma stem cells-derived exosomes promote the angiogenic ability of endothelial cells through miR-21/VEGF signal. Oncotarget. 2017 May 30;8(22):36137-36148. doi: 10.18632/oncotarget.16661. PubMed PMID: 28410224; PubMed Central PMCID: PMC5482644.
Liu H, Wang J, Chen Y, Chen Y, Ma X, Bihl JC, Yang Y. NPC-EXs Alleviate Endothelial Oxidative Stress and Dysfunction through the miR-210 Downstream Nox2 and VEGFR2 Pathways. Oxid Med Cell Longev. 2017;2017:9397631. doi: 10.1155/2017/9397631. Epub 2017 May 28. PubMed PMID: 28630660; PubMed Central PMCID: PMC5467331.
Pan Q, He C, Liu H, Liao X, Dai B, Chen Y, Yang Y, Zhao B, Bihl J, Ma X. Microvascular endothelial cells-derived microvesicles imply in ischemic stroke by modulating astrocyte and blood brain barrier function and cerebral blood flow. Mol Brain. 2016 Jun 7;9(1):63. doi: 10.1186/s13041-016-0243-1. PubMed PMID: 27267759; PubMed Central PMCID: PMC4897950.
Wu K, Yang Y, Zhong Y, Ammar HM, Zhang P, Guo R, Liu H, Cheng C, Koroscil TM, Chen Y, Liu S, Bihl JC. The effects of microvesicles on endothelial progenitor cells are compromised in type 2 diabetic patients via downregulation of the miR-126/VEGFR2 pathway. Am J Physiol Endocrinol Metab. 2016 May 15;310(10):E828-37. doi: 10.1152/ajpendo.00056.2016. Epub 2016 Mar 8. PubMed PMID: 26956185; PubMed Central PMCID: PMC4895450.
Bihl JC, Rapp CM, Chen Y, Travers JB. UVB Generates Microvesicle Particle Release in Part Due to Platelet-activating Factor Signaling. Photochem Photobiol. 2016 May;92(3):503-6. doi: 10.1111/php.12577. Epub 2016 Mar 14. PubMed PMID: 26876152; PubMed Central PMCID: PMC5426906.
Wang J, Zhong Y, Ma X, Xiao X, Cheng C, Chen Y, Iwuchukwu I, Gaines KJ, Zhao B, Liu S, Travers JB, Bihl JC, Chen Y. Analyses of Endothelial Cells and Endothelial Progenitor Cells Released Microvesicles by Using Microbead and Q-dot Based Nanoparticle Tracking Analysis. Sci Rep. 2016 Apr 20;6:24679. doi: 10.1038/srep24679. PubMed PMID: 27094208; PubMed Central PMCID: PMC4837394.
Wang J, Guo R, Yang Y, Jacobs B, Chen S, Iwuchukwu I, Gaines KJ, Chen Y, Simman R, Lv G, Wu K, Bihl JC. The Novel Methods for Analysis of Exosomes Released from Endothelial Cells and Endothelial Progenitor Cells. Stem Cells Int. 2016;2016:2639728. doi: 10.1155/2016/2639728. Epub 2016 Mar 28. PubMed PMID: 27118976; PubMed Central PMCID: PMC4826946.
Wang J, Chen Y, Yang Y, Xiao X, Chen S, Zhang C, Jacobs B, Zhao B, Bihl J, Chen Y. Endothelial progenitor cells and neural progenitor cells synergistically protect cerebral endothelial cells from Hypoxia/reoxygenation-induced injury via activating the PI3K/Akt pathway. Mol Brain. 2016 Feb 3;9:12. doi: 10.1186/s13041-016-0193-7. PubMed PMID: 26842559; PubMed Central PMCID: PMC4738765.
Bihl J, Rapp C, Chen Y, Travers J. UVB generates microvesicle particle release in part due to platelet-activating factor signaling. [revised 2016 January]. Photochemistry and Photobiology; 2016. .
Chen Y, Xiao Y, Lin Z, Xiao X, He C, Bihl JC, Zhao B, Ma X, Chen Y. The Role of Circulating Platelets Microparticles and Platelet Parameters in Acute Ischemic Stroke Patients. J Stroke Cerebrovasc Dis. 2015 Oct;24(10):2313-20. doi: 10.1016/j.jstrokecerebrovasdis.2015.06.018. Epub 2015 Jul 11. PubMed PMID: 26169549; PubMed Central PMCID: PMC4592794.
Bihl JC, Zhang C, Zhao Y, Xiao X, Ma X, Chen Y, Chen S, Zhao B, Chen Y. Angiotensin-(1-7) counteracts the effects of Ang II on vascular smooth muscle cells, vascular remodeling and hemorrhagic stroke: Role of the NFкB inflammatory pathway. Vascul Pharmacol. 2015 Oct;73:115-123. doi: 10.1016/j.vph.2015.08.007. Epub 2015 Aug 8. PubMed PMID: 26264508; PubMed Central PMCID: PMC4617528.
Xiao X, Zhang C, Ma X, Miao H, Wang J, Liu L, Chen S, Zeng R, Chen Y, Bihl JC. Angiotensin-(1-7) counteracts angiotensin II-induced dysfunction in cerebral endothelial cells via modulating Nox2/ROS and PI3K/NO pathways. Exp Cell Res. 2015 Aug 1;336(1):58-65. doi: 10.1016/j.yexcr.2015.06.010. Epub 2015 Jun 19. PubMed PMID: 26101159; PubMed Central PMCID: PMC4509813.
Xiao X, Ma X, Liu L, Wang J, Bi K, Liu Y, Fan R, Zhao B, Chen Y, Bihl JC. Cellular Membrane Microparticles: Potential Targets of Combinational Therapy for Vascular Disease. Curr Vasc Pharmacol. 2015;13(4):449-58. doi: 10.2174/1570161112666141014145440. Review. PubMed PMID: 25360845.
Yi D, Bihl J, Newman MS, Chen Y, Simman R. The preliminary study of effects of tolfenamic Acid on cell proliferation, cell apoptosis, and intracellular collagen deposition in keloid fibroblasts in vitro. Dermatol Res Pract. 2014;2014:736957. doi: 10.1155/2014/736957. Epub 2014 Sep 22. PubMed PMID: 25328513; PubMed Central PMCID: PMC4190122.
Zheng J, Li G, Chen S, Bihl J, Buck J, Zhu Y, Xia H, Lazartigues E, Chen Y, Olson JE. Activation of the ACE2/Ang-(1-7)/Mas pathway reduces oxygen-glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction. Neuroscience. 2014 Jul 25;273:39-51. doi: 10.1016/j.neuroscience.2014.04.060. Epub 2014 May 9. PubMed PMID: 24814023; PubMed Central PMCID: PMC4159741.
Chen J, Zhao Y, Chen S, Wang J, Xiao X, Ma X, Penchikala M, Xia H, Lazartigues E, Zhao B, Chen Y. Neuronal over-expression of ACE2 protects brain from ischemia-induced damage. Neuropharmacology. 2014 Apr;79:550-8. doi: 10.1016/j.neuropharm.2014.01.004. Epub 2014 Jan 15. PubMed PMID: 24440367; PubMed Central PMCID: PMC3992949.
Gu S, Zhang W, Chen J, Ma R, Xiao X, Ma X, Yao Z, Chen Y. EPC-derived microvesicles protect cardiomyocytes from Ang II-induced hypertrophy and apoptosis. PLoS One. 2014;9(1):e85396. doi: 10.1371/journal.pone.0085396. eCollection 2014. PubMed PMID: 24392165; PubMed Central PMCID: PMC3879348.
Ma X, Zhang H, Pan Q, Zhao Y, Chen J, Zhao B, Chen Y. Hypoxia/Aglycemia-induced endothelial barrier dysfunction and tight junction protein downregulation can be ameliorated by citicoline. PLoS One. 2013;8(12):e82604. doi: 10.1371/journal.pone.0082604. eCollection 2013. PubMed PMID: 24358213; PubMed Central PMCID: PMC3865100.
Wang J, Chen S, Ma X, Cheng C, Xiao X, Chen J, Liu S, Zhao B, Chen Y. Effects of endothelial progenitor cell-derived microvesicles on hypoxia/reoxygenation-induced endothelial dysfunction and apoptosis. Oxid Med Cell Longev. 2013;2013:572729. doi: 10.1155/2013/572729. Epub 2013 Oct 28. PubMed PMID: 24288585; PubMed Central PMCID: PMC3830832.
Chen J, Xiao X, Chen S, Zhang C, Chen J, Yi D, Shenoy V, Raizada MK, Zhao B, Chen Y. Angiotensin-converting enzyme 2 priming enhances the function of endothelial progenitor cells and their therapeutic efficacy. Hypertension. 2013 Mar;61(3):681-9. doi: 10.1161/HYPERTENSIONAHA.111.00202. Epub 2012 Dec 24. PubMed PMID: 23266545; PubMed Central PMCID: PMC4011714.
Zhao YH, Yuan B, Chen J, Feng DH, Zhao B, Qin C, Chen YF. Endothelial progenitor cells: therapeutic perspective for ischemic stroke. CNS Neurosci Ther. 2013 Feb;19(2):67-75. doi: 10.1111/cns.12040. Epub 2012 Dec 11. Review. PubMed PMID: 23230897; PubMed Central PMCID: PMC4043291.
Chen J, Chen J, Chen S, Zhang C, Zhang L, Xiao X, Das A, Zhao Y, Yuan B, Morris M, Zhao B, Chen Y. Transfusion of CXCR4-primed endothelial progenitor cells reduces cerebral ischemic damage and promotes repair in db/db diabetic mice. PLoS One. 2012;7(11):e50105. doi: 10.1371/journal.pone.0050105. Epub 2012 Nov 21. PubMed PMID: 23185548; PubMed Central PMCID: PMC3503762.
Chen J, Tang YX, Liu YM, Chen J, Hu XQ, Liu N, Wang SX, Zhang Y, Zeng WG, Ni HJ, Zhao B, Chen YF, Tang ZP. Transplantation of adipose-derived stem cells is associated with neural differentiation and functional improvement in a rat model of intracerebral hemorrhage. CNS Neurosci Ther. 2012 Oct;18(10):847-54. doi: 10.1111/j.1755-5949.2012.00382.x. Epub 2012 Aug 31. PubMed PMID: 22934896; PubMed Central PMCID: PMC6493568.
Gu X, Lu Y, Chen J, He H, Li P, Yang T, Li L, Liu G, Chen Y, Zhang L. Mechanisms mediating propofol protection of pulmonary epithelial cells against lipopolysaccharide-induced cell death. Clin Exp Pharmacol Physiol. 2012 May;39(5):447-53. doi: 10.1111/j.1440-1681.2012.05694.x. PubMed PMID: 22360610.
Chen J, Chen S, Chen Y, Zhang C, Wang J, Zhang W, Liu G, Zhao B, Chen Y. Circulating endothelial progenitor cells and cellular membrane microparticles in db/db diabetic mouse: possible implications in cerebral ischemic damage. Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E62-71. doi: 10.1152/ajpendo.00026.2011. Epub 2011 Apr 19. PubMed PMID: 21505143; PubMed Central PMCID: PMC3129837.
Chen J, Wang XM, Wu XJ, Wang Y, Zhao H, Shen B, Wang GQ. Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B. Inflamm Res. 2011 Jan;60(1):47-53. doi: 10.1007/s00011-010-0233-1. Epub 2010 Jul 27. PubMed PMID: 20661763.
Chen J, Wang Y, Wu XJ, Li J, Hou FQ, Wang GQ. Pegylated interferon α-2b up-regulates specific CD8+ T cells in patients with chronic hepatitis B. World J Gastroenterol. 2010 Dec 28;16(48):6145-50. doi: 10.3748/wjg.v16.i48.6145. PubMed PMID: 21182232; PubMed Central PMCID: PMC3012572.
Zhu P, Chen JM, Chen SZ, Zhang C, Zheng SY, Long G, Chen J, Zhou ZL, Fan RX, Fan XP, Chen YF, Zhuang J. Matrine inhibits vascular smooth muscle cell proliferation by modulating the expression of cell cycle regulatory genes. Acta Pharmacol Sin. 2010 Oct;31(10):1329-35. doi: 10.1038/aps.2010.145. Epub 2010 Sep 13. PubMed PMID: 20835268; PubMed Central PMCID: PMC4012916.
Wu XJ, Wang Y, Chen J, Wang GQ. Baseline predictors of virological response for chronic hepatitis B patients. World J Gastroenterol. 2009 Sep 14;15(34):4311-5. doi: 10.3748/wjg.15.4311. PubMed PMID: 19750575; PubMed Central PMCID: PMC2744188.
Chen J, Wu XJ, Wang GQ. Hepatoma cells up-regulate expression of programmed cell death-1 on T cells. World J Gastroenterol. 2008 Nov 28;14(44):6853-7. doi: 10.3748/wjg.14.6853. PubMed PMID: 19058313; PubMed Central PMCID: PMC2773882.
Wu XJ, Chen J, Zhu MH, Hong Y, Zhong L, Wang GQ. [HBV transinfected enhances the PD-L expression of cytokines stimulating]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008 Oct;22(5):333-5. PubMed PMID: 19469166.
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