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  1. Myers A, Lithgow GJ. Drugs that target aging: how do we discover them?. Expert Opin Drug Discov. 2019 Jun;14(6):541-548. doi: 10.1080/17460441.2019.1597049. Epub 2019 Apr 11. PubMed PMID: 30973028; PubMed Central PMCID: PMC6497572.
  2. Peters TW, Nelson CS, Gerencser AA, Dumas KJ, Tavshanjian B, Chang KC, Lithgow GJ, Hughes RE. Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation. G3 (Bethesda). 2018 Nov 6;8(11):3421-3431. doi: 10.1534/g3.118.200289. PubMed PMID: 30194090; PubMed Central PMCID: PMC6222566.
  3. Lucanic M, Garrett T, Gill MS, Lithgow GJ. A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans. J Vis Exp. 2018 Mar 20;(133). doi: 10.3791/56892. PubMed PMID: 29630057; PubMed Central PMCID: PMC5933220.
  4. Lithgow GJ, Driscoll M, Phillips P. A long journey to reproducible results. Nature. 2017 Aug 22;548(7668):387-388. doi: 10.1038/548387a. PubMed PMID: 28836615; PubMed Central PMCID: PMC5762131.
  5. Leonoudakis D, Rane A, Angeli S, Lithgow GJ, Andersen JK, Chinta SJ. Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease. Mediators Inflamm. 2017;2017:8302636. doi: 10.1155/2017/8302636. Epub 2017 Apr 4. PubMed PMID: 28473732; PubMed Central PMCID: PMC5394397.
  6. Lucanic M, Plummer WT, Chen E, Harke J, Foulger AC, Onken B, Coleman-Hulbert AL, Dumas KJ, Guo S, Johnson E, Bhaumik D, Xue J, Crist AB, Presley MP, Harinath G, Sedore CA, Chamoli M, Kamat S, Chen MK, Angeli S, Chang C, Willis JH, Edgar D, Royal MA, Chao EA, Patel S, Garrett T, Ibanez-Ventoso C, Hope J, Kish JL, Guo M, Lithgow GJ, Driscoll M, Phillips PC. Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects. Nat Commun. 2017 Feb 21;8:14256. doi: 10.1038/ncomms14256. PubMed PMID: 28220799; PubMed Central PMCID: PMC5321775.
  7. Plummer WT, Harke J, Lucanic M, Chen E, Bhaumik D, Harinath G, Coleman-Hulbert A, Dumas K, Onken B, Johnson E, Foulger A, Guo S, Crist A, Presley M, Xue J, Sedore C, Chamoli M, Chang C, Chen M, Angeli S, Royal MA, Willis J, Edgar D, Patel S, Chao E, Kamat S, Hope J, Ibanez-Ventoso C, Kish J, Guo M, Phillips P, Lithgow G, Driscoll M. Standardized Protocols from the Caenorhabditis Intervention Testing Program 2013-2016: Conditions and Assays used for Quantifying the Development, Fertility and Lifespan of Hermaphroditic Caenorhabditis Strains. [Internet]. London: Nature Protocols Exchange; 2017 February. Available from: https://www.nature.com/protocolexchange/protocols/5341. DOI: 10.1038/protex.2016.086.
  8. Chaudhuri J, Bose N, Gong J, Hall D, Rifkind A, Bhaumik D, Peiris TH, Chamoli M, Le CH, Liu J, Lithgow GJ, Ramanathan A, Xu XZS, Kapahi P. A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification. Curr Biol. 2016 Nov 21;26(22):3014-3025. doi: 10.1016/j.cub.2016.09.024. Epub 2016 Oct 20. PubMed PMID: 27773573; PubMed Central PMCID: PMC5135008.
  9. Mark KA, Dumas KJ, Bhaumik D, Schilling B, Davis S, Oron TR, Sorensen DJ, Lucanic M, Brem RB, Melov S, Ramanathan A, Gibson BW, Lithgow GJ. Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1. Cell Rep. 2016 Oct 25;17(5):1227-1237. doi: 10.1016/j.celrep.2016.09.086. PubMed PMID: 27783938; PubMed Central PMCID: PMC5689451.
  10. Lucanic M, Garrett T, Yu I, Calahorro F, Asadi Shahmirzadi A, Miller A, Gill MS, Hughes RE, Holden-Dye L, Lithgow GJ. Chemical activation of a food deprivation signal extends lifespan. Aging Cell. 2016 Oct;15(5):832-41. doi: 10.1111/acel.12492. Epub 2016 May 24. PubMed PMID: 27220516; PubMed Central PMCID: PMC5013014.
  11. Kumar J, Barhydt T, Awasthi A, Lithgow GJ, Killilea DW, Kapahi P. Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans. PLoS One. 2016;11(4):e0153513. doi: 10.1371/journal.pone.0153513. eCollection 2016. PubMed PMID: 27078872; PubMed Central PMCID: PMC4831763.
  12. Martins R, Lithgow GJ, Link W. Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell. 2016 Apr;15(2):196-207. doi: 10.1111/acel.12427. Epub 2015 Dec 8. Review. PubMed PMID: 26643314; PubMed Central PMCID: PMC4783344.
  13. Siddiqui A, Bhaumik D, Chinta SJ, Rane A, Rajagopalan S, Lieu CA, Lithgow GJ, Andersen JK. Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin. J Neurosci. 2015 Sep 16;35(37):12833-44. doi: 10.1523/JNEUROSCI.0109-15.2015. PubMed PMID: 26377470; PubMed Central PMCID: PMC4571606.
  14. Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F. Geroscience: linking aging to chronic disease. Cell. 2014 Nov 6;159(4):709-13. doi: 10.1016/j.cell.2014.10.039. PubMed PMID: 25417146; PubMed Central PMCID: PMC4852871.
  15. Klang IM, Schilling B, Sorensen DJ, Sahu AK, Kapahi P, Andersen JK, Swoboda P, Killilea DW, Gibson BW, Lithgow GJ. Iron promotes protein insolubility and aging in C. elegans. Aging (Albany NY). 2014 Nov;6(11):975-91. doi: 10.18632/aging.100689. PubMed PMID: 25554795; PubMed Central PMCID: PMC4276790.
  16. Angeli S, Barhydt T, Jacobs R, Killilea DW, Lithgow GJ, Andersen JK. Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans. Metallomics. 2014 Oct;6(10):1816-23. doi: 10.1039/c4mt00168k. Epub 2014 Jul 24. PubMed PMID: 25057947; PubMed Central PMCID: PMC4309368.
  17. Epel ES, Lithgow GJ. Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity. J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S10-6. doi: 10.1093/gerona/glu055. Review. PubMed PMID: 24833580; PubMed Central PMCID: PMC4022128.
  18. Brejning J, Nørgaard S, Schøler L, Morthorst TH, Jakobsen H, Lithgow GJ, Jensen LT, Olsen A. Loss of NDG-4 extends lifespan and stress resistance in Caenorhabditis elegans. Aging Cell. 2014 Feb;13(1):156-64. doi: 10.1111/acel.12165. Epub 2013 Nov 28. PubMed PMID: 24286221; PubMed Central PMCID: PMC3919970.
  19. Angeli S, Klang I, Sivapatham R, Mark K, Zucker D, Bhaumik D, Lithgow GJ, Andersen JK. A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans. Aging (Albany NY). 2013 Oct;5(10):759-69. doi: 10.18632/aging.100605. PubMed PMID: 24123581; PubMed Central PMCID: PMC3838778.
  20. Lucanic M, Graham J, Scott G, Bhaumik D, Benz CC, Hubbard A, Lithgow GJ, Melov S. Age-related micro-RNA abundance in individual C. elegans. Aging (Albany NY). 2013 Jun;5(6):394-411. doi: 10.18632/aging.100564. PubMed PMID: 23793570; PubMed Central PMCID: PMC3824409.
  21. Frankowski H, Alavez S, Spilman P, Mark KA, Nelson JD, Mollahan P, Rao RV, Chen SF, Lithgow GJ, Ellerby HM. Dimethyl sulfoxide and dimethyl formamide increase lifespan of C. elegans in liquid. Mech Ageing Dev. 2013 Mar;134(3-4):69-78. doi: 10.1016/j.mad.2012.10.002. Epub 2013 Jan 11. PubMed PMID: 23313473.
  22. Chinta SJ, Ganesan A, Reis-Rodrigues P, Lithgow GJ, Andersen JK. Anti-inflammatory role of the isoflavone diadzein in lipopolysaccharide-stimulated microglia: implications for Parkinson's disease. Neurotox Res. 2013 Feb;23(2):145-53. doi: 10.1007/s12640-012-9328-5. Epub 2012 May 10. PubMed PMID: 22573480; PubMed Central PMCID: PMC3597389.
  23. Monroy A, Lithgow GJ, Alavez S. Curcumin and neurodegenerative diseases. Biofactors. 2013 Jan-Feb;39(1):122-32. doi: 10.1002/biof.1063. Epub 2013 Jan 10. Review. PubMed PMID: 23303664; PubMed Central PMCID: PMC3578106.
  24. Lucanic M, Lithgow GJ, Alavez S. Pharmacological lifespan extension of invertebrates. Ageing Res Rev. 2013 Jan;12(1):445-58. doi: 10.1016/j.arr.2012.06.006. Epub 2012 Jul 6. Review. PubMed PMID: 22771382; PubMed Central PMCID: PMC3552093.
  25. Peters TW, Rardin MJ, Czerwieniec G, Evani US, Reis-Rodrigues P, Lithgow GJ, Mooney SD, Gibson BW, Hughes RE. Tor1 regulates protein solubility in Saccharomyces cerevisiae. Mol Biol Cell. 2012 Dec;23(24):4679-88. doi: 10.1091/mbc.E12-08-0620. Epub 2012 Oct 24. PubMed PMID: 23097491; PubMed Central PMCID: PMC3521677.
  26. Lithgow GJ, Lord JM, Kirkland JL. Translating longevity research into healthspan. Longev Healthspan. 2012;1:1. doi: 10.1186/2046-2395-1-1. eCollection 2012. PubMed PMID: 24764507; PubMed Central PMCID: PMC3886258.
  27. Page KE, White KN, McCrohan CR, Killilea DW, Lithgow GJ. Aluminium exposure disrupts elemental homeostasis in Caenorhabditis elegans. Metallomics. 2012 May;4(5):512-22. doi: 10.1039/c2mt00146b. Epub 2012 Apr 26. PubMed PMID: 22534883; PubMed Central PMCID: PMC3589999.
  28. Alavez S, Lithgow GJ. Pharmacological maintenance of protein homeostasis could postpone age-related disease. Aging Cell. 2012 Apr;11(2):187-91. doi: 10.1111/j.1474-9726.2012.00789.x. Epub 2012 Feb 1. PubMed PMID: 22226190; PubMed Central PMCID: PMC3306462.
  29. Reis-Rodrigues P, Czerwieniec G, Peters TW, Evani US, Alavez S, Gaman EA, Vantipalli M, Mooney SD, Gibson BW, Lithgow GJ, Hughes RE. Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan. Aging Cell. 2012 Feb;11(1):120-7. doi: 10.1111/j.1474-9726.2011.00765.x. Epub 2011 Dec 11. PubMed PMID: 22103665; PubMed Central PMCID: PMC3437485.
  30. Rogers AN, Chen D, McColl G, Czerwieniec G, Felkey K, Gibson BW, Hubbard A, Melov S, Lithgow GJ, Kapahi P. Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab. 2011 Jul 6;14(1):55-66. doi: 10.1016/j.cmet.2011.05.010. PubMed PMID: 21723504; PubMed Central PMCID: PMC3220185.
  31. Lucanic M, Held JM, Vantipalli MC, Klang IM, Graham JB, Gibson BW, Lithgow GJ, Gill MS. N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. Nature. 2011 May 12;473(7346):226-9. doi: 10.1038/nature10007. PubMed PMID: 21562563; PubMed Central PMCID: PMC3093655.
  32. Alavez S, Vantipalli MC, Zucker DJ, Klang IM, Lithgow GJ. Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan. Nature. 2011 Apr 14;472(7342):226-9. doi: 10.1038/nature09873. Epub 2011 Mar 30. PubMed PMID: 21451522; PubMed Central PMCID: PMC3610427.
  33. Alavez S, Lithgow GJ. A new look at old compounds. Aging (Albany NY). 2011 Apr;3(4):338-9. doi: 10.18632/aging.100317. PubMed PMID: 21512207; PubMed Central PMCID: PMC3117445.
  34. McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P, Lithgow GJ. Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metab. 2010 Sep 8;12(3):260-72. doi: 10.1016/j.cmet.2010.08.004. PubMed PMID: 20816092; PubMed Central PMCID: PMC2945254.
  35. Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, Rodier F, Lithgow GJ, Campisi J. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY). 2009 Apr;1(4):402-11. doi: 10.18632/aging.100042. PubMed PMID: 20148189; PubMed Central PMCID: PMC2818025.
  36. Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ. Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol. 2008 Oct;43(10):882-91. doi: 10.1016/j.exger.2008.08.049. Epub 2008 Sep 20. PubMed PMID: 18755260; PubMed Central PMCID: PMC2603168.
  37. Fisher AL, Page KE, Lithgow GJ, Nash L. The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia. J Biol Chem. 2008 Apr 4;283(14):9127-35. doi: 10.1074/jbc.M708341200. Epub 2008 Jan 28. PubMed PMID: 18227072; PubMed Central PMCID: PMC2431024.
  38. McColl G, Killilea DW, Hubbard AE, Vantipalli MC, Melov S, Lithgow GJ. Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem. 2008 Jan 4;283(1):350-7. doi: 10.1074/jbc.M705028200. Epub 2007 Oct 24. PubMed PMID: 17959600; PubMed Central PMCID: PMC2739662.
  39. Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ, Kapahi P. Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell. 2007 Feb;6(1):111-9. doi: 10.1111/j.1474-9726.2006.00266.x. PubMed PMID: 17266680; PubMed Central PMCID: PMC2745345.
  40. Lithgow GJ. Why aging isn't regulated: a lamentation on the use of language in aging literature. Exp Gerontol. 2006 Oct;41(10):890-3. doi: 10.1016/j.exger.2006.06.051. Epub 2006 Sep 7. Review. PubMed PMID: 16959457.
  41. Held JM, White MP, Fisher AL, Gibson BW, Lithgow GJ, Gill MS. DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid. Aging Cell. 2006 Aug;5(4):283-91. doi: 10.1111/j.1474-9726.2006.00218.x. PubMed PMID: 16913876.
  42. Olsen A, Vantipalli MC, Lithgow GJ. Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments. Biogerontology. 2006 Aug;7(4):221-30. doi: 10.1007/s10522-006-9018-x. Epub 2006 Jul 7. PubMed PMID: 16826446.
  43. Olsen A, Vantipalli MC, Lithgow GJ. Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans. Science. 2006 Jun 2;312(5778):1381-5. doi: 10.1126/science.1124981. PubMed PMID: 16741121; PubMed Central PMCID: PMC2568993.
  44. Olsen A, Vantipalli MC, Lithgow GJ. Using Caenorhabditis elegans as a model for aging and age-related diseases. Ann N Y Acad Sci. 2006 May;1067:120-8. doi: 10.1196/annals.1354.015. Review. PubMed PMID: 16803977.
  45. Lin YT, Hoang H, Hsieh SI, Rangel N, Foster AL, Sampayo JN, Lithgow GJ, Srinivasan C. Manganous ion supplementation accelerates wild type development, enhances stress resistance, and rescues the life span of a short-lived Caenorhabditis elegans mutant. Free Radic Biol Med. 2006 Apr 1;40(7):1185-93. doi: 10.1016/j.freeradbiomed.2005.11.007. Epub 2005 Dec 12. PubMed PMID: 16545686.
  46. Fisher AL, Lithgow GJ. The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms. Aging Cell. 2006 Apr;5(2):127-38. doi: 10.1111/j.1474-9726.2006.00203.x. PubMed PMID: 16626392.
  47. Lithgow GJ, Gill MS, Olsen A, Sampayo JN. Pharmacological intervention in invertebrate aging. Age (Dordr). 2005 Sep;27(3):213-23. doi: 10.1007/s11357-005-3625-3. Epub 2005 Dec 31. PubMed PMID: 23598654; PubMed Central PMCID: PMC3458493.
  48. Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BF, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T, Lithgow G, Martin G, Masoro E, Melov S, Miller RA, Olshansky SJ, Partridge L, Pereira-Smith O, Perls T, Richardson A, Smith J, von Zglinicki T, Wang E, Wei JY, Williams TF. Science fact and the SENS agenda. What can we reasonably expect from ageing research?. EMBO Rep. 2005 Nov;6(11):1006-8. doi: 10.1038/sj.embor.7400555. PubMed PMID: 16264422; PubMed Central PMCID: PMC1371037.
  49. McColl G, Vantipalli MC, Lithgow GJ. The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span. FASEB J. 2005 Oct;19(12):1716-8. doi: 10.1096/fj.04-2447fje. Epub 2005 Aug 12. PubMed PMID: 16099946; PubMed Central PMCID: PMC1400606.
  50. Jenkins NL, McColl G, Lithgow GJ. Fitness cost of extended lifespan in Caenorhabditis elegans. Proc Biol Sci. 2004 Dec 7;271(1556):2523-6. doi: 10.1098/rspb.2004.2897. PubMed PMID: 15590605; PubMed Central PMCID: PMC1440519.