Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Aquilina R, Vaidya JS, Varghese J. Pausing NHSBSP during COVID-19 did not increase advanced cancers and may have avoided overdiagnosis. British Journal of Surgery. 2023 May; 110(Supplement_3):znad101.075. doi: 10.1093/bjs/znad101.075.
Rafik ST, Vaidya JS, MacRobert AJ, Yaghini E. Organic Nanodelivery Systems as a New Platform in the Management of Breast Cancer: A Comprehensive Review from Preclinical to Clinical Studies. J Clin Med. 2023 Apr 2;12(7). doi: 10.3390/jcm12072648. Review. PubMed PMID: 37048731; PubMed Central PMCID: PMC10095028.
Vaidya JS, Patkar V. Fast Facts: Early Breast Cancer (2nd edition). Karger Publications. 2023 March. doi: 10.1159/isbn.978-3-318-07002-6.
Kolberg HC, Niesing H, Vaidya JS, Akpolat-Basci L, Maguz A, Hoffmann O, Loevey G, Stephanou M, Kolberg-Liedtke C. Breast Conserving Surgery in Combination With Targeted Intraoperative Radiotherapy Compared to Mastectomy for In-breast-tumor-recurrence. Anticancer Res. 2023 Feb;43(2):733-739. doi: 10.21873/anticanres.16212. PubMed PMID: 36697057.
Vaidya JS, Bulsara M, Wenz F, Sperk E, Massarut S, Alvarado M, Williams NR, Brew-Graves C, Bernstein M, Holmes D, Vinante L, Pigorsch S, Lundgren S, Uhl V, Joseph D, Tobias JS. The TARGIT-A Randomized Trial: TARGIT-IORT Versus Whole Breast Radiation Therapy: Long-Term Local Control and Survival. Int J Radiat Oncol Biol Phys. 2023 Jan 1;115(1):77-82. doi: 10.1016/j.ijrobp.2022.08.029. Epub 2022 Aug 23. PubMed PMID: 35998867.
Vaidya JS, Bulsara M, Wenz F, Sperk E, Massarut S, Alvarado M, Williams NR, Brew-Graves C, Bernstein M, Holmes D, Vinante L, Pigorsch S, Lundgren S, Uhl V, Joseph D, Tobias JS. In Reply to Ward et al. Int J Radiat Oncol Biol Phys. 2023 Jan 1;115(1):256-259. doi: 10.1016/j.ijrobp.2022.10.009. PubMed PMID: 36526392.
Bergamino MA, López-Knowles E, Morani G, Tovey H, Kilburn L, Schuster EF, Alataki A, Hills M, Xiao H, Holcombe C, Skene A, Robertson JF, Smith IE, Bliss JM, Dowsett M, Cheang MCU. HER2-enriched subtype and novel molecular subgroups drive aromatase inhibitor resistance and an increased risk of relapse in early ER+/HER2+ breast cancer. EBioMedicine. 2022 Sep;83:104205. doi: 10.1016/j.ebiom.2022.104205. Epub 2022 Aug 16. PubMed PMID: 35985932; PubMed Central PMCID: PMC9482930.
Vaidya JS, Vaidya UJ, Baum M, Bulsara MK, Joseph D, Tobias JS. Global adoption of single-shot targeted intraoperative radiotherapy (TARGIT-IORT) for breast cancer-better for patients, better for healthcare systems. Front Oncol. 2022;12:786515. doi: 10.3389/fonc.2022.786515. eCollection 2022. PubMed PMID: 36033486; PubMed Central PMCID: PMC9406153.
Pickles K, Hersch J, Nickel B, Vaidya JS, McCaffery K, Barratt A. Effects of awareness of breast cancer overdiagnosis among women with screen-detected or incidentally found breast cancer: a qualitative interview study. BMJ Open. 2022 Jun 8;12(6):e061211. doi: 10.1136/bmjopen-2022-061211. PubMed PMID: 35676016; PubMed Central PMCID: PMC9185559.
Pal UM, Nayak A, Medisetti T, Gogoi G, Shekhar H, Prasad MSN, Vaidya JS, Pandya HJ. Hybrid Spectral-IRDx: Near-IR and Ultrasound Attenuation System for Differentiating Breast Cancer From Adjacent Normal Tissue. IEEE Trans Biomed Eng. 2021 Dec;68(12):3554-3563. doi: 10.1109/TBME.2021.3077582. Epub 2021 Nov 19. PubMed PMID: 33945469.
Joshi A, Vishnu G K A, Sakorikar T, Kamal AM, Vaidya JS, Pandya HJ. Recent advances in biosensing approaches for point-of-care breast cancer diagnostics: challenges and future prospects. Nanoscale Adv. 2021 Sep 28;3(19):5542-5564. doi: 10.1039/d1na00453k. eCollection 2021 Sep 28. Review. PubMed PMID: 36133274; PubMed Central PMCID: PMC9417675.
Coombes RC, Tovey H, Kilburn L, Mansi J, Palmieri C, Bartlett J, Hicks J, Makris A, Evans A, Loibl S, Denkert C, Murray E, Grieve R, Coleman R, Borley A, Schmidt M, Rautenberg B, Kunze CA, Rhein U, Mehta K, Mousa K, Dibble T, Lu XL, von Minckwitz G, Bliss JM. Effect of Celecoxib vs Placebo as Adjuvant Therapy on Disease-Free Survival Among Patients With Breast Cancer: The REACT Randomized Clinical Trial. JAMA Oncol. 2021 Sep 1;7(9):1291-1301. doi: 10.1001/jamaoncol.2021.2193. PubMed PMID: 34264305; PubMed Central PMCID: PMC8283666.
Pal UM, Vishnu Gk A, Varma M, Vaidya JS, Pandya HJ. Thermo-optic measurements and their inter-dependencies for delineating cancerous breast biopsy tissue from adjacent normal. J Biophotonics. 2021 Aug;14(8):e202100041. doi: 10.1002/jbio.202100041. Epub 2021 May 31. PubMed PMID: 34042303.
Vaidya JS, Bulsara M, Baum M, Wenz F, Massarut S, Pigorsch S, Alvarado M, Douek M, Saunders C, Flyger H, Eiermann W, Brew-Graves C, Williams NR, Potyka I, Roberts N, Bernstein M, Brown D, Sperk E, Laws S, Sütterlin M, Corica T, Lundgren S, Holmes D, Vinante L, Bozza F, Pazos M, Blanc-Onfroy ML, Gruber G, Polkowski W, Dedes KJ, Niewald M, Blohmer J, McReady D, Hoefer R, Kelemen P, Petralia G, Falzon M, Joseph D, Tobias JS. New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer. Br J Cancer. 2021 Aug;125(3):380-389. doi: 10.1038/s41416-021-01440-8. Epub 2021 May 25. PubMed PMID: 34035435; PubMed Central PMCID: PMC8329051.
Lloyd KE, Hall LH, Ziegler L, Smith SG. Breast cancer worry in higher-risk women offered preventive therapy: a UK multicentre prospective study. Breast Cancer Res Treat. 2021 Aug;188(3):703-712. doi: 10.1007/s10549-021-06183-x. Epub 2021 Mar 17. PubMed PMID: 33733302; PubMed Central PMCID: PMC8720078.
Vaidya JS, Bulsara M, Sperk E, Massarut S, Douek M, Alvarado M, Pigorsch S, Holmes D, Bernstein M, Saunders C, Flyger H, Joseph D, Wenz F, Tobias JS. In Regard to Polgar et al. Int J Radiat Oncol Biol Phys. 2021 Jul 1;110(3):905-907. doi: 10.1016/j.ijrobp.2021.01.059. Epub 2021 Feb 25. PubMed PMID: 33640419.
Vaidya JS, Bulsara M, Sperk E, Massarut S, Douek M, Alvarado M, Pigorsch S, Holmes D, Bernstein M, Saunders C, Flyger H, Joseph D, Wenz F, Tobias JS. TARGIT-IORT during lumpectomy for breast cancer - better for patients than other PBI approaches - In regard to Polgar et al https://bit.ly/3KCu01n. Int J of Rad Oncol Biol Phys. 2021 July; 110(3):905 - 907. doi: 10.1016/j.ijrobp.2021.01.059.
Vaidya JS, Bulsara M, Massarut S, Sperk E, Wenz F, Tobias JS. Partial breast irradiation with intraoperative radiotherapy in the ELIOT trial. Lancet Oncol. 2021 Jul;22(7):e295-e296. doi: 10.1016/S1470-2045(21)00278-3. PubMed PMID: 34197756.
Tobias JS, Vaidya JS, Baum M. Single-dose intra-operative breast cancer radiotherapy (TARGIT-IORT) – innovative, effective, far less trouble to the patient. Full text: https://bit.ly/30PY9XZ. RAD Magazine. 2021 May; 47(552):27-28.
Vaidya JS, Bulsara M, Baum M, Tobias JS. Single-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatment. Br J Cancer. 2021 Apr;124(9):1469-1474. doi: 10.1038/s41416-020-01233-5. Epub 2021 Feb 2. PubMed PMID: 33531693; PubMed Central PMCID: PMC7851812.
Vaidya JS, Bulsara M, Baum M, Alvarado M, Bernstein M, Massarut S, Saunders C, Sperk E, Wenz F, Tobias JS. Intraoperative radiotherapy for breast cancer: powerful evidence to change practice. Nat Rev Clin Oncol. 2021 Mar;18(3):187-188. doi: 10.1038/s41571-021-00471-7. PubMed PMID: 33495552; PubMed Central PMCID: PMC7830040.
Vaidya JS. Long-term data confirms that single dose radiotherapy during surgery for breast cancer (TARGIT-IORT) is as effective as whole breast radiotherapy. Full text: https://bit.ly/3GMtigX. Association of Breast Surgeons Yearbook. 2021 January; :96.
Vaidya JS. Breakthrough for breast cancer patients. Full text: https://discovery.ucl.ac.uk/id/eprint/10117969/1/Swasthya-Breakthrough-for-breast-cancer-patients-A-commentary-by-Prof-Jayant-S-VaidyaWinter-Edition-Vol-1-Issu-3-2020-Circulation-copy-BP.pdf. Swasthya- A Journal for Health Professionals. 2020 November; 1(3):24-25.
Vaidya JS, Bulsara M, Baum M. Targeted Intraoperative Radiotherapy for Early Breast Cancer-Reply. JAMA Oncol. 2020 Oct 1;6(10):1637-1638. doi: 10.1001/jamaoncol.2020.2730. PubMed PMID: 32789486.
Vaidya JS, Bulsara M, Baum M, Wenz F, Massarut S, Pigorsch S, Alvarado M, Douek M, Saunders C, Flyger HL, Eiermann W, Brew-Graves C, Williams NR, Potyka I, Roberts N, Bernstein M, Brown D, Sperk E, Laws S, Sütterlin M, Corica T, Lundgren S, Holmes D, Vinante L, Bozza F, Pazos M, Le Blanc-Onfroy M, Gruber G, Polkowski W, Dedes KJ, Niewald M, Blohmer J, McCready D, Hoefer R, Kelemen P, Petralia G, Falzon M, Joseph DJ, Tobias JS. Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial. BMJ. 2020 Aug 19;370:m2836. doi: 10.1136/bmj.m2836. PubMed PMID: 32816842; PubMed Central PMCID: PMC7500441.
Pal UM, Gk AV, Gogoi G, Rila S, Shroff S, Am G, Borah P, Varma M, Kurpad V, Baruah D, Vaidya JS, Pandya HJ. Towards a Portable Platform Integrated With Multispectral Noncontact Probes for Delineating Normal and Breast Cancer Tissue Based on Near-Infrared Spectroscopy. IEEE Trans Biomed Circuits Syst. 2020 Aug;14(4):879-888. doi: 10.1109/TBCAS.2020.3005971. Epub 2020 Jun 30. PubMed PMID: 32746350.
Vaidya JS, Bulsara M, Saunders C, Flyger H, Tobias JS, Corica T, Massarut S, Wenz F, Pigorsch S, Alvarado M, Douek M, Eiermann W, Brew-Graves C, Williams N, Potyka I, Roberts N, Bernstein M, Brown D, Sperk E, Laws S, Sütterlin M, Lundgren S, Holmes D, Vinante L, Bozza F, Pazos M, Le Blanc-Onfroy M, Gruber G, Polkowski W, Dedes KJ, Niewald M, Blohmer J, McCready D, Hoefer R, Kelemen P, Petralia G, Falzon M, Baum M, Joseph D. Effect of Delayed Targeted Intraoperative Radiotherapy vs Whole-Breast Radiotherapy on Local Recurrence and Survival: Long-term Results From the TARGIT-A Randomized Clinical Trial in Early Breast Cancer. JAMA Oncol. 2020 Jul 1;6(7):e200249. doi: 10.1001/jamaoncol.2020.0249. Epub 2020 Jul 9. PubMed PMID: 32239210; PubMed Central PMCID: PMC7348682.
Retsky M, Demicheli R, Hrushesky W, James T, Rogers R, Baum M, Vaidya JS, Erhabor O, Forget P. Breast cancer and the black swan. Ecancermedicalscience. 2020;14:1050. doi: 10.3332/ecancer.2020.1050. eCollection 2020. Review. PubMed PMID: 32565903; PubMed Central PMCID: PMC7289621.
Simcock R, Thomas TV, Estes C, Filippi AR, Katz MA, Pereira IJ, Saeed H. COVID-19: Global radiation oncology's targeted response for pandemic preparedness. Clin Transl Radiat Oncol. 2020 May;22:55-68. doi: 10.1016/j.ctro.2020.03.009. eCollection 2020 May. PubMed PMID: 32274425; PubMed Central PMCID: PMC7102593.
Pal UM, Saxena M, Vishnu G, Parsana D, Sarvani B, Varma M, Jayachandra M, Kurpad V, Baruch D, Gogoi G, Vaidya JS, Pandya HJ. Optical spectroscopy-based imaging techniques for the diagnosis of breast cancer: A novel approach. Applied Spectroscopy Reviews. 2020 April. doi: 10.1080/05704928.2020.1749651.
Thorneloe RJ, Hall LH, Walter FM, Side L, Lloyd KE, Smith SG. Knowledge of Potential Harms and Benefits of Tamoxifen among Women Considering Breast Cancer Preventive Therapy. Cancer Prev Res (Phila). 2020 Apr;13(4):411-422. doi: 10.1158/1940-6207.CAPR-19-0424. Epub 2020 Jan 27. PubMed PMID: 31988145; PubMed Central PMCID: PMC7611305.
Vaidya JS, Douek M, Baum M. Pragmatic Management of Breast Cancer during COVID-19. [Internet]. London, UK: BASO-ACS - The Association for Cancer Surgery; 2020 March. Available from: https://baso.org.uk/media/98159/covid_19_and_breast_cancer_march_2020.pdf.
Davis CR, Than PA, Khong SML, Rodrigues M, Findlay MW, Navarrete DJ, Ghali S, Vaidya JS, Gurtner GC. Therapeutic Breast Reconstruction Using Gene Therapy-Delivered IFNγ Immunotherapy. Mol Cancer Ther. 2020 Feb;19(2):697-705. doi: 10.1158/1535-7163.MCT-19-0315. Epub 2019 Oct 28. PubMed PMID: 31658961; NIHMSID:NIHMS1541590.
Cuzick J, Sestak I, Forbes JF, Dowsett M, Cawthorn S, Mansel RE, Loibl S, Bonanni B, Evans DG, Howell A. Use of anastrozole for breast cancer prevention (IBIS-II): long-term results of a randomised controlled trial. Lancet. 2020 Jan 11;395(10218):117-122. doi: 10.1016/S0140-6736(19)32955-1. Epub 2019 Dec 12. PubMed PMID: 31839281; PubMed Central PMCID: PMC6961114.
Vaidya JS, Douek M, Coombs N, Singer J, Tobias JS. Targeted radiotherapy as part of breast conserving therapy. In: Kronowitz SJ, Benson JR, Nava MB, editors. Oncoplastic and Reconstructive Management of the Breast, Third Edition. [Internet] 3rd ed. London: CRC Press, Taylor & Francis Group; 2020. Chapter 29; p.405-410. 480p. Available from: https://www.routledge.com/Oncoplastic-and-Reconstructive-Management-of-the-Breast-Third-Edition/Kronowitz-Benson-Nava/p/book/9781003005476.
Gao Q, López-Knowles E, Cheang MCU, Morden J, Ribas R, Sidhu K, Evans D, Martins V, Dodson A, Skene A, Holcombe C, Mallon E, Evans A, Bliss JM, Robertson J, Smith I, Martin LA, Dowsett M. Impact of aromatase inhibitor treatment on global gene expression and its association with antiproliferative response in ER+ breast cancer in postmenopausal patients. Breast Cancer Res. 2019 Dec 31;22(1):2. doi: 10.1186/s13058-019-1223-z. PubMed PMID: 31892336; PubMed Central PMCID: PMC6938628.
Kolberg HC, Uhl V, Massarut S, Holmes D, Kolberg-Liedtke C, Kelly EW, Lövey G, Vaidya JS. Targeted Intraoperative Radiotherapy During Breast-conserving Surgery for Breast Cancer in Patients After Implant Augmentation. Anticancer Res. 2019 Aug;39(8):4215-4218. doi: 10.21873/anticanres.13582. PubMed PMID: 31366508.
Earl HM, Hiller L, Vallier AL, Loi S, McAdam K, Hughes-Davies L, Harnett AN, Ah-See ML, Simcock R, Rea D, Raj S, Woodings P, Harries M, Howe D, Raynes K, Higgins HB, Wilcox M, Plummer C, Mansi J, Gounaris I, Mahler-Araujo B, Provenzano E, Chhabra A, Abraham JE, Caldas C, Hall PS, McCabe C, Hulme C, Miles D, Wardley AM, Cameron DA, Dunn JA. 6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE): 4-year disease-free survival results of a randomised phase 3 non-inferiority trial. Lancet. 2019 Jun 29;393(10191):2599-2612. doi: 10.1016/S0140-6736(19)30650-6. Epub 2019 Jun 6. PubMed PMID: 31178152; PubMed Central PMCID: PMC6615016.
Schuster EF, Gellert P, Segal CV, López-Knowles E, Buus R, Cheang MCU, Morden J, Robertson J, Bliss JM, Smith I, Dowsett M. Genomic Instability and TP53 Genomic Alterations Associate With Poor Antiproliferative Response and Intrinsic Resistance to Aromatase Inhibitor Treatment. JCO Precis Oncol. 2019;3. doi: 10.1200/PO.18.00286. eCollection 2019. PubMed PMID: 32914010; PubMed Central PMCID: PMC7446335.
Thorneloe RJ, Horne R, Side L, Wolf MS, Smith SG. Beliefs About Medication and Uptake of Preventive Therapy in Women at Increased Risk of Breast Cancer: Results From a Multicenter Prospective Study. Clin Breast Cancer. 2019 Feb;19(1):e116-e126. doi: 10.1016/j.clbc.2018.10.008. Epub 2018 Dec 3. PubMed PMID: 30518498; PubMed Central PMCID: PMC6395889.
Cutress RI, McIntosh SA, Potter S, Goyal A, Kirwan CC, Harvey J, Francis A, Carmichael AR, Vidya R, Vaidya JS, Fairbrother P, Benson JR, Reed MWR. Opportunities and priorities for breast surgical research. Lancet Oncol. 2018 Oct;19(10):e521-e533. doi: 10.1016/S1470-2045(18)30511-4. Epub 2018 Oct 1. Review. PubMed PMID: 30303126.
Winters ZE, Horsnell J, Elvers KT, Maxwell AJ, Jones LJ, Shaaban AM, Schmid P, Williams NR, Beswick A, Greenwood R, Ingram JC, Saunders C, Vaidya JS, Esserman L, Jatoi I, Brunt AM. Systematic review of the impact of breast-conserving surgery on cancer outcomes of multiple ipsilateral breast cancers. BJS Open. 2018 Aug;2(4):162-174. doi: 10.1002/bjs5.53. eCollection 2018 Aug. Review. PubMed PMID: 30079385; PubMed Central PMCID: PMC6069349.
Kolberg H, Uhl V, Massarut S, Liedtke C, Lovey G, Vaidya JS. Targeted intraoperative radiotherapy (TARGIT) during breast conserving surgery for early breast cancer in patient after breast augmentation with implants- a case series (n=8). Senologie - Zeitschrift für Mammadiagnostik und -therapie. 2018 May; 15(2):e27. doi: 10.1055/s-0038-1651746.
Gao Q, López-Knowles E, U Cheang MC, Morden J, Ribas R, Sidhu K, Evans D, Martins V, Dodson A, Skene A, Holcombe C, Mallon E, Evans A, Bliss JM, Robertson J, Smith I, Martin LA, Dowsett M. Major Impact of Sampling Methodology on Gene Expression in Estrogen Receptor-Positive Breast Cancer. JNCI Cancer Spectr. 2018 Apr;2(2):pky005. doi: 10.1093/jncics/pky005. eCollection 2018 Apr. PubMed PMID: 31360844; PubMed Central PMCID: PMC6649758.
Corica T, Nowak AK, Saunders CM, Bulsara MK, Taylor M, Williams NR, Keshtgar M, Joseph DJ, Vaidya JS. Cosmetic outcome as rated by patients, doctors, nurses and BCCT.core software assessed over 5 years in a subset of patients in the TARGIT-A Trial. Radiat Oncol. 2018 Apr 13;13(1):68. doi: 10.1186/s13014-018-0998-x. PubMed PMID: 29653541; PubMed Central PMCID: PMC5899392.
Kolberg H, Uhl V, Massarut S, Lidtke C, Lovy G, Vaidya JS. Targeted intraoperative radiotherapy (TARGIT) during breast conserving surgery for early breast cancer in patients after breast augmentation with implants - a case series. Oncology Research and Treatment. 2018 March; 41(Suppl 1):30. doi: 10.1159/000487109.
Vaidya JS, Wenz F, Tobias JS. Trial supports targeted radiotherapy for early breast cancer but protocol still requires 3 weeks of daily therapy. BMJ Evid Based Med. 2018 Feb;23(1):38-39. doi: 10.1136/ebmed-2017-110849. Review. PubMed PMID: 29367327.
Copson ER, Maishman TC, Tapper WJ, Cutress RI, Greville-Heygate S, Altman DG, Eccles B, Gerty S, Durcan LT, Jones L, Evans DG, Thompson AM, Pharoah P, Easton DF, Dunning AM, Hanby A, Lakhani S, Eeles R, Gilbert FJ, Hamed H, Hodgson S, Simmonds P, Stanton L, Eccles DM. Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study. Lancet Oncol. 2018 Feb;19(2):169-180. doi: 10.1016/S1470-2045(17)30891-4. Epub 2018 Jan 11. PubMed PMID: 29337092; PubMed Central PMCID: PMC5805863.
Vaidya JS, Massarut S, Vaidya HJ, Alexander EC, Richards T, Caris JA, Sirohi B, Tobias JS. Rethinking neoadjuvant chemotherapy for breast cancer. BMJ. 2018 Jan 11;360:j5913. doi: 10.1136/bmj.j5913. PubMed PMID: 29326104.
Vaidya JS, Bulsara M, Wenz F, Tobias JS, Joseph D, Baum M. Targeted radiotherapy for early breast cancer. Lancet. 2018 Jan 6;391(10115):26-27. doi: 10.1016/S0140-6736(17)33316-0. PubMed PMID: 29323648.
What would you like to do?