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Banse SA, Sedore CA, Johnson E, Coleman-Hulbert AL, Onken B, Hall D, Jackson EG, Huynh P, Foulger AC, Guo S, Garrett T, Xue J, Inman D, Morshead ML, Plummer WT, Chen E, Bhaumik D, Chen MK, Harinath G, Chamoli M, Quinn RP, Falkowski R, Edgar D, Schmidt MO, Lucanic M, Guo M, Driscoll M, Lithgow GJ, Phillips PC. Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain-specific lifespan and health effects in Caenorhabditis nematodes. Geroscience. 2024 Apr;46(2):2239-2251. doi: 10.1007/s11357-023-00978-0. Epub 2023 Nov 4. PubMed PMID: 37923874; PubMed Central PMCID: PMC10828308.
Chamoli M, Rane A, Foulger A, Chinta SJ, Shahmirzadi AA, Kumsta C, Nambiar DK, Hall D, Holcom A, Angeli S, Schmidt M, Pitteri S, Hansen M, Lithgow GJ, Andersen JK. A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan. Nat Aging. 2023 Dec;3(12):1529-1543. doi: 10.1038/s43587-023-00524-9. Epub 2023 Nov 13. PubMed PMID: 37957360; PubMed Central PMCID: PMC10797806.
Miller B, Kim SJ, Mehta HH, Cao K, Kumagai H, Thumaty N, Leelaprachakul N, Braniff RG, Jiao H, Vaughan J, Diedrich J, Saghatelian A, Arpawong TE, Crimmins EM, Ertekin-Taner N, Tubi MA, Hare ET, Braskie MN, Décarie-Spain L, Kanoski SE, Grodstein F, Bennett DA, Zhao L, Toga AW, Wan J, Yen K, Cohen P. Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE. Mol Psychiatry. 2023 Apr;28(4):1813-1826. doi: 10.1038/s41380-022-01769-3. Epub 2022 Sep 21. PubMed PMID: 36127429; PubMed Central PMCID: PMC10027624.
Arputhasamy C, Foulger AC, Lucanic M, Rane A, Schmidt M, Garrett T, Broussalian M, Battistoni E, Brem RB, Lithgow GJ, Chamoli M, Andersen JK. Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity. Geroscience. 2023 Apr;45(2):1237-1245. doi: 10.1007/s11357-022-00647-8. Epub 2022 Aug 26. PubMed PMID: 36018536; PubMed Central PMCID: PMC9886731.
Ballesteros-Álvarez J, Nguyen W, Sivapatham R, Rane A, Andersen JK. Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer's disease. Geroscience. 2023 Apr;45(2):1095-1113. doi: 10.1007/s11357-022-00708-y. Epub 2022 Dec 28. PubMed PMID: 36576642; PubMed Central PMCID: PMC9886708.
Kumagai H, Miller B, Kim SJ, Leelaprachakul N, Kikuchi N, Yen K, Cohen P. Novel Insights into Mitochondrial DNA: Mitochondrial Microproteins and mtDNA Variants Modulate Athletic Performance and Age-Related Diseases. Genes (Basel). 2023 Jan 21;14(2). doi: 10.3390/genes14020286. Review. PubMed PMID: 36833212; PubMed Central PMCID: PMC9956216.
Lee M, Du H, Winer DA, Clemente-Casares X, Tsai S. Mechanosensing in macrophages and dendritic cells in steady-state and disease. Front Cell Dev Biol. 2022;10:1044729. doi: 10.3389/fcell.2022.1044729. eCollection 2022. Review. PubMed PMID: 36467420; PubMed Central PMCID: PMC9712790.
Yerevanian A, Murphy LM, Emans S, Zhou Y, Ahsan FM, Baker D, Li S, Adedoja A, Cedillo L, Stuhr NL, Gnanatheepam E, Dao K, Jain M, Curran SP, Georgakoudi I, Soukas AA. Riboflavin depletion promotes longevity and metabolic hormesis in Caenorhabditis elegans. Aging Cell. 2022 Nov;21(11):e13718. doi: 10.1111/acel.13718. Epub 2022 Sep 30. PubMed PMID: 36181246; PubMed Central PMCID: PMC9649603.
Yap KN, Wong HS, Ramanathan C, Rodriguez-Wagner CA, Roberts MD, Freeman DA, Buffenstein R, Zhang Y. Naked mole-rat and Damaraland mole-rat exhibit lower respiration in mitochondria, cellular and organismal levels. Biochim Biophys Acta Bioenerg. 2022 Oct 1;1863(7):148582. doi: 10.1016/j.bbabio.2022.148582. Epub 2022 Jun 3. PubMed PMID: 35667393; PubMed Central PMCID: PMC10316699.
Wong HS, Freeman DA, Zhang Y. Not just a cousin of the naked mole-rat: Damaraland mole-rats offer unique insights into biomedicine. Comp Biochem Physiol B Biochem Mol Biol. 2022 Oct-Dec;262:110772. doi: 10.1016/j.cbpb.2022.110772. Epub 2022 Jun 13. Review. PubMed PMID: 35710053; PubMed Central PMCID: PMC10155858.
Begelman DV, Woods G, Bhaumik D, Angeli S, Foulger AC, Lucanic M, Lan J, Andersen JK, Lithgow GJ. An aco-2::gfp knock-in enables the monitoring of mitochondrial morphology throughout C. elegans lifespan. MicroPubl Biol. 2022;2022. doi: 10.17912/micropub.biology.000599. eCollection 2022. PubMed PMID: 35903774; PubMed Central PMCID: PMC9315405.
Lee M, Chu K, Chakraborty M, Kotoulas N, Akbari M, Goh C, Clemente-Casares X, Winer DA, Shrestha A, Tsai S. PDMS hydrogel-coated tissue culture plates for studying the impact of substrate stiffness on dendritic cell function. STAR Protoc. 2022 Jun 17;3(2):101233. doi: 10.1016/j.xpro.2022.101233. eCollection 2022 Jun 17. PubMed PMID: 35313712; PubMed Central PMCID: PMC8933837.
Nashine S, Cohen P, Wan J, Kenney MC. Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD). Aging (Albany NY). 2022 May 16;14(10):4247-4269. doi: 10.18632/aging.204074. Epub 2022 May 16. PubMed PMID: 35576057; PubMed Central PMCID: PMC9186758.
Miller B, Kim SJ, Kumagai H, Yen K, Cohen P. Mitochondria-derived peptides in aging and healthspan. J Clin Invest. 2022 May 2;132(9). doi: 10.1172/JCI158449. Review. PubMed PMID: 35499074; PubMed Central PMCID: PMC9057581.
Villa O, Stuhr NL, Yen CA, Crimmins EM, Arpawong TE, Curran SP. Genetic variation in ALDH4A1 is associated with muscle health over the lifespan and across species. Elife. 2022 Apr 26;11. doi: 10.7554/eLife.74308. PubMed PMID: 35470798; PubMed Central PMCID: PMC9106327.
Raffaele M, Kovacovicova K, Biagini T, Lo Re O, Frohlich J, Giallongo S, Nhan JD, Giannone AG, Cabibi D, Ivanov M, Tonchev AB, Mistrik M, Lacey M, Dzubak P, Gurska S, Hajduch M, Bartek J, Mazza T, Micale V, Curran SP, Vinciguerra M. Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects. Geroscience. 2022 Feb;44(1):463-483. doi: 10.1007/s11357-021-00487-y. Epub 2021 Nov 24. PubMed PMID: 34820764; PubMed Central PMCID: PMC8612119.
Teterina AA, Coleman-Hulbert AL, Banse SA, Willis JH, Perez VI, Lithgow GJ, Driscoll M, Phillips PC. Genetic diversity estimates for the Caenorhabditis Intervention Testing Program screening panel. MicroPubl Biol. 2022;2022. doi: 10.17912/micropub.biology.000518. eCollection 2022. PubMed PMID: 35098051; PubMed Central PMCID: PMC8796004.
Onken B, Sedore CA, Coleman-Hulbert AL, Hall D, Johnson E, Jones EG, Banse SA, Huynh P, Guo S, Xue J, Chen E, Harinath G, Foulger AC, Chao EA, Hope J, Bhaumik D, Plummer T, Inman D, Morshead M, Guo M, Lithgow GJ, Phillips PC, Driscoll M. Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes. Aging Cell. 2022 Jan;21(1):e13488. doi: 10.1111/acel.13488. Epub 2021 Nov 27. PubMed PMID: 34837316; PubMed Central PMCID: PMC8761014.
DeVito LM, Barzilai N, Cuervo AM, Niedernhofer LJ, Milman S, Levine M, Promislow D, Ferrucci L, Kuchel GA, Mannick J, Justice J, Gonzales MM, Kirkland JL, Cohen P, Campisi J. Extending human healthspan and longevity: a symposium report. Ann N Y Acad Sci. 2022 Jan;1507(1):70-83. doi: 10.1111/nyas.14681. Epub 2021 Sep 8. Review. PubMed PMID: 34498278; PubMed Central PMCID: PMC10231756.
Curran SP, Lithgow GJ, Verdin E, P C. University of Southern California and buck institute nathan shock center: multidimensional models of aging. Geroscience. 2021 Oct;43(5):2119-2127. doi: 10.1007/s11357-021-00416-z. Epub 2021 Jul 16. PubMed PMID: 34269983; PubMed Central PMCID: PMC8599784.
Osman HC, Sedore CA, Jackson EG, Battistoni ET, Hall D, Foulger A, Lucanic M, Guo M, Driscoll M, Phillips P, Lithgow GJ. Caenorhabditis Intervention Testing Program: the herbicide diuron does not robustly extend lifespan in nematodes. MicroPubl Biol. 2021;2021. doi: 10.17912/micropub.biology.000448. eCollection 2021. PubMed PMID: 34585102; PubMed Central PMCID: PMC8461457.
Sierra F, Caspi A, Fortinsky RH, Haynes L, Lithgow GJ, Moffitt TE, Olshansky SJ, Perry D, Verdin E, Kuchel GA. Moving geroscience from the bench to clinical care and health policy. J Am Geriatr Soc. 2021 Sep;69(9):2455-2463. doi: 10.1111/jgs.17301. Epub 2021 Jun 19. PubMed PMID: 34145908; PubMed Central PMCID: PMC10202082.
Dieli-Conwright CM, Sami N, Norris MK, Wan J, Kumagai H, Kim SJ, Cohen P. Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors. Sci Rep. 2021 Aug 19;11(1):16916. doi: 10.1038/s41598-021-96419-z. PubMed PMID: 34413391; PubMed Central PMCID: PMC8376922.
Schmidt MY, Chamoli M, Lithgow GJ, Andersen JK. Swimming exercise reduces native ⍺-synuclein protein species in a transgenic C. elegans model of Parkinson's disease. MicroPubl Biol. 2021 Jun 29;2021. doi: 10.17912/micropub.biology.000413. PubMed PMID: 34222835; PubMed Central PMCID: PMC8243224.
Mendenhall AR, Lithgow GJ, Kim S, Friedman D, Newell-Stamper BL, Johnson TE. Career Retrospective: Tom Johnson-Genetics, Genomics, Stress, Stochastic Variation, and Aging. J Gerontol A Biol Sci Med Sci. 2021 Jun 14;76(7):e85-e91. doi: 10.1093/gerona/glab050. PubMed PMID: 33609361; PubMed Central PMCID: PMC8600024.
Evans DS, O'Leary MN, Murphy R, Schmidt M, Koenig K, Presley M, Garrett B, Kim HN, Han L, Academia EC, Laye MJ, Edgar D, Zambataro CA, Barhydt T, Dewey CM, Mayfield J, Wilson J, Alavez S, Lucanic M, Kennedy BK, Almeida M, Andersen JK, Kapahi P, Lithgow GJ, Melov S. Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs. JBMR Plus. 2021 Mar;5(3):e10466. doi: 10.1002/jbm4.10466. eCollection 2021 Mar. PubMed PMID: 33778327; PubMed Central PMCID: PMC7990142.
Neri F, Basisty N, Desprez PY, Campisi J, Schilling B. Quantitative Proteomic Analysis of the Senescence-Associated Secretory Phenotype by Data-Independent Acquisition. Curr Protoc. 2021 Feb;1(2):e32. doi: 10.1002/cpz1.32. PubMed PMID: 33524224; PubMed Central PMCID: PMC7898702.
Abbott M, Banse SA, Melentijevic I, Jarrett CM, Ange JS, Sedore CA, Falkowski R, Blue BW, Coleman-Hulbert AL, Johnson E, Guo M, Lithgow GJ, Phillips PC, Driscoll M. A simplified design for the C. elegans lifespan machine. J Biol Methods. 2020;7(4):e137. doi: 10.14440/jbm.2020.332. eCollection 2020. PubMed PMID: 33204740; PubMed Central PMCID: PMC7666331.
Chamoli M, Goyala A, Tabrez SS, Siddiqui AA, Singh A, Antebi A, Lithgow GJ, Watts JL, Mukhopadhyay A. Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction. Nat Commun. 2020 Sep 25;11(1):4865. doi: 10.1038/s41467-020-18690-4. PubMed PMID: 32978396; PubMed Central PMCID: PMC7519657.
Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metab. 2020 Sep 1;32(3):447-456.e6. doi: 10.1016/j.cmet.2020.08.004. PubMed PMID: 32877690; PubMed Central PMCID: PMC8508957.
Xie X, Chamoli M, Bhaumik D, Sivapatham R, Angeli S, Andersen JK, Lithgow GJ, Schilling B. Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow. J Vis Exp. 2020 Aug 7;(162). doi: 10.3791/61366. PubMed PMID: 32831297; PubMed Central PMCID: PMC7519758.
Anand N, Holcom A, Broussalian M, Schmidt M, Chinta SJ, Lithgow GJ, Andersen JK, Chamoli M. Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function. Neurobiol Dis. 2020 Jun;139:104786. doi: 10.1016/j.nbd.2020.104786. Epub 2020 Feb 5. PubMed PMID: 32032734; PubMed Central PMCID: PMC7150649.
Morshead ML, Sedore CA, Jones EG, Hall D, Plummer WT, Garrett T, Lucanic M, Guo M, Driscoll M, Phillips PC, Lithgow G. Caenorhabditis Intervention Testing Program: the farnesoid X receptor agonist obeticholic acid does not robustly extend lifespan in nematodes. MicroPubl Biol. 2020 May 27;2020. doi: 10.17912/micropub.biology.000257. PubMed PMID: 32550518; PubMed Central PMCID: PMC7253371.
Chamoli M, Chinta SJ, Andersen JK, Lithgow GJ. Kavain suppresses human Aβ-induced paralysis in C. elegans. MicroPubl Biol. 2020 May 21;2020. doi: 10.17912/micropub.biology.000254. PubMed PMID: 32550490; PubMed Central PMCID: PMC7252289.
Adams KJ, Pratt B, Bose N, Dubois LG, St John-Williams L, Perrott KM, Ky K, Kapahi P, Sharma V, MacCoss MJ, Moseley MA, Colton CA, MacLean BX, Schilling B, Thompson JW. Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics. J Proteome Res. 2020 Apr 3;19(4):1447-1458. doi: 10.1021/acs.jproteome.9b00640. Epub 2020 Mar 26. PubMed PMID: 31984744; PubMed Central PMCID: PMC7127945.
Coleman-Hulbert AL, Johnson E, Sedore CA, Banse SA, Guo M, Driscoll M, Lithgow GJ, Phillips PC. Caenorhabditis Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes. MicroPubl Biol. 2020;2020. doi: 10.17912/micropub.biology.000207. Epub 2020 Jan 2. PubMed PMID: 31998863; PubMed Central PMCID: PMC6988715.
Banse SA, Lucanic M, Sedore CA, Coleman-Hulbert AL, Plummer WT, Chen E, Kish JL, Hall D, Onken B, Presley MP, Jones EG, Blue BW, Garrett T, Abbott M, Xue J, Guo S, Johnson E, Foulger AC, Chamoli M, Falkowski R, Melentijevic I, Harinath G, Huynh P, Patel S, Edgar D, Jarrett CM, Guo M, Kapahi P, Lithgow GJ, Driscoll M, Phillips PC. Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions. Geroscience. 2019 Dec;41(6):945-960. doi: 10.1007/s11357-019-00108-9. Epub 2019 Dec 10. PubMed PMID: 31820364; PubMed Central PMCID: PMC6925072.
Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. From discoveries in ageing research to therapeutics for healthy ageing. Nature. 2019 Jul;571(7764):183-192. doi: 10.1038/s41586-019-1365-2. Epub 2019 Jul 10. Review. PubMed PMID: 31292558; PubMed Central PMCID: PMC7205183.
Coleman-Hulbert AL, Johnson E, Sedore CA, Banse SA, Guo M, Driscoll M, Lithgow GJ, Phillips PC. Caenorhabditis Intervention Testing Program: the tyrosine kinase inhibitor imatinib mesylate does not extend lifespan in nematodes. MicroPubl Biol. 2019;2019. doi: 10.17912/micropub.biology.000131. Epub 2019 Jul 3. PubMed PMID: 32010883; PubMed Central PMCID: PMC6993932.
Myers A, Lithgow GJ. Drugs that target aging: how do we discover them?. Expert Opin Drug Discov. 2019 Jun;14(6):541-548. doi: 10.1080/17460441.2019.1597049. Epub 2019 Apr 11. Review. PubMed PMID: 30973028; PubMed Central PMCID: PMC6497572.
Harrison DE, Strong R, Alavez S, Astle CM, DiGiovanni J, Fernandez E, Flurkey K, Garratt M, Gelfond JAL, Javors MA, Levi M, Lithgow GJ, Macchiarini F, Nelson JF, Sukoff Rizzo SJ, Slaga TJ, Stearns T, Wilkinson JE, Miller RA. Acarbose improves health and lifespan in aging HET3 mice. Aging Cell. 2019 Apr;18(2):e12898. doi: 10.1111/acel.12898. Epub 2019 Jan 27. PubMed PMID: 30688027; PubMed Central PMCID: PMC6413665.
Peters TW, Nelson CS, Gerencser AA, Dumas KJ, Tavshanjian B, Chang KC, Lithgow GJ, Hughes RE. Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation. G3 (Bethesda). 2018 Nov 6;8(11):3421-3431. doi: 10.1534/g3.118.200289. PubMed PMID: 30194090; PubMed Central PMCID: PMC6222566.
Lucanic M, Garrett T, Gill MS, Lithgow GJ. A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans. J Vis Exp. 2018 Mar 20;(133). doi: 10.3791/56892. PubMed PMID: 29630057; PubMed Central PMCID: PMC5933220.
Lithgow GJ, Driscoll M, Phillips P. A long journey to reproducible results. Nature. 2017 Aug 22;548(7668):387-388. doi: 10.1038/548387a. PubMed PMID: 28836615; PubMed Central PMCID: PMC5762131.
Leonoudakis D, Rane A, Angeli S, Lithgow GJ, Andersen JK, Chinta SJ. Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease. Mediators Inflamm. 2017;2017:8302636. doi: 10.1155/2017/8302636. Epub 2017 Apr 4. PubMed PMID: 28473732; PubMed Central PMCID: PMC5394397.
Lucanic M, Plummer WT, Chen E, Harke J, Foulger AC, Onken B, Coleman-Hulbert AL, Dumas KJ, Guo S, Johnson E, Bhaumik D, Xue J, Crist AB, Presley MP, Harinath G, Sedore CA, Chamoli M, Kamat S, Chen MK, Angeli S, Chang C, Willis JH, Edgar D, Royal MA, Chao EA, Patel S, Garrett T, Ibanez-Ventoso C, Hope J, Kish JL, Guo M, Lithgow GJ, Driscoll M, Phillips PC. Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects. Nat Commun. 2017 Feb 21;8:14256. doi: 10.1038/ncomms14256. PubMed PMID: 28220799; PubMed Central PMCID: PMC5321775.
Plummer WT, Harke J, Lucanic M, Chen E, Bhaumik D, Harinath G, Coleman-Hulbert A, Dumas K, Onken B, Johnson E, Foulger A, Guo S, Crist A, Presley M, Xue J, Sedore C, Chamoli M, Chang C, Chen M, Angeli S, Royal MA, Willis J, Edgar D, Patel S, Chao E, Kamat S, Hope J, Ibanez-Ventoso C, Kish J, Guo M, Phillips P, Lithgow G, Driscoll M. Standardized Protocols from the Caenorhabditis Intervention Testing Program 2013-2016: Conditions and Assays used for Quantifying the Development, Fertility and Lifespan of Hermaphroditic Caenorhabditis Strains. [Internet]. London: Nature Protocols Exchange; 2017 February. Available from: https://www.nature.com/protocolexchange/protocols/5341. DOI: 10.1038/protex.2016.086.
Chaudhuri J, Bose N, Gong J, Hall D, Rifkind A, Bhaumik D, Peiris TH, Chamoli M, Le CH, Liu J, Lithgow GJ, Ramanathan A, Xu XZS, Kapahi P. A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification. Curr Biol. 2016 Nov 21;26(22):3014-3025. doi: 10.1016/j.cub.2016.09.024. Epub 2016 Oct 20. PubMed PMID: 27773573; PubMed Central PMCID: PMC5135008.
Mark KA, Dumas KJ, Bhaumik D, Schilling B, Davis S, Oron TR, Sorensen DJ, Lucanic M, Brem RB, Melov S, Ramanathan A, Gibson BW, Lithgow GJ. Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1. Cell Rep. 2016 Oct 25;17(5):1227-1237. doi: 10.1016/j.celrep.2016.09.086. PubMed PMID: 27783938; PubMed Central PMCID: PMC5689451.
Lucanic M, Garrett T, Yu I, Calahorro F, Asadi Shahmirzadi A, Miller A, Gill MS, Hughes RE, Holden-Dye L, Lithgow GJ. Chemical activation of a food deprivation signal extends lifespan. Aging Cell. 2016 Oct;15(5):832-41. doi: 10.1111/acel.12492. Epub 2016 May 24. PubMed PMID: 27220516; PubMed Central PMCID: PMC5013014.
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