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van Schooten J, Schorcht A, Farokhi E, Umotoy JC, Gao H, van den Kerkhof TLGM, Dorning J, Rijkhold Meesters TG, van der Woude P, Burger JA, Bijl T, Ghalaiyini R, Torrents de la Peña A, Turner HL, Labranche CC, Stanfield RL, Sok D, Schuitemaker H, Montefiori DC, Burton DR, Ozorowski G, Seaman MS, Wilson IA, Sanders RW, Ward AB, van Gils MJ. Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer. PLoS Pathog. 2022 Nov;18(11):e1010945. doi: 10.1371/journal.ppat.1010945. eCollection 2022 Nov. PubMed PMID: 36395347; PubMed Central PMCID: PMC9714913.
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He L, Chaudhary A, Lin X, Sou C, Alkutkar T, Kumar S, Ngo T, Kosviner E, Ozorowski G, Stanfield RL, Ward AB, Wilson IA, Zhu J. Author Correction: Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines. Nat Commun. 2022 Oct 25;13(1):6343. doi: 10.1038/s41467-022-34108-9. PubMed PMID: 36284102; PubMed Central PMCID: PMC9596408.
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Tan TJC, Mou Z, Lei R, Ouyang WO, Yuan M, Song G, Andrabi R, Wilson IA, Kieffer C, Dai X, Matreyek KA, Wu NC. High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike. bioRxiv. 2022 Sep 26;. doi: 10.1101/2022.09.24.509341. PubMed PMID: 36203547; PubMed Central PMCID: PMC9536033.
Liu H, Wilson IA. Protective neutralizing epitopes in SARS-CoV-2. Immunol Rev. 2022 Sep;310(1):76-92. doi: 10.1111/imr.13084. Epub 2022 May 22. Review. PubMed PMID: 35599305; PubMed Central PMCID: PMC9348472.
Dacon C, Tucker C, Peng L, Lee CD, Lin TH, Yuan M, Cong Y, Wang L, Purser L, Williams JK, Pyo CW, Kosik I, Hu Z, Zhao M, Mohan D, Cooper AJR, Peterson M, Skinner J, Dixit S, Kollins E, Huzella L, Perry D, Byrum R, Lembirik S, Drawbaugh D, Eaton B, Zhang Y, Yang ES, Chen M, Leung K, Weinberg RS, Pegu A, Geraghty DE, Davidson E, Douagi I, Moir S, Yewdell JW, Schmaljohn C, Crompton PD, Holbrook MR, Nemazee D, Mascola JR, Wilson IA, Tan J. Broadly neutralizing antibodies target the coronavirus fusion peptide. Science. 2022 Aug 12;377(6607):728-735. doi: 10.1126/science.abq3773. Epub 2022 Jul 12. PubMed PMID: 35857439; PubMed Central PMCID: PMC9348754.
van Schooten J, Farokhi E, Schorcht A, van den Kerkhof TLGM, Gao H, van der Woude P, Burger JA, Meesters TGR, Bijl T, Ghalaiyini R, Turner HL, Dorning J, van Schaik BDC, van Kampen AHC, Labranche CC, Stanfield RL, Sok D, Montefiori DC, Burton DR, Seaman MS, Ozorowski G, Wilson IA, Sanders RW, Ward AB, van Gils MJ. Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein. Nat Commun. 2022 Aug 3;13(1):4515. doi: 10.1038/s41467-022-32208-0. PubMed PMID: 35922441; PubMed Central PMCID: PMC9349188.
Liu H, Kaku CI, Song G, Yuan M, Andrabi R, Burton DR, Walker LM, Wilson IA. Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron. Commun Biol. 2022 Jul 29;5(1):766. doi: 10.1038/s42003-022-03700-6. PubMed PMID: 35906394; PubMed Central PMCID: PMC9336126.
Yuan M, Zhu X, He WT, Zhou P, Kaku CI, Capozzola T, Zhu CY, Yu X, Liu H, Yu W, Hua Y, Tien H, Peng L, Song G, Cottrell CA, Schief WR, Nemazee D, Walker LM, Andrabi R, Burton DR, Wilson IA. A broad and potent neutralization epitope in SARS-related coronaviruses. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2205784119. doi: 10.1073/pnas.2205784119. Epub 2022 Jun 29. PubMed PMID: 35767670; PubMed Central PMCID: PMC9304036.
Xiang Y, Huang W, Liu H, Sang Z, Nambulli S, Tubiana J, Williams KL Jr, Duprex WP, Schneidman-Duhovny D, Wilson IA, Taylor DJ, Shi Y. Superimmunity by pan-sarbecovirus nanobodies. Cell Rep. 2022 Jun 28;39(13):111004. doi: 10.1016/j.celrep.2022.111004. Epub 2022 Jun 8. PubMed PMID: 35738279; PubMed Central PMCID: PMC9174178.
Lv H, So RTY, Teo QW, Yuan M, Liu H, Lee CD, Yip GK, Ng WW, Wilson IA, Peiris M, Wu NC, Mok CKP. Neutralizing Antibody Response to Sarbecovirus Is Delayed in Sequential Heterologous Immunization. Viruses. 2022 Jun 24;14(7). doi: 10.3390/v14071382. PubMed PMID: 35891363; PubMed Central PMCID: PMC9318566.
Wang Y, Yuan M, Lv H, Peng J, Wilson IA, Wu NC. A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2. Immunity. 2022 Jun 14;55(6):1105-1117.e4. doi: 10.1016/j.immuni.2022.03.019. Epub 2022 Mar 25. PubMed PMID: 35397794; PubMed Central PMCID: PMC8947961.
He WT, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Schäfer A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R. Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses. Nat Immunol. 2022 Jun;23(6):960-970. doi: 10.1038/s41590-022-01222-1. Epub 2022 Jun 2. PubMed PMID: 35654851.
Pfaff-Kilgore JM, Davidson E, Kadash-Edmondson K, Hernandez M, Rosenberg E, Chambers R, Castelli M, Clementi N, Mancini N, Bailey JR, Crowe JE Jr, Law M, Doranz BJ. Sites of vulnerability in HCV E1E2 identified by comprehensive functional screening. Cell Rep. 2022 May 24;39(8):110859. doi: 10.1016/j.celrep.2022.110859. PubMed PMID: 35613596; PubMed Central PMCID: PMC9281441.
Zhu X, Han J, Sun W, Puente-Massaguer E, Yu W, Palese P, Krammer F, Ward AB, Wilson IA. Influenza chimeric hemagglutinin structures in complex with broadly protective antibodies to the stem and trimer interface. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2200821119. doi: 10.1073/pnas.2200821119. Epub 2022 May 20. PubMed PMID: 35594401; PubMed Central PMCID: PMC9173763.
Yuan M, Wang Y, Lv H, Wilson IA, Wu NC. Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2. bioRxiv. 2022 May 18;. doi: 10.1101/2022.05.17.492220. PubMed PMID: 35611339; PubMed Central PMCID: PMC9128778.
Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB. Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2120976119. doi: 10.1073/pnas.2120976119. Epub 2022 May 12. PubMed PMID: 35549549; PubMed Central PMCID: PMC9171815.
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Dacon C, Tucker C, Peng L, Lee CD, Lin TH, Yuan M, Cong Y, Wang L, Purser L, Williams JK, Pyo CW, Kosik I, Hu Z, Zhao M, Mohan D, Cooper A, Peterson M, Skinner J, Dixit S, Kollins E, Huzella L, Perry D, Byrum R, Lembirik S, Zhang Y, Yang ES, Chen M, Leung K, Weinberg RS, Pegu A, Geraghty DE, Davidson E, Douagi I, Moir S, Yewdell JW, Schmaljohn C, Crompton PD, Holbrook MR, Nemazee D, Mascola JR, Wilson IA, Tan J. Broadly neutralizing antibodies target the coronavirus fusion peptide. bioRxiv. 2022 Apr 12;. doi: 10.1101/2022.04.11.487879. PubMed PMID: 35441178; PubMed Central PMCID: PMC9016638.
Beutler N, Pholcharee T, Oyen D, Flores-Garcia Y, MacGill RS, Garcia E, Calla J, Parren M, Yang L, Volkmuth W, Locke E, Regules JA, Dutta S, Emerling D, Early AM, Neafsey DE, Winzeler EA, King CR, Zavala F, Burton DR, Wilson IA, Rogers TF. A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum. PLoS Pathog. 2022 Mar;18(3):e1010409. doi: 10.1371/journal.ppat.1010409. eCollection 2022 Mar. PubMed PMID: 35344575; PubMed Central PMCID: PMC8989322.
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Yan NL, Nair R, Chu A, Wilson IA, Johnson KA, Morgan GJ, Kelly JW. Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site. Bioorg Med Chem Lett. 2022 Mar 15;60:128571. doi: 10.1016/j.bmcl.2022.128571. Epub 2022 Jan 19. PubMed PMID: 35065233; PubMed Central PMCID: PMC8857066.
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He WT, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Schäfer A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R. Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses. bioRxiv. 2022 Feb 8;. doi: 10.1101/2021.09.08.459480. PubMed PMID: 35169804; PubMed Central PMCID: PMC8845431.
Zhou P, Yuan M, Song G, Beutler N, Shaabani N, Huang D, He WT, Zhu X, Callaghan S, Yong P, Anzanello F, Peng L, Ricketts J, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Teijaro JR, Rogers TF, Wilson IA, Burton DR, Andrabi R. A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection. bioRxiv. 2022 Jan 21;. doi: 10.1101/2021.03.30.437769. PubMed PMID: 33821273; PubMed Central PMCID: PMC8020973.
Qiang M, Ma P, Li Y, Liu H, Harding A, Min C, Wang F, Liu L, Yuan M, Ji Q, Tao P, Shi X, Li Z, Li T, Wang X, Zhang Y, Wu NC, Lee CD, Zhu X, Gilbert-Jaramillo J, Zhang C, Saxena A, Huang X, Wang H, James W, Dwek RA, Wilson IA, Yang G, Lerner RA. Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago. Adv Sci (Weinh). 2022 Jan;9(1):e2102181. doi: 10.1002/advs.202102181. Epub 2021 Oct 29. PubMed PMID: 34716683; PubMed Central PMCID: PMC8646600.
Strohmeier S, Amanat F, Zhu X, McMahon M, Deming ME, Pasetti MF, Neuzil KM, Wilson IA, Krammer F. A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model. mBio. 2021 Dec 21;12(6):e0224121. doi: 10.1128/mBio.02241-21. Epub 2021 Nov 23. PubMed PMID: 34809451; PubMed Central PMCID: PMC8609353.
Omorodion O, Wilson IA. Structural and Biochemical Characterization of Cysteinylation in Broadly Neutralizing Antibodies to HIV-1. J Mol Biol. 2021 Dec 3;433(24):167303. doi: 10.1016/j.jmb.2021.167303. Epub 2021 Oct 16. PubMed PMID: 34666044; PubMed Central PMCID: PMC8641059.
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Gebert LFR, Law M, MacRae IJ. A structured RNA motif locks Argonaute2:miR-122 onto the 5' end of the HCV genome. Nat Commun. 2021 Nov 25;12(1):6836. doi: 10.1038/s41467-021-27177-9. PubMed PMID: 34824224; PubMed Central PMCID: PMC8616905.
Yin V, Lai SH, Caniels TG, Brouwer PJM, Brinkkemper M, Aldon Y, Liu H, Yuan M, Wilson IA, Sanders RW, van Gils MJ, Heck AJR. Probing Affinity, Avidity, Anticooperativity, and Competition in Antibody and Receptor Binding to the SARS-CoV-2 Spike by Single Particle Mass Analyses. ACS Cent Sci. 2021 Nov 24;7(11):1863-1873. doi: 10.1021/acscentsci.1c00804. Epub 2021 Nov 4. PubMed PMID: 34845440; PubMed Central PMCID: PMC8577368.
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Lv H, Tsang OT, So RTY, Wang Y, Yuan M, Liu H, Yip GK, Teo QW, Lin Y, Liang W, Wang J, Ng WW, Wilson IA, Peiris JSM, Wu NC, Mok CKP. Homologous and heterologous serological response to the N-terminal domain of SARS-CoV-2 in humans and mice. Eur J Immunol. 2021 Sep;51(9):2296-2305. doi: 10.1002/eji.202149234. Epub 2021 Jun 22. PubMed PMID: 34089541; PubMed Central PMCID: PMC8237060.
Yuan M, Huang D, Lee CD, Wu NC, Jackson AM, Zhu X, Liu H, Peng L, van Gils MJ, Sanders RW, Burton DR, Reincke SM, Prüss H, Kreye J, Nemazee D, Ward AB, Wilson IA. Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants. Science. 2021 Aug 13;373(6556):818-823. doi: 10.1126/science.abh1139. Epub 2021 May 20. PubMed PMID: 34016740; PubMed Central PMCID: PMC8284396.
Kumar S, Lin X, Ngo T, Shapero B, Sou C, Allen JD, Copps J, Zhang L, Ozorowski G, He L, Crispin M, Ward AB, Wilson IA, Zhu J. Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles. mBio. 2021 Jun 29;12(3):e0042921. doi: 10.1128/mBio.00429-21. Epub 2021 Jun 22. PubMed PMID: 34156262; PubMed Central PMCID: PMC8262854.
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Tan TJC, Yuan M, Kuzelka K, Padron GC, Beal JR, Chen X, Wang Y, Rivera-Cardona J, Zhu X, Stadtmueller BM, Brooke CB, Wilson IA, Wu NC. Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain. Nat Commun. 2021 Jun 21;12(1):3815. doi: 10.1038/s41467-021-24123-7. PubMed PMID: 34155209; PubMed Central PMCID: PMC8217500.
McKitrick TR, Bernard SM, Noll AJ, Collins BC, Goth CK, McQuillan AM, Heimburg-Molinaro J, Herrin BR, Wilson IA, Cooper MD, Cummings RD. Novel lamprey antibody recognizes terminal sulfated galactose epitopes on mammalian glycoproteins. Commun Biol. 2021 Jun 3;4(1):674. doi: 10.1038/s42003-021-02199-7. PubMed PMID: 34083726; PubMed Central PMCID: PMC8175384.
Schoenle MV, Li Y, Yuan M, Clarkson MW, Wilson IA, Peti W, Page R. NMR Based SARS-CoV-2 Antibody Screening. J Am Chem Soc. 2021 Jun 2;143(21):7930-7934. doi: 10.1021/jacs.1c03945. Epub 2021 May 21. PubMed PMID: 34018723; PubMed Central PMCID: PMC8171107.
Montague Z, Lv H, Otwinowski J, DeWitt WS, Isacchini G, Yip GK, Ng WW, Tsang OT, Yuan M, Liu H, Wilson IA, Peiris JSM, Wu NC, Nourmohammad A, Mok CKP. Dynamics of B cell repertoires and emergence of cross-reactive responses in patients with different severities of COVID-19. Cell Rep. 2021 May 25;35(8):109173. doi: 10.1016/j.celrep.2021.109173. Epub 2021 May 9. PubMed PMID: 33991510; PubMed Central PMCID: PMC8106887.
Yan NL, Santos-Martins D, Nair R, Chu A, Wilson IA, Johnson KA, Forli S, Morgan GJ, Petrassi HM, Kelly JW. Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design. J Med Chem. 2021 May 13;64(9):6273-6299. doi: 10.1021/acs.jmedchem.1c00339. Epub 2021 May 3. PubMed PMID: 33939422; PubMed Central PMCID: PMC8428256.
Liu H, Yuan M, Huang D, Bangaru S, Zhao F, Lee CD, Peng L, Barman S, Zhu X, Nemazee D, Burton DR, van Gils MJ, Sanders RW, Kornau HC, Reincke SM, Prüss H, Kreye J, Wu NC, Ward AB, Wilson IA. A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection. Cell Host Microbe. 2021 May 12;29(5):806-818.e6. doi: 10.1016/j.chom.2021.04.005. Epub 2021 Apr 15. PubMed PMID: 33894127; PubMed Central PMCID: PMC8049401.
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