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Nowak MB, Greer-Short A, Wan X, Wu X, Deschênes I, Weinberg SH, Poelzing S. Intercellular Sodium Regulates Repolarization in Cardiac Tissue with Sodium Channel Gain of Function. Biophys J. 2020 Jun 2;118(11):2829-2843. doi: 10.1016/j.bpj.2020.04.014. Epub 2020 Apr 21. PubMed PMID: 32402243; PubMed Central PMCID: PMC7264809.
Bektik E, Dennis A, Pawlowski G, Zhou C, Maleski D, Takahashi S, Laurita KR, Deschênes I, Fu JD. S-phase Synchronization Facilitates the Early Progression of Induced-Cardiomyocyte Reprogramming through Enhanced Cell-Cycle Exit. Int J Mol Sci. 2018 May 4;19(5). doi: 10.3390/ijms19051364. PubMed PMID: 29734659; PubMed Central PMCID: PMC5983785.
Chai S, Wan X, Ramirez-Navarro A, Tesar PJ, Kaufman ES, Ficker E, George AL Jr, Deschênes I. Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity. J Clin Invest. 2018 Mar 1;128(3):1043-1056. doi: 10.1172/JCI94996. Epub 2018 Feb 12. PubMed PMID: 29431731; PubMed Central PMCID: PMC5824853.
Clatot J, Hoshi M, Wan X, Liu H, Jain A, Shinlapawittayatorn K, Marionneau C, Ficker E, Ha T, Deschênes I. Voltage-gated sodium channels assemble and gate as dimers. Nat Commun. 2017 Dec 12;8(1):2077. doi: 10.1038/s41467-017-02262-0. PubMed PMID: 29233994; PubMed Central PMCID: PMC5727259.
Kaufman ES, Deschênes I. T-Wave Morphology Analysis to Detect High Risk in Long-QT Syndrome. Circ Arrhythm Electrophysiol. 2017 Nov;10(11). doi: 10.1161/CIRCEP.117.005920. PubMed PMID: 29141847.
Sun Y, Timofeyev V, Dennis A, Bektik E, Wan X, Laurita KR, Deschênes I, Li RA, Fu JD. A Singular Role of IK1 Promoting the Development of Cardiac Automaticity during Cardiomyocyte Differentiation by IK1 -Induced Activation of Pacemaker Current. Stem Cell Rev Rep. 2017 Oct;13(5):631-643. doi: 10.1007/s12015-017-9745-1. PubMed PMID: 28623610; PubMed Central PMCID: PMC5784831.
Chai S, Wan X, Nassal DM, Liu H, Moravec CS, Ramirez-Navarro A, Deschênes I. Contribution of two-pore K+ channels to cardiac ventricular action potential revealed using human iPSC-derived cardiomyocytes. Am J Physiol Heart Circ Physiol. 2017 Jun 1;312(6):H1144-H1153. doi: 10.1152/ajpheart.00107.2017. Epub 2017 Mar 24. PubMed PMID: 28341634; PubMed Central PMCID: PMC5495933.
Nassal MMJ, Wan X, Dale Z, Deschênes I, Wilson LD, Piktel JS. Mild hypothermia preserves myocardial conduction during ischemia by maintaining gap junction intracellular communication and Na+ channel function. Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H886-H895. doi: 10.1152/ajpheart.00298.2016. Epub 2017 Mar 10. PubMed PMID: 28283549; PubMed Central PMCID: PMC5451586.
Nassal DM, Wan X, Liu H, Laurita KR, Deschênes I. KChIP2 regulates the cardiac Ca2+ transient and myocyte contractility by targeting ryanodine receptor activity. PLoS One. 2017;12(4):e0175221. doi: 10.1371/journal.pone.0175221. eCollection 2017. PubMed PMID: 28384221; PubMed Central PMCID: PMC5383259.
Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 Apr 1;595(7):2229-2252. doi: 10.1113/JP272883. Epub 2017 Jan 5. Review. PubMed PMID: 27808412; PubMed Central PMCID: PMC5374105.
Nassal DM, Wan X, Liu H, Maleski D, Ramirez-Navarro A, Moravec CS, Ficker E, Laurita KR, Deschênes I. KChIP2 is a core transcriptional regulator of cardiac excitability. Elife. 2017 Mar 6;6. doi: 10.7554/eLife.17304. PubMed PMID: 28263709; PubMed Central PMCID: PMC5338919.
Sattayaprasert P, Nassal DM, Wan X, Deschenes I, Laurita KR. Mesenchymal stem cells suppress cardiac alternans by activation of PI3K mediated nitroso-redox pathway. J Mol Cell Cardiol. 2016 Sep;98:138-45. doi: 10.1016/j.yjmcc.2016.05.014. Epub 2016 May 26. PubMed PMID: 27238412; PubMed Central PMCID: PMC5155447.
Nassal DM, Wan X, Liu H, Deschênes I. Myocardial KChIP2 Expression in Guinea Pig Resolves an Expanded Electrophysiologic Role. PLoS One. 2016;11(1):e0146561. doi: 10.1371/journal.pone.0146561. eCollection 2016. PubMed PMID: 26764482; PubMed Central PMCID: PMC4713065.
Nassal MM, Werdich AA, Wan X, Hoshi M, Deschênes I, Rosenbaum DS, Donahue JK. Phosphorylation at Connexin43 Serine-368 Is Necessary for Myocardial Conduction During Metabolic Stress. J Cardiovasc Electrophysiol. 2016 Jan;27(1):110-9. doi: 10.1111/jce.12833. Epub 2015 Oct 13. PubMed PMID: 26459193; PubMed Central PMCID: PMC4879887.
Hoshi M, Liu H, Kaufman ES, Deschênes I. Polygenic Case of Long QT Syndrome Confirmed through Functional Characterization Informs the Interpretation of Genetic Screening Results. HeartRhythm Case Rep. 2015 Jul 1;1(4):201-205. doi: 10.1016/j.hrcr.2015.02.011. PubMed PMID: 26213684; PubMed Central PMCID: PMC4509597.
Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428. Review. PubMed PMID: 25772290; PubMed Central PMCID: PMC4376415.
Plummer BN, Liu H, Wan X, Deschênes I, Laurita KR. Targeted antioxidant treatment decreases cardiac alternans associated with chronic myocardial infarction. Circ Arrhythm Electrophysiol. 2015 Feb;8(1):165-73. doi: 10.1161/CIRCEP.114.001789. Epub 2014 Dec 9. PubMed PMID: 25491741; PubMed Central PMCID: PMC4334735.
Ziyadeh-Isleem A, Clatot J, Duchatelet S, Gandjbakhch E, Denjoy I, Hidden-Lucet F, Hatem S, Deschênes I, Coulombe A, Neyroud N, Guicheney P. A truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation. Heart Rhythm. 2014 Jun;11(6):1015-1023. doi: 10.1016/j.hrthm.2014.02.021. Epub 2014 Feb 25. PubMed PMID: 24582607; PubMed Central PMCID: PMC4056672.
Hoshi M, Du XX, Shinlapawittayatorn K, Liu H, Chai S, Wan X, Ficker E, Deschênes I. Brugada syndrome disease phenotype explained in apparently benign sodium channel mutations. Circ Cardiovasc Genet. 2014 Apr;7(2):123-31. doi: 10.1161/CIRCGENETICS.113.000292. Epub 2014 Feb 26. PubMed PMID: 24573164; PubMed Central PMCID: PMC3989843.
Khan S, Abu Jawdeh BG, Goel M, Schilling WP, Parker MD, Puchowicz MA, Yadav SP, Harris RC, El-Meanawy A, Hoshi M, Shinlapawittayatorn K, Deschênes I, Ficker E, Schelling JR. Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis. J Clin Invest. 2014 Mar;124(3):1057-68. doi: 10.1172/JCI71863. Epub 2014 Feb 17. PubMed PMID: 24531551; PubMed Central PMCID: PMC3934167.
Jeyaraj D, Wan X, Ficker E, Stelzer JE, Deschenes I, Liu H, Wilson LD, Decker KF, Said TH, Jain MK, Rudy Y, Rosenbaum DS. Ionic bases for electrical remodeling of the canine cardiac ventricle. Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H410-9. doi: 10.1152/ajpheart.00213.2013. Epub 2013 May 24. PubMed PMID: 23709598; PubMed Central PMCID: PMC3742876.
Jehle J, Ficker E, Wan X, Deschenes I, Kisselbach J, Wiedmann F, Staudacher I, Schmidt C, Schweizer PA, Becker R, Katus HA, Thomas D. Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells. Br J Pharmacol. 2013 Mar;168(5):1215-29. doi: 10.1111/bph.12002. PubMed PMID: 23061993; PubMed Central PMCID: PMC3594678.
Cutler MJ, Plummer BN, Wan X, Sun QA, Hess D, Liu H, Deschenes I, Rosenbaum DS, Stamler JS, Laurita KR. Aberrant S-nitrosylation mediates calcium-triggered ventricular arrhythmia in the intact heart. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18186-91. doi: 10.1073/pnas.1210565109. Epub 2012 Oct 15. PubMed PMID: 23071315; PubMed Central PMCID: PMC3497770.
Cutler MJ, Wan X, Plummer BN, Liu H, Deschenes I, Laurita KR, Hajjar RJ, Rosenbaum DS. Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart. Circulation. 2012 Oct 23;126(17):2095-104. doi: 10.1161/CIRCULATIONAHA.111.071480. Epub 2012 Sep 27. PubMed PMID: 23019291; PubMed Central PMCID: PMC3538142.
Clatot J, Ziyadeh-Isleem A, Maugenre S, Denjoy I, Liu H, Dilanian G, Hatem SN, Deschênes I, Coulombe A, Guicheney P, Neyroud N. Dominant-negative effect of SCN5A N-terminal mutations through the interaction of Na(v)1.5 α-subunits. Cardiovasc Res. 2012 Oct 1;96(1):53-63. doi: 10.1093/cvr/cvs211. Epub 2012 Jun 27. PubMed PMID: 22739120; PubMed Central PMCID: PMC3444234.
Dennis AT, Wang L, Wan H, Nassal D, Deschenes I, Ficker E. Molecular determinants of pentamidine-induced hERG trafficking inhibition. Mol Pharmacol. 2012 Feb;81(2):198-209. doi: 10.1124/mol.111.075135. Epub 2011 Nov 1. PubMed PMID: 22046004; PubMed Central PMCID: PMC3263949.
Abu Jawdeh BG, Khan S, Deschênes I, Hoshi M, Goel M, Lock JT, Shinlapawittayatorn K, Babcock G, Lakhe-Reddy S, DeCaro G, Yadav SP, Mohan ML, Naga Prasad SV, Schilling WP, Ficker E, Schelling JR. Phosphoinositide binding differentially regulates NHE1 Na+/H+ exchanger-dependent proximal tubule cell survival. J Biol Chem. 2011 Dec 9;286(49):42435-45. doi: 10.1074/jbc.M110.212845. Epub 2011 Oct 21. PubMed PMID: 22020933; PubMed Central PMCID: PMC3234923.
Shinlapawittayatorn K, Dudash LA, Du XX, Heller L, Poelzing S, Ficker E, Deschênes I. A novel strategy using cardiac sodium channel polymorphic fragments to rescue trafficking-deficient SCN5A mutations. Circ Cardiovasc Genet. 2011 Oct;4(5):500-9. doi: 10.1161/CIRCGENETICS.111.960633. Epub 2011 Aug 12. PubMed PMID: 21840964; PubMed Central PMCID: PMC3197758.
Dennis AT, Nassal D, Deschenes I, Thomas D, Ficker E. Antidepressant-induced ubiquitination and degradation of the cardiac potassium channel hERG. J Biol Chem. 2011 Sep 30;286(39):34413-25. doi: 10.1074/jbc.M111.254367. Epub 2011 Aug 9. PubMed PMID: 21832094; PubMed Central PMCID: PMC3190784.
Shinlapawittayatorn K, Du XX, Liu H, Ficker E, Kaufman ES, Deschênes I. A common SCN5A polymorphism modulates the biophysical defects of SCN5A mutations. Heart Rhythm. 2011 Mar;8(3):455-62. doi: 10.1016/j.hrthm.2010.11.034. Epub 2010 Nov 23. PubMed PMID: 21109022; PubMed Central PMCID: PMC3050092.
Hsu K, Han J, Shinlapawittayatorn K, Deschenes I, Marbán E. Membrane potential depolarization as a triggering mechanism for Vpu-mediated HIV-1 release. Biophys J. 2010 Sep 22;99(6):1718-25. doi: 10.1016/j.bpj.2010.07.027. PubMed PMID: 20858415; PubMed Central PMCID: PMC2941015.
Shinlapawittayatorn K, Deschênes I. Alteration of tyrosine kinase signaling: another player in the arrhythmogenesis of atrial fibrillation?. Heart Rhythm. 2010 Sep;7(9):1253-4. doi: 10.1016/j.hrthm.2010.06.021. Epub 2010 Jun 17. PubMed PMID: 20601156.
Christé G, Thériault O, Chahine M, Millat G, Rodriguez-Lafrasse C, Rousson R, Deschênes I, Ficker E, Chevalier P. A new C-terminal hERG mutation A915fs+47X associated with symptomatic LQT2 and auditory-trigger syncope. Heart Rhythm. 2008 Nov;5(11):1577-86. doi: 10.1016/j.hrthm.2008.08.031. Epub 2008 Aug 31. PubMed PMID: 18984536; PubMed Central PMCID: PMC2602805.
Deschênes I, Armoundas AA, Jones SP, Tomaselli GF. Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents. J Mol Cell Cardiol. 2008 Sep;45(3):336-46. doi: 10.1016/j.yjmcc.2008.05.001. Epub 2008 May 12. PubMed PMID: 18565539; PubMed Central PMCID: PMC2580777.
Biswas S, Deschênes I, Disilvestre D, Tian Y, Halperin VL, Tomaselli GF. Calmodulin regulation of Nav1.4 current: role of binding to the carboxyl terminus. J Gen Physiol. 2008 Mar;131(3):197-209. doi: 10.1085/jgp.200709863. Epub 2008 Feb 11. PubMed PMID: 18270170; PubMed Central PMCID: PMC2248716.
Jeyaraj D, Wilson LD, Deschênes I. Stretch the heart: get memory. Heart Rhythm. 2008 Jan;5(1):114-5. doi: 10.1016/j.hrthm.2007.10.012. Epub 2007 Oct 9. PubMed PMID: 18065282.
Kjølbye AL, Dikshteyn M, Eloff BC, Deschênes I, Rosenbaum DS. Maintenance of intercellular coupling by the antiarrhythmic peptide rotigaptide suppresses arrhythmogenic discordant alternans. Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H41-9. doi: 10.1152/ajpheart.01089.2006. Epub 2007 Nov 2. PubMed PMID: 17982010.
Jeyaraj D, Wilson LD, Zhong J, Flask C, Saffitz JE, Deschênes I, Yu X, Rosenbaum DS. Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling. Circulation. 2007 Jun 26;115(25):3145-55. doi: 10.1161/CIRCULATIONAHA.107.688317. Epub 2007 Jun 11. PubMed PMID: 17562957.
Deschênes I, Laurita KR. How can a single mutation cause such arrhythmic havoc?. Heart Rhythm. 2007 Feb;4(2):198-9. doi: 10.1016/j.hrthm.2006.11.010. Epub 2006 Nov 17. PubMed PMID: 17275756; PubMed Central PMCID: PMC3552356.
Poelzing S, Forleo C, Samodell M, Dudash L, Sorrentino S, Anaclerio M, Troccoli R, Iacoviello M, Romito R, Guida P, Chahine M, Pitzalis M, Deschênes I. SCN5A polymorphism restores trafficking of a Brugada syndrome mutation on a separate gene. Circulation. 2006 Aug 1;114(5):368-76. doi: 10.1161/CIRCULATIONAHA.105.601294. Epub 2006 Jul 24. PubMed PMID: 16864729.
Akar FG, Wu RC, Deschenes I, Armoundas AA, Piacentino V 3rd, Houser SR, Tomaselli GF. Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: insights into molecular composition of ventricular Ito. Am J Physiol Heart Circ Physiol. 2004 Feb;286(2):H602-9. doi: 10.1152/ajpheart.00673.2003. Epub 2003 Oct 2. PubMed PMID: 14527940.
Neyroud N, Deschênes I, Akao M, Nuss HB, Marbán E. Somatic gene transfer of tagged K+ channel fragments to probe trafficking and electrical function in epithelial cells and cardiac myocytes. J Membr Biol. 2002 Nov 15;190(2):133-44. doi: 10.1007/s00232-002-1033-5. PubMed PMID: 12474078.
Deschênes I, Tomaselli GF. Modulation of Kv4.3 current by accessory subunits. FEBS Lett. 2002 Sep 25;528(1-3):183-8. doi: 10.1016/s0014-5793(02)03296-9. PubMed PMID: 12297301.
Deschênes I, DiSilvestre D, Juang GJ, Wu RC, An WF, Tomaselli GF. Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)?. Circulation. 2002 Jul 23;106(4):423-9. doi: 10.1161/01.cir.0000025417.65658.b6. PubMed PMID: 12135940.
Deschênes I, Neyroud N, DiSilvestre D, Marbán E, Yue DT, Tomaselli GF. Isoform-specific modulation of voltage-gated Na(+) channels by calmodulin. Circ Res. 2002 Mar 8;90(4):E49-57. doi: 10.1161/01.res.0000012502.92751.e6. PubMed PMID: 11884381.
Deschênes I, Trottier E, Chahine M. Implication of the C-terminal region of the alpha-subunit of voltage-gated sodium channels in fast inactivation. J Membr Biol. 2001 Sep 15;183(2):103-14. doi: 10.1007/s00232-001-0058-5. PubMed PMID: 11562792.
Deschênes I, Baroudi G, Berthet M, Barde I, Chalvidan T, Denjoy I, Guicheney P, Chahine M. Electrophysiological characterization of SCN5A mutations causing long QT (E1784K) and Brugada (R1512W and R1432G) syndromes. Cardiovasc Res. 2000 Apr;46(1):55-65. doi: 10.1016/s0008-6363(00)00006-7. PubMed PMID: 10727653.
Deschênes I, Trottier E, Chahine M. Cysteine scanning analysis of the IFM cluster in the inactivation gate of a human heart sodium channel. Cardiovasc Res. 1999 May;42(2):521-9. doi: 10.1016/s0008-6363(99)00064-4. PubMed PMID: 10533587.
Deschênes I, Chen L, Kallen RG, Chahine M. Electrophysiological study of chimeric sodium channels from heart and skeletal muscle. J Membr Biol. 1998 Jul 1;164(1):25-34. doi: 10.1007/s002329900390. PubMed PMID: 9636241.
Chahine M, Deschênes I, Trottier E, Chen LQ, Kallen RG. Restoration of fast inactivation in an inactivation-defective human heart sodium channel by the cysteine modifying reagent benzyl-MTS: analysis of IFM-ICM mutation. Biochem Biophys Res Commun. 1997 Apr 28;233(3):606-10. doi: 10.1006/bbrc.1997.6510. PubMed PMID: 9168898.
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