My Bibliography

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Tempera I, Cipriani R, Campagna G, Mancini P, Gatti A, Guidobaldi L, Pantellini F, Mandosi E, Sensi M, Quesada P, Mario UD, D'Erme M, Morano S. Poly(ADP-ribose)polymerase activity is reduced in circulating mononuclear cells from type 2 diabetic patients. J Cell Physiol. 2005 Dec;205(3):387-92. doi: 10.1002/jcp.20414. PubMed PMID: 15895395.

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Mattiussi S, Tempera I, Matusali G, Mearini G, Lenti L, Fratarcangeli S, Mosca L, D'Erme M, Mattia E. Inhibition of Poly(ADP-ribose)polymerase impairs Epstein Barr Virus lytic cycle progression. Infect Agent Cancer. 2007 Oct 11;2:18. doi: 10.1186/1750-9378-2-18. PubMed PMID: 17931416; PubMed Central PMCID: PMC2170434.

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Mosca L, Tempera I, Lendaro E, Di Francesco L, d'Erme M. Characterization of catechol-thioether-induced apoptosis in human SH-SY5Y neuroblastoma cells. J Neurosci Res. 2008 Mar;86(4):954-60. doi: 10.1002/jnr.21536. PubMed PMID: 17929313.

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Tempera I, Buchetti B, Lococo E, Gradini R, Mastronardi A, Mascellino MT, Sale P, Mosca L, d'Erme M, Lenti L. GD3 nuclear localization after apoptosis induction in HUT-78 cells. Biochem Biophys Res Commun. 2008 Apr 11;368(3):495-500. doi: 10.1016/j.bbrc.2007.12.196. Epub 2008 Feb 7. PubMed PMID: 18261989.

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Tempera I, Lieberman PM. Chromatin organization of gammaherpesvirus latent genomes. Biochim Biophys Acta. 2010 Mar-Apr;1799(3-4):236-45. doi: 10.1016/j.bbagrm.2009.10.004. Epub 2009 Oct 22. Review. PubMed PMID: 19853673; PubMed Central PMCID: PMC2839031.

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Tempera I, Deng Z, Atanasiu C, Chen CJ, D'Erme M, Lieberman PM. Regulation of Epstein-Barr virus OriP replication by poly(ADP-ribose) polymerase 1. J Virol. 2010 May;84(10):4988-97. doi: 10.1128/JVI.02333-09. Epub 2010 Mar 10. PubMed PMID: 20219917; PubMed Central PMCID: PMC2863838.

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Tempera I, Wiedmer A, Dheekollu J, Lieberman PM. CTCF prevents the epigenetic drift of EBV latency promoter Qp. PLoS Pathog. 2010 Aug 12;6(8):e1001048. doi: 10.1371/journal.ppat.1001048. PubMed PMID: 20730088; PubMed Central PMCID: PMC2921154.

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Mosca L, Rotili D, Tempera I, Masci A, Fontana M, Chiaraluce R, Mastromarino P, d'Erme M, Mai A. Biological effects of MC2050, a quinazoline-based PARP-1 inhibitor, in human neuroblastoma and EBV-positive Burkitt's lymphoma cells. ChemMedChem. 2011 Apr 4;6(4):606-11. doi: 10.1002/cmdc.201000536. Epub 2011 Mar 1. PubMed PMID: 21365766.

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Tempera I, Klichinsky M, Lieberman PM. EBV latency types adopt alternative chromatin conformations. PLoS Pathog. 2011 Jul;7(7):e1002180. doi: 10.1371/journal.ppat.1002180. Epub 2011 Jul 28. PubMed PMID: 21829357; PubMed Central PMCID: PMC3145795.

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Arvey A, Tempera I, Tsai K, Chen HS, Tikhmyanova N, Klichinsky M, Leslie C, Lieberman PM. An atlas of the Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactions. Cell Host Microbe. 2012 Aug 16;12(2):233-45. doi: 10.1016/j.chom.2012.06.008. PubMed PMID: 22901543; PubMed Central PMCID: PMC3424516.

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Arvey A, Tempera I, Lieberman PM. Interpreting the Epstein-Barr Virus (EBV) epigenome using high-throughput data. Viruses. 2013 Apr 2;5(4):1042-54. doi: 10.3390/v5041042. Review. PubMed PMID: 23549386; PubMed Central PMCID: PMC3705264.

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Martire S, Fuso A, Rotili D, Tempera I, Giordano C, De Zottis I, Muzi A, Vernole P, Graziani G, Lococo E, Faraldi M, Maras B, Scarpa S, Mosca L, d'Erme M. PARP-1 modulates amyloid beta peptide-induced neuronal damage. PLoS One. 2013;8(9):e72169. doi: 10.1371/journal.pone.0072169. eCollection 2013. PubMed PMID: 24086258; PubMed Central PMCID: PMC3782458.

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Plasschaert RN, Vigneau S, Tempera I, Gupta R, Maksimoska J, Everett L, Davuluri R, Mamorstein R, Lieberman PM, Schultz D, Hannenhalli S, Bartolomei MS. CTCF binding site sequence differences are associated with unique regulatory and functional trends during embryonic stem cell differentiation. Nucleic Acids Res. 2014 Jan;42(2):774-89. doi: 10.1093/nar/gkt910. Epub 2013 Oct 10. PubMed PMID: 24121688; PubMed Central PMCID: PMC3902912.

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Lu F, Tempera I, Lee HT, Dewispelaere K, Lieberman PM. EBNA1 binding and epigenetic regulation of gastrokine tumor suppressor genes in gastric carcinoma cells. Virol J. 2014 Jan 24;11:12. doi: 10.1186/1743-422X-11-12. PubMed PMID: 24460791; PubMed Central PMCID: PMC3904692.

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Chen HS, Martin KA, Lu F, Lupey LN, Mueller JM, Lieberman PM, Tempera I. Epigenetic deregulation of the LMP1/LMP2 locus of Epstein-Barr virus by mutation of a single CTCF-cohesin binding site. J Virol. 2014 Feb;88(3):1703-13. doi: 10.1128/JVI.02209-13. Epub 2013 Nov 20. PubMed PMID: 24257606; PubMed Central PMCID: PMC3911611.

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Tempera I, Lieberman PM. Epigenetic regulation of EBV persistence and oncogenesis. Semin Cancer Biol. 2014 Jun;26:22-9. doi: 10.1016/j.semcancer.2014.01.003. Epub 2014 Jan 24. Review. PubMed PMID: 24468737; PubMed Central PMCID: PMC4048758.

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Martin KA, Cesaroni M, Denny MF, Lupey LN, Tempera I. Global Transcriptome Analysis Reveals That Poly(ADP-Ribose) Polymerase 1 Regulates Gene Expression through EZH2. Mol Cell Biol. 2015 Dec;35(23):3934-44. doi: 10.1128/MCB.00635-15. Epub 2015 Sep 14. PubMed PMID: 26370511; PubMed Central PMCID: PMC4628063.

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Tempera I, De Leo A, Kossenkov AV, Cesaroni M, Song H, Dawany N, Showe L, Lu F, Wikramasinghe P, Lieberman PM. Identification of MEF2B, EBF1, and IL6R as Direct Gene Targets of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Critical for EBV-Infected B-Lymphocyte Survival. J Virol. 2016 Jan 1;90(1):345-55. doi: 10.1128/JVI.02318-15. Print 2016 Jan 1. PubMed PMID: 26468528; PubMed Central PMCID: PMC4702570.

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Singh N, Johnstone DB, Martin KA, Tempera I, Kaplan MJ, Denny MF. Alterations in nuclear structure promote lupus autoimmunity in a mouse model. Dis Model Mech. 2016 Aug 1;9(8):885-97. doi: 10.1242/dmm.024851. Epub 2016 Jun 9. PubMed PMID: 27483354; PubMed Central PMCID: PMC5007980.

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Martin KA, Lupey LN, Tempera I. Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1. J Virol. 2016 Oct 1;90(19):8520-30. doi: 10.1128/JVI.01180-16. Print 2016 Oct 1. PubMed PMID: 27440880; PubMed Central PMCID: PMC5021435.

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Samakai E, Hooper R, Martin KA, Shmurak M, Zhang Y, Kappes DJ, Tempera I, Soboloff J. Novel STIM1-dependent control of Ca2+ clearance regulates NFAT activity during T-cell activation. FASEB J. 2016 Nov;30(11):3878-3886. doi: 10.1096/fj.201600532R. Epub 2016 Aug 15. PubMed PMID: 27528628; PubMed Central PMCID: PMC5067253.

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Wang Y, Santerre M, Tempera I, Martin K, Mukerjee R, Sawaya BE. HIV-1 Vpr disrupts mitochondria axonal transport and accelerates neuronal aging. Neuropharmacology. 2017 May 1;117:364-375. doi: 10.1016/j.neuropharm.2017.02.008. Epub 2017 Feb 14. PubMed PMID: 28212984; PubMed Central PMCID: PMC5397298.

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Lupey-Green LN, Moquin SA, Martin KA, McDevitt SM, Hulse M, Caruso LB, Pomerantz RT, Miranda JL, Tempera I. PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter. Virology. 2017 Jul;507:220-230. doi: 10.1016/j.virol.2017.04.006. Epub 2017 Apr 26. PubMed PMID: 28456021; PubMed Central PMCID: PMC5521201.

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Maifrede S, Martin K, Podszywalow-Bartnicka P, Sullivan-Reed K, Langer SK, Nejati R, Dasgupta Y, Hulse M, Gritsyuk D, Nieborowska-Skorska M, Lupey-Green LN, Zhao H, Piwocka K, Wasik MA, Tempera I, Skorski T. IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors. Mol Cancer Res. 2017 Aug;15(8):967-972. doi: 10.1158/1541-7786.MCR-16-0468. Epub 2017 Jun 20. PubMed PMID: 28634224; PubMed Central PMCID: PMC5540764.

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Maifrede S, Martinez E, Nieborowska-Skorska M, Di Marcantonio D, Hulse M, Le BV, Zhao H, Piwocka K, Tempera I, Sykes SM, Skorski T. MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs. Blood Adv. 2017 Aug 22;1(19):1467-1472. doi: 10.1182/bloodadvances.2017006247. eCollection 2017 Aug 22. PubMed PMID: 29296788; PubMed Central PMCID: PMC5728460.

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Giorgi A, Tempera I, Napoletani G, Drovandi D, Potestà C, Martire S, Mandosi E, Filardi T, Eugenia Schininà M, Morano S, d'Erme M, Maras B. Poly(ADP-ribosylated) proteins in mononuclear cells from patients with type 2 diabetes identified by proteomic studies. Acta Diabetol. 2017 Sep;54(9):833-842. doi: 10.1007/s00592-017-1013-y. Epub 2017 Jun 12. PubMed PMID: 28608282.

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Mo X, Zhang H, Preston S, Martin K, Zhou B, Vadalia N, Gamero AM, Soboloff J, Tempera I, Zaidi MR. Interferon-γ Signaling in Melanocytes and Melanoma Cells Regulates Expression of CTLA-4. Cancer Res. 2018 Jan 15;78(2):436-450. doi: 10.1158/0008-5472.CAN-17-1615. Epub 2017 Nov 17. PubMed PMID: 29150430; PubMed Central PMCID: PMC5771950.

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Caruso LB, Martin KA, Lauretti E, Hulse M, Siciliano M, Lupey-Green LN, Abraham A, Skorski T, Tempera I. Poly(ADP-ribose) Polymerase 1, PARP1, modifies EZH2 and inhibits EZH2 histone methyltransferase activity after DNA damage. Oncotarget. 2018 Feb 13;9(12):10585-10605. doi: 10.18632/oncotarget.24291. eCollection 2018 Feb 13. PubMed PMID: 29535829; PubMed Central PMCID: PMC5828221.

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Lupey-Green LN, Caruso LB, Madzo J, Martin KA, Tan Y, Hulse M, Tempera I. PARP1 Stabilizes CTCF Binding and Chromatin Structure To Maintain Epstein-Barr Virus Latency Type. J Virol. 2018 Sep 15;92(18). doi: 10.1128/JVI.00755-18. Print 2018 Sep 15. PubMed PMID: 29976663; PubMed Central PMCID: PMC6146685.

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Hulse M, Caruso LB, Madzo J, Tan Y, Johnson S, Tempera I. Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1. PLoS Pathog. 2018 Nov;14(11):e1007394. doi: 10.1371/journal.ppat.1007394. eCollection 2018 Nov. PubMed PMID: 30395643; PubMed Central PMCID: PMC6237423.

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Mattioli R, Mosca L, Sánchez-Lamar A, Tempera I, Hausmann R. Natural Bioactive Compounds Acting against Oxidative Stress in Chronic, Degenerative, and Infectious Diseases. Oxid Med Cell Longev. 2018;2018:3894381. doi: 10.1155/2018/3894381. eCollection 2018. PubMed PMID: 30622666; PubMed Central PMCID: PMC6304897.

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Correani V, Martire S, Mignogna G, Caruso LB, Tempera I, Giorgi A, Grieco M, Mosca L, Schininà ME, Maras B, d'Erme M. Poly(ADP-ribosylated) proteins in β-amyloid peptide-stimulated microglial cells. Biochem Pharmacol. 2019 Sep;167:50-57. doi: 10.1016/j.bcp.2018.10.026. Epub 2018 Nov 9. PubMed PMID: 30414941.

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Le BV, Podszywalow-Bartnicka P, Maifrede S, Sullivan-Reed K, Nieborowska-Skorska M, Golovine K, Yao JC, Nejati R, Cai KQ, Caruso LB, Swatler J, Dabrowski M, Lian Z, Valent P, Paietta EM, Levine RL, Fernandez HF, Tallman MS, Litzow MR, Huang J, Challen GA, Link D, Tempera I, Wasik MA, Piwocka K, Skorski T. TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment. Cell Rep. 2020 Oct 6;33(1):108221. doi: 10.1016/j.celrep.2020.108221. PubMed PMID: 33027668; PubMed Central PMCID: PMC7578922.

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Hulse M, Johnson SM, Boyle S, Caruso LB, Tempera I. Epstein-Barr Virus-Encoded Latent Membrane Protein 1 and B-Cell Growth Transformation Induce Lipogenesis through Fatty Acid Synthase. J Virol. 2021 Jan 28;95(4). doi: 10.1128/JVI.01857-20. Print 2021 Jan 28. PubMed PMID: 33208446; PubMed Central PMCID: PMC7851568.

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Su C, Lu F, Soldan SS, Lamontagne RJ, Tang HY, Napoletani G, Farrell PJ, Tempera I, Kossenkov AV, Lieberman PM. EBNA2 driven enhancer switching at the CIITA-DEXI locus suppresses HLA class II gene expression during EBV infection of B-lymphocytes. PLoS Pathog. 2021 Aug;17(8):e1009834. doi: 10.1371/journal.ppat.1009834. eCollection 2021 Aug. PubMed PMID: 34352044; PubMed Central PMCID: PMC8370649.

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Soldan SS, Anderson EM, Frase DM, Zhang Y, Caruso LB, Wang Y, Deakyne JS, Gewurz BE, Tempera I, Lieberman PM, Messick TE. EBNA1 inhibitors have potent and selective antitumor activity in xenograft models of Epstein-Barr virus-associated gastric cancer. Gastric Cancer. 2021 Sep;24(5):1076-1088. doi: 10.1007/s10120-021-01193-6. Epub 2021 Apr 30. PubMed PMID: 33929613; PubMed Central PMCID: PMC8338878.

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Maifrede S, Le BV, Nieborowska-Skorska M, Golovine K, Sullivan-Reed K, Dunuwille WMB, Nacson J, Hulse M, Keith K, Madzo J, Caruso LB, Gazze Z, Lian Z, Padella A, Chitrala KN, Bartholdy BA, Matlawska-Wasowska K, Di Marcantonio D, Simonetti G, Greiner G, Sykes SM, Valent P, Paietta EM, Tallman MS, Fernandez HF, Litzow MR, Minden MD, Huang J, Martinelli G, Vassiliou GS, Tempera I, Piwocka K, Johnson N, Challen GA, Skorski T. TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors. Cancer Res. 2021 Oct 1;81(19):5089-5101. doi: 10.1158/0008-5472.CAN-20-3761. Epub 2021 Jul 2. PubMed PMID: 34215619; PubMed Central PMCID: PMC8487956.

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Tempera I, Lieberman PM. Oncogenic Viruses as Entropic Drivers of Cancer Evolution. Front Virol. 2021 Nov;1. doi: 10.3389/fviro.2021.753366. Epub 2021 Nov 15. PubMed PMID: 35141704; PubMed Central PMCID: PMC8822580.

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Morgan SM, Tanizawa H, Caruso LB, Hulse M, Kossenkov A, Madzo J, Keith K, Tan Y, Boyle S, Lieberman PM, Tempera I. The three-dimensional structure of Epstein-Barr virus genome varies by latency type and is regulated by PARP1 enzymatic activity. Nat Commun. 2022 Jan 17;13(1):187. doi: 10.1038/s41467-021-27894-1. PubMed PMID: 35039491; PubMed Central PMCID: PMC8764100.

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Caruso LB, Guo R, Keith K, Madzo J, Maestri D, Boyle S, Wasserman J, Kossenkov A, Gewurz BE, Tempera I. The nuclear lamina binds the EBV genome during latency and regulates viral gene expression. PLoS Pathog. 2022 Apr;18(4):e1010400. doi: 10.1371/journal.ppat.1010400. eCollection 2022 Apr. PubMed PMID: 35421198; PubMed Central PMCID: PMC9009669.

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Kuan MI, Caruso LB, Zavala AG, Rana PSJB, O'Dowd JM, Tempera I, Fortunato EA. Human Cytomegalovirus Utilizes Multiple Viral Proteins to Regulate the Basement Membrane Protein Nidogen 1. J Virol. 2022 Oct 26;96(20):e0133622. doi: 10.1128/jvi.01336-22. Epub 2022 Oct 11. PubMed PMID: 36218358; PubMed Central PMCID: PMC9599421.