My Bibliography

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Amorim MR, Wang X, Aung O, Bevans-Fonti S, Anokye-Danso F, Ribeiro C, Escobar J, Freire C, Pho H, Dergacheva O, Branco LGS, Ahima RS, Mendelowitz D, Polotsky VY. Leptin signaling in the dorsomedial hypothalamus couples breathing and metabolism in obesity. Cell Rep. 2023 Dec 26;42(12):113512. doi: 10.1016/j.celrep.2023.113512. Epub 2023 Nov 30. PubMed PMID: 38039129; PubMed Central PMCID: PMC10804286.

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Conde SV, Polotsky VY, Joseph V, Kinkead R. On the origins of sleep disordered breathing, cardiorespiratory and metabolic dysfunction: which came first, the chicken or the egg?. J Physiol. 2023 Dec;601(24):5509-5525. doi: 10.1113/JP284113. Epub 2023 Apr 15. PubMed PMID: 36988138; PubMed Central PMCID: PMC10539476.

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Duan D, Perin J, Osman A, Sgambati F, Kim LJ, Pham LV, Polotsky VY, Jun JC. Effects of sex, age, and body mass index on serum bicarbonate. Front Sleep. 2023;2. doi: 10.3389/frsle.2023.1195823. Epub 2023 Jul 20. PubMed PMID: 37736141; PubMed Central PMCID: PMC10512520.

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Kim LJ, Pho H, Pham LV, Polotsky VY. Isocapnic CO2 administration stabilizes breathing and eliminates apneas during sleep in obese mice exposed to hypoxia. Sleep. 2023 Feb 8;46(2). doi: 10.1093/sleep/zsac243. PubMed PMID: 36183293; PubMed Central PMCID: PMC9905775.

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Duan D, Kim LJ, Jun JC, Polotsky VY. Connecting insufficient sleep and insomnia with metabolic dysfunction. Ann N Y Acad Sci. 2023 Jan;1519(1):94-117. doi: 10.1111/nyas.14926. Epub 2022 Nov 13. Review. PubMed PMID: 36373239; PubMed Central PMCID: PMC9839511.

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Kim LJ, Alexandre C, Pho H, Latremoliere A, Polotsky VY, Pham LV. Diet-induced obesity leads to sleep fragmentation independently of the severity of sleep-disordered breathing. J Appl Physiol (1985). 2022 Dec 1;133(6):1284-1294. doi: 10.1152/japplphysiol.00386.2022. Epub 2022 Oct 6. PubMed PMID: 36201322; PubMed Central PMCID: PMC9678416.

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Kim LJ, Shin MK, Pho H, Tang WY, Hosamane N, Anokye-Danso F, Ahima RS, Sham JSK, Pham LV, Polotsky VY. TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies. J Physiol. 2022 Dec;600(23):5145-5162. doi: 10.1113/JP283678. Epub 2022 Oct 21. PubMed PMID: 36214387.

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Amorim MR, Aung O, Mokhlesi B, Polotsky VY. Leptin-mediated neural targets in obesity hypoventilation syndrome. Sleep. 2022 Sep 8;45(9). doi: 10.1093/sleep/zsac153. Review. PubMed PMID: 35778900; PubMed Central PMCID: PMC9453616.

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Lin DC, Zheng SY, Zhang ZG, Luo JH, Zhu ZL, Li L, Chen LS, Lin X, Sham JSK, Lin MJ, Zhou RX. TRPC3 promotes tumorigenesis of gastric cancer via the CNB2/GSK3β/NFATc2 signaling pathway. Cancer Lett. 2021 Oct 28;519:211-225. doi: 10.1016/j.canlet.2021.07.038. Epub 2021 Jul 24. PubMed PMID: 34311033.

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Kim LJ, Pham LV, Polotsky VY. Sleep Apnea, Hypoxia Inducible Factor, and Fatty Liver: More Questions Than Answers?. Am J Respir Cell Mol Biol. 2021 Oct;65(4):337-338. doi: 10.1165/rcmb.2021-0204ED. PubMed PMID: 34101539; PubMed Central PMCID: PMC8525207.

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Sun H, Paudel O, Sham JSK. Increased intracellular Cl(-) concentration in pulmonary arterial myocytes is associated with chronic hypoxic pulmonary hypertension. Am J Physiol Cell Physiol. 2021 Aug 1;321(2):C297-C307. doi: 10.1152/ajpcell.00172.2021. Epub 2021 Jun 23. PubMed PMID: 34161154; PubMed Central PMCID: PMC8526344.

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Yeung BH, Griffiths K, Berger L, Paudel O, Shin MK, Rui L, Sham JSK, Polotsky VY, Tang WY. Leptin Induces Epigenetic Regulation of Transient Receptor Potential Melastatin 7 in Rat Adrenal Pheochromocytoma Cells. Am J Respir Cell Mol Biol. 2021 Aug;65(2):214-221. doi: 10.1165/rcmb.2020-0374OC. PubMed PMID: 33891828; PubMed Central PMCID: PMC8399575.

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Shin MK, Mitrut R, Gu C, Kim LJ, Yeung BHY, Lee R, Pham L, Tang WY, Sham JSK, Cui H, Polotsky VY. Pharmacological and Genetic Blockade of Trpm7 in the Carotid Body Treats Obesity-Induced Hypertension. Hypertension. 2021 Jul;78(1):104-114. doi: 10.1161/HYPERTENSIONAHA.120.16527. Epub 2021 May 17. PubMed PMID: 33993722; PubMed Central PMCID: PMC8192446.

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Song JL, Zheng SY, He RL, Gui LX, Lin MJ, Sham JSK. Serotonin and chronic hypoxic pulmonary hypertension activate a NADPH oxidase 4 and TRPM2 dependent pathway for pulmonary arterial smooth muscle cell proliferation and migration. Vascul Pharmacol. 2021 Jun;138:106860. doi: 10.1016/j.vph.2021.106860. Epub 2021 Mar 29. PubMed PMID: 33794383.

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Wang D, Zhu ZL, Lin DC, Zheng SY, Chuang KH, Gui LX, Yao RH, Zhu WJ, Sham JSK, Lin MJ. Magnesium Supplementation Attenuates Pulmonary Hypertension via Regulation of Magnesium Transporters. Hypertension. 2021 Feb;77(2):617-631. doi: 10.1161/HYPERTENSIONAHA.120.14909. Epub 2020 Dec 28. PubMed PMID: 33356397.

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Xia Y, Xia L, Jin Z, Jin R, Paudel O, Sham JSK. Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension. Anal Cell Pathol (Amst). 2020;2020:8927381. doi: 10.1155/2020/8927381. eCollection 2020. PubMed PMID: 32399392; PubMed Central PMCID: PMC7204149.

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Shin MK, Eraso CC, Mu YP, Gu C, Yeung BHY, Kim LJ, Liu XR, Wu ZJ, Paudel O, Pichard LE, Shirahata M, Tang WY, Sham JSK, Polotsky VY. Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body. Circ Res. 2019 Nov 8;125(11):989-1002. doi: 10.1161/CIRCRESAHA.119.315338. Epub 2019 Sep 23. PubMed PMID: 31545149; PubMed Central PMCID: PMC6842127.

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Caballero-Eraso C, Shin MK, Pho H, Kim LJ, Pichard LE, Wu ZJ, Gu C, Berger S, Pham L, Yeung HB, Shirahata M, Schwartz AR, Tang WW, Sham JSK, Polotsky VY. Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response. J Physiol. 2019 Jan;597(1):151-172. doi: 10.1113/JP276900. Epub 2018 Nov 29. PubMed PMID: 30285278; PubMed Central PMCID: PMC6312428.

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Yip KP, Balasubramanian L, Kan C, Wang L, Liu R, Ribeiro-Silva L, Sham JSK. Intraluminal pressure triggers myogenic response via activation of calcium spark and calcium-activated chloride channel in rat renal afferent arteriole. Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1592-F1600. doi: 10.1152/ajprenal.00239.2018. Epub 2018 Aug 8. PubMed PMID: 30089032; PubMed Central PMCID: PMC6336985.

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Mu YP, Lin DC, Zheng SY, Jiao HX, Sham JSK, Lin MJ. Transient Receptor Potential Melastatin-8 Activation Induces Relaxation of Pulmonary Artery by Inhibition of Store-Operated Calcium Entry in Normoxic and Chronic Hypoxic Pulmonary Hypertensive Rats. J Pharmacol Exp Ther. 2018 Jun;365(3):544-555. doi: 10.1124/jpet.117.247320. Epub 2018 Apr 5. PubMed PMID: 29622593.

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Mu YP, Huang QH, Zhu JL, Zheng SY, Yan FR, Zhuang XL, Sham JSK, Lin MJ. Magnesium attenuates endothelin-1-induced vasoreactivity and enhances vasodilatation in mouse pulmonary arteries: Modulation by chronic hypoxic pulmonary hypertension. Exp Physiol. 2018 Apr 1;103(4):604-616. doi: 10.1113/EP086655. Epub 2018 Feb 25. PubMed PMID: 29363240.

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Jiao HX, Mu YP, Gui LX, Yan FR, Lin DC, Sham JS, Lin MJ. Increase in caveolae and caveolin-1 expression modulates agonist-induced contraction and store- and receptor-operated Ca(2+) entry in pulmonary arteries of pulmonary hypertensive rats. Vascul Pharmacol. 2016 Sep;84:55-66. doi: 10.1016/j.vph.2016.06.004. Epub 2016 Jun 14. PubMed PMID: 27311393.

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Lin AH, Sun H, Paudel O, Lin MJ, Sham JS. Conformation of ryanodine receptor-2 gates store-operated calcium entry in rat pulmonary arterial myocytes. Cardiovasc Res. 2016 Jul 1;111(1):94-104. doi: 10.1093/cvr/cvw067. Epub 2016 Mar 24. PubMed PMID: 27013634; PubMed Central PMCID: PMC4909159.

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Lin AH, Shang Y, Mitzner W, Sham JS, Tang WY. Aberrant DNA Methylation of Phosphodiesterase [corrected] 4D Alters Airway Smooth Muscle Cell Phenotypes. Am J Respir Cell Mol Biol. 2016 Feb;54(2):241-9. doi: 10.1165/rcmb.2015-0079OC. PubMed PMID: 26181301; PubMed Central PMCID: PMC4821043.

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Huang C, Hu J, Subedi KP, Lin AH, Paudel O, Ran P, Sham JS. Extracellular Adenosine Diphosphate Ribose Mobilizes Intracellular Ca2+ via Purinergic-Dependent Ca2+ Pathways in Rat Pulmonary Artery Smooth Muscle Cells. Cell Physiol Biochem. 2015;37(5):2043-59. doi: 10.1159/000438564. Epub 2015 Nov 20. PubMed PMID: 26584302.

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Wang RX, He RL, Jiao HX, Dai M, Mu YP, Hu Y, Wu ZJ, Sham JS, Lin MJ. Ginsenoside Rb1 attenuates agonist-induced contractile response via inhibition of store-operated calcium entry in pulmonary arteries of normal and pulmonary hypertensive rats. Cell Physiol Biochem. 2015;35(4):1467-81. doi: 10.1159/000373966. Epub 2015 Mar 12. PubMed PMID: 25791507.

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Lee S, Paudel O, Jiang Y, Yang XR, Sham JS. CD38 mediates angiotensin II-induced intracellular Ca(2+) release in rat pulmonary arterial smooth muscle cells. Am J Respir Cell Mol Biol. 2015 Mar;52(3):332-41. doi: 10.1165/rcmb.2014-0141OC. PubMed PMID: 25078456; PubMed Central PMCID: PMC4370261.

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Subedi KP, Paudel O, Sham JS. Detection of differentially regulated subsarcolemmal calcium signals activated by vasoactive agonists in rat pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol. 2014 Apr 1;306(7):C659-69. doi: 10.1152/ajpcell.00341.2013. Epub 2013 Dec 18. PubMed PMID: 24352334; PubMed Central PMCID: PMC3962597.

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Cheng RY, Shang Y, Limjunyawong N, Dao T, Das S, Rabold R, Sham JS, Mitzner W, Tang WY. Alterations of the lung methylome in allergic airway hyper-responsiveness. Environ Mol Mutagen. 2014 Apr;55(3):244-55. doi: 10.1002/em.21851. Epub 2014 Jan 21. PubMed PMID: 24446183; PubMed Central PMCID: PMC4125208.

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Jiang Y, Dai A, Zhou Y, Peng G, Hu G, Li B, Sham JS, Ran P. Nicotine elevated intracellular Ca²⁺ in rat airway smooth muscle cells via activating and up-regulating α7-nicotinic acetylcholine receptor. Cell Physiol Biochem. 2014;33(2):389-401. doi: 10.1159/000356678. Epub 2014 Feb 6. PubMed PMID: 24525957.

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Xia Y, Yang XR, Fu Z, Paudel O, Abramowitz J, Birnbaumer L, Sham JS. Classical transient receptor potential 1 and 6 contribute to hypoxic pulmonary hypertension through differential regulation of pulmonary vascular functions. Hypertension. 2014 Jan;63(1):173-80. doi: 10.1161/HYPERTENSIONAHA.113.01902. Epub 2013 Oct 21. PubMed PMID: 24144647; PubMed Central PMCID: PMC4102175.

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Xia Y, Fu Z, Hu J, Huang C, Paudel O, Cai S, Liedtke W, Sham JS. TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension. Am J Physiol Cell Physiol. 2013 Oct 1;305(7):C704-15. doi: 10.1152/ajpcell.00099.2013. Epub 2013 Jun 5. PubMed PMID: 23739180; PubMed Central PMCID: PMC3798671.

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Shang Y, Das S, Rabold R, Sham JS, Mitzner W, Tang WY. Epigenetic alterations by DNA methylation in house dust mite-induced airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2013 Aug;49(2):279-87. doi: 10.1165/rcmb.2012-0403OC. PubMed PMID: 23526225; PubMed Central PMCID: PMC3824034.

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Liu XR, Liu Q, Chen GY, Hu Y, Sham JS, Lin MJ. Down-regulation of TRPM8 in pulmonary arteries of pulmonary hypertensive rats. Cell Physiol Biochem. 2013;31(6):892-904. doi: 10.1159/000350107. Epub 2013 Jun 17. PubMed PMID: 23817166; PubMed Central PMCID: PMC4034698.

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Jiang YL, Lin AH, Xia Y, Lee S, Paudel O, Sun H, Yang XR, Ran P, Sham JS. Nicotinic acid adenine dinucleotide phosphate (NAADP) activates global and heterogeneous local Ca2+ signals from NAADP- and ryanodine receptor-gated Ca2+ stores in pulmonary arterial myocytes. J Biol Chem. 2013 Apr 12;288(15):10381-94. doi: 10.1074/jbc.M112.423053. Epub 2013 Feb 26. PubMed PMID: 23443655; PubMed Central PMCID: PMC3624421.

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Balasubramanian L, Lo CM, Sham JS, Yip KP. Remanent cell traction force in renal vascular smooth muscle cells induced by integrin-mediated mechanotransduction. Am J Physiol Cell Physiol. 2013 Feb 15;304(4):C382-91. doi: 10.1152/ajpcell.00234.2012. Epub 2013 Jan 16. PubMed PMID: 23325413; PubMed Central PMCID: PMC3566537.

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Sun H, Xia Y, Paudel O, Yang XR, Sham JS. Chronic hypoxia-induced upregulation of Ca2+-activated Cl- channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity. J Physiol. 2012 Aug 1;590(15):3507-21. doi: 10.1113/jphysiol.2012.232520. Epub 2012 Jun 6. PubMed PMID: 22674716; PubMed Central PMCID: PMC3547266.

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Yip KP, Sham JS. Tracking stars: automated two-dimensional analysis of Ca²⁺ events. Focus on "Automated region of interest analysis of dynamic Ca²⁺ signals in image sequences". Am J Physiol Cell Physiol. 2012 Aug 1;303(3):C233-5. doi: 10.1152/ajpcell.00178.2012. Epub 2012 May 30. PubMed PMID: 22648951; PubMed Central PMCID: PMC3423027.

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Yang XR, Lin AH, Hughes JM, Flavahan NA, Cao YN, Liedtke W, Sham JS. Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15;302(6):L555-68. doi: 10.1152/ajplung.00005.2011. Epub 2011 Dec 29. PubMed PMID: 22207590; PubMed Central PMCID: PMC3311528.

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Liu XR, Zhang MF, Yang N, Liu Q, Wang RX, Cao YN, Yang XR, Sham JS, Lin MJ. Enhanced store-operated Ca²+ entry and TRPC channel expression in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats. Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C77-87. doi: 10.1152/ajpcell.00247.2011. Epub 2011 Sep 21. PubMed PMID: 21940663; PubMed Central PMCID: PMC3328901.

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Umesh A, Paudel O, Cao YN, Myers AC, Sham JS. Alteration of pulmonary artery integrin levels in chronic hypoxia and monocrotaline-induced pulmonary hypertension. J Vasc Res. 2011;48(6):525-37. doi: 10.1159/000329593. Epub 2011 Aug 10. PubMed PMID: 21829038; PubMed Central PMCID: PMC3169367.

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Deshpande DA, Robinett KS, Wang WC, Sham JS, An SS, Liggett SB. Bronchodilator activity of bitter tastants in human tissue. Nat Med. 2011 Jul 7;17(7):776-8. doi: 10.1038/nm0711-776b. PubMed PMID: 21738150; PubMed Central PMCID: PMC4576926.

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Yip KP, Sham JS. Mechanisms of vasopressin-induced intracellular Ca2+ oscillations in rat inner medullary collecting duct. Am J Physiol Renal Physiol. 2011 Feb;300(2):F540-8. doi: 10.1152/ajprenal.00544.2009. Epub 2010 Dec 8. PubMed PMID: 21147839; PubMed Central PMCID: PMC3044002.

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Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat Med. 2010 Nov;16(11):1299-304. doi: 10.1038/nm.2237. Epub 2010 Oct 24. PubMed PMID: 20972434; PubMed Central PMCID: PMC3066567.

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Yang XR, Lin MJ, Sham JS. Physiological functions of transient receptor potential channels in pulmonary arterial smooth muscle cells. Adv Exp Med Biol. 2010;661:109-22. doi: 10.1007/978-1-60761-500-2_7. Review. PubMed PMID: 20204726.

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Reuter H, Louch WE, Brette F, Sham JS, Sun H, Yang XR, Soeller C, Lakatta EG, Balijepalli RC. Commentaries on viewpoint: The cardiac contraction cycle: is Ca2+ going local? Counterpoint. J Appl Physiol (1985). 2009 Dec;107(6):1985-7; author reply 1988. doi: 10.1152/japplphysiol.01028.2009. PubMed PMID: 19952386; PubMed Central PMCID: PMC3774344.

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Balasubramanian L, Sham JS, Yip KP. Calcium signaling in vasopressin-induced aquaporin-2 trafficking. Pflugers Arch. 2008 Jul;456(4):747-54. doi: 10.1007/s00424-007-0371-7. Epub 2007 Oct 24. Review. PubMed PMID: 17957381; NIHMSID:NIHMS230940.

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Balasubramanian L, Ahmed A, Lo CM, Sham JS, Yip KP. Integrin-mediated mechanotransduction in renal vascular smooth muscle cells: activation of calcium sparks. Am J Physiol Regul Integr Comp Physiol. 2007 Oct;293(4):R1586-94. doi: 10.1152/ajpregu.00025.2007. Epub 2007 Aug 15. PubMed PMID: 17699564; NIHMSID:NIHMS230941.

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Lin MJ, Yang XR, Cao YN, Sham JS. Hydrogen peroxide-induced Ca2+ mobilization in pulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1598-608. doi: 10.1152/ajplung.00323.2006. Epub 2007 Mar 16. PubMed PMID: 17369291; NIHMSID:NIHMS233935.

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Umesh A, Thompson MA, Chini EN, Yip KP, Sham JS. Integrin ligands mobilize Ca2+ from ryanodine receptor-gated stores and lysosome-related acidic organelles in pulmonary arterial smooth muscle cells. J Biol Chem. 2006 Nov 10;281(45):34312-23. doi: 10.1074/jbc.M606765200. Epub 2006 Sep 9. PubMed PMID: 16963791.