My Bibliography

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Voelkel NF, Tuder RM, Bridges J, Arend WP. Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline. Am J Respir Cell Mol Biol. 1994 Dec;11(6):664-75. doi: 10.1165/ajrcmb.11.6.7946395. PubMed PMID: 7946395.

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Chetham PM, Sefton WD, Bridges JP, Stevens T, McMurtry IF. Inhaled nitric oxide pretreatment but not posttreatment attenuates ischemia-reperfusion-induced pulmonary microvascular leak. Anesthesiology. 1997 Apr;86(4):895-902. doi: 10.1097/00000542-199704000-00020. PubMed PMID: 9105234.

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Chetham PM, Guldemeester HA, Mons N, Brough GH, Bridges JP, Thompson WJ, Stevens T. Ca(2+)-inhibitable adenylyl cyclase and pulmonary microvascular permeability. Am J Physiol. 1997 Jul;273(1 Pt 1):L22-30. doi: 10.1152/ajplung.1997.273.1.L22. PubMed PMID: 9252536.

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Chetham PM, Babál P, Bridges JP, Moore TM, Stevens T. Segmental regulation of pulmonary vascular permeability by store-operated Ca2+ entry. Am J Physiol. 1999 Jan;276(1):L41-50. doi: 10.1152/ajplung.1999.276.1.L41. PubMed PMID: 9887054.

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Tomlinson LA, Carpenter TC, Baker EH, Bridges JB, Weil JV. Hypoxia reduces airway epithelial sodium transport in rats. Am J Physiol. 1999 Nov;277(5):L881-6. doi: 10.1152/ajplung.1999.277.5.L881. PubMed PMID: 10564171.

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Bridges JP, Davis HW, Damodarasamy M, Kuroki Y, Howles G, Hui DY, McCormack FX. Pulmonary surfactant proteins A and D are potent endogenous inhibitors of lipid peroxidation and oxidative cellular injury. J Biol Chem. 2000 Dec 8;275(49):38848-55. doi: 10.1074/jbc.M005322200. PubMed PMID: 10969075.

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Conkright JJ, Bridges JP, Na CL, Voorhout WF, Trapnell B, Glasser SW, Weaver TE. Secretion of surfactant protein C, an integral membrane protein, requires the N-terminal propeptide. J Biol Chem. 2001 May 4;276(18):14658-64. doi: 10.1074/jbc.M011770200. Epub 2001 Jan 30. PubMed PMID: 11278984.

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Bridges JP, Wert SE, Nogee LM, Weaver TE. Expression of a human surfactant protein C mutation associated with interstitial lung disease disrupts lung development in transgenic mice. J Biol Chem. 2003 Dec 26;278(52):52739-46. doi: 10.1074/jbc.M309599200. Epub 2003 Oct 2. PubMed PMID: 14525980.

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Kuzmenko AI, Wu H, Bridges JP, McCormack FX. Surfactant lipid peroxidation damages surfactant protein A and inhibits interactions with phospholipid vesicles. J Lipid Res. 2004 Jun;45(6):1061-8. doi: 10.1194/jlr.M300360-JLR200. Epub 2004 Mar 16. PubMed PMID: 15026426.

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Bridges JP, Xu Y, Na CL, Wong HR, Weaver TE. Adaptation and increased susceptibility to infection associated with constitutive expression of misfolded SP-C. J Cell Biol. 2006 Jan 30;172(3):395-407. doi: 10.1083/jcb.200508016. PubMed PMID: 16449190; PubMed Central PMCID: PMC2063649.

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Bridges JP, Weaver TE. Use of transgenic mice to study lung morphogenesis and function. ILAR J. 2006;47(1):22-31. doi: 10.1093/ilar.47.1.22. Review. PubMed PMID: 16391428.

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Dong M, Bridges JP, Apsley K, Xu Y, Weaver TE. ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. Mol Biol Cell. 2008 Jun;19(6):2620-30. doi: 10.1091/mbc.e07-07-0674. Epub 2008 Apr 9. PubMed PMID: 18400946; PubMed Central PMCID: PMC2397301.

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Ahmad A, Ahmad S, Glover L, Miller SM, Shannon JM, Guo X, Franklin WA, Bridges JP, Schaack JB, Colgan SP, White CW. Adenosine A2A receptor is a unique angiogenic target of HIF-2alpha in pulmonary endothelial cells. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10684-9. doi: 10.1073/pnas.0901326106. Epub 2009 Jun 17. PubMed PMID: 19541651; PubMed Central PMCID: PMC2705563.

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Wang M, Bridges JP, Na CL, Xu Y, Weaver TE. Meckel-Gruber syndrome protein MKS3 is required for endoplasmic reticulum-associated degradation of surfactant protein C. J Biol Chem. 2009 Nov 27;284(48):33377-83. doi: 10.1074/jbc.M109.034371. Epub 2009 Oct 8. PubMed PMID: 19815549; PubMed Central PMCID: PMC2785181.

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Bridges JP, Ikegami M, Brilli LL, Chen X, Mason RJ, Shannon JM. LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice. J Clin Invest. 2010 May;120(5):1736-48. doi: 10.1172/JCI38061. Epub 2010 Apr 19. PubMed PMID: 20407208; PubMed Central PMCID: PMC2860922.

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Bridges JP, Panos RJ. Mutations in Surfactant Protein C and Interstitial Lung Disease. In: McCormack FX, Rounds S, Trapnell BC, Panos RJ, editors. Molecular Basis of Pulmonary Disease: Insights from Rare Lung Disorders New York: Humana Press; 2010. Chapter 6; p.133-166. 438p.

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Bridges JP, Lin S, Ikegami M, Shannon JM. Conditional hypoxia inducible factor-1α induction in embryonic pulmonary epithelium impairs maturation and augments lymphangiogenesis. Dev Biol. 2012 Feb 1;362(1):24-41. doi: 10.1016/j.ydbio.2011.10.033. Epub 2011 Nov 6. PubMed PMID: 22094019; PubMed Central PMCID: PMC3262673.

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Starnes SL, Pathrose P, Wang J, Succop P, Morris JC, Bridges J, Kupert EY, Anderson M. Clinical and molecular predictors of recurrence in stage I non-small cell lung cancer. Ann Thorac Surg. 2012 May;93(5):1606-12. doi: 10.1016/j.athoracsur.2012.01.048. Epub 2012 Mar 20. PubMed PMID: 22440368.

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Young LR, Gulleman PM, Bridges JP, Weaver TE, Deutsch GH, Blackwell TS, McCormack FX. The alveolar epithelium determines susceptibility to lung fibrosis in Hermansky-Pudlak syndrome. Am J Respir Crit Care Med. 2012 Nov 15;186(10):1014-24. doi: 10.1164/rccm.201207-1206OC. Epub 2012 Oct 4. PubMed PMID: 23043085; PubMed Central PMCID: PMC3530211.

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Bridges JP, Ludwig MG, Mueller M, Kinzel B, Sato A, Xu Y, Whitsett JA, Ikegami M. Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size. Am J Respir Cell Mol Biol. 2013 Sep;49(3):348-57. doi: 10.1165/rcmb.2012-0439OC. PubMed PMID: 23590306; PubMed Central PMCID: PMC3824053.

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Bridges JP, Schehr A, Wang Y, Huo L, Besnard V, Ikegami M, Whitsett JA, Xu Y. Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation. PLoS One. 2014;9(5):e91376. doi: 10.1371/journal.pone.0091376. eCollection 2014. PubMed PMID: 24806461; PubMed Central PMCID: PMC4012993.

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Bittencourt FM, Wu SE, Bridges JP, Miller WE. The M33 G protein-coupled receptor encoded by murine cytomegalovirus is dispensable for hematogenous dissemination but is required for growth within the salivary gland. J Virol. 2014 Oct;88(20):11811-24. doi: 10.1128/JVI.01006-14. Epub 2014 Aug 6. PubMed PMID: 25100846; PubMed Central PMCID: PMC4178735.

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Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2014 Dec;1333(1):43-64. doi: 10.1111/nyas.12580. Epub 2014 Nov 25. PubMed PMID: 25424900; PubMed Central PMCID: PMC4278406.

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Saito A, Nikolaidis NM, Amlal H, Uehara Y, Gardner JC, LaSance K, Pitstick LB, Bridges JP, Wikenheiser-Brokamp KA, McGraw DW, Woods JC, Sabbagh Y, Schiavi SC, Altinişik G, Jakopović M, Inoue Y, McCormack FX. Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment. Sci Transl Med. 2015 Nov 11;7(313):313ra181. doi: 10.1126/scitranslmed.aac8577. PubMed PMID: 26560359; PubMed Central PMCID: PMC4764987.

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Ludwig M, Seuwen K, Bridges J. Adhesion GPCR Function in Pulmonary Development and Disease. In: Handbook of Experimental Pharmacology [Internet] Cham: Springer International Publishing; 2016. Chapter Chapter 14; 309-327p. Available from: http://link.springer.com/10.1007/978-3-319-41523-9_14.

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Du Y, Kitzmiller JA, Sridharan A, Perl AK, Bridges JP, Misra RS, Pryhuber GS, Mariani TJ, Bhattacharya S, Guo M, Potter SS, Dexheimer P, Aronow B, Jobe AH, Whitsett JA, Xu Y. Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development. Thorax. 2017 May;72(5):481-484. doi: 10.1136/thoraxjnl-2016-209598. Epub 2017 Jan 9. PubMed PMID: 28070014; PubMed Central PMCID: PMC5520249.

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Brown K, Filuta A, Ludwig MG, Seuwen K, Jaros J, Vidal S, Arora K, Naren AP, Kandasamy K, Parthasarathi K, Offermanns S, Mason RJ, Miller WE, Whitsett JA, Bridges JP. Epithelial Gpr116 regulates pulmonary alveolar homeostasis via Gq/11 signaling. JCI Insight. 2017 Jun 2;2(11). doi: 10.1172/jci.insight.93700. eCollection 2017 Jun 2. PubMed PMID: 28570277; PubMed Central PMCID: PMC5453702.

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Sallese A, Suzuki T, McCarthy C, Bridges J, Filuta A, Arumugam P, Shima K, Ma Y, Wessendarp M, Black D, Chalk C, Carey B, Trapnell BC. Targeting cholesterol homeostasis in lung diseases. Sci Rep. 2017 Aug 31;7(1):10211. doi: 10.1038/s41598-017-10879-w. PubMed PMID: 28860566; PubMed Central PMCID: PMC5579240.

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Huang R, Hayashi Y, Yan X, Bu J, Wang J, Zhang Y, Zhou Y, Tang Y, Wu L, Xu Z, Liu X, Wang Q, Zhou J, Xiao Z, Bridges JP, Marsh RA, Zhang K, Jordan MB, Li Y, Huang G. HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis. Haematologica. 2017 Nov;102(11):1956-1968. doi: 10.3324/haematol.2017.174979. Epub 2017 Aug 31. PubMed PMID: 28860338; PubMed Central PMCID: PMC5664400.

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Trapnell BC, Bridges J. Does Granulocyte-Macrophage Colony-Stimulating Factor Coordinate a Hepatopulmonary Axis of Lipid Metabolism?. Am J Respir Cell Mol Biol. 2017 Oct;57(4):383-385. doi: 10.1165/rcmb.2017-0191ED. PubMed PMID: 28960104.

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Wang J, Hayashi Y, Yokota A, Xu Z, Zhang Y, Huang R, Yan X, Liu H, Ma L, Azam M, Bridges JP, Cancelas JA, Kalfa TA, An X, Xiao Z, Huang G. Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models. Haematologica. 2018 Jan;103(1):40-50. doi: 10.3324/haematol.2017.172775. Epub 2017 Oct 19. PubMed PMID: 29051279; PubMed Central PMCID: PMC5777189.

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Rindler TN, Stockman CA, Filuta AL, Brown KM, Snowball JM, Zhou W, Veldhuizen R, Zink EM, Dautel SE, Clair G, Ansong C, Xu Y, Bridges JP, Whitsett JA. Alveolar injury and regeneration following deletion of ABCA3. JCI Insight. 2017 Dec 21;2(24). doi: 10.1172/jci.insight.97381. PubMed PMID: 29263307; PubMed Central PMCID: PMC5752264.

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Moreno-Fernandez ME, Giles DA, Stankiewicz TE, Sheridan R, Karns R, Cappelletti M, Lampe K, Mukherjee R, Sina C, Sallese A, Bridges JP, Hogan SP, Aronow BJ, Hoebe K, Divanovic S. Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease. JCI Insight. 2018 Mar 22;3(6). doi: 10.1172/jci.insight.93626. PubMed PMID: 29563328; PubMed Central PMCID: PMC5926941.

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van Lieshout LP, Domm JM, Rindler TN, Frost KL, Sorensen DL, Medina SJ, Booth SA, Bridges JP, Wootton SK. A Novel Triple-Mutant AAV6 Capsid Induces Rapid and Potent Transgene Expression in the Muscle and Respiratory Tract of Mice. Mol Ther Methods Clin Dev. 2018 Jun 15;9:323-329. doi: 10.1016/j.omtm.2018.04.005. eCollection 2018 Jun 15. PubMed PMID: 30038936; PubMed Central PMCID: PMC6054702.

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McCarthy C, Lee E, Bridges JP, Sallese A, Suzuki T, Woods JC, Bartholmai BJ, Wang T, Chalk C, Carey BC, Arumugam P, Shima K, Tarling EJ, Trapnell BC. Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis. Nat Commun. 2018 Aug 7;9(1):3127. doi: 10.1038/s41467-018-05491-z. PubMed PMID: 30087322; PubMed Central PMCID: PMC6081448.

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Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger GM, Wang J, Dong Y, Zhou Y, Wang J, Wu L, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, Watanabe M, Romick-Rosendale LE, Harada H, Shih LY, Tse W, Bridges JP, Caligiuri MA, Huang T, Zheng Y, Witte DP, Wang QF, Qu CK, Salomonis N, Grimes HL, Nimer SD, Xiao Z, Huang G. Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer Discov. 2018 Nov;8(11):1438-1457. doi: 10.1158/2159-8290.CD-17-1203. Epub 2018 Aug 23. PubMed PMID: 30139811; PubMed Central PMCID: PMC8783373.

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Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP, Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S, Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A. The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2019 Nov;1456(1):5-25. doi: 10.1111/nyas.14094. Epub 2019 Jun 6. PubMed PMID: 31168816; PubMed Central PMCID: PMC7891679.

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Balczon R, Pittet JF, Wagener BM, Moser SA, Voth S, Vorhees CV, Williams MT, Bridges JP, Alvarez DF, Koloteva A, Xu Y, Zha XM, Audia JP, Stevens T, Lin MT. Infection-induced endothelial amyloids impair memory. FASEB J. 2019 Sep;33(9):10300-10314. doi: 10.1096/fj.201900322R. Epub 2019 Jun 18. PubMed PMID: 31211919; PubMed Central PMCID: PMC6704457.

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Schmidt AF, Kannan PS, Bridges JP, Filuta A, Lipps D, Kemp M, Miller LA, Kallapur SG, Xu Y, Whitsett JA, Jobe AH. Dosing and formulation of antenatal corticosteroids for fetal lung maturation and gene expression in rhesus macaques. Sci Rep. 2019 Jun 21;9(1):9039. doi: 10.1038/s41598-019-45171-6. PubMed PMID: 31227752; PubMed Central PMCID: PMC6588577.

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Sitaraman S, Na CL, Yang L, Filuta A, Bridges JP, Weaver TE. Proteasome dysfunction in alveolar type 2 epithelial cells is associated with acute respiratory distress syndrome. Sci Rep. 2019 Aug 29;9(1):12509. doi: 10.1038/s41598-019-49020-4. PubMed PMID: 31467330; PubMed Central PMCID: PMC6715642.

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Kemp MW, Saito M, Schmidt AF, Usuda H, Watanabe S, Sato S, Hanita T, Kumagai Y, Takahashi T, Musk GC, Furfaro L, Stinson L, Fee EL, Eddershaw PJ, Payne MS, Smallwood K, Bridges J, Newnham JP, Jobe AH. The duration of fetal antenatal steroid exposure determines the durability of preterm ovine lung maturation. Am J Obstet Gynecol. 2020 Feb;222(2):183.e1-183.e9. doi: 10.1016/j.ajog.2019.08.046. Epub 2019 Sep 5. PubMed PMID: 31494126.

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Schmidt AF, Kemp MW, Milad M, Miller LA, Bridges JP, Clarke MW, Kannan PS, Jobe AH. Oral dosing for antenatal corticosteroids in the Rhesus macaque. PLoS One. 2019;14(9):e0222817. doi: 10.1371/journal.pone.0222817. eCollection 2019. PubMed PMID: 31536601; PubMed Central PMCID: PMC6752828.

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Oherle K, Acker E, Bonfield M, Wang T, Gray J, Lang I, Bridges J, Lewkowich I, Xu Y, Ahlfeld S, Zacharias W, Alenghat T, Deshmukh H. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity. 2020 Feb 18;52(2):275-294.e9. doi: 10.1016/j.immuni.2020.01.005. PubMed PMID: 32075728; PubMed Central PMCID: PMC7382307.

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Oherle K, Acker E, Bonfield M, Wang T, Gray J, Lang I, Bridges J, Lewkowich I, Xu Y, Ahlfeld S, Zacharias W, Alenghat T, Deshmukh H. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity. 2020 Apr 14;52(4):716-718. doi: 10.1016/j.immuni.2020.03.018. PubMed PMID: 32294410; PubMed Central PMCID: PMC7446937.

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Bridges JP, Sudha P, Lipps D, Wagner A, Guo M, Du Y, Brown K, Filuta A, Kitzmiller J, Stockman C, Chen X, Weirauch MT, Jobe AH, Whitsett JA, Xu Y. Glucocorticoid regulates mesenchymal cell differentiation required for perinatal lung morphogenesis and function. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L239-L255. doi: 10.1152/ajplung.00459.2019. Epub 2020 May 27. PubMed PMID: 32460513; PubMed Central PMCID: PMC7473939.

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van Lieshout LP, Stegelmeier AA, Rindler TN, Lawder JJ, Sorensen DL, Frost KL, Booth SA, Bridges JP, Wootton SK. Engineered AAV8 capsid acquires heparin and AVB sepharose binding capacity but has altered in vivo transduction efficiency. Gene Ther. 2023 Apr;30(3-4):236-244. doi: 10.1038/s41434-020-00198-7. Epub 2020 Oct 7. PubMed PMID: 33028973; PubMed Central PMCID: PMC8024426.

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Bridges JP, Safina C, Pirard B, Brown K, Filuta A, Bouhlel R, Patel S, Seuwen K, Miller WE, Ludwig M. Activation of GPR116/ADGRF5 by its tethered agonist requires key amino acids in extracellular loop 2 of the transmembrane region. bioRxiv 2021.04.01.438115 [Preprint]. 2021 April. [24 pages]. Available from: https://www.biorxiv.org/content/10.1101/2021.04.01.438115v1. doi: https://doi.org/10.1101/2021.04.01.438115.

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Rindler TN, Brown KM, Stockman CA, van Lieshout LP, Martin EP, Weaver TE, Zacharias WJ, Wootton SK, Whitsett JA, Bridges JP. Efficient Transduction of Alveolar Type 2 Cells with Adeno-associated Virus for the Study of Lung Regeneration. Am J Respir Cell Mol Biol. 2021 Jul;65(1):118-121. doi: 10.1165/rcmb.2021-0049LE. PubMed PMID: 34241584; PubMed Central PMCID: PMC8320123.

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Schweitzer KS, Crue T, Nall JM, Foster D, Sajuthi S, Correll KA, Nakamura M, Everman JL, Downey GP, Seibold MA, Bridges JP, Serban KA, Chu HW, Petrache I. Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells. Eur Respir J. 2021 Jul;58(1). doi: 10.1183/13993003.03988-2020. Print 2021 Jul. PubMed PMID: 33419885; PubMed Central PMCID: PMC8378143.

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Sitaraman S, Martin EP, Na CL, Zhao S, Green J, Deshmukh H, Perl AT, Bridges JP, Xu Y, Weaver TE. Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease. JCI Insight. 2021 Jul 22;6(14). doi: 10.1172/jci.insight.142501. PubMed PMID: 34138759; PubMed Central PMCID: PMC8410047.