Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity.
Geroscience.
2023 Apr;45(2):1237-1245. doi: 10.1007/s11357-022-00647-8. Epub 2022 Aug 26. PubMed PMID:
36018536.
Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE.
Mol Psychiatry.
2022 Sep 21;. doi: 10.1038/s41380-022-01769-3. [Epub ahead of print] PubMed PMID:
36127429; NIHMSID:NIHMS1838127.
An aco-2::gfp knock-in enables the monitoring of mitochondrial morphology throughout C. elegans lifespan.
MicroPubl Biol.
2022;2022. doi: 10.17912/micropub.biology.000599. eCollection 2022. PubMed PMID:
35903774; PubMed Central PMCID:
PMC9315405.
Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD).
Aging (Albany NY).
2022 May 16;14(10):4247-4269. doi: 10.18632/aging.204074. Epub 2022 May 16. PubMed PMID:
35576057; PubMed Central PMCID:
PMC9186758.
Mitochondria-derived peptides in aging and healthspan.
J Clin Invest.
2022 May 2;132(9). doi: 10.1172/JCI158449. Review. PubMed PMID:
35499074; PubMed Central PMCID:
PMC9057581.
Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects.
Geroscience.
2022 Feb;44(1):463-483. doi: 10.1007/s11357-021-00487-y. Epub 2021 Nov 24. PubMed PMID:
34820764; PubMed Central PMCID:
PMC8612119.
Genetic diversity estimates for the Caenorhabditis Intervention Testing Program screening panel.
MicroPubl Biol.
2022;2022. doi: 10.17912/micropub.biology.000518. eCollection 2022. PubMed PMID:
35098051; PubMed Central PMCID:
PMC8796004.
Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes.
Aging Cell.
2022 Jan;21(1):e13488. doi: 10.1111/acel.13488. Epub 2021 Nov 27. PubMed PMID:
34837316; PubMed Central PMCID:
PMC8761014.
University of Southern California and buck institute nathan shock center: multidimensional models of aging.
Geroscience.
2021 Oct;43(5):2119-2127. doi: 10.1007/s11357-021-00416-z. Epub 2021 Jul 16. PubMed PMID:
34269983; PubMed Central PMCID:
PMC8599784.
Caenorhabditis Intervention Testing Program: the herbicide diuron does not robustly extend lifespan in nematodes.
MicroPubl Biol.
2021;2021. doi: 10.17912/micropub.biology.000448. eCollection 2021. PubMed PMID:
34585102; PubMed Central PMCID:
PMC8461457.
Moving geroscience from the bench to clinical care and health policy.
J Am Geriatr Soc.
2021 Sep;69(9):2455-2463. doi: 10.1111/jgs.17301. Epub 2021 Jun 19. PubMed PMID:
34145908.
Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors.
Sci Rep.
2021 Aug 19;11(1):16916. doi: 10.1038/s41598-021-96419-z. PubMed PMID:
34413391; PubMed Central PMCID:
PMC8376922.
Swimming exercise reduces native ⍺-synuclein protein species in a transgenic C. elegans model of Parkinson's disease.
MicroPubl Biol.
2021 Jun 29;2021. doi: 10.17912/micropub.biology.000413. PubMed PMID:
34222835; PubMed Central PMCID:
PMC8243224.
Career Retrospective: Tom Johnson-Genetics, Genomics, Stress, Stochastic Variation, and Aging.
J Gerontol A Biol Sci Med Sci.
2021 Jun 14;76(7):e85-e91. doi: 10.1093/gerona/glab050. PubMed PMID:
33609361; PubMed Central PMCID:
PMC8600024.
Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs.
JBMR Plus.
2021 Mar;5(3):e10466. doi: 10.1002/jbm4.10466. eCollection 2021 Mar. PubMed PMID:
33778327; PubMed Central PMCID:
PMC7990142.
Quantitative Proteomic Analysis of the Senescence-Associated Secretory Phenotype by Data-Independent Acquisition.
Curr Protoc.
2021 Feb;1(2):e32. doi: 10.1002/cpz1.32. PubMed PMID:
33524224; PubMed Central PMCID:
PMC7898702.
A simplified design for the C. elegans lifespan machine.
J Biol Methods.
2020;7(4):e137. doi: 10.14440/jbm.2020.332. eCollection 2020. PubMed PMID:
33204740; PubMed Central PMCID:
PMC7666331.
Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction.
Nat Commun.
2020 Sep 25;11(1):4865. doi: 10.1038/s41467-020-18690-4. PubMed PMID:
32978396; PubMed Central PMCID:
PMC7519657.
Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice.
Cell Metab.
2020 Sep 1;32(3):447-456.e6. doi: 10.1016/j.cmet.2020.08.004. PubMed PMID:
32877690; PubMed Central PMCID:
PMC8508957.
Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow.
J Vis Exp.
2020 Aug 7;(162). doi: 10.3791/61366. PubMed PMID:
32831297; PubMed Central PMCID:
PMC7519758.
Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function.
Neurobiol Dis.
2020 Jun;139:104786. doi: 10.1016/j.nbd.2020.104786. Epub 2020 Feb 5. PubMed PMID:
32032734; PubMed Central PMCID:
PMC7150649.
Caenorhabditis Intervention Testing Program: the farnesoid X receptor agonist obeticholic acid does not robustly extend lifespan in nematodes.
MicroPubl Biol.
2020 May 27;2020. doi: 10.17912/micropub.biology.000257. PubMed PMID:
32550518; PubMed Central PMCID:
PMC7253371.
Kavain suppresses human Aβ-induced paralysis in C. elegans.
MicroPubl Biol.
2020 May 21;2020. doi: 10.17912/micropub.biology.000254. PubMed PMID:
32550490; PubMed Central PMCID:
PMC7252289.
Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics.
J Proteome Res.
2020 Apr 3;19(4):1447-1458. doi: 10.1021/acs.jproteome.9b00640. Epub 2020 Mar 26. PubMed PMID:
31984744; PubMed Central PMCID:
PMC7127945.
Caenorhabditis Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes.
MicroPubl Biol.
2020;2020. doi: 10.17912/micropub.biology.000207. Epub 2020 Jan 2. PubMed PMID:
31998863; PubMed Central PMCID:
PMC6988715.
Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions.
Geroscience.
2019 Dec;41(6):945-960. doi: 10.1007/s11357-019-00108-9. Epub 2019 Dec 10. PubMed PMID:
31820364; PubMed Central PMCID:
PMC6925072.
From discoveries in ageing research to therapeutics for healthy ageing.
Nature.
2019 Jul;571(7764):183-192. doi: 10.1038/s41586-019-1365-2. Epub 2019 Jul 10. Review. PubMed PMID:
31292558; PubMed Central PMCID:
PMC7205183.
Caenorhabditis Intervention Testing Program: the tyrosine kinase inhibitor imatinib mesylate does not extend lifespan in nematodes.
MicroPubl Biol.
2019;2019. doi: 10.17912/micropub.biology.000131. Epub 2019 Jul 3. PubMed PMID:
32010883; PubMed Central PMCID:
PMC6993932.
Drugs that target aging: how do we discover them?.
Expert Opin Drug Discov.
2019 Jun;14(6):541-548. doi: 10.1080/17460441.2019.1597049. Epub 2019 Apr 11. Review. PubMed PMID:
30973028; PubMed Central PMCID:
PMC6497572.
Acarbose improves health and lifespan in aging HET3 mice.
Aging Cell.
2019 Apr;18(2):e12898. doi: 10.1111/acel.12898. Epub 2019 Jan 27. PubMed PMID:
30688027; PubMed Central PMCID:
PMC6413665.
Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation.
G3 (Bethesda).
2018 Nov 6;8(11):3421-3431. doi: 10.1534/g3.118.200289. PubMed PMID:
30194090; PubMed Central PMCID:
PMC6222566.
A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans.
J Vis Exp.
2018 Mar 20;(133). doi: 10.3791/56892. PubMed PMID:
29630057; PubMed Central PMCID:
PMC5933220.
A long journey to reproducible results.
Nature.
2017 Aug 22;548(7668):387-388. doi: 10.1038/548387a. PubMed PMID:
28836615; PubMed Central PMCID:
PMC5762131.
Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease.
Mediators Inflamm.
2017;2017:8302636. doi: 10.1155/2017/8302636. Epub 2017 Apr 4. PubMed PMID:
28473732; PubMed Central PMCID:
PMC5394397.
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects.
Nat Commun.
2017 Feb 21;8:14256. doi: 10.1038/ncomms14256. PubMed PMID:
28220799; PubMed Central PMCID:
PMC5321775.
Standardized Protocols from the Caenorhabditis Intervention Testing Program 2013-2016: Conditions and Assays used for Quantifying the Development, Fertility and Lifespan of Hermaphroditic Caenorhabditis Strains. [Internet]. London: Nature Protocols Exchange; 2017 February. Available from: https://www.nature.com/protocolexchange/protocols/5341. DOI: 10.1038/protex.2016.086.
A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification.
Curr Biol.
2016 Nov 21;26(22):3014-3025. doi: 10.1016/j.cub.2016.09.024. Epub 2016 Oct 20. PubMed PMID:
27773573; PubMed Central PMCID:
PMC5135008.
Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.
Cell Rep.
2016 Oct 25;17(5):1227-1237. doi: 10.1016/j.celrep.2016.09.086. PubMed PMID:
27783938; PubMed Central PMCID:
PMC5689451.
Chemical activation of a food deprivation signal extends lifespan.
Aging Cell.
2016 Oct;15(5):832-41. doi: 10.1111/acel.12492. Epub 2016 May 24. PubMed PMID:
27220516; PubMed Central PMCID:
PMC5013014.
Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans.
PLoS One.
2016;11(4):e0153513. doi: 10.1371/journal.pone.0153513. eCollection 2016. PubMed PMID:
27078872; PubMed Central PMCID:
PMC4831763.
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity.
Aging Cell.
2016 Apr;15(2):196-207. doi: 10.1111/acel.12427. Epub 2015 Dec 8. Review. PubMed PMID:
26643314; PubMed Central PMCID:
PMC4783344.
Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin.
J Neurosci.
2015 Sep 16;35(37):12833-44. doi: 10.1523/JNEUROSCI.0109-15.2015. PubMed PMID:
26377470; PubMed Central PMCID:
PMC4571606.
Geroscience: linking aging to chronic disease.
Cell.
2014 Nov 6;159(4):709-13. doi: 10.1016/j.cell.2014.10.039. PubMed PMID:
25417146; PubMed Central PMCID:
PMC4852871.
Iron promotes protein insolubility and aging in C. elegans.
Aging (Albany NY).
2014 Nov;6(11):975-91. doi: 10.18632/aging.100689. PubMed PMID:
25554795; PubMed Central PMCID:
PMC4276790.
Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans.
Metallomics.
2014 Oct;6(10):1816-23. doi: 10.1039/c4mt00168k. Epub 2014 Jul 24. PubMed PMID:
25057947; PubMed Central PMCID:
PMC4309368.
Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity.
J Gerontol A Biol Sci Med Sci.
2014 Jun;69 Suppl 1:S10-6. doi: 10.1093/gerona/glu055. Review. PubMed PMID:
24833580; PubMed Central PMCID:
PMC4022128.
Loss of NDG-4 extends lifespan and stress resistance in Caenorhabditis elegans.
Aging Cell.
2014 Feb;13(1):156-64. doi: 10.1111/acel.12165. Epub 2013 Nov 28. PubMed PMID:
24286221; PubMed Central PMCID:
PMC3919970.
A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans.
Aging (Albany NY).
2013 Oct;5(10):759-69. doi: 10.18632/aging.100605. PubMed PMID:
24123581; PubMed Central PMCID:
PMC3838778.
Age-related micro-RNA abundance in individual C. elegans.
Aging (Albany NY).
2013 Jun;5(6):394-411. doi: 10.18632/aging.100564. PubMed PMID:
23793570; PubMed Central PMCID:
PMC3824409.
Dimethyl sulfoxide and dimethyl formamide increase lifespan of C. elegans in liquid.
Mech Ageing Dev.
2013 Mar;134(3-4):69-78. doi: 10.1016/j.mad.2012.10.002. Epub 2013 Jan 11. PubMed PMID:
23313473.
What would you like to do?