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Guo H, Ha S, Botten JW, Xu K, Zhang N, An Z, Strohl WR, Shiver JW, Fu TM. SARS-CoV-2 Omicron: Viral Evolution, Immune Evasion, and Alternative Durable Therapeutic Strategies. Viruses. 2024 Apr 28;16(5). doi: 10.3390/v16050697. Review. PubMed PMID: 38793580; PubMed Central PMCID: PMC11125895.
Guo H, Cho B, Hinton PR, He S, Yu Y, Ramesh AK, Sivaccumar JP, Ku Z, Campo K, Holland S, Sachdeva S, Mensch C, Dawod M, Whitaker A, Eisenhauer P, Falcone A, Honce R, Botten JW, Carroll SF, Keyt BA, Womack AW, Strohl WR, Xu K, Zhang N, An Z, Ha S, Shiver JW, Fu TM. An ACE2 decamer viral trap as a durable intervention solution for current and future SARS-CoV. Emerg Microbes Infect. 2023 Dec;12(2):2275598. doi: 10.1080/22221751.2023.2275598. Epub 2023 Dec 11. PubMed PMID: 38078382; PubMed Central PMCID: PMC10768737.
Shrestha L, Lin MJ, Xie H, Mills MG, Mohamed Bakhash SA, Gaur VP, Livingston RJ, Castor J, Bruce EA, Botten JW, Huang ML, Jerome KR, Greninger AL, Roychoudhury P. Clinical Performance Characteristics of the Swift Normalase Amplicon Panel for Sensitive Recovery of Severe Acute Respiratory Syndrome Coronavirus 2 Genomes. J Mol Diagn. 2022 Sep;24(9):963-976. doi: 10.1016/j.jmoldx.2022.05.007. Epub 2022 Jul 18. PubMed PMID: 35863699; PubMed Central PMCID: PMC9290336.
Bruce EA, Mills MG, Sampoleo R, Perchetti GA, Huang ML, Despres HW, Schmidt MM, Roychoudhury P, Shirley DJ, Jerome KR, Greninger AL, Botten JW. Predicting infectivity: comparing four PCR-based assays to detect culturable SARS-CoV-2 in clinical samples. EMBO Mol Med. 2022 Feb 7;14(2):e15290. doi: 10.15252/emmm.202115290. Epub 2021 Dec 13. PubMed PMID: 34862752; PubMed Central PMCID: PMC8819313.
Mills MG, Bruce E, Huang ML, Crothers JW, Hyrien O, Oura CAL, Blake L, Brown Jordan A, Hester S, Wehmas L, Mari B, Barby P, Lacoux C, Fassy J, Vial P, Vial C, Martinez JRW, Oladipo OO, Inuwa B, Shittu I, Meseko CA, Chammas R, Santos CF, Dionísio TJ, Garbieri TF, Parisi VA, Mendes-Correa MC, de Paula AV, Romano CM, Góes LGB, Minoprio P, Campos AC, Cunha MP, Vilela APP, Nyirenda T, Mkakosya RS, Muula AS, Dumm RE, Harris RM, Mitchell CA, Pettit S, Botten J, Jerome KR. An international, interlaboratory ring trial confirms the feasibility of an extraction-less "direct" RT-qPCR method for reliable detection of SARS-CoV-2 RNA in clinical samples. PLoS One. 2022;17(1):e0261853. doi: 10.1371/journal.pone.0261853. eCollection 2022. PubMed PMID: 35025926; PubMed Central PMCID: PMC8758094.
Manuelyan I, Schmoker SM, Yount Jr BL, Eisenhauer P, Keller JI, Gold , Terino D, Ziegler CM, Alexander J, Driscoll H, Hutchinson E, Bhella D, Syme CD, Widman DG, Heise MT, Baric RS, Ballif BA, Botten JW. A global map of the Zika virus phosphoproteome reveals host-driven regulation of viral budding. Version: 1. bioRxiv [preprint]. 2021 November. bioRxiv 2021.11.24.469793Available from: https://doi.org/10.1101/2021.11.24.469793.
Victor J, Deutsch J, Whitaker A, Lamkin EN, March A, Zhou P, Botten JW, Chatterjee N. SARS-CoV-2 triggers DNA damage response in Vero E6 cells. Biochem Biophys Res Commun. 2021 Nov 19;579:141-145. doi: 10.1016/j.bbrc.2021.09.024. Epub 2021 Sep 15. PubMed PMID: 34600299; PubMed Central PMCID: PMC8440005.
Rissanen I, Krumm SA, Stass R, Whitaker A, Voss JE, Bruce EA, Rothenberger S, Kunz S, Burton DR, Huiskonen JT, Botten JW, Bowden TA, Doores KJ. Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen. mBio. 2021 Aug 31;12(4):e0253120. doi: 10.1128/mBio.02531-20. Epub 2021 Jul 6. PubMed PMID: 34225492; PubMed Central PMCID: PMC8406324.
Drayman N, DeMarco JK, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Han KY, O'Brien A, Tomatsidou A, Meyer B, Vignuzzi M, Missiakas D, Botten JW, Brooke CB, Lee H, Baker SC, Mounce BC, Heaton NS, Severson WE, Palmer KE, Dickinson BC, Joachimiak A, Randall G, Tay S. Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2. Science. 2021 Aug 20;373(6557):931-936. doi: 10.1126/science.abg5827. Epub 2021 Jul 20. PubMed PMID: 34285133; PubMed Central PMCID: PMC8809056.
Bruce EA, Mills MG, Sampoleo R, Perchetti GA, Huang M, Despres HW, Shirley D , Jerome KR, Greninger AL, Botten JW. Predicting Infectivity: Comparing Four PCR-based Assays to Detect Culturable SARS-CoV-2 in Clinical Samples. medRxiv https://doi.org/10.1101/2021.07.14.21260544. 2021 July.
Montgomery TL, Paavola M, Bruce EA, Botten JW, Crothers JW, Krementsov DN. Laboratory Worker Self-Contamination with Noninfectious SARS-CoV-2 DNA Can Result in False-Positive Reverse Transcriptase PCR-Based Surveillance Testing. J Clin Microbiol. 2021 Jun 18;59(7):e0072321. doi: 10.1128/JCM.00723-21. Epub 2021 Jun 18. PubMed PMID: 33952597; PubMed Central PMCID: PMC8218757.
Hanley JP, Tu HA, Dragon JA, Dickson DM, Rio-Guerra RD, Tighe SW, Eckstrom KM, Selig N, Scarpino SV, Whitehead SS, Durbin AP, Pierce KK, Kirkpatrick BD, Rizzo DM, Frietze S, Diehl SA. Immunotranscriptomic profiling the acute and clearance phases of a human challenge dengue virus serotype 2 infection model. Nat Commun. 2021 May 24;12(1):3054. doi: 10.1038/s41467-021-22930-6. PubMed PMID: 34031380; PubMed Central PMCID: PMC8144425.
Mills MG, Bruce E, Huang ML, Crothers JW, Hyrien O, Oura CAL, Blake L, Jordan AB, Hester S, Wehmas L, Mari B, Barby P, Lacoux C, Fassy J, Vial P, Vial C, Martinez JRW, Oladipo OO, Inuwa B, Shittu I, Meseko CA, Chammas R, Santos CF, José Dionísio T, Garbieri TF, Parisi VA, Mendes-Correa MC, dePaula AV, Romano CM, Góes LGB, Minoprio P, Campos AC, Cunha MP, Vilela APP, Nyirenda T, Mkakosya RS, Muula AS, Dumm RE, Harris RM, Mitchell CA, Pettit S, Botten J, Jerome KR. An international, interlaboratory ring trial confirms the feasibility of an open-source, extraction-less "direct" RT-qPCR method for reliable detection of SARS-CoV-2 RNA in clinical samples. medRxiv. 2021 Apr 16;. doi: 10.1101/2021.04.10.21254091. PubMed PMID: 33880478; PubMed Central PMCID: PMC8057246.
Tu HA, Nivarthi UK, Graham NR, Eisenhauer P, Delacruz MJ, Pierce KK, Whitehead SS, Boyson JE, Botten JW, Kirkpatrick BD, Durbin AP, deSilva AM, Diehl SA. Stimulation of B Cell Immunity in Flavivirus-Naive Individuals by the Tetravalent Live Attenuated Dengue Vaccine TV003. Cell Rep Med. 2020 Dec 22;1(9):100155. doi: 10.1016/j.xcrm.2020.100155. eCollection 2020 Dec 22. PubMed PMID: 33377126; PubMed Central PMCID: PMC7762770.
Banerjee AK, Blanco MR, Bruce EA, Honson DD, Chen LM, Chow A, Bhat P, Ollikainen N, Quinodoz SA, Loney C, Thai J, Miller ZD, Lin AE, Schmidt MM, Stewart DG, Goldfarb D, De Lorenzo G, Rihn SJ, Voorhees RM, Botten JW, Majumdar D, Guttman M. SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses. Cell. 2020 Nov 25;183(5):1325-1339.e21. doi: 10.1016/j.cell.2020.10.004. Epub 2020 Oct 8. PubMed PMID: 33080218; PubMed Central PMCID: PMC7543886.
Graham NR, Whitaker AN, Strother CA, Miles AK, Grier D, McElvany BD, Bruce EA, Poynter ME, Pierce KK, Kirkpatrick BD, Stapleton RD, An G, van den Broek-Altenburg E, Botten JW, Crothers JW, Diehl SA. Kinetics and isotype assessment of antibodies targeting the spike protein receptor-binding domain of severe acute respiratory syndrome-coronavirus-2 in COVID-19 patients as a function of age, biological sex and disease severity. Clin Transl Immunology. 2020;9(10):e1189. doi: 10.1002/cti2.1189. eCollection 2020. PubMed PMID: 33072323; PubMed Central PMCID: PMC7541824.
Bruce EA, Huang ML, Perchetti GA, Tighe S, Laaguiby P, Hoffman JJ, Gerrard DL, Nalla AK, Wei Y, Greninger AL, Diehl SA, Shirley DJ, Leonard DGB, Huston CD, Kirkpatrick BD, Dragon JA, Crothers JW, Jerome KR, Botten JW. Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step. PLoS Biol. 2020 Oct;18(10):e3000896. doi: 10.1371/journal.pbio.3000896. eCollection 2020 Oct. PubMed PMID: 33006983; PubMed Central PMCID: PMC7556528.
Vial C, Whitaker A, Wilhelm J, Ovalle J, Perez R, Valdivieso F, Ferres M, Martinez-Valdebenito C, Eisenhauer P, Mertz GJ, Hooper JW, Botten JW, Vial PA. Comparison of VSV Pseudovirus and Focus Reduction Neutralization Assays for Measurement of Anti-Andes orthohantavirus Neutralizing Antibodies in Patient Samples. Front Cell Infect Microbiol. 2020;10:444. doi: 10.3389/fcimb.2020.00444. eCollection 2020. PubMed PMID: 33042854; PubMed Central PMCID: PMC7527604.
Drayman N, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Botten JW, Brooke CB, Baker SC, Mounce BC, Heaton NS, Dickinson BC, Jaochimiak A, Randall G, Tay S. Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro. bioRxiv. 2020 Sep 1;. doi: 10.1101/2020.08.31.274639. PubMed PMID: 32908976; PubMed Central PMCID: PMC7480023.
Graham NR, Whitaker AN, Strother CA, Miles AK, Grier D, McElvany BD, Bruce EA, Poynter ME, Pierce KK, Kirkpatrick BD, Stapleton RD, An G, Botten JW, Crothers JW, Diehl SA. Kinetics and Isotype Assessment of Antibodies Targeting the Spike Protein Receptor Binding Domain of SARS-CoV-2 In COVID-19 Patients as a function of Age and Biological Sex. medRxiv. 2020 Jul 16;. doi: 10.1101/2020.07.15.20154443. PubMed PMID: 32743592; PubMed Central PMCID: PMC7386516.
Ziegler CM, Botten JW. Defective Interfering Particles of Negative-Strand RNA Viruses. Trends Microbiol. 2020 Jul;28(7):554-565. doi: 10.1016/j.tim.2020.02.006. Epub 2020 Mar 26. Review. PubMed PMID: 32544442; PubMed Central PMCID: PMC7298151.
Pettit SD, Jerome KR, Rouquié D, Mari B, Barbry P, Kanda Y, Matsumoto M, Hester S, Wehmas L, Botten JW, Bruce EA. 'All In': a pragmatic framework for COVID-19 testing and action on a global scale. EMBO Mol Med. 2020 Jun 8;12(6):e12634. doi: 10.15252/emmm.202012634. Epub 2020 May 27. PubMed PMID: 32375201; PubMed Central PMCID: PMC7267598.
Bruce EA, Huang ML, Perchetti GA, Tighe S, Laaguiby P, Hoffman JJ, Gerrard DL, Nalla AK, Wei Y, Greninger AL, Diehl SA, Shirley DJ, Leonard DGB, Huston CD, Kirkpatrick BD, Dragon JA, Crothers JW, Jerome KR, Botten JW. DIRECT RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWABS WITHOUT AN RNA EXTRACTION STEP. bioRxiv. 2020 Apr 6;. doi: 10.1101/2020.03.20.001008. PubMed PMID: 32511328; PubMed Central PMCID: PMC7239058.
Clement J, Ahlm C, Avšič-Županc T, Botten J, Chandran K, Jonsson CB, Kariwa H, Klingström J, Klempa B, Krüger DH, Leirs H, Li D, Liang M, Markotić A, Papa A, Schmaljohn CS, Tischler ND, Ulrich RG, Vaheri A, Vial C, Yanagihara R, Maes P. Meeting report: Eleventh International Conference on Hantaviruses. Antiviral Res. 2020 Apr;176:104733. doi: 10.1016/j.antiviral.2020.104733. Epub 2020 Feb 15. Review. PubMed PMID: 32068071.
Graham N, Eisenhauer P, Diehl SA, Pierce KK, Whitehead SS, Durbin AP, Kirkpatrick BD, Sette A, Weiskopf D, Boyson JE, Botten JW. Rapid Induction and Maintenance of Virus-Specific CD8(+) T(EMRA) and CD4(+) T(EM) Cells Following Protective Vaccination Against Dengue Virus Challenge in Humans. Front Immunol. 2020;11:479. doi: 10.3389/fimmu.2020.00479. eCollection 2020. PubMed PMID: 32265929; PubMed Central PMCID: PMC7105617.
Ziegler CM, Dang L, Eisenhauer P, Kelly JA, King BR, Klaus JP, Manuelyan I, Mattice EB, Shirley DJ, Weir ME, Bruce EA, Ballif BA, Botten J. NEDD4 family ubiquitin ligases associate with LCMV Z's PPXY domain and are required for virus budding, but not via direct ubiquitination of Z. PLoS Pathog. 2019 Nov;15(11):e1008100. doi: 10.1371/journal.ppat.1008100. eCollection 2019 Nov. PubMed PMID: 31710650; PubMed Central PMCID: PMC6874086.
Ziegler CM, Eisenhauer P, Manuelyan I, Weir ME, Bruce EA, Ballif BA, Botten J. Host-Driven Phosphorylation Appears to Regulate the Budding Activity of the Lassa Virus Matrix Protein. Pathogens. 2018 Dec 9;7(4). doi: 10.3390/pathogens7040097. PubMed PMID: 30544850; PubMed Central PMCID: PMC6313517.
Burgess EJ, Hoyt LR, Randall MJ, Mank MM, Bivona JJ 3rd, Eisenhauer PL, Botten JW, Ballif BA, Lam YW, Wargo MJ, Boyson JE, Ather JL, Poynter ME. Bacterial Lipoproteins Constitute the TLR2-Stimulating Activity of Serum Amyloid A. J Immunol. 2018 Oct 15;201(8):2377-2384. doi: 10.4049/jimmunol.1800503. Epub 2018 Aug 29. PubMed PMID: 30158125; PubMed Central PMCID: PMC6179936.
King BR, Samacoits A, Eisenhauer PL, Ziegler CM, Bruce EA, Zenklusen D, Zimmer C, Mueller F, Botten J. Visualization of Arenavirus RNA Species in Individual Cells by Single-Molecule Fluorescence In Situ Hybridization Suggests a Model of Cyclical Infection and Clearance during Persistence. J Virol. 2018 Jun 15;92(12). doi: 10.1128/JVI.02241-17. Print 2018 Jun 15. PubMed PMID: 29643234; PubMed Central PMCID: PMC5974494.
Ziegler CM, Eisenhauer P, Kelly JA, Dang LN, Beganovic V, Bruce EA, King BR, Shirley DJ, Weir ME, Ballif BA, Botten J. A Proteomics Survey of Junín Virus Interactions with Human Proteins Reveals Host Factors Required for Arenavirus Replication. J Virol. 2018 Feb 15;92(4). doi: 10.1128/JVI.01565-17. Print 2018 Feb 15. PubMed PMID: 29187543; PubMed Central PMCID: PMC5790945.
Ziegler CM, Bruce EA, Kelly JA, King BR, Botten JW. The use of novel epitope-tagged arenaviruses reveals that Rab5c-positive endosomal membranes are targeted by the LCMV matrix protein. J Gen Virol. 2018 Feb;99(2):187-193. doi: 10.1099/jgv.0.001004. PubMed PMID: 29393022; PubMed Central PMCID: PMC5884964.
King BR, Kellner S, Eisenhauer PL, Bruce EA, Ziegler CM, Zenklusen D, Botten JW. Visualization of the lymphocytic choriomeningitis mammarenavirus (LCMV) genome reveals the early endosome as a possible site for genome replication and viral particle  pre-assembly. J Gen Virol. 2017 Oct;98(10):2454-2460. doi: 10.1099/jgv.0.000930. PubMed PMID: 28949905; PubMed Central PMCID: PMC5725993.
King BR, Hershkowitz D, Eisenhauer PL, Weir ME, Ziegler CM, Russo J, Bruce EA, Ballif BA, Botten J. A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR). J Virol. 2017 Aug 1;91(15). doi: 10.1128/JVI.00763-17. Print 2017 Aug 1. PubMed PMID: 28539447; PubMed Central PMCID: PMC5512243.
Grifoni A, Angelo M, Sidney J, Paul S, Peters B, de Silva AD, Phillips E, Mallal S, Diehl SA, Botten J, Boyson J, Kirkpatrick BD, Whitehead SS, Durbin AP, Sette A, Weiskopf D. Patterns of Cellular Immunity Associated with Experimental Infection with rDEN2Δ30 (Tonga/74) Support Its Suitability as a Human Dengue Virus Challenge Strain. J Virol. 2017 Apr 15;91(8). doi: 10.1128/JVI.02133-16. Print 2017 Apr 15. PubMed PMID: 28148797; PubMed Central PMCID: PMC5375662.
Ziegler CM, Eisenhauer P, Bruce EA, Beganovic V, King BR, Weir ME, Ballif BA, Botten J. A novel phosphoserine motif in the LCMV matrix protein Z regulates the release of infectious virus and defective interfering particles. J Gen Virol. 2016 Sep;97(9):2084-2089. doi: 10.1099/jgv.0.000550. Epub 2016 Jul 15. PubMed PMID: 27421645; PubMed Central PMCID: PMC5756487.
Ziegler CM, Eisenhauer P, Bruce EA, Weir ME, King BR, Klaus JP, Krementsov DN, Shirley DJ, Ballif BA, Botten J. The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles. PLoS Pathog. 2016 Mar;12(3):e1005501. doi: 10.1371/journal.ppat.1005501. eCollection 2016 Mar. PubMed PMID: 27010636; PubMed Central PMCID: PMC4806877.
Klaus JP, Botten J. Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment. J Vis Exp. 2016 Mar 2;(109):e53682. doi: 10.3791/53682. PubMed PMID: 26966937; PubMed Central PMCID: PMC4828211.
Haist K, Ziegler C, Botten J. Strand-Specific Quantitative Reverse Transcription-Polymerase Chain Reaction Assay for Measurement of Arenavirus Genomic and Antigenomic RNAs. PLoS One. 2015;10(5):e0120043. doi: 10.1371/journal.pone.0120043. eCollection 2015. PubMed PMID: 25978311; PubMed Central PMCID: PMC4433285.
Klaus JP, Eisenhauer P, Russo J, Mason AB, Do D, King B, Taatjes D, Cornillez-Ty C, Boyson JE, Thali M, Zheng C, Liao L, Yates JR 3rd, Zhang B, Ballif BA, Botten JW. The intracellular cargo receptor ERGIC-53 is required for the production of infectious arenavirus, coronavirus, and filovirus particles. Cell Host Microbe. 2013 Nov 13;14(5):522-34. doi: 10.1016/j.chom.2013.10.010. PubMed PMID: 24237698; PubMed Central PMCID: PMC3999090.
Hosking MP, Flynn CT, Botten J, Whitton JL. CD8+ memory T cells appear exhausted within hours of acute virus infection. J Immunol. 2013 Oct 15;191(8):4211-22. doi: 10.4049/jimmunol.1300920. Epub 2013 Sep 11. PubMed PMID: 24026080; PubMed Central PMCID: PMC3795851.
Kemball CC, Flynn CT, Hosking MP, Botten J, Whitton JL. Wild-type coxsackievirus infection dramatically alters the abundance, heterogeneity, and immunostimulatory capacity of conventional dendritic cells in vivo. Virology. 2012 Jul 20;429(1):74-90. doi: 10.1016/j.virol.2012.04.005. Epub 2012 May 1. PubMed PMID: 22551767; PubMed Central PMCID: PMC3358485.
Botten J, Whitton JL, Barrowman P, Sidney J, Whitmire JK, Alexander J, Kotturi MF, Sette A, Buchmeier MJ. A multivalent vaccination strategy for the prevention of Old World arenavirus infection in humans. J Virol. 2010 Oct;84(19):9947-56. doi: 10.1128/JVI.00672-10. Epub 2010 Jul 28. PubMed PMID: 20668086; PubMed Central PMCID: PMC2937778.
Botten J, Sidney J, Mothé BR, Peters B, Sette A, Kotturi MF. Coverage of related pathogenic species by multivalent and cross-protective vaccine design: arenaviruses as a model system. Microbiol Mol Biol Rev. 2010 Jun;74(2):157-70. doi: 10.1128/MMBR.00045-09. Review. PubMed PMID: 20508245; PubMed Central PMCID: PMC2884409.
Kotturi MF, Botten J, Maybeno M, Sidney J, Glenn J, Bui HH, Oseroff C, Crotty S, Peters B, Grey H, Altmann DM, Buchmeier MJ, Sette A. Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage. Immunome Res. 2010 May 17;6:4. doi: 10.1186/1745-7580-6-4. PubMed PMID: 20478058; PubMed Central PMCID: PMC2880318.
Alexander J, Bilsel P, del Guercio MF, Marinkovic-Petrovic A, Southwood S, Stewart S, Ishioka G, Kotturi MF, Botten J, Sidney J, Newman M, Sette A. Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus. Hum Immunol. 2010 May;71(5):468-74. doi: 10.1016/j.humimm.2010.02.014. Epub 2010 Mar 10. PubMed PMID: 20156506; PubMed Central PMCID: PMC2856764.
Alexander J, Bilsel P, del Guercio MF, Stewart S, Marinkovic-Petrovic A, Southwood S, Crimi C, Vang L, Walker L, Ishioka G, Chitnis V, Sette A, Assarsson E, Hannaman D, Botten J, Newman MJ. Universal influenza DNA vaccine encoding conserved CD4+ T cell epitopes protects against lethal viral challenge in HLA-DR transgenic mice. Vaccine. 2010 Jan 8;28(3):664-72. doi: 10.1016/j.vaccine.2009.10.103. Epub 2009 Nov 4. PubMed PMID: 19895924; PubMed Central PMCID: PMC3364000.
Kotturi MF, Botten J, Sidney J, Bui HH, Giancola L, Maybeno M, Babin J, Oseroff C, Pasquetto V, Greenbaum JA, Peters B, Ting J, Do D, Vang L, Alexander J, Grey H, Buchmeier MJ, Sette A. A multivalent and cross-protective vaccine strategy against arenaviruses associated with human disease. PLoS Pathog. 2009 Dec;5(12):e1000695. doi: 10.1371/journal.ppat.1000695. Epub 2009 Dec 18. PubMed PMID: 20019801; PubMed Central PMCID: PMC2787016.
Mothé BR, Stewart BS, Oseroff C, Bui HH, Stogiera S, Garcia Z, Dow C, Rodriguez-Carreno MP, Kotturi M, Pasquetto V, Botten J, Crotty S, Janssen E, Buchmeier MJ, Sette A. Chronic lymphocytic choriomeningitis virus infection actively down-regulates CD4+ T cell responses directed against a broad range of epitopes. J Immunol. 2007 Jul 15;179(2):1058-67. doi: 10.4049/jimmunol.179.2.1058. PubMed PMID: 17617598.
Kotturi MF, Peters B, Buendia-Laysa F Jr, Sidney J, Oseroff C, Botten J, Grey H, Buchmeier MJ, Sette A. The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus. J Virol. 2007 May;81(10):4928-40. doi: 10.1128/JVI.02632-06. Epub 2007 Feb 28. PubMed PMID: 17329346; PubMed Central PMCID: PMC1900207.
Botten J, Whitton JL, Barrowman P, Sidney J, Whitmire JK, Alexander J, Ting JP, Bui HH, Sette A, Buchmeier MJ. HLA-A2-restricted protection against lethal lymphocytic choriomeningitis. J Virol. 2007 Mar;81(5):2307-17. doi: 10.1128/JVI.02063-06. Epub 2006 Dec 13. PubMed PMID: 17166907; PubMed Central PMCID: PMC1865925.
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