My Bibliography

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Gracey EG, Kandel SE, Lampe JN. Pseudomonas aeruginosa co-opts host antibiotic metabolism by pyocyanin induction of cytochrome P450 enzymes. bioRxiv. 2026 Jul 27;. doi: 10.64898/2026.07.25.740721. PubMed PMID: 42619675; PubMed Central PMCID: PMC13483869.

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Cheruzel L, Argikar UA, Brunetti P, Chatzopoulou M, Chen L, Cho S, Dhaware D, Heck CJS, Honrao C, Khojasteh SC, Lampe JN, Lang J, Ma B, Ma S, Rehm K, Rowley JA, Seneviratne HK, Seo H, Tang LWT, Wang YT, Wei C. Biotransformation research advances-2025 year in review. Drug Metab Rev. 2026 Aug;58(3):306-354. doi: 10.1080/03602532.2026.2666155. Epub 2026 May 25. Review. PubMed PMID: 42059906.

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Gracey EG, Kandel SE, Lampe JN. A CYP3A7 metabolically competent human induced pluripotent stem cell-derived hepatocyte-like cell (hHLC(3A7)) model for drug safety assessment in the newborn. Drug Metab Dispos. 2026 Jun;54(6):100314. doi: 10.1016/j.dmd.2026.100314. Epub 2026 Apr 30. PubMed PMID: 42224858.

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Hvizdak M, Kandel SE, Lampe JN. New Mechanistic Evidence for Perfluorodecanoic Acid (PFDA) Teratogenicity via CYP26A1-Mediated Retinoic Acid Metabolism and Signaling. Chem Res Toxicol. 2026 Apr 20;39(4):566-583. doi: 10.1021/acs.chemrestox.5c00468. Epub 2026 Mar 30. PubMed PMID: 41910604; PubMed Central PMCID: PMC13100982.

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Gracey EG, Lampe JN. Novel emerging cell and organoid systems for the study of drug metabolism and toxicity in humans. Drug Metab Dispos. 2025 Dec;53(12):100188. doi: 10.1016/j.dmd.2025.100188. Epub 2025 Oct 22. Review. PubMed PMID: 41252796; PubMed Central PMCID: PMC13095430.

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Kandel SE, Lampe JN. The anti-inflammatory drug celecoxib is metabolized by Pseudomonas aeruginosa CYP107S1 in vitro and in vivo. Drug Metab Dispos. 2025 Dec;53(12):100184. doi: 10.1016/j.dmd.2025.100184. Epub 2025 Oct 21. PubMed PMID: 41237685; PubMed Central PMCID: PMC13095469.

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Pentyala A, Kandel SE, Lampe JN. Mechanistic insights into human carboxylesterase 2 (CES2) inhibition by the CES1 prodrug substrate remdesivir. Drug Metab Dispos. 2025 Oct;53(10):100158. doi: 10.1016/j.dmd.2025.100158. Epub 2025 Sep 8. PubMed PMID: 41061301; PubMed Central PMCID: PMC13095431.

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Work HM, Kandel SE, Lampe JN. Comparison of the CYP3A Selective Inhibitors CYP3cide, Clobetasol, and Azamulin for Their Potential to Distinguish CYP3A7 Activity in the Presence of CYP3A4/5. Drug Metab Dispos. 2024 Oct 16;52(11):1224-1233. doi: 10.1124/dmd.124.001598. PubMed PMID: 38702193; PubMed Central PMCID: PMC11495666.

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Kandel SE, Tooker BC, Lampe JN. Drug metabolism of ciprofloxacin, ivacaftor, and raloxifene by Pseudomonas aeruginosa cytochrome P450 CYP107S1. J Biol Chem. 2024 Aug;300(8):107594. doi: 10.1016/j.jbc.2024.107594. Epub 2024 Jul 18. PubMed PMID: 39032655; PubMed Central PMCID: PMC11382314.

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Work HM, Hackett JC, Lampe JN. HCV Antiviral Drugs Have the Potential to Adversely Perturb the Fetal-Maternal Communication Axis through Inhibition of CYP3A7 DHEA-S Oxidation. Drug Metab Dispos. 2024 May 16;52(6):516-525. doi: 10.1124/dmd.123.001434. PubMed PMID: 38267095; PubMed Central PMCID: PMC11114604.

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Liu J, Kandel SE, Lampe JN, Scott EE. Correction: Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate. J Biol Chem. 2023 Oct;299(10):105283. doi: 10.1016/j.jbc.2023.105283. Epub 2023 Sep 30. PubMed PMID: 37783037; PubMed Central PMCID: PMC10551884.

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Kandel SE, Gracey EG, Lampe JN. Consideration of Nevirapine Analogs To Reduce Metabolically Linked Hepatotoxicity: A Cautionary Tale of the Deuteration Approach. Chem Res Toxicol. 2023 Oct 16;36(10):1631-1642. doi: 10.1021/acs.chemrestox.3c00192. Epub 2023 Sep 28. PubMed PMID: 37769118; PubMed Central PMCID: PMC10583834.

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Liu J, Kandel SE, Lampe JN, Scott EE. Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate. J Biol Chem. 2023 Aug;299(8):104993. doi: 10.1016/j.jbc.2023.104993. Epub 2023 Jun 29. PubMed PMID: 37392852; PubMed Central PMCID: PMC10388207.

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Malachowska B, Yang WL, Qualman A, Muro I, Boe DM, Lampe JN, Kovacs EJ, Idrovo JP. Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims. Commun Biol. 2023 Jun 2;6(1):597. doi: 10.1038/s42003-023-04964-2. PubMed PMID: 37268765; PubMed Central PMCID: PMC10238406.

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Hvizdak M, Kandel SE, Work HM, Gracey EG, McCullough RL, Lampe JN. Per- and polyfluoroalkyl substances (PFAS) inhibit cytochrome P450 CYP3A7 through direct coordination to the heme iron and water displacement. J Inorg Biochem. 2023 Mar;240:112120. doi: 10.1016/j.jinorgbio.2023.112120. Epub 2023 Jan 4. PubMed PMID: 36638633; PubMed Central PMCID: PMC10016736.

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Haynes AS, Prinzi A, Silveira LJ, Parker SK, Lampe JN, Kavanaugh JS, Horswill AR, Fish D. Cefadroxil Comparable to Cephalexin: Minimum Inhibitory Concentrations among Methicillin-Susceptible Staphylococcus aureus Isolates from Pediatric Musculoskeletal Infections. Microbiol Spectr. 2022 Aug 31;10(4):e0103922. doi: 10.1128/spectrum.01039-22. Epub 2022 Jun 22. PubMed PMID: 35730963; PubMed Central PMCID: PMC9431593.

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Hicks EG, Kandel SE, Lampe JN. Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (M(pro)) inhibitors. Bioorg Med Chem Lett. 2022 Jun 15;66:128732. doi: 10.1016/j.bmcl.2022.128732. Epub 2022 Apr 12. PubMed PMID: 35427739; PubMed Central PMCID: PMC9004148.

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Tooker BC, Kandel SE, Work HM, Lampe JN. Pseudomonas aeruginosa cytochrome P450 CYP168A1 is a fatty acid hydroxylase that metabolizes arachidonic acid to the vasodilator 19-HETE. J Biol Chem. 2022 Mar;298(3):101629. doi: 10.1016/j.jbc.2022.101629. Epub 2022 Jan 24. PubMed PMID: 35085556; PubMed Central PMCID: PMC8913318.

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Tooker B, Kandel S, Work H, Lampe J. <i>Pseudomonas aeruginosa</i> cytochrome P450 CYP168A1 is a fatty acid hydroxylase that metabolizes arachidonic acid to the vasodilator 19-HETE. [Preprint]. 2021 October. doi: 10.1101/2021.10.19.465045.

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Work HM, Kandel SE, Lampe JN. Characterization of fluorescent probe substrates to develop an efficient high-throughput assay for neonatal hepatic CYP3A7 inhibition screening. Sci Rep. 2021 Sep 30;11(1):19443. doi: 10.1038/s41598-021-98219-x. PubMed PMID: 34593846; PubMed Central PMCID: PMC8484451.

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Kandel SE, Lampe JN. Inhibition of CYP3A7 DHEA-S Oxidation by Lopinavir and Ritonavir: An Alternative Mechanism for Adrenal Impairment in HIV Antiretroviral-Treated Neonates. Chem Res Toxicol. 2021 Apr 19;34(4):1150-1160. doi: 10.1021/acs.chemrestox.1c00028. Epub 2021 Apr 6. PubMed PMID: 33821626; PubMed Central PMCID: PMC8058764.

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Shum S, Isoherranen N. Human Fetal Liver Metabolism of Oxycodone Is Mediated by CYP3A7. AAPS J. 2021 Jan 12;23(1):24. doi: 10.1208/s12248-020-00537-x. PubMed PMID: 33438174; PubMed Central PMCID: PMC8106324.

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Li H, Lampe JN. Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism. Arch Biochem Biophys. 2019 Sep 30;673:108078. doi: 10.1016/j.abb.2019.108078. Epub 2019 Aug 22. Review. PubMed PMID: 31445893; PubMed Central PMCID: PMC6739124.

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Bishop SC, Winefield R, Anbanandam A, Lampe JN. Aqueous synthesis of a small-molecule lanthanide chelator amenable to copper-free click chemistry. PLoS One. 2019;14(3):e0209726. doi: 10.1371/journal.pone.0209726. eCollection 2019. PubMed PMID: 30917122; PubMed Central PMCID: PMC6436693.

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Boxberger KH, Hagenbuch B, Lampe JN. Ligand-dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channel. Biochem Pharmacol. 2018 Oct;156:371-384. doi: 10.1016/j.bcp.2018.08.028. Epub 2018 Aug 20. PubMed PMID: 30138624; PubMed Central PMCID: PMC6195816.

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Kandel SE, Han LW, Mao Q, Lampe JN. Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7. Drug Metab Dispos. 2017 Dec;45(12):1266-1275. doi: 10.1124/dmd.117.078055. Epub 2017 Oct 6. PubMed PMID: 28986474; PubMed Central PMCID: PMC5697443.

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Lampe JN. Advances in the Understanding of Protein-Protein Interactions in Drug Metabolizing Enzymes through the Use of Biophysical Techniques. Front Pharmacol. 2017;8:521. doi: 10.3389/fphar.2017.00521. eCollection 2017. Review. PubMed PMID: 28848438; PubMed Central PMCID: PMC5550701.

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Beggs KM, McGreal SR, McCarthy A, Gunewardena S, Lampe JN, Lau C, Apte U. The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction. Toxicol Appl Pharmacol. 2016 Aug 1;304:18-29. doi: 10.1016/j.taap.2016.05.001. Epub 2016 May 3. PubMed PMID: 27153767; PubMed Central PMCID: PMC5367386.

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Basudhar D, Madrona Y, Kandel S, Lampe JN, Nishida CR, de Montellano PR. Analysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography. J Biol Chem. 2015 Apr 17;290(16):10000-17. doi: 10.1074/jbc.M114.627935. Epub 2015 Feb 10. PubMed PMID: 25670859; PubMed Central PMCID: PMC4400317.

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Kandel SE, Wienkers LC, Lampe JN. Cytochrome P450 Enzyme Metabolites in Lead Discovery and Development. Annu Rep Med Chem. 2014;49:347-359. doi: 10.1016/B978-0-12-800167-7.00022-5. PubMed PMID: 25797999; PubMed Central PMCID: PMC4365796.

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Kandel SE, Lampe JN. Role of protein-protein interactions in cytochrome P450-mediated drug metabolism and toxicity. Chem Res Toxicol. 2014 Sep 15;27(9):1474-86. doi: 10.1021/tx500203s. Epub 2014 Aug 29. Review. PubMed PMID: 25133307; PubMed Central PMCID: PMC4164225.

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Boxberger KH, Hagenbuch B, Lampe JN. Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake. Drug Metab Dispos. 2014 Jun;42(6):990-5. doi: 10.1124/dmd.113.055095. Epub 2014 Mar 31. PubMed PMID: 24688079; PubMed Central PMCID: PMC4014663.

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Varfaj F, Lampe JN, Ortiz de Montellano PR. Role of cysteine residues in heme binding to human heme oxygenase-2 elucidated by two-dimensional NMR spectroscopy. J Biol Chem. 2012 Oct 12;287(42):35181-35191. doi: 10.1074/jbc.M112.378042. Epub 2012 Aug 24. PubMed PMID: 22923613; PubMed Central PMCID: PMC3471713.

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Williams CD, Koerner MR, Lampe JN, Farhood A, Jaeschke H. Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation. Toxicol Appl Pharmacol. 2011 Dec 15;257(3):449-58. doi: 10.1016/j.taap.2011.10.006. Epub 2011 Oct 14. PubMed PMID: 22023962; PubMed Central PMCID: PMC3226924.

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Brandman R, Lampe JN, Brandman Y, de Montellano PR. Active-site residues move independently from the rest of the protein in a 200 ns molecular dynamics simulation of cytochrome P450 CYP119. Arch Biochem Biophys. 2011 May 15;509(2):127-32. doi: 10.1016/j.abb.2011.02.020. Epub 2011 Feb 26. PubMed PMID: 21356195; PubMed Central PMCID: PMC3085956.

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Lampe JN, Brandman R, Sivaramakrishnan S, de Montellano PRO. Two-dimensional NMR and all-atom molecular dynamics of cytochrome P450 CYP119 reveal hidden conformational substates. J Biol Chem. 2010 Mar 26;285(13):9594-9603. doi: 10.1074/jbc.M109.087593. Epub 2010 Jan 22. PubMed PMID: 20097757; PubMed Central PMCID: PMC2843209.

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Lampe JN, Floor SN, Gross JD, Nishida CR, Jiang Y, Trnka MJ, Ortiz de Montellano PR. Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine. J Am Chem Soc. 2008 Dec 3;130(48):16168-9. doi: 10.1021/ja8071463. PubMed PMID: 18998650; PubMed Central PMCID: PMC2645923.

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Nath A, Fernández C, Lampe JN, Atkins WM. Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4. Arch Biochem Biophys. 2008 Jun 1;474(1):198-204. doi: 10.1016/j.abb.2008.03.017. Epub 2008 Mar 25. PubMed PMID: 18395506; PubMed Central PMCID: PMC2474736.

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Lampe JN, Fernandez C, Nath A, Atkins WM. Nile Red is a fluorescent allosteric substrate of cytochrome P450 3A4. Biochemistry. 2008 Jan 15;47(2):509-16. doi: 10.1021/bi7013807. Epub 2007 Dec 20. PubMed PMID: 18092806.

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Siahpush SH, Vaughan TL, Lampe JN, Freeman R, Lewis S, Odze RD, Blount PL, Ayub K, Rabinovitch PS, Reid BJ, Chen C. Longitudinal study of insulin-like growth factor, insulin-like growth factor binding protein-3, and their polymorphisms: risk of neoplastic progression in Barrett's esophagus. Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2387-95. doi: 10.1158/1055-9965.EPI-06-0986. PubMed PMID: 18006928.

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Lampe JN, Atkins WM. Time-resolved fluorescence studies of heterotropic ligand binding to cytochrome P450 3A4. Biochemistry. 2006 Oct 10;45(40):12204-15. doi: 10.1021/bi060083h. PubMed PMID: 17014074.

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Wen B, Lampe JN, Roberts AG, Atkins WM, David Rodrigues A, Nelson SD. Cysteine 98 in CYP3A4 contributes to conformational integrity required for P450 interaction with CYP reductase. Arch Biochem Biophys. 2006 Oct 1;454(1):42-54. doi: 10.1016/j.abb.2006.08.003. Epub 2006 Aug 22. PubMed PMID: 16959210; PubMed Central PMCID: PMC2001172.

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Roberts AG, Díaz MD, Lampe JN, Shireman LM, Grinstead JS, Dabrowski MJ, Pearson JT, Bowman MK, Atkins WM, Campbell AP. NMR studies of ligand binding to P450(eryF) provides insight into the mechanism of cooperativity. Biochemistry. 2006 Feb 14;45(6):1673-84. doi: 10.1021/bi0518895. PubMed PMID: 16460014.

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Wen B, Doneanu CE, Lampe JN, Roberts AG, Atkins WM, Nelson SD. Probing the CYP3A4 active site by cysteine scanning mutagenesis and photoaffinity labeling. Arch Biochem Biophys. 2005 Dec 15;444(2):100-11. doi: 10.1016/j.abb.2005.09.010. Epub 2005 Oct 21. PubMed PMID: 16289363.

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Compagno D, Lampe JN, Bourget C, Kutyavin IV, Yurchenko L, Lukhtanov EA, Gorn VV, Gamper HB Jr, Toulmé JJ. Antisense oligonucleotides containing modified bases inhibit in vitro translation of Leishmania amazonensis mRNAs by invading the mini-exon hairpin. J Biol Chem. 1999 Mar 19;274(12):8191-8. doi: 10.1074/jbc.274.12.8191. PubMed PMID: 10075723.

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Lampe JN, Kutyavin IV, Rhinehart R, Reed MW, Meyer RB, Gamper HB Jr. Factors influencing the extent and selectivity of alkylation within triplexes by reactive G/A motif oligonucleotides. Nucleic Acids Res. 1997 Oct 15;25(20):4123-31. doi: 10.1093/nar/25.20.4123. PubMed PMID: 9321668; PubMed Central PMCID: PMC146991.