Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Wilson JD, Gerlach AR, Karim HT, Aizenstein HJ, Andreescu C. Sex matters: acute functional connectivity changes as markers of remission in late-life depression differ by sex. Mol Psychiatry. 2023 Jul 6;. doi: 10.1038/s41380-023-02158-0. [Epub ahead of print] PubMed PMID: 37414928.
Malec SA, Taneja SB, Albert SM, Elizabeth Shaaban C, Karim HT, Levine AS, Munro P, Callahan TJ, Boyce RD. Causal feature selection using a knowledge graph combining structured knowledge from the biomedical literature and ontologies: A use case studying depression as a risk factor for Alzheimer's disease. J Biomed Inform. 2023 Jun;142:104368. doi: 10.1016/j.jbi.2023.104368. Epub 2023 Apr 21. PubMed PMID: 37086959; PubMed Central PMCID: PMC10355339.
Brier MR, Li Z, Ly M, Karim HT, Liang L, Du W, McCarthy JE, Cross AH, Benzinger TLS, Naismith RT, Chahin S. "Brain age" predicts disability accumulation in multiple sclerosis. Ann Clin Transl Neurol. 2023 Jun;10(6):990-1001. doi: 10.1002/acn3.51782. Epub 2023 Apr 29. PubMed PMID: 37119507; PubMed Central PMCID: PMC10270248.
Karim HT, Aizenstein HJ, Mizuno A, Ly M, Andreescu C, Wu M, Hong CH, Roh HW, Park B, Lee H, Kim NR, Choi JW, Seo SW, Choi SH, Kim EJ, Kim BC, Cheong JY, Lee E, Lee DG, Cho YH, Moon SY, Son SJ. Independent replication of advanced brain age in mild cognitive impairment and dementia: detection of future cognitive dysfunction. Mol Psychiatry. 2022 Dec;27(12):5235-5243. doi: 10.1038/s41380-022-01728-y. Epub 2022 Aug 16. PubMed PMID: 35974140; PubMed Central PMCID: PMC9763106.
Clarkson BD, Karim HT, Chermansky CJ, Banihashemi L, Tyagi S, Griffiths DJ, Resnick NM. Changes in brain response to urgency before and after treatment of urgency urinary incontinence with onabotulinumtoxin A. Neurourol Urodyn. 2022 Nov;41(8):1703-1710. doi: 10.1002/nau.25012. Epub 2022 Jul 29. PubMed PMID: 35904238; NIHMSID:NIHMS1834897.
Gerlach AR, Karim HT, Peciña M, Ajilore O, Taylor WD, Butters MA, Andreescu C. MRI predictors of pharmacotherapy response in major depressive disorder. Neuroimage Clin. 2022;36:103157. doi: 10.1016/j.nicl.2022.103157. Epub 2022 Aug 17. Review. PubMed PMID: 36027717; PubMed Central PMCID: PMC9420953.
Kolobaric A, Karim HT, Banihashemi L, Mizuno A, Aizenstein HJ, Andreescu C. Are All Anxieties Created Equal? Stress-related Networks and Anxiety Phenotypes in Old Age. Am J Geriatr Psychiatry. 2022 Jul;30(7):801-812. doi: 10.1016/j.jagp.2021.12.007. Epub 2021 Dec 11. PubMed PMID: 35000866; PubMed Central PMCID: PMC9177511.
Mizuno A, Karim HT, Newmark J, Khan F, Rosenblatt MJ, Neppach AM, Lowe M, Aizenstein HJ, Mennin DS, Andreescu C. Thinking of Me or Thinking of You? Behavioral Correlates of Self vs. Other Centered Worry and Reappraisal in Late-Life. Front Psychiatry. 2022;13:780745. doi: 10.3389/fpsyt.2022.780745. eCollection 2022. PubMed PMID: 35815034; PubMed Central PMCID: PMC9256986.
Banihashemi L, Peng CW, Rangarajan A, Karim HT, Wallace ML, Sibbach BM, Singh J, Stinley MM, Germain A, Aizenstein HJ. Childhood Threat Is Associated With Lower Resting-State Connectivity Within a Central Visceral Network. Front Psychol. 2022;13:805049. doi: 10.3389/fpsyg.2022.805049. eCollection 2022. PubMed PMID: 35310241; PubMed Central PMCID: PMC8927539.
Karim HT, Vahia IV, Iaboni A, Lee EE. Editorial: Artificial Intelligence in Geriatric Mental Health Research and Clinical Care. Front Psychiatry. 2022;13:859175. doi: 10.3389/fpsyt.2022.859175. eCollection 2022. PubMed PMID: 35299825; PubMed Central PMCID: PMC8921095.
Clarkson BD, Wei Z, Karim HT, Tyagi S, Resnick NM, Salkeld RP, Conklin CA. Neuroimaging of situational urgency and incontinence provoked by personal urgency cues. Neurourol Urodyn. 2022 Jan;41(1):166-173. doi: 10.1002/nau.24800. Epub 2021 Sep 27. PubMed PMID: 34570403; PubMed Central PMCID: PMC8738101.
Srirambhatla R, Karim HT. Prediction of COVID-19 Diagnosis from Healthy and Pneumonia CT scans using Convolutional Neural Networks. medRxiv : the preprint server for health sciences. 2022 January. doi:
Karim HT. The Elusive 'White Whale' of Treatment Response Prediction: Leveraging the Curse of Heterogeneity in Late-Life Depression. Am J Geriatr Psychiatry. 2021 Dec;29(12):1199-1201. doi: 10.1016/j.jagp.2021.04.001. Epub 2021 Apr 9. PubMed PMID: 33992524; PubMed Central PMCID: PMC8501143.
Gerlach AR, Karim HT, Kazan J, Aizenstein HJ, Krafty RT, Andreescu C. Networks of worry-towards a connectivity-based signature of late-life worry using higher criticism. Transl Psychiatry. 2021 Oct 28;11(1):550. doi: 10.1038/s41398-021-01648-5. PubMed PMID: 34711810; PubMed Central PMCID: PMC8553743.
Lin C, Huang CM, Karim HT, Liu HL, Lee TM, Wu CW, Toh CH, Tsai YF, Yen TH, Lee SH. Greater white matter hyperintensities and the association with executive function in suicide attempters with late-life depression. Neurobiol Aging. 2021 Jul;103:60-67. doi: 10.1016/j.neurobiolaging.2020.12.016. Epub 2021 Mar 15. PubMed PMID: 33845397.
Vogt KM, Ibinson JW, Smith CT, Citro AT, Norton CM, Karim HT, Popov V, Mahajan A, Aizenstein HJ, Reder LM, Fiez JA. Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain. Anesthesiology. 2021 Jul 1;135(1):69-82. doi: 10.1097/ALN.0000000000003774. PubMed PMID: 33872345; PubMed Central PMCID: PMC8249346.
Smagula SF, Karim HT, Ibrahim TS, Krafty RT, Stahl ST, Rodakowski J, Reynolds CF, Hall MH, Aizenstein HJ. Resting-State Function Connectivity Associated With Being a "Morning-Type" Dementia Caregiver and Having Lower Depression Symptom Severity. J Gerontol B Psychol Sci Soc Sci. 2021 Jun 14;76(6):1071-1076. doi: 10.1093/geronb/gbaa115. PubMed PMID: 32750139; PubMed Central PMCID: PMC8200349.
Li J, Mountz EJ, Mizuno A, Shah AM, Weinstein A, Cohen AD, Klunk WE, Snitz BE, Aizenstein HJ, Karim HT. Neural asymmetry during memory encoding and its association with markers of preclinical Alzheimers Disease. [preprint]. 2021 June. Available from: doi:
Karim HT, Ly M, Yu G, Krafty R, Tudorascu DL, Aizenstein HJ, Andreescu C. Aging faster: worry and rumination in late life are associated with greater brain age. Neurobiol Aging. 2021 May;101:13-21. doi: 10.1016/j.neurobiolaging.2021.01.009. Epub 2021 Jan 20. PubMed PMID: 33561786; PubMed Central PMCID: PMC8122027.
Price RB, Gillan CM, Hanlon C, Ferrarelli F, Kim T, Karim HT, Renard M, Kaskie R, Degutis M, Wears A, Vienneau EP, Peterchev AV, Brown V, Siegle GJ, Wallace ML, Ahmari SE. Effect of Experimental Manipulation of the Orbitofrontal Cortex on Short-Term Markers of Compulsive Behavior: A Theta Burst Stimulation Study. Am J Psychiatry. 2021 May 1;178(5):459-468. doi: 10.1176/appi.ajp.2020.20060821. Epub 2021 Mar 17. PubMed PMID: 33726523; PubMed Central PMCID: PMC8119344.
Yu GZ, Ly M, Karim HT, Muppidi N, Aizenstein HJ, Ibinson JW. Accelerated brain aging in chronic low back pain. Brain Res. 2021 Mar 15;1755:147263. doi: 10.1016/j.brainres.2020.147263. Epub 2021 Jan 7. PubMed PMID: 33422525; PubMed Central PMCID: PMC7939694.
Ly M, Karim HT, Becker JT, Lopez OL, Anderson SJ, Aizenstein HJ, Reynolds CF, Zmuda MD, Butters MA. Late-life depression and increased risk of dementia: a longitudinal cohort study. Transl Psychiatry. 2021 Mar 2;11(1):147. doi: 10.1038/s41398-021-01269-y. PubMed PMID: 33654078; PubMed Central PMCID: PMC7925518.
Peciña M, Dombrovski AY, Price R, Karim HT. Understanding the Neurocomputational Mechanisms of Antidepressant Placebo Effects. J Psychiatr Brain Sci. 2021;6. doi: 10.20900/jpbs.20210001. Epub 2021 Feb 15. PubMed PMID: 33732892; PubMed Central PMCID: PMC7963355.
Clarkson BD, Karim HT, Griffiths DJ, Resnick NM. Testing a new, intensified infusion-withdrawal protocol for urinary urgency provocation in brain-bladder studies. Neurourol Urodyn. 2021 Jan;40(1):131-136. doi: 10.1002/nau.24559. Epub 2020 Oct 29. PubMed PMID: 33118637; PubMed Central PMCID: PMC7902294.
Mizuno A, Karim HT, Ly MJ, Cohen AD, Lopresti BJ, Mathis CA, Klunk WE, Aizenstein HJ, Snitz BE. An Effect of Education on Memory-Encoding Activation in Subjective Cognitive Decline. J Alzheimers Dis. 2021;81(3):1065-1078. doi: 10.3233/JAD-201087. PubMed PMID: 33843669; PubMed Central PMCID: PMC8382028.
Lee DY, Cho J, You SC, Park RW, Kim CS, Lee EY, Aizenstein H, Andreescu C, Karim H, Hong CH, Rho HW, Park B, Son SJ. Risk of Mortality in Elderly Coronavirus Disease 2019 Patients With Mental Health Disorders: A Nationwide Retrospective Study in South Korea. Am J Geriatr Psychiatry. 2020 Dec;28(12):1308-1316. doi: 10.1016/j.jagp.2020.09.016. Epub 2020 Sep 28. PubMed PMID: 33023798; PubMed Central PMCID: PMC7521355.
Chen J, Mizuno A, Lyew T, Karim HT, Karp JF, Dombrovski AY, Peciña M. Naltrexone modulates contextual processing in depression. Neuropsychopharmacology. 2020 Nov;45(12):2070-2078. doi: 10.1038/s41386-020-00809-2. Epub 2020 Aug 25. PubMed PMID: 32843703; PubMed Central PMCID: PMC7547720.
Karim HT, Rosso A, Aizenstein HJ, Bohnen NI, Studenski S, Rosano C. Resting state connectivity within the basal ganglia and gait speed in older adults with cerebral small vessel disease and locomotor risk factors. Neuroimage Clin. 2020;28:102401. doi: 10.1016/j.nicl.2020.102401. Epub 2020 Aug 28. PubMed PMID: 32932053; PubMed Central PMCID: PMC7495101.
Chen N, Rosano C, Karim HT, Studenski SA, Rosso AL. Regional Gray Matter Density Associated With Fast-Paced Walking in Older Adults: A Voxel-Based Morphometry Study. J Gerontol A Biol Sci Med Sci. 2020 Jul 13;75(8):1530-1536. doi: 10.1093/gerona/glaa091. PubMed PMID: 32285095; PubMed Central PMCID: PMC7357587.
Ly M, Yu GZ, Karim HT, Muppidi NR, Mizuno A, Klunk WE, Aizenstein HJ. Improving brain age prediction models: incorporation of amyloid status in Alzheimer's disease. Neurobiol Aging. 2020 Mar;87:44-48. doi: 10.1016/j.neurobiolaging.2019.11.005. Epub 2019 Nov 14. PubMed PMID: 31843257; PubMed Central PMCID: PMC7064421.
Camacho C, Fishburn F, Karim HT, Wakschlag LS, Perlman SB. Dysfunctional Attention Processing in Children with Clinical Irritability. PsyArXiv. 2020 February. doi: 10.31234/
Ward MJ, Karim HT, Jessen ZF, Ghuman AS, Richardson RM, Reynolds CF 3rd, Karp JF. Association between increased theta cordance and early response to ECT in late-life depression. Int J Geriatr Psychiatry. 2020 Feb;35(2):147-152. doi: 10.1002/gps.5220. Epub 2019 Dec 1. PubMed PMID: 31617234; PubMed Central PMCID: PMC7047608.
Rangarajan A, Wu M, Joseph N, Karim HT, Laymon C, Tudorascu DL, Cohen A, Klunk W, Aizenstein H. Multimodal magnetic resonance imaging predicts regional amyloid-β burden in the brain. bioRxiv : the preprint server for biology. 2020 January. doi:
Lin C, Ly M, Karim HT, Wei W, Snitz BE, Klunk WE, Aizenstein HJ. The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adults. Alzheimers Res Ther. 2020 Jan 6;12(1):7. doi: 10.1186/s13195-019-0573-1. PubMed PMID: 31907079; PubMed Central PMCID: PMC6945413.
Ding T, Cohen AD, O'Connor EE, Karim HT, Crainiceanu A, Muschelli J, Lopez O, Klunk WE, Aizenstein HJ, Krafty R, Crainiceanu CM, Tudorascu DL. An improved algorithm of white matter hyperintensity detection in elderly adults. Neuroimage Clin. 2020;25:102151. doi: 10.1016/j.nicl.2019.102151. Epub 2019 Dec 27. PubMed PMID: 31927502; PubMed Central PMCID: PMC6957792.
Karim HT, Reynolds CF, Smagula SF. Neuroimaging biomarkers of late-life major depressive disorder pathophysiology, pathogenesis, and treatment response. In: Personalized Psychiatry [Internet] 1 ed. London: Academic Press; 2020. Chapter 27; p.339-356. Available from:
Andreescu C, Ajilore O, Aizenstein HJ, Albert K, Butters MA, Landman BA, Karim HT, Krafty R, Taylor WD. Disruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression. Am J Geriatr Psychiatry. 2019 Dec;27(12):1316-1330. doi: 10.1016/j.jagp.2019.07.016. Epub 2019 Aug 7. Review. PubMed PMID: 31477459; PubMed Central PMCID: PMC6842700.
Karim HT, Tudorascu DL, Cohen A, Price JC, Lopresti B, Mathis C, Klunk W, Snitz BE, Aizenstein HJ. Relationships Between Executive Control Circuit Activity, Amyloid Burden, and Education in Cognitively Healthy Older Adults. Am J Geriatr Psychiatry. 2019 Dec;27(12):1360-1371. doi: 10.1016/j.jagp.2019.07.008. Epub 2019 Jul 19. PubMed PMID: 31402087; PubMed Central PMCID: PMC7047647.
Wu M, Mennin DS, Ly M, Karim HT, Banihashemi L, Tudorascu DL, Aizenstein HJ, Andreescu C. When worry may be good for you: Worry severity and limbic-prefrontal functional connectivity in late-life generalized anxiety disorder. J Affect Disord. 2019 Oct 1;257:650-657. doi: 10.1016/j.jad.2019.07.022. Epub 2019 Jul 5. PubMed PMID: 31357162; PubMed Central PMCID: PMC6711791.
Rangarajan A, Karim HT, Tudorascu DL, Walker S, Aizenstein HJ, Andreescu C. Dorsal Anterior Cingulate Cortical Thickness Is Associated with Improvement in Worry Severity Following Treatment in Late-Life Generalized Anxiety Disorder. PsyArXiv. 2019 September. doi: 10.31234/
Wu M, Thurston RC, Tudorascu DL, Karim HT, Mathis CA, Lopresti BJ, Kamboh MI, Cohen AD, Snitz BE, Klunk WE, Aizenstein HJ. Amyloid deposition is associated with different patterns of hippocampal connectivity in men versus women. Neurobiol Aging. 2019 Apr;76:141-150. doi: 10.1016/j.neurobiolaging.2018.11.020. Epub 2018 Dec 1. PubMed PMID: 30711677; PubMed Central PMCID: PMC6584958.
Camacho MC, Karim HT, Perlman SB. Neural architecture supporting active emotion processing in children: A multivariate approach. Neuroimage. 2019 Mar;188:171-180. doi: 10.1016/j.neuroimage.2018.12.013. Epub 2018 Dec 8. PubMed PMID: 30537564; PubMed Central PMCID: PMC6401267.
Kay DB, Karim HT, Hasler BP, James JA, Germain A, Hall MH, Franzen PL, Price JC, Nofzinger EA, Buysse DJ. Impact of acute sleep restriction on cerebral glucose metabolism during recovery non-rapid eye movement sleep among individuals with primary insomnia and good sleeper controls. Sleep Med. 2019 Mar;55:81-91. doi: 10.1016/j.sleep.2018.12.007. Epub 2019 Jan 4. PubMed PMID: 30772698; PubMed Central PMCID: PMC8232888.
Lin C, Karim HT, Pecina M, Aizenstein HJ, Lenze EJ, Blumberger DM, Mulsant BH, Kharasch ED, Reynolds Iii CF, Karp JF. Low-dose augmentation with buprenorphine increases emotional reactivity but not reward activity in treatment resistant mid- and late-life depression. Neuroimage Clin. 2019;21:101679. doi: 10.1016/j.nicl.2019.101679. Epub 2019 Jan 22. PubMed PMID: 30685701; PubMed Central PMCID: PMC6356006.
Clarkson BD, Karim HT, Griffiths DJ, Resnick NM. Functional connectivity of the brain in older women with urgency urinary incontinence. Neurourol Urodyn. 2018 Nov;37(8):2763-2775. doi: 10.1002/nau.23766. Epub 2018 Jul 27. PubMed PMID: 30054930; PubMed Central PMCID: PMC6469490.
Wei W, Karim HT, Lin C, Mizuno A, Andreescu C, Karp JF, Reynolds CF 3rd, Aizenstein HJ. Trajectories in Cerebral Blood Flow Following Antidepressant Treatment in Late-Life Depression: Support for the Vascular Depression Hypothesis. J Clin Psychiatry. 2018 Oct 23;79(6). doi: 10.4088/JCP.18m12106. PubMed PMID: 30358242; PubMed Central PMCID: PMC6419103.
Ryan JP, Aizenstein HJ, Orchard TJ, Nunley KA, Karim H, Rosano C. Basal ganglia cerebral blood flow associates with psychomotor speed in adults with type 1 diabetes. Brain Imaging Behav. 2018 Oct;12(5):1271-1278. doi: 10.1007/s11682-017-9783-y. PubMed PMID: 29164504; PubMed Central PMCID: PMC6394218.
Karim HT, Wang M, Andreescu C, Tudorascu D, Butters MA, Karp JF, Reynolds CF 3rd, Aizenstein HJ. Acute trajectories of neural activation predict remission to pharmacotherapy in late-life depression. Neuroimage Clin. 2018;19:831-839. doi: 10.1016/j.nicl.2018.06.006. eCollection 2018. PubMed PMID: 30013927; PubMed Central PMCID: PMC6024196.
Smagula SF, Karim HT, Rangarajan A, Santos FP, Wood SC, Santini T, Jakicic JM, Reynolds CF 3rd, Cameron JL, Vallejo AN, Butters MA, Rosano C, Ibrahim TS, Erickson KI, Aizenstein HJ. Association of Hippocampal Substructure Resting-State Functional Connectivity with Memory Performance in Older Adults. Am J Geriatr Psychiatry. 2018 Jun;26(6):690-699. doi: 10.1016/j.jagp.2018.03.003. Epub 2018 Mar 13. PubMed PMID: 29628321; PubMed Central PMCID: PMC5993618.
Ryan JP, Karim HT, Aizenstein HJ, Helbling NL, Toledo FGS. Insulin sensitivity predicts brain network connectivity following a meal. Neuroimage. 2018 May 1;171:268-276. doi: 10.1016/j.neuroimage.2018.01.024. Epub 2018 Jan 13. PubMed PMID: 29339315; PubMed Central PMCID: PMC5857474.
What would you like to do?