My Bibliography

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Aalling NN, Todorov PV, Hassan S, Belmont-Rausch DM, Christensen OP, Laurentiussen CO, Jørgensen AM, Alonge KM, Scarlett JM, Mirzadeh Z, Brown JM, Schwartz MW, Pers TH. Sustained diabetes remission induced by FGF1 involves a shift in transcriptionally distinct AgRP neuron subpopulations. Mol Metab. 2026 Jan;103:102300. doi: 10.1016/j.molmet.2025.102300. Epub 2025 Dec 9. PubMed PMID: 41371441; PubMed Central PMCID: PMC12808567.

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Gou Y, Glat M, Damian V, Bryan CL, Phan BA, Faber CL, Trivedi A, Hwang MK, Scarlett JM, Morton GJ, Schwartz MW. AgRP neuron hyperactivity drives hyperglycemia in a mouse model of type 2 diabetes. J Clin Invest. 2025 May 15;135(10). doi: 10.1172/JCI189842. eCollection 2025 May 15. PubMed PMID: 40371641; PubMed Central PMCID: PMC12077889.

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Scarlett JM, Hwang E, Richardson NE, Bryan CL, Redford I, Quah E, Odderson ETR, Choi PP, Hwang MK, Phan BA, Kadlec K, Alonge KM, Morton GJ, Williams KW, Schwartz MW. A key role for parabrachial nucleus CGRP neurons in FGF1-Induced anorexia. Mol Metab. 2025 Jun;96:102138. doi: 10.1016/j.molmet.2025.102138. Epub 2025 Apr 4. PubMed PMID: 40189100; PubMed Central PMCID: PMC12142633.

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Francis KL, Zheng HB, Suskind DL, Murphree TA, Phan BA, Quah E, Hendrickson AS, Zhou X, Nuding M, Hudson AS, Guttman M, Morton GJ, Schwartz MW, Alonge KM, Scarlett JM. Characterizing the human intestinal chondroitin sulfate glycosaminoglycan sulfation signature in inflammatory bowel disease. Sci Rep. 2024 May 23;14(1):11839. doi: 10.1038/s41598-024-60959-x. PubMed PMID: 38782973; PubMed Central PMCID: PMC11116513.

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Hendrickson AS, Francis KL, Kumar A, Le JP, Scarlett JM, Keene CD, Tovar DA, Alonge KM. Assessing translational applicability of perineuronal net dysfunction in Alzheimer's disease across species. Front Neurosci. 2024;18:1396101. doi: 10.3389/fnins.2024.1396101. eCollection 2024. PubMed PMID: 38745932; PubMed Central PMCID: PMC11091253.

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Francis KL, Alonge KM, Pacheco MC, Hu SJ, Krutzsch CA, Morton GJ, Schwartz MW, Scarlett JM. Diabetes exacerbates inflammatory bowel disease in mice with diet-induced obesity. World J Gastroenterol. 2023 Sep 7;29(33):4991-5004. doi: 10.3748/wjg.v29.i33.4991. PubMed PMID: 37731997; PubMed Central PMCID: PMC10507503.

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Deem JD, Tingley D, Bjerregaard AM, Secher A, Chan O, Uzo C, Richardson NE, Giering E, Doan T, Phan BA, Wu B, Scarlett JM, Morton GJ, Schwartz MW. Identification of Hypothalamic Glucoregulatory Neurons That Sense and Respond to Changes in Glycemia. Diabetes. 2023 Sep 1;72(9):1207-1213. doi: 10.2337/db23-0139. PubMed PMID: 37347793; PubMed Central PMCID: PMC10450823.

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Deem JD, Phan BA, Ogimoto K, Cheng A, Bryan CL, Scarlett JM, Schwartz MW, Morton GJ. Warm Responsive Neurons in the Hypothalamic Preoptic Area are Potent Regulators of Glucose Homeostasis in Male Mice. Endocrinology. 2023 Jun 6;164(7). doi: 10.1210/endocr/bqad074. PubMed PMID: 37279930; PubMed Central PMCID: PMC10653198.

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Hwang E, Scarlett JM, Baquero AF, Bennett CM, Dong Y, Chau D, Brown JM, Mercer AJ, Meek TH, Grove KL, Phan BAN, Morton GJ, Williams KW, Schwartz MW. Sustained inhibition of NPY/AgRP neuronal activity by FGF1. JCI Insight. 2022 Sep 8;7(17). doi: 10.1172/jci.insight.160891. PubMed PMID: 35917179; PubMed Central PMCID: PMC9536267.

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Scarlett JM, Hu SJ, Alonge KM. The "Loss" of Perineuronal Nets in Alzheimer's Disease: Missing or Hiding in Plain Sight?. Front Integr Neurosci. 2022;16:896400. doi: 10.3389/fnint.2022.896400. eCollection 2022. PubMed PMID: 35694184; PubMed Central PMCID: PMC9174696.

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Brown JM, Phan BA, Aalling N, Morton GJ, Schwartz MW, Scarlett JM. Combined micro-osmotic pump infusion and intracerebroventricular injection to study FGF1 signaling pathways in the mouse brain. STAR Protoc. 2022 Jun 17;3(2):101329. doi: 10.1016/j.xpro.2022.101329. eCollection 2022 Jun 17. PubMed PMID: 35479117; PubMed Central PMCID: PMC9035806.

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Logsdon AF, Francis KL, Richardson NE, Hu SJ, Faber CL, Phan BA, Nguyen V, Setthavongsack N, Banks WA, Woltjer RL, Keene CD, Latimer CS, Schwartz MW, Scarlett JM, Alonge KM. Decoding perineuronal net glycan sulfation patterns in the Alzheimer's disease brain. Alzheimers Dement. 2022 May;18(5):942-954. doi: 10.1002/alz.12451. Epub 2021 Sep 5. PubMed PMID: 34482642; PubMed Central PMCID: PMC8897514.

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Brown JM, Bentsen MA, Rausch DM, Phan BA, Wieck D, Wasanwala H, Matsen ME, Acharya N, Richardson NE, Zhao X, Zhai P, Secher A, Morton GJ, Pers TH, Schwartz MW, Scarlett JM. Role of hypothalamic MAPK/ERK signaling and central action of FGF1 in diabetes remission. iScience. 2021 Sep 24;24(9):102944. doi: 10.1016/j.isci.2021.102944. eCollection 2021 Sep 24. PubMed PMID: 34430821; PubMed Central PMCID: PMC8368994.

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Deem JD, Faber CL, Pedersen C, Phan BA, Larsen SA, Ogimoto K, Nelson JT, Damian V, Tran MA, Palmiter RD, Kaiyala KJ, Scarlett JM, Bruchas MR, Schwartz MW, Morton GJ. Cold-induced hyperphagia requires AgRP neuron activation in mice. Elife. 2020 Dec 15;9. doi: 10.7554/eLife.58764. PubMed PMID: 33320088; PubMed Central PMCID: PMC7837681.

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Alonge KM, Mirzadeh Z, Scarlett JM, Logsdon AF, Brown JM, Cabrales E, Chan CK, Kaiyala KJ, Bentsen MA, Banks WA, Guttman M, Wight TN, Morton GJ, Schwartz MW. Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats. Nat Metab. 2020 Oct;2(10):1025-1033. doi: 10.1038/s42255-020-00275-6. Epub 2020 Sep 7. PubMed PMID: 32895577; PubMed Central PMCID: PMC7572652.

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Bentsen MA, Rausch DM, Mirzadeh Z, Muta K, Scarlett JM, Brown JM, Herranz-Pérez V, Baquero AF, Thompson J, Alonge KM, Faber CL, Kaiyala KJ, Bennett C, Pyke C, Ratner C, Egerod KL, Holst B, Meek TH, Kutlu B, Zhang Y, Sparso T, Grove KL, Morton GJ, Kornum BR, García-Verdugo JM, Secher A, Jorgensen R, Schwartz MW, Pers TH. Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission. Nat Commun. 2020 Sep 7;11(1):4458. doi: 10.1038/s41467-020-17720-5. PubMed PMID: 32895383; PubMed Central PMCID: PMC7477234.

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Brown JM, Scarlett JM, Schwartz MW. Rethinking the role of the brain in glucose homeostasis and diabetes pathogenesis. J Clin Invest. 2019 Jul 22;129(8):3035-3037. doi: 10.1172/JCI130904. eCollection 2019 Jul 22. Review. PubMed PMID: 31329157; PubMed Central PMCID: PMC6668663.

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Arndt MB, Richardson BA, Mahfuz M, Ahmed T, Haque R, Gazi MA, John-Stewart GC, Denno DM, Scarlett JM, Walson JL, coordination with The Interactions of Malnutrition & Enteric Infections: Consequences for Child Health and Development Project Network. Plasma Fibroblast Growth Factor 21 Is Associated with Subsequent Growth in a Cohort of Underweight Children in Bangladesh. Curr Dev Nutr. 2019 May;3(5):nzz024. doi: 10.1093/cdn/nzz024. eCollection 2019 May. Review. PubMed PMID: 31093598; PubMed Central PMCID: PMC6511337.

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Hultman K, Scarlett JM, Baquero AF, Cornea A, Zhang Y, Salinas CBG, Brown J, Morton GJ, Whalen EJ, Grove KL, Koegler FH, Schwartz MW, Mercer AJ. The central fibroblast growth factor receptor/beta klotho system: Comprehensive mapping in Mus musculus and comparisons to nonhuman primate and human samples using an automated in situ hybridization platform. J Comp Neurol. 2019 Aug 15;527(12):2069-2085. doi: 10.1002/cne.24668. Epub 2019 Mar 9. PubMed PMID: 30809795; PubMed Central PMCID: PMC6546511.

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Brown JM, Scarlett JM, Matsen ME, Nguyen HT, Secher A, Jorgensen R, Morton GJ, Schwartz MW. The Hypothalamic Arcuate Nucleus-Median Eminence Is a Target for Sustained Diabetes Remission Induced by Fibroblast Growth Factor 1. Diabetes. 2019 May;68(5):1054-1061. doi: 10.2337/db19-0025. Epub 2019 Feb 22. PubMed PMID: 30796029; PubMed Central PMCID: PMC6477902.

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Mirzadeh Z, Alonge KM, Cabrales E, Herranz-Pérez V, Scarlett JM, Brown JM, Hassouna R, Matsen ME, Nguyen HT, Garcia-Verdugo JM, Zeltser LM, Schwartz MW. Perineuronal Net Formation during the Critical Period for Neuronal Maturation in the Hypothalamic Arcuate Nucleus. Nat Metab. 2019 Feb;1(2):212-221. doi: 10.1038/s42255-018-0029-0. Epub 2019 Jan 21. PubMed PMID: 31245789; PubMed Central PMCID: PMC6594569.

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Scarlett JM, Muta K, Brown JM, Rojas JM, Matsen ME, Acharya NK, Secher A, Ingvorsen C, Jorgensen R, Høeg-Jensen T, Stefanovski D, Bergman RN, Piccinini F, Kaiyala KJ, Shiota M, Morton GJ, Schwartz MW. Peripheral Mechanisms Mediating the Sustained Antidiabetic Action of FGF1 in the Brain. Diabetes. 2019 Mar;68(3):654-664. doi: 10.2337/db18-0498. Epub 2018 Dec 6. PubMed PMID: 30523024; PubMed Central PMCID: PMC6385755.

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Meek TH, Matsen ME, Faber CL, Samstag CL, Damian V, Nguyen HT, Scarlett JM, Flak JN, Myers MG Jr, Morton GJ. In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus. Endocrinology. 2018 Apr 1;159(4):1585-1594. doi: 10.1210/en.2017-03199. PubMed PMID: 29438473; PubMed Central PMCID: PMC5939636.

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Deem JD, Muta K, Scarlett JM, Morton GJ, Schwartz MW. How Should We Think About the Role of the Brain in Glucose Homeostasis and Diabetes?. Diabetes. 2017 Jul;66(7):1758-1765. doi: 10.2337/dbi16-0067. Epub 2017 Jun 11. PubMed PMID: 28603139; PubMed Central PMCID: PMC5482090.

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Morton GJ, Muta K, Kaiyala KJ, Rojas JM, Scarlett JM, Matsen ME, Nelson JT, Acharya NK, Piccinini F, Stefanovski D, Bergman RN, Taborsky GJ Jr, Kahn SE, Schwartz MW. Evidence That the Sympathetic Nervous System Elicits Rapid, Coordinated, and Reciprocal Adjustments of Insulin Secretion and Insulin Sensitivity During Cold Exposure. Diabetes. 2017 Apr;66(4):823-834. doi: 10.2337/db16-1351. Epub 2017 Jan 23. PubMed PMID: 28115396; PubMed Central PMCID: PMC5360298.

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Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP. Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity. Diabetes. 2017 Apr;66(4):920-934. doi: 10.2337/db16-0482. Epub 2017 Jan 10. PubMed PMID: 28073831; PubMed Central PMCID: PMC5360303.

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Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW. Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents. Nat Med. 2016 Jul;22(7):800-6. doi: 10.1038/nm.4101. Epub 2016 May 23. PubMed PMID: 27213816; PubMed Central PMCID: PMC4938755.

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Meek TH, Nelson JT, Matsen ME, Dorfman MD, Guyenet SJ, Damian V, Allison MB, Scarlett JM, Nguyen HT, Thaler JP, Olson DP, Myers MG Jr, Schwartz MW, Morton GJ. Functional identification of a neurocircuit regulating blood glucose. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2073-82. doi: 10.1073/pnas.1521160113. Epub 2016 Mar 21. PubMed PMID: 27001850; PubMed Central PMCID: PMC4833243.

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Scarlett JM, Schwartz MW. Gut-brain mechanisms controlling glucose homeostasis. F1000Prime Rep. 2015;7:12. doi: 10.12703/P7-12. eCollection 2015. Review. PubMed PMID: 25705395; PubMed Central PMCID: PMC4311273.

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Scarlett JM, Bowe DD, Zhu X, Batra AK, Grant WF, Marks DL. Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure. J Endocrinol. 2010 Jul;206(1):121-30. doi: 10.1677/JOE-09-0397. Epub 2010 Apr 6. PubMed PMID: 20371568; PubMed Central PMCID: PMC2887273.

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Grossberg AJ, Scarlett JM, Marks DL. Hypothalamic mechanisms in cachexia. Physiol Behav. 2010 Jul 14;100(5):478-89. doi: 10.1016/j.physbeh.2010.03.011. Epub 2010 Mar 25. Review. PubMed PMID: 20346963; PubMed Central PMCID: PMC2927357.

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Grossberg AJ, Scarlett JM, Zhu X, Bowe DD, Batra AK, Braun TP, Marks DL. Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130. Endocrinology. 2010 Feb;151(2):606-16. doi: 10.1210/en.2009-1135. Epub 2009 Dec 16. PubMed PMID: 20016025; PubMed Central PMCID: PMC2817620.

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DeBoer MD, Scarlett JM, Levasseur PR, Grant WF, Marks DL. Administration of IL-1beta to the 4th ventricle causes anorexia that is blocked by agouti-related peptide and that coincides with activation of tyrosine-hydroxylase neurons in the nucleus of the solitary tract. Peptides. 2009 Feb;30(2):210-8. doi: 10.1016/j.peptides.2008.10.019. Epub 2008 Nov 5. PubMed PMID: 19028534; PubMed Central PMCID: PMC2853249.

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Scarlett JM, Zhu X, Enriori PJ, Bowe DD, Batra AK, Levasseur PR, Grant WF, Meguid MM, Cowley MA, Marks DL. Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation. Endocrinology. 2008 Oct;149(10):4837-45. doi: 10.1210/en.2007-1680. Epub 2008 Jun 26. PubMed PMID: 18583425; PubMed Central PMCID: PMC2582916.

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Madison LD, Scarlett JM, Levasseur P, Zhu X, Newcomb K, Batra A, Bowe D, Marks DL. Prostacyclin signaling regulates circulating ghrelin during acute inflammation. J Endocrinol. 2008 Feb;196(2):263-73. doi: 10.1677/JOE-07-0478. PubMed PMID: 18252949.

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Scarlett JM, Jobst EE, Enriori PJ, Bowe DD, Batra AK, Grant WF, Cowley MA, Marks DL. Regulation of central melanocortin signaling by interleukin-1 beta. Endocrinology. 2007 Sep;148(9):4217-25. doi: 10.1210/en.2007-0017. Epub 2007 May 24. PubMed PMID: 17525125.

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Pan YW, Scarlett JM, Luoh TT, Kurre P. Prolonged adherence of human immunodeficiency virus-derived vector particles to hematopoietic target cells leads to secondary transduction in vitro and in vivo. J Virol. 2007 Jan;81(2):639-49. doi: 10.1128/JVI.01089-06. Epub 2006 Oct 11. PubMed PMID: 17035328; PubMed Central PMCID: PMC1797443.

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Scarlett JM, Marks DL. The use of melanocortin antagonists in cachexia of chronic disease. Expert Opin Investig Drugs. 2005 Oct;14(10):1233-9. doi: 10.1517/13543784.14.10.1233. Review. PubMed PMID: 16185165.

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Fraley GS, Scarlett JM, Shimada I, Teklemichael DN, Acohido BV, Clifton DK, Steiner RA. Effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the rat. Diabetes. 2004 May;53(5):1237-42. doi: 10.2337/diabetes.53.5.1237. PubMed PMID: 15111492.

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Cunningham MJ, Shahab M, Grove KL, Scarlett JM, Plant TM, Cameron JL, Smith MS, Clifton DK, Steiner RA. Galanin-like peptide as a possible link between metabolism and reproduction in the macaque. J Clin Endocrinol Metab. 2004 Apr;89(4):1760-6. doi: 10.1210/jc.2003-031628. PubMed PMID: 15070942.

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Cunningham MJ, Scarlett JM, Steiner RA. Cloning and distribution of galanin-like peptide mRNA in the hypothalamus and pituitary of the macaque. Endocrinology. 2002 Mar;143(3):755-63. doi: 10.1210/endo.143.3.8661. PubMed PMID: 11861493.