My Bibliography

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West KA, Zhang H, Brown MC, Nikolopoulos SN, Riedy MC, Horwitz AF, Turner CE. The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL). J Cell Biol. 2001 Jul 9;154(1):161-76. doi: 10.1083/jcb.200101039. PubMed PMID: 11448998; PubMed Central PMCID: PMC2196859.

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Zhang H, Webb DJ, Asmussen H, Horwitz AF. Synapse formation is regulated by the signaling adaptor GIT1. J Cell Biol. 2003 Apr 14;161(1):131-42. doi: 10.1083/jcb.200211002. PubMed PMID: 12695502; PubMed Central PMCID: PMC2172873.

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Zhang H, Webb DJ, Asmussen H, Niu S, Horwitz AF. A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC. J Neurosci. 2005 Mar 30;25(13):3379-88. doi: 10.1523/JNEUROSCI.3553-04.2005. PubMed PMID: 15800193; PubMed Central PMCID: PMC6724907.

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Webb DJ, Zhang H, Horwitz AF. Cell migration: an overview. Methods Mol Biol. 2005;294:3-11. Review. PubMed PMID: 15576900.

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Zhang H, Macara IG. The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis. Nat Cell Biol. 2006 Mar;8(3):227-37. doi: 10.1038/ncb1368. Epub 2006 Feb 12. PubMed PMID: 16474385.

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Webb DJ, Zhang H, Majumdar D, Horwitz AF. alpha5 integrin signaling regulates the formation of spines and synapses in hippocampal neurons. J Biol Chem. 2007 Mar 9;282(10):6929-35. doi: 10.1074/jbc.M610981200. Epub 2007 Jan 9. PubMed PMID: 17213186; PubMed Central PMCID: PMC2750863.

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Zhang H, Macara IG. The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase. Dev Cell. 2008 Feb;14(2):216-26. doi: 10.1016/j.devcel.2007.11.020. PubMed PMID: 18267090; PubMed Central PMCID: PMC2768076.

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Zhang H. Rho GTPases and spines. In: Squire LR, editor. Encyclopedia of Neuroscience Oxford: Academic Press; 2009. Chapter 8; p.357-364.

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Kim JY, Oh MH, Bernard LP, Macara IG, Zhang H. The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons. J Biol Chem. 2011 Oct 28;286(43):37615-24. doi: 10.1074/jbc.M111.268029. Epub 2011 Sep 7. PubMed PMID: 21900250; PubMed Central PMCID: PMC3199506.

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Wu Q, DiBona VL, Bernard LP, Zhang H. The polarity protein partitioning-defective 1 (PAR-1) regulates dendritic spine morphogenesis through phosphorylating postsynaptic density protein 95 (PSD-95). J Biol Chem. 2012 Aug 31;287(36):30781-8. doi: 10.1074/jbc.M112.351452. Epub 2012 Jul 17. PubMed PMID: 22807451; PubMed Central PMCID: PMC3436321.

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Sun M, Bernard LP, Dibona VL, Wu Q, Zhang H. Calcium phosphate transfection of primary hippocampal neurons. J Vis Exp. 2013 Nov 12;(81):e50808. doi: 10.3791/50808. PubMed PMID: 24300106; PubMed Central PMCID: PMC3989506.

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Yasuda K, Zhang H, Loiselle D, Haystead T, Macara IG, Mili S. The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules. J Cell Biol. 2013 Dec 9;203(5):737-46. doi: 10.1083/jcb.201306058. Epub 2013 Dec 2. PubMed PMID: 24297750; PubMed Central PMCID: PMC3857475.

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Bernard LP, Zhang H. MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism. PLoS One. 2015;10(5):e0124816. doi: 10.1371/journal.pone.0124816. eCollection 2015. PubMed PMID: 25932647; PubMed Central PMCID: PMC4416788.

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Zhang H. Polarity Determinants in Dendritic Spine Development and Plasticity. Neural Plast. 2016;2016:3145019. doi: 10.1155/2016/3145019. Epub 2015 Dec 29. Review. PubMed PMID: 26839714; PubMed Central PMCID: PMC4709733.

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Sun M, Asghar SZ, Zhang H. The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb. Neurobiol Dis. 2016 Sep;93:1-11. doi: 10.1016/j.nbd.2016.03.022. Epub 2016 Apr 9. PubMed PMID: 27072891; PubMed Central PMCID: PMC4930744.

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Lim CS, Kang X, Mirabella V, Zhang H, Bu Q, Araki Y, Hoang ET, Wang S, Shen Y, Choi S, Kaang BK, Chang Q, Pang ZP, Huganir RL, Zhu JJ. BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method. Genes Dev. 2017 Mar 15;31(6):537-552. doi: 10.1101/gad.294413.116. PubMed PMID: 28404629; PubMed Central PMCID: PMC5393050.

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Wu Q, Sun M, Bernard LP, Zhang H. Postsynaptic density 95 (PSD-95) serine 561 phosphorylation regulates a conformational switch and bidirectional dendritic spine structural plasticity. J Biol Chem. 2017 Sep 29;292(39):16150-16160. doi: 10.1074/jbc.M117.782490. Epub 2017 Aug 8. PubMed PMID: 28790172; PubMed Central PMCID: PMC5625046.

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Lim CS, Wen C, Sheng Y, Wang G, Zhou Z, Wang S, Zhang H, Ye A, Zhu JJ. Piconewton-Scale Analysis of Ras-BRaf Signal Transduction with Single-Molecule Force Spectroscopy. Small. 2017 Oct;13(40). doi: 10.1002/smll.201701972. Epub 2017 Aug 15. PubMed PMID: 28809097; PubMed Central PMCID: PMC6272124.

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Sun M, Zhang H. Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1. Neurobiol Aging. 2017 Dec;60:129-140. doi: 10.1016/j.neurobiolaging.2017.08.024. Epub 2017 Sep 21. PubMed PMID: 28946017; PubMed Central PMCID: PMC5653456.

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Eyo UB, Bispo A, Liu J, Sabu S, Wu R, DiBona VL, Zheng J, Murugan M, Zhang H, Tang Y, Wu LJ. The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions. Sci Rep. 2018 Jan 16;8(1):828. doi: 10.1038/s41598-018-19205-4. PubMed PMID: 29339791; PubMed Central PMCID: PMC5770428.

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Zhang H, Winckler B, Cai Q. Introduction to the special issue on membrane trafficking in neurons. Dev Neurobiol. 2018 Mar;78(3):167-169. doi: 10.1002/dneu.22573. PubMed PMID: 29453802; PubMed Central PMCID: PMC5856451.

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Zhang L, Zhang P, Wang G, Zhang H, Zhang Y, Yu Y, Zhang M, Xiao J, Crespo P, Hell JW, Lin L, Huganir RL, Zhu JJ. Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains. Neuron. 2018 May 16;98(4):783-800.e4. doi: 10.1016/j.neuron.2018.03.049. Epub 2018 Apr 26. PubMed PMID: 29706584; PubMed Central PMCID: PMC6192044.

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Winckler B, Faundez V, Maday S, Cai Q, Guimas Almeida C, Zhang H. The Endolysosomal System and Proteostasis: From Development to Degeneration. J Neurosci. 2018 Oct 31;38(44):9364-9374. doi: 10.1523/JNEUROSCI.1665-18.2018. Review. PubMed PMID: 30381428; PubMed Central PMCID: PMC6209849.

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DiBona VL, Zhu W, Shah MK, Rafalia A, Ben Cheikh H, Crockett DP, Zhang H. Loss of Par1b/MARK2 primes microglia during brain development and enhances their sensitivity to injury. J Neuroinflammation. 2019 Jan 17;16(1):11. doi: 10.1186/s12974-018-1390-3. PubMed PMID: 30654821; PubMed Central PMCID: PMC6335724.

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Sun M, Huang C, Wang H, Zhang H. Par3 regulates polarized convergence between APP and BACE1 in hippocampal neurons. Neurobiol Aging. 2019 May;77:87-93. doi: 10.1016/j.neurobiolaging.2019.01.023. Epub 2019 Jan 30. PubMed PMID: 30784815; PubMed Central PMCID: PMC6528466.

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Yu W, Zhang H, Shin MR, Sesti F. Oxidation of KCNB1 potassium channels in the murine brain during aging is associated with cognitive impairment. Biochem Biophys Res Commun. 2019 May 14;512(4):665-669. doi: 10.1016/j.bbrc.2019.03.130. Epub 2019 Mar 25. PubMed PMID: 30922570; PubMed Central PMCID: PMC6471606.

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Norton SA, Gifford JJ, Pawlak AP, Derbaly A, Sherman SL, Zhang H, Wagner GC, Kusnecov AW. Long-lasting Behavioral and Neuroanatomical Effects of Postnatal Valproic Acid Treatment. Neuroscience. 2020 May 10;434:8-21. doi: 10.1016/j.neuroscience.2020.02.029. Epub 2020 Feb 27. PubMed PMID: 32112916.

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Popovitchenko T, Park Y, Page NF, Luo X, Krsnik Z, Liu Y, Salamon I, Stephenson JD, Kraushar ML, Volk NL, Patel SM, Wijeratne HRS, Li D, Suthar KS, Wach A, Sun M, Arnold SJ, Akamatsu W, Okano H, Paillard L, Zhang H, Buyske S, Kostovic I, De Rubeis S, Hart RP, Rasin MR. Translational derepression of Elavl4 isoforms at their alternative 5' UTRs determines neuronal development. Nat Commun. 2020 Apr 3;11(1):1674. doi: 10.1038/s41467-020-15412-8. PubMed PMID: 32245946; PubMed Central PMCID: PMC7125149.

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Zhang H. Synaptic dysregulation in autism spectrum disorders. J Neurosci Res. 2020 Nov;98(11):2111-2114. doi: 10.1002/jnr.24711. Epub 2020 Aug 11. Review. PubMed PMID: 32780523.

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DiBona VL, Shah MK, Krause KJ, Zhu W, Voglewede MM, Smith DM, Crockett DP, Zhang H. Metformin reduces neuroinflammation and improves cognitive functions after traumatic brain injury. Neurosci Res. 2021 Nov;172:99-109. doi: 10.1016/j.neures.2021.05.007. Epub 2021 May 21. PubMed PMID: 34023358; PubMed Central PMCID: PMC8449802.

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Liu Y, Gokhale S, Jung J, Zhu S, Luo C, Saha D, Guo JY, Zhang H, Kyin S, Zong WX, White E, Xie P. Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes. Front Immunol. 2021;12:670338. doi: 10.3389/fimmu.2021.670338. eCollection 2021. PubMed PMID: 34745083; PubMed Central PMCID: PMC8564014.

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Voglewede MM, Zhang H. Polarity proteins: Shaping dendritic spines and memory. Dev Biol. 2022 Aug;488:68-73. doi: 10.1016/j.ydbio.2022.05.007. Epub 2022 May 14. Review. PubMed PMID: 35580729; PubMed Central PMCID: PMC9953585.

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Huang C, Voglewede MM, Ozsen EN, Wang H, Zhang H. SHANK3 Mutations Associated with Autism and Schizophrenia Lead to Shared and Distinct Changes in Dendritic Spine Dynamics in the Developing Mouse Brain. Neuroscience. 2023 Sep 15;528:1-11. doi: 10.1016/j.neuroscience.2023.07.024. Epub 2023 Jul 31. PubMed PMID: 37532012; PubMed Central PMCID: PMC10528879.

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Voglewede MM, Ozsen EN, Ivak N, Bernabucci M, Sun M, Pang ZP, Zhang H. Loss of the polarity protein Par3 promotes dendritic spine neoteny and enhances learning and memory. bioRxiv. 2023 Sep 1;. doi: 10.1101/2023.08.30.555530. PubMed PMID: 37693426; PubMed Central PMCID: PMC10491238.

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Kelly-Castro EC, Shear R, Dindigal AH, Bhagwat M, Zhang H. MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo. bioRxiv. 2023 Dec 4;. doi: 10.1101/2023.12.03.569757. PubMed PMID: 38105977; PubMed Central PMCID: PMC10723299.

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Caiola HO, Wu Q, Soni S, Wang XF, Monahan K, Pang ZP, Wagner GC, Zhang H. Neuronal connectivity, behavioral, and transcriptional alterations associated with the loss of MARK2. bioRxiv. 2023 Dec 7;. doi: 10.1101/2023.12.05.569759. PubMed PMID: 38105965; PubMed Central PMCID: PMC10723285.

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Kelly-Castro EC, Shear R, Dindigal AH, Bhagwat M, Zhang H. MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo. Exp Neurol. 2024 Jun;376:114752. doi: 10.1016/j.expneurol.2024.114752. Epub 2024 Mar 12. PubMed PMID: 38484863; PubMed Central PMCID: PMC12230765.

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Karas BF, Terez KR, Mowla S, Battula N, Flannery KP, Gural BM, Aboussleman G, Mubin N, Manzini MC. Removal of pomt1 in zebrafish leads to loss of α-dystroglycan glycosylation and dystroglycanopathy phenotypes. Hum Mol Genet. 2024 Apr 8;33(8):709-723. doi: 10.1093/hmg/ddae006. PubMed PMID: 38272461; PubMed Central PMCID: PMC11000664.

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Voglewede MM, Ozsen EN, Ivak N, Bernabucci M, Tang R, Sun M, Pang ZP, Zhang H. Loss of the polarity protein Par3 promotes dendritic spine neoteny and enhances learning and memory. iScience. 2024 Jul 19;27(7):110308. doi: 10.1016/j.isci.2024.110308. eCollection 2024 Jul 19. PubMed PMID: 39045101; PubMed Central PMCID: PMC11263792.

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Caiola HO, Wu Q, Li J, Wang XF, Soni S, Monahan K, Wagner GC, Pang ZP, Zhang H. Neuronal connectivity, behavioral, and transcriptional alterations associated with the loss of MARK2. FASEB J. 2024 Oct 31;38(20):e70124. doi: 10.1096/fj.202400454R. PubMed PMID: 39436150; PubMed Central PMCID: PMC13271256.

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Arbuckle K, Sharma R, Drake FE, Usiyevich A, Usman S, Matikainen-Ankney BA. Isocaloric high-fat diet decreases motivation in the absence of obesity. Obesity (Silver Spring). 2025 Feb;33(2):243-249. doi: 10.1002/oby.24227. Epub 2025 Jan 21. PubMed PMID: 39838525; PubMed Central PMCID: PMC11774000.

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Eubanks E, VanderSleen K, Mody J, Patel N, Sacks B, Farahani MD, Wang J, Elliott J, Jaber N, Akçimen F, Bandres-Ciga S, Helweh F, Liu J, Archakam S, Kimelman R, Sharma B, Socha P, Guntur A, Huang Y, Ramalingam N, Guadagno E, Bartels T, Dettmer U, Mouradian MM, Bahrami AH, Dai W, Baum J, Shi Z, Hardy J, Kara E. Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease. Cell Rep. 2025 May 27;44(5):115636. doi: 10.1016/j.celrep.2025.115636. Epub 2025 May 1. PubMed PMID: 40317721; PubMed Central PMCID: PMC12258067.

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Jia N, Guan H, Zuo Y, Jeong YY, Amireddy N, Rajapaksha G, Gonzalez CU, Jaber N, Lee YK, Nissenbaum M, Margolis DJ, Dai W, Kusnecov AW, Cai Q. Dysregulation of autophagosome-mitochondria contacts contributes to autophagy dysfunction and neurodegeneration in tauopathy. Proc Natl Acad Sci U S A. 2026 Jun 16;123(24):e2520331123. doi: 10.1073/pnas.2520331123. Epub 2026 Jun 8. PubMed PMID: 42258714; PubMed Central PMCID: PMC13273284.

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Jia N, Zuo Y, Guan H, Rajapaksha G, Cai Q. Dysregulation of a novel autophagosome-mitochondria contact contributes to tauopathy-related neurodegeneration by disrupting autophagy. Autophagy. 2026 Jun 23;:1-3. doi: 10.1080/15548627.2026.2692613. [Epub ahead of print] PubMed PMID: 42316849; PubMed Central PMCID: PMC13334575.